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Hydrophobic Effect in a Continuum model of the Lipid Bilayer

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Communications in Computational Physics 2009年第8期6卷 655-672页

作者： Phillip L.wilson Huaxiong Huang Shu Takagi Department of.mathematics and Statistics University of CanterburyPrivate Bag 4800Christchurch 8140New Zealand Department of.mathematics and Statistics York UniversityTorontoM3J 1P3Canada Department of.mechanical Engineering The University of TokyoTokyoJapan

We study a continuum paradigm of the lipid bilayer based on minimizing the free energy of a mixture of water and lipid *** paper extends previous work of Blom and Peletier[European ***.,15(2004),pp.487-508]in the following ways.(a)It formulates a more general model of the hydrophobic effect to facilitate connections with microscale simulations and first-principles analysis.(b)It clarifies the meaning and role of the model parameters.(c)It outlines a method for determining parameter values so that physically-realistic bilayer density profiles can be obtained,for example for use in macroscale ***(a)-(c)suggest that the model has potential to robustly connect some micro-and macroscale levels of.multiscale blood flow *** mathematical modelling in point(a)is based upon a consideration of the underlying physics of inter-molecular *** governing equations thus obtained are minimized by gradient flows via a novel numerical approach;this enables point(b).The numerical results are shown to behave physically in terms of the effect of background concentration,in contrast to the earlier model which is shown here to not display the expected behaviour.A“short-tail”approximation of the lipid molecules also gives an analytical tool which yields critical values of some parameters under certain ***(c)involves the first quantitative comparison of the numerical data with physical experimental results.

关键词： Lipid bilayer free energy continuum model numerical minimization

Treatment of recurrent Clostridium difficile colitis:a narrative review

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Gastroenterology Report 2018年第1期6卷 21-28,I0001页

作者： Roy J.Hopkins Robert B.wilson Department of Upper GI Surgery Liverpool HospitalSydneyNew South WalesAustralia

Clostridium difficile is a gram-positive,spore-forming,obligate anaerobic bacillus that was originally isolated from the stool of a healthy neonate in *** high-income countries,*** is the most common cause of infectious diarrhoea in hospitalized *** incidence of *** infection in the USA has increased markedly since 2000,with hospitalizations for *** infections in non-pregnant adults doubling between 2000 and *** 20%and 35%of patients with *** infection will fail initial antibiotic treatment and,of these,40–60%will have a second *** of *** infection after initial treatment causes substantial morbidity and is a major burden on health care *** this article,current treatments for recurrent *** infection are reviewed and future directions *** include the use of antibiotics,probiotics,donor faecal transplants,anion resins,secondary bile acids or anti-toxin antibodies.

关键词： Clostridium difficile recurrent infection faecal microbiota transplant anion-binding resins monoclonal antibodies secondary bile acid

Examining the practical limits of batch effect-correction algorithms:When should you care about batch effects?

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Journal of Genetics and Genomics 2019年第9期46卷 433-443页

作者： Longjian Zhou Andrew Chi-Hau Sue wilson Wen Bin Goh School of Pharmaceutical Science and Technology Tianjin UniversityTianjin30072China School of Biological Sciences Nanyang Technological University60 Nanyang Drive637551Singapore

Batch effects are technical sources of variation and can confound *** many performance ranking exercises have been conducted to establish the best batch effect-correction algorithm(BECA),we hold the viewpoint that the notion of best is ***,alternative questions beyond the simplistic notion of "best" are also interesting:are BECAs robust against various degrees of confounding and if so,what is the limit?Using two different methods for simulating class(phenotype) and batch effects and taking various representative datasets across both genomics(RNA-Seq) and proteomics platforms,we demonstrate that under situations where sample classes and batch factors are moderately confounded,most BECAs are remarkably robust and only weakly affected by upstream normalization *** observation is consistently supported across the multitude of test *** do have limits:When sample classes and batch factors are strongly confounded,BECA performance declines,with variable performance in precision,recall and also batch *** also report that while conventional normalization methods have minimal impact on batch effect correction,they do not affect downstream statistical feature selection,and in strongly confounded scenarios,may even outperform *** other words,removing batch effects is no guarantee of optimal functional ***,this study suggests that simplistic performance ranking exercises are quite trivial,and all BECAs are compromises in some context or another.

关键词： Batch effects Bioinformatics feature selection Normalization Statistics

Analysing the power transformer temperature limitation for avoidance of bubble formation

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High Voltage 2019年第3期4卷 210-216页

作者： James Hill Zhongdong Wang Qiang Liu Christoph Krause Gordon wilson The University of.manchester ManchesterM139PLUK Weidmann Electrical Technology AG Rapperswil-JonaCH 8640Switzerland National Grid WarwickCV346DAUK

failure of a transformer is a costly incident which can impact power system operation and result in loss of supply to *** can fail through a number of.mechanisms,one of which is from the formation of bubbles within the ***,the loading guidance is set to avoid certain overload temperatures as high temperature is the main cause of bubbles *** paper analyses the limit set within the loading guides,comparing the most commonly cited temperature limit of 140℃ with values taken from across the full spectra of available studies in *** is concluded that there is sufficient evidence for further investigation into formation of bubbles from transformer insulation as employing a single temperature limit may be *** of a single temperature value is unsuitable,given the wide range of potential scenarios that the transformer fleet can *** has become the go-to rationale that the moisture content of the solid insulation is the key driver for transformer bubbling *** is true,however,it is shown that other factors such as solid insulation aged condition(determined through degree of polymerisation value)and the insulation type are also important considerations.

关键词： insulation limit power

Plasticity in the antipredator behavior of the orange-footed sea cucumber under shifting hydrodynamic forces

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Current Zoology 2019年第6期65卷 685-695页

作者： Nicholas A.W.BROWN David R.wilson Patrick GAGNON Department of Ocean Sciences Memorial University of NewfoundlandSt.John'sNewfoundlandA1C 5S7Canada Department of Psychology Memorial University of NewfoundlandSt.John'sNewfoundlandA1B 3X9Canada

marine invertebrates that move too slowly to evade unfavorable environmental change may instead exhibit phenotypic plasticity,allowing them to adjust to varying *** orange-footed sea cucumber Cucumaria frondosa is a slow-moving suspension feeder that is preyed on by the purple sunstar Solaster *** sea cucumber's antipredator behavior involves changing shape and detaching from the substratum,which might increase its probability of being displaced by water motion into an unsuitable *** hypothesized that sea cucumbers'antipredator responses would be diminished under stronger hydrodynamic forces,and that behavioral strategies would be flexible so that individuals could adjust to frequent changes in water *** a natural orange-footed sea cucumber habitat,individuals lived along a pronounced hydrodynamic gradient,allowing us to measure antipredator behavior under different water flow *** placed purple sunstars in physical contact with sea cucumbers living at various points along the gradient to elicit antipredator *** then repeated this procedure in a laboratory mesocosm that generated weak and strong hydrodynamic forces similar to those observed at the field *** in the mesocosm experiment were tested in both wave conditions to determine if their antipredator behavior would change in response to sudden environmental change,as would be experienced under deteriorating sea *** responses did not covary with hydrodynamic forces in the ***,antipredator responses in the mesocosm experiment increased when individuals were transplanted from strong to weak forces and decreased when transplanted from weak to strong ***,our results indicate environmentally induced plasticity in the antipredator behavior of the orange-footed sea cucumber.

关键词： behavioral plasticity benthic invertebrate predator-prey interaction reciprocal transplant experiment Solaster endeca.wave environment

Effect of hydrostatic pressure and polaronic mass of the binding energy in a spherical quantum dot

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Chinese Physics B 2015年第11期24卷 92-97页

作者： A.Rejo Jeice Sr.Gerardin Jayam K.S.Joseph wilson Department of Physics Annai Velankanni College Department of Physics Holy Cross College Departmant of Physics Arul Anandar College (Autonomous)

Simultaneous effect of hydrostatic pressure and polaronic mass on the binding energies of the ground and excited states of an on-center hydrogenic impurity confined in a GaAs/GaA1As spherical quantum dot are theoretically investigated by the variational method within the effective mass approximation. The binding energy is calculated as a function of dot radius and pressure. Our findings proved that the hydrostatic pressure led to the decrease of confined energy and the increase of donor binding energy. Conduction band non-parabolicity and the polaron masses are effective in the donor binding energy which is significant for narrow dots not in the confined energy. The maximum donor binding energy achieved by the polaronic mass in the ground and excited states are 2%-19% for the narrow dots. The confined and donor binding energies approach zero as the dot size approaches infinity.

关键词： spherical quantum dot square well confinement confined energies effective mass approximation

The CELLULOSE-SYNTHASE LIKE C （CSLC） f.mily of Barley Includes members that Are Integral membrane Proteins Targeted to the Plasma membrane

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molecular Plant 2009年第5期2卷 1025-1039页

作者： fenny m. Dwivany Dina Yulia Rachel A, Burton Neil J. Shirley Sarah m. wilson Geoffrey B, fincher Antony Bacic Ed Newbigin monika S. Doblin Plant Cell Biology Research Centre School of Botany. University of Melbourne Victoria 3010 Australia Australian Centre for Plant functional Genomics School of Agriculture and Wine University of Adelaide South Australia 5064 Australia Australian Centre for Plant functional Genomics School of Botany University of Melbourne Victoria 3010 Australia Present address: Department of Biology Institut Teknologi Bandung Bandung Indonesia Present address: Stem Cell and Cancer Institute Jh Jend. Ahmad Yani No.2 Pulo Mas Jakarta 13210 Indonesia

The CELLULOSE SYNTHASE-LIKE C （CSLC） f.mily is an ancient lineage within the CELLULOSE SYNTHASE/CELLULOSE SYNTHASE-LIKE （CESA/CSL） polysaccharide synthase superf.mily that is thought to have arisen before the divergence of.mosses and vascular plants. As studies in the flowering plant Arabidopsis have suggested synthesis of the （1,4）-β-glucan backbone of xyloglucan （XyG）, a wall polysaccharide that tethers adjacent cellulose microfibrils to each other, as a probable function for the CSLCs, CSLC function was investigated in barley （Hordeum vulgate L.）, a species with low amounts of XyG in its walls. four barley CSLCgenes were identified （designated HvCSLC1-4）. Phylogenetic analysis reveals three well supported clades of CSLCs in flowering plants, with barley having representatives in two of these clades. The four barley CSLCs were expressed in various tissues, with in situ PCR detecting transcripts in all cell types of the coleoptile and root, including cells with primary and secondary cell walls. Co-expression analysis showed that HvCSLC3 was coordinately expressed with putative XyG xylosyltransferase genes. Both immuno-Em and membrane fractionation showed that HvCSLC2 was located in the plasma membrane of barley suspension-cultured cells and was not in internal membranes such as endoplasmic reticulum or Golgi apparatus. Based on our current knowledge of the sub-cellular locations of polysaccharide synthesis, we conclude that the CSLC f.mily probably contains more than one type of polysaccharide synthase.

关键词： Cellulose synthase-like f.mily C plant cell wall biosynthesis xyloglucan cellulose glycosyltransferase

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多跨连续曲线梁在移动荷载下的动力响应

土木工程学报 1999年第4期32卷 33-36页

作者：王元丰 J.f.wilson 北京交通大学美国Duke大学

在对多跨曲线梁在移动荷载下动力响应的控制微分方程进行无量纲化处理、转换后，采用Ｒａｌｅｉｇｈ－Ｒｉｔｚ法对无量纲化方程进行解耦简化，得到以广义挠度和广义扭转角为未知量的运动微分方程。采用Ｍａｔｈｅｍａｔ－ｉｃａ３．... 详细信息

在对多跨曲线梁在移动荷载下动力响应的控制微分方程进行无量纲化处理、转换后，采用Ｒａｌｅｉｇｈ－Ｒｉｔｚ法对无量纲化方程进行解耦简化，得到以广义挠度和广义扭转角为未知量的运动微分方程。采用Ｍａｔｈｅｍａｔ－ｉｃａ３．０软件对所得到的方程进行求解，首次得到此问题的理论解。计算结果与试验结果比较证明此方法正确、可靠。

关键词：多跨曲线梁动力响应解析解移动荷载

Syringoid eccrine carcinoma of the eyelid presenting as cicatricial entropion

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 912-913页

作者： manjool m.Shah Eric A.Steele Kevin P.White David J.wilson Department of Ophthalmology Casey Eye InstituteOregon Health&Science University Portland Veteran's Affairs medical Center Department of Dermatology Oregon Health&Science University

Dear Sir,my name is manjool ***,from the Casey Eye Institute at Oregon Health&Science University in Portland,Oregon,USA.I wish to write to you with regards to an interesting presentation of a rare eyelid malignancy.A ... 详细信息

关键词： mICROCYSTIC ADNEXAL CARCINOmA SYRINGOmATOUS CARCINOmA ORBIT