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Primary hepatic carcinoid:A case report and literature review

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World Journal of Gastroenterology 2009年第19期15卷 2418-2422页

作者： Luigi Maria Fenoglio Sara Severini Domenico Ferrigno Giovanni Gollè Cristina Serraino Christian Bracco Elisabetta Castagna Chiara Brignone Fulvio Pomero Elena Migliore ezio david Mauro Salizzoni Department of Internal Medicine Santa Croce and Carle Hospital12100 CuneoItaly Department of Pathology San Giovanni Battista Hospital10126 TurinItaly Liver Transplantation Center San Giovanni Battista Hospital10126 TurinItaly

Carcinoids are tumors derived from neuroendocrine cells and often produce functional peptide *** 54.5% arise in the gastrointestinal tract and frequently metastasize to the *** hepatic carcinoid tumors(PHCT) are extremely rare;only 95 cases have been reported.A 65-year-old man came to our attention due to occasional ultrasound findings in absence of clinical *** previous medical history,since 2003,included an echotomography of the dishomogeneous parenchymal area but no focal lesions.A computed tomography scan performed in 2005 showed an enhanced pseudonodular-like lesion of about 2 ***-magnetic resonance imaging identified the lesion as a possible *** positive findings were obtained with positron emission *** suggested a secondary localization in the liver caused by a low-grade malignant neuroendocrine *** was positive for anti chromogranin antibodies,Ki67 antibodies and *** scintigraphy indicated intense activity in the *** investigations were performed to exclude the presence of extrahepatic *** of PHCT was *** patient underwent left hepatectomy,followed by hormone therapy with sandostatine *** months after surgery he had a lymph nodal relapse along the celiac trunk and caudate lobe,which was histologically *** postoperative clinical course was uneventful,with a negative follow-up for hematochemical,clinical and radiological investigations at 18 mo *** of PHCT is based principally on the histopathological confi rmation of a carcinoid tumor and the exclusion of a non-hepatic primary *** resection is the recommended primary treatment for *** rate and survival rate in patients treated with resection were 18% and 74%,respectively.

关键词： Carcinoid Primary hepatic carcinoid Neuroendocrine neoplasm Therapy Surgical treatment Prognosis

Making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex david J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Melatonin in the seasonal response of the aphid Acyrthosiphon pisum

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Insect Science 2020年第2期27卷 224-238页

作者： Miquel Barbera Laura Escriva Jorge Mariano Collantes-Alegre Giuseppe Meca ezio Rosato david Martinez-Torres Institut de Biologia Integrativa de Sistemes&Institut Cavanilles de Biodiversitati Biologia Evolutiva Parc Cientific Universitat de ValenciaC/Catedmtico Jose Beltran n°246980PaternaValenciaSpain Laboratory of Food Chemistry and Toxicology Faculty of PharmacyUniversitat de ValenciaBurjassotSpain Department of Genetics University of LeicesterLeicesterLE17RHUK

Aphids display life cycles largely determined by the *** the warm long-day *** aphid species reproduce by viviparous *** shortening of the photoperiod in autumn induces a switch to sexual *** and sexual females mate to produce overwintering resistant *** addition to this full life cycle(holocycle),there are anholocyelic lineages that do not respond to changes in photoperiod and reproduce continuously by *** molecular or hormonal events that trigger the scasonal response(i.c,induction of the sexual phenotypes)are still *** circadian synthesis of melatonin is known to play a key role in vertebrate photoperiodism,the involvement of the circadian clock and/or of the hor-mone melatonin in insect seasonal responses is not so well *** we show that melatonin levels in the aphid Acyrthosiphon pisum are significantly higher in holocyclice aphids reared under short days than under long days,while no differences were found between anholoeyelic aphids under the same *** also found that melatonin is localized in the aphid suboesophageal ganglion(SOG)and in the thoracic ganglionic mass(TGM).In analogy to vertcbrates,insect-type arylalkxylamine N-acetyltransferases(i-AANATs)are thought to play a key role in melatonin *** measured the expression of four I-AANAT genes identified in *** and localized two of them in situ in the insect central nervous systems(CNS).Levels of expression of these genes were compatible with the quantities of melatonin ***,like melatonin,expression of these genes was found in the SOG and the TGM.

关键词： AANAT aphid in situ hybridization melatonin photoperiodism quantification

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller david Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph david Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Droplet 3D cryobioprinting for fabrication of free-standing and volumetric structures

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Aggregate 2024年第5期5卷 433-444页

作者： Joshua Weygant Ali Entezari Fritz Koch Ricardo AndréGalaviz Carlos ezio Garciamendez Pável Hernández Vanessa Ortiz david Sebastián Rendon Ruiz Francisco Aguilar Andrea Andolﬁ Ling Cai Sushila Maharjan Anayancy Osorio Yu Shrike Zhang Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMassachusettsUSA School of Biomedical Engineering University of Technology SydneyBroadwayNew South WalesAustralia Laboratory for Bioinspired Materials for Biomedical Engineering IMTEK—Department of Microsystems EngineeringUniversity of FreiburgFreiburgGermany Department of Informatics BioengineeringRobotics and Systems Engineering(DIBRIS)University of GenovaGenovaItaly Department of Engineering University of CambridgeCB21PZ CambridgeUK

Droplet-based bioprinting has shown remarkable potential in tissue engineering and regenerative ***,it requires bioinks with low viscosities,which makes it challenging to create complex 3D structures and spatially pattern them with different *** study introduces a novel approach to bioprinting sophisti-cated volumetric objects by merging droplet-based bioprinting and cryobioprinting *** leveraging the beneﬁts of cryopreservation,we fabricated,for theﬁrst time,intricate,self-supporting cell-free or cell-laden structures with single or multiple materials in a simple droplet-based bioprinting process that is facilitated by depositing the droplets onto a cryoplate followed by crosslinking during *** feasibility of this approach is demonstrated by bioprinting several cell types,with cell viability increasing to 80%–90%after up to 2 or 3 weeks of ***,the applicational capabilities of this approach are showcased by bio-printing an endothelialized breast cancer *** results indicate that merging droplet and cryogenic bioprinting complements current droplet-based bioprinting techniques and opens new avenues for the fabrication of volumetric objects with enhanced complexity and functionality,presenting exciting potential for biomedical applications.

关键词： 3D bioprinting biofabrication cryogenic bioprinting droplet printing inkjet tissue engineering

Redox physiology in animal function:The struggle of living in an oxidant environment

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Current Zoology 2010年第6期56卷 687-702页

作者： david COSTANTINI Division of Ecology and Evolutionary Biology Faculty of Biomedical and Life SciencesUniversity of Glasgow

A strong focus of ecological research for several decades has been to understand the factors underlying the variation in animal life-histories. In recent times, ecological studies have begun to show that oxidative stress may represent another important modulator of competitive trade-offs among fitness traits or of positively integrated patterns of traits. Therefore, incorporating mechanisms underlying oxidative physiology into evolutionary ecology has the potential to help understand variation in life-history strategies. In this review, I provide a general overview of oxidative stress physiology, and subsequently focus on topics that have been neglected in previous ecological reviews on oxidative stress. Specifically, I introduce and discuss the adaptations that animals have evolved to cope with oxidative stress; the environmental stressors that can generate changes in oxidative balance; the role of reactive species in transduction of environmental stimuli and cell signaling; and the range of hormetic responses to oxidative stress [Current Zoology 56 （6）： 687-702, 2010].

关键词： Antioxidants Free radicals Life-history Oxidative stress Stress response Vertebrates

Software, Software Engineering and Software Engineering Research: Some Unconventional Thoughts

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Journal of Computer Science & Technology 2009年第2期24卷 189-197页

作者： david Notkin Computer Science and Engineering University of Washington Seattle

Software engineering is broadly discussed as falling far short of expectations. Data and examples are used to justify how software itself is often poor, how the engineering of software leaves much to be desired, and how research in software engineering has not made enough progress to help overcome these weaknesses. However, these data and examples are presented and interpreted in ways that are arguably imbalanced. This imbalance, usually taken at face value, may be distracting the field from making significant progress towards improving the effective engineering of software, a goal the entire community shares. Research dichotomies, which tend to pit one approach against another, often subtly hint that there is a best way to engineer software or a best way to perform research on software. This, too, may be distracting the field from important classes of progress.

关键词： software engineering/general software engineering process/life cycle