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A decade without diagnosis: Sheehan’s syndrome

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Case Reports in Clinical Medicine 2013年第8期2卷 490-493页

作者： fábio A. Nascimento Juliane nery Gustavo Lenci Marques felipe Dunin dos Santos Mauricio de Carvalho Department of Internal Medicine Federal University of Paraná Curitiba Brazil faculty of Medicine Federal University of Paraná Curitiba Brazil

Sheehan’s Syndrome (SS) occurs as a result of ischemic pituitary necrosis due to severe post-partum hemorrhage. We report a 41-year-old woman with a history of severe postpartum hemorrhage 18 years prior to presentation. During this period of time, she experienced severe fatigue. Three months prior to being admitted to our hospital, the patient started to notice alopecia, generalized edema and cognitive impairment. After proper investigation, laboratory tests and clinical findings indicated panhypopituitarism. In addition to neuroimaging and past medical history, SS was diagnosed and treatment started. We emphasize the importance of thorough investigation, further diagnosis and management of this condition (especially in third world countries), since SS is a neurological and endocrinological emergency and potentially life threatening.

关键词： Sheehan’s Syndrome Pituitary Insufficiency Empty Sella

Classical olfactory conditioning promotes long-term memory and improves odor-cued flight orientation in the South American native bumblebee Bombus pauloensis

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Current Zoology 2021年第5期67卷 561-563页

作者： Denise nery florencia PALOTTINI Walter M.fARINA Laboratorio de Insectos Sociales Departamento de Biodiversidad y Biologia ExperimentalFacultad de Ciencias NaturalesUniversidad de Buenos AiresBuenos AiresArgentina Instituto de fisiologia Biologia Molecular y Neurociencias(IFIBYNE)CONICET-Universidad de Buenos AiresBuenos AiresArgentina

When collecting a flower,bumblebees learn to associate floral features with reward,preferring,and specializing in the most profitable ones they visit(Chittka et al.1999).The proboscis extension reflex(PER)occurs naturally in the feeding context allowing individuals to access the floral *** controlled conditions,the PER paradigm is a well-established controlled learning procedure used in honeybees(Takeda 1961),and some bumblebees of the genus Bombus(Laloi et al.1999).The assessment of cognitive capacities in an operant context has been studied mainly in *** and ***(Chittka 1998;Mirwan and Kevan 2014).However,little is known about the ability to evoke associative memories in an operant context,which had been acquired in a classical *** turn,on the contrary,the Bombus genus also has the capacity to form longterm memories(Chittka 1998;McAulay et al.2015).In particular,the South American bumblebee ***(***)can learn a pure odor when it is presented in a paired association with a sugar reward within a PER paradigm(Palottini et al.2018).As other species,this one is a commercially reared pollinator that is increasingly managed in pollination services of some South American countries and they could be important for increasing production of crops(Palottini et al.2018).

关键词： crops sugar associative

Retention of eucalyptus harvest residues reduces soil compaction caused by deep subsoiling

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Journal of forestry Research 2022年第2期33卷 643-651页

作者： Raphael Oliveira de Melo AymbiréAngeletti da fonseca Nairam félix de Barros Raphael Bragança Alves fernandes Rafael da Silva Teixeira Iago nery Melo Ricardo Previdente Martins Soil Science Department Universidade Federal de ViçosaViçosaMinas GeraisBrazil BRACELL Company AlagoinhasBahiaBrazil

Eucalyptus harvesting,forwarding and soil tillage operations are among the main causes for compaction of forest soils,with potential impacts on *** concern is especially important in areas with soils that are naturally compacted(fragipans and duripans).In these soils,tillage operations include the use of subsoilers that can reach depths of more than one meter and require heavy tractors that exert high pressure on the *** of the ways to try to minimize the effect of this compaction is by retaining harvest *** objective of this study was to evaluate the impacts of eucalyptus harvesting on soil physical attributes,as well as to determine the potential of different types of residue management to reduce compaction from the soil tillage *** experiments were conducted in the same area with a Yellow *** the first experiment,compaction caused by mechanized harvesting with harvester+forwarder was *** the second experiment,different managements of harvest residues were examined as potential modifiers of soil compaction during tillage for new *** this,three managements systems were tested:(1)retention of all harvest residues and litter from the previous rotation(HR+L),(2)retention of litter from the previous rotation(L),and(3)removal of harvest residues and litter from the previous rotation(WR).Before and after harvest,sampling was carried out in the planting rows and inter-rows,and after tillage,samples were collected in the traffic line of the subsoiler-tractor *** both experiments,undisturbed soil samples were collected from the center of the 0-10,10-20,20-40,40-60,and 60-100 cm layers to determine soil density and total *** each period and site of evaluation,mechanical resistance to penetration up to the 60-cm depth was also *** harvesting operation increased soil density at 0-10 and 60-100 cm depths only in the *** of harvest residues and litter(HR+L)after harvesting avoi

关键词： Soil penetration resistance Harvester+forwarder Soil tillage Soil density Cohesive soils

Effectiveness of ivermectin mass drug administration in the control of soil-transmitted helminth infections in endemic populations: a systematic review and meta-analysis

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Infectious Diseases of Poverty 2024年第1期13卷 1-15页

作者： Brandon Le Naomi E.Clarke Nicolas Legrand Susana Vaz nery The Kirby Institute University of New South WalesLevel 6Wallace Wurth BuildingSydneyNSW2052Australia

Background Current soil-transmitted helminth(STH)control guidelines endorse the use of albendazole or meben-dazole for school-based targeted preventive chemotherapy(PC),yet their reduced efficacy against Strongyloides sterc-oralis and Trichuris trichiura presents significant *** evidence indicates that community-wide PC[or mass drug administration(MDA)]using ivermectin,commonly used in other neglected tropical disease(NTD)control programs,may play an important role in controlling these *** conducted a systematic review and meta-analysis to evaluate the effectiveness of ivermectin PC in reducing STH prevalence in endemic *** We searched Pubmed,EMBASE,and Web of Science on february 14,2023,for studies that investigated the effectiveness of ivermectin PC,either alone or in combination with other anthelmintic drugs,on STH infec-tions,and provided a measure of STH prevalence before and after *** calculated pooled prevalence reductions for each STH using random-effects *** protocol is available on PROSPERO(registration number CRD42023401219).Results A total of 21 were eligible for the systematic review,of which 15 were eligible for *** studies delivered ivermectin through *** pooled prevalence reduction of *** following MDA with ivermec-tin alone was 84.49%(95%CI:54.96-94.66)across five studies and 81.37%(95% CI:61.62-90.96)across seven studies with or without *** prevalence reduction of *** was 49.93%(95%CI:18.23-69.34)across five studies with ivermectin alone,and 89.40%(95%CI:73.66-95.73)across three studies with the addition of *** was high heterogeneity for all syntheses(I^(2)>65%).Conclusions This study underscores the key role of ivermectin-based MDA in addressing limitations in current global STH guidelines in terms of limited efficacy against *** and *** on these findings,revising inter-national STH guidelines to include i

关键词： Soil-transmitted helminths Ivermectin Albendazole Mass drug administration Preventive chemotherapy

Bone marrow-derived mesenchymal stem cells versus adipose-derived mesenchymal stem cells for peripheral nerve regeneration

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Neural Regeneration Research 2018年第1期13卷 100-104页

作者： Marcela fernandes Sandra Gomes Valente Rodrigo Guerra Sabongi Joao Baptista Gomes dos Santos Vilnei Mattioli Leite Henning Ulrich Arthur Andrade nery Maria José da Silva fernandes Division of Hand and Upper Limb Surgery Department of Orthopedics and Traumatology Universidade Federal de Sao Paulo Sao Paulo Brazil Department of biochemistry Institute of Chemistry Universidade de Sao Paulo Sao Paulo Brazil Division of Neurosciences Department of Neurology and Neurosurgery Universidade Federal de Sao Paulo Sao Paulo Brazil

Studies have confirmed that bone marrow-derived mesenchymal stem cells （MSCs） can be used for treatment of several nervous system diseases. However, isolation of bone marrow-derived MSCs （BMSCs） is an invasive and painful process and the yield is very low. Therefore, there is a need to search for other alterative stem cell sources. Adipose-derived MSCs （ADSCs） have phenotypic and gene expression profiles similar to those of BMSCs. The production of ADSCs is greater than that of BMSCs, and ADSCs proliferate faster than BMSCs. To compare the effects of venous grafts containing BMSCs or ADSCs on sciatic nerve injury, in this study, rats were randomly divided into four groups： sham （only sciatic nerve exposed）, Matrigel （MG; sciatic nerve injury ＋ intravenous transplantation of MG vehicle）, ADSCs （sciatic nerve injury ＋ intravenous MG containing ADSCs）, and BMSCs （sciatic nerve injury ＋ intravenous MG containing BMSCs） groups. Sciatic functional index was calculated to evaluate the function of injured sciatic nerve. Morphologic characteristics of nerves distal to the lesion were observed by toluidine blue staining. Spinal motor neurons labeled with fluoro-Gold were quantitatively assessed. Compared with sham-operated rats, sciatic functional index was lower, the density of small-diameter fibers was significantly increased, and the number of motor neurons significantly decreased in rats with sciatic nerve injury. Neither ADSCs nor BMSCs significantly improved the sciatic nerve function of rats with sciatic nerve injury,increased fiber density, fiber diameters, axonal diameters, myelin sheath thickness, and G ratios （axonal diameter/fiber diameter ratios） in the sciatic nerve distal to the lesion site. There was no significant difference in the number of spinal motor neurons among ADSCs, BMSCs and MG groups. These results suggest that neither BMSCs nor ADSCs provide satisfactory results for peripheral nerve repair when using MG as the conductor for engraftment.

关键词： nerve regeneration mesenchymal stem cells adipose-derived mesenchmal stem cells sciatic nerve Matrigel sciatic functional index neural regeneration

Acute Left Main Coronary Occlusion following Transcatheter Aortic Valve Implantation

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World Journal of Cardiovascular Diseases 2024年第11期14卷 695-700页

作者： Alekhya Abburu Basharat Ahmad Abdallah Masri David nery Sharon Rufus Aultman Deuble Heart and Vascular Center Canton OH USA Department of Cardiology Aultman Deuble Heart and Vascular Center Canton OH USA

Background: Aortic stenosis (AS) is caused by either age-related degeneration of aortic valve or congenital malformation of aortic cusps. Severe aortic valve stenosis is a clinically emerging diagnosis in the current world. The three cardinal signs of severe AS are dyspnea, syncope, and angina. Transcatheter aortic valve implantation is one of the safe and effective methods for treating severe aortic valve stenosis, and an alternative to surgery in high-risk patients. Aortic valve calcification and changes after TAVI were specifically assessed by computed tomography. Excessive aortic valve calcification is related to procedural complications. A possible consequence is obstruction of coronary ostia. Heavy calcification of the aortic valve and surrounding structure is an important risk factor for coronary obstruction, heart block, and embolization during aortic valve implantation (TAVI). Here we present a case of an elderly old man, where critical ostial left main coronary artery (LMCA) disease was caused by shifting of a calcium speck rather than obstruction with native leaflet. He was successfully rescued by an emergent CABG. Methods and Results: This is a case of a 69-year-old man with severe calcific aortic stenosis and single-vessel CAD who underwent TAVI with a relatively unremarkable course. Notably, his pre-operative TAVI angiography showed no LMCA stenosis. But 10 days later he presented to the ER with acute myocardial infarction with peak high-intensity troponins, diffuse ST changes, and cardiogenic shock. Urgent coronary angiography and intravascular ultrasound showed critical LMCA stenosis caused by a speck of calcium externally abating the vessel. He underwent emergency coronary artery bypass grafting;intraoperative TEE confirmed the etiology. He had an uneventful postoperative course and was successfully weaned off vasoactive medications. Conclusion: This case illustrates that obstruction of coronary ostia could be a possible complication of TAVI. Calciu

关键词： TAVI (Transcatheter Aortic Valve Implantation) LMCA (Left Main Coronary Artery) CAD (Coronary Artery Disease) TEE (Transoesophageal Echocardiography) Intravascular Ultrasound Severe Calcific Aortic Stenosis CABG (Coronary Artery Bypass Grafting)

Stem cell homing, tracking and therapeutic efficiency evaluation for stroke treatment using nanoparticles: A systematic review

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World Journal of Stem Cells 2020年第5期12卷 381-405页

作者： Mariana Penteado Nucci Igor Salerno filgueiras Joao Matias ferreira fernando Anselmo de Oliveira Leopoldo Penteado Nucci Javier Bustamante Mamani Gabriel nery Albuquerque Rego Lionel fernel Gamarra LIM44 Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao Paulo 05529-060Brazil Hospital Israelita Albert Einstein Sao Paulo 05529-060Brazil Centro Universitário do Planalto Central BrasíliaDFBrazil

BACKGROUND Stroke is the second leading cause of death *** is a real need to develop treatment strategies for reducing neurological deficits in stroke survivors,and stem cell(SC)therapeutics appear to be a promising alternative for stroke therapy that can be used in combination with approved thrombolytic or thrombectomy ***,the efficacy of SC therapy depends on the SC homing ability and engraftment into the injury site over a long period of ***,tracking SCs from their niche to the target tissues is a complex *** To evaluate SC migration homing,tracking and therapeutic efficacy in the treatment of stroke using nanoparticles METHODS A systematic literature search was performed to identify articles published prior to November 2019 that were indexed in PubMed and *** following inclusion criteria were used:(1)Studies that used in vivo models of stroke or ischemic brain lesions;(2)Studies of SCs labeled with some type of contrast agent for cell migration detection;and(3)Studies that involved in vivo cellular homing and tracking *** A total of 82 articles were identified by indexing in Scopus and Pub *** inclusion criteria were applied,35 studies were selected,and the articles were assessed for eligibility;ultimately,only 25 studies were *** of the selected studies used SCs from human and mouse bone marrow labeled with magnetic nanoparticles alone or combined with fluorophore *** cells were administered in the stroke model(to treat middle cerebral artery occlusion in 74%of studies and for photothrombotic induction in 26%of studies).fiftythree percent of studies used xenogeneic grafts for cell therapy,and the migration homing and tracking evaluation was performed by magnetic resonance imaging as well as other techniques,such as near-infrared fluorescence imaging(12%)or bioluminescence assays(12%).CONCLUSION Our systematic review provided an up-to-date evaluation of SC migration hom

关键词： Stem cell Nanoparticles Homing Tracking Near-infrared fluorescence image Cellular therapy Magnetic resonance image bioluminescence Stroke

Analysis of Rain Variability Using the Daily and Monthly Concentration Indexes in Southeastern Brazil

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Atmospheric and Climate Sciences 2017年第2期7卷 176-190页

作者： Jonas T. nery Ana Claudia Carfan Javier Martin-Vide Department of Geography UNESP Ourinhos Brazil Climatology Group University of Barcelona Barcelona Spain

Daily and monthly rainfall was analyzed by the Concentration Index (CI) of [1] and the Annual Precipitation Concentration Index (PCI) of [2] in southeastern Brazil. About 120 rainfall stations were used in the period from 1976 to 2010. Data were obtained from the National Water Agency (ANA). These data were selected by observing their spatial and temporal distribution in the study area. In general, the Concentration Index and the Precipitation Concentration Index were consistent for the study of rainfall variability in the study area. High percentages of annual rainfall concentration in a few very rainy days can increase the risk of flooding and soil instability. In this work, a survey of the spatial and temporal patterns of daily and monthly rainfall concentration in southeast Brazil was conducted. The results showed a relatively homogeneous temporal distribution of daily rainfall in the study area. In addition, the Mann-Kendall test showed a clear trend towards a seasonal rainfall distribution.

关键词： Concentration Indices Variability Rain Southeast Brazil

Burden and factors associated with schistosomiasis and soil-transmitted helminth infections among school-age children in Huambo,Uige and Zaire provinces,Angola

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Infectious Diseases of Poverty 2022年第3期11卷 99-100页

作者： Adam W.Bartlett Jose C.Sousa-figueiredo Roelofje Cvan Goor Paul Monaghan Warren Lancaster Rukaaka Mugizi Elsa P.Mendes Susana Vaz nery Sergio Lopes 不详 The Mentor Initiative 4Th Floor(South Suite)Burns HouseHarlands RoadHaywards HeathR161PGUK

Background:Schistosomiasis and soil-transmitted helminths(STHs)contribute high disease burdens amongst the neglected tropical diseases(NTDs)and are public health problems in *** study reports the prevalence,intensity and risk factors for schistosomiasis and STH infection in Huambo,Uige and Zaire provinces,Angola,to inform a school-based preventive chemotherapy ***:A two-stage cluster design was used to select schools and schoolchildren to participate in parasitological and water,sanitation and hygiene(WASH)surveys across Huambo,Uige,and Zaire ***-of-care circulating cathodic antigen and urinalysis rapid diagnostic tests(RDTs)were used to determine the prevalence of Schistosoma mansoni and ***,***-Katz was used to identify and quantify STH species and quantify and compare with RDTs for *** filtration was used to quantify and compare with RDTs for *** statistics were used for prevalence and infection intensity of schistosomiasis and STH *** of RDTs was assessed through specificity and Cohen’s Kappa agreement with microscopy.A multivariate regression analysis was used to determine demographic and WASH factors associated with schistosomiasis and STH ***:A total 575 schools and 17,093 schoolchildren participated in the schistosomiasis survey,of which 121 schools and 3649 schoolchildren participated in the STH *** prevalence of *** was 21.2%(municipality range 0.9–74.8%)and *** 13.6%(range 0–31.2%),with an overall prevalence of schistosomiasis of 31.4%(range 5.9–77.3%).Overall prevalence of Ascaris lumbricoides was 25.1%(range 0–89.7%),hookworm 5.2%(range 0–42.6%),and Trichuris trichiura 3.6%(range 0–24.2%),with an overall prevalence of STH infection of 29.5%(range 0.8–89.7%).Ecological zone and ethnicity were factors associated with schistosomiasis and STH infection,with older age and female sex additional risk factors for S

关键词： Schistosomiasis Soil-transmitted helminths Circulating cathodic antigen Rapid diagnostic test Water,sanitation and hygiene