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Soil organic carbon stocks in native forest of Argentina:a useful surrogate for mitigation and conservation planning under climate variability

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Ecological Processes 2024年第1期13卷 3-24页

作者： Pablo L.Peri Juan Gaitán Matías Mastrangelo Marcelo Nosetto Pablo E.Villagra ezequiel balducci Martín Pinazo Roxana P.Eclesia Alejandra Von Wallis Sebastián Villarino Francisco Alaggia Marina González Polo Silvina Manrique Pablo A.Meglioli Julián Rodríguez-Souilla Martín Mónaco Jimena E.Chaves Ariel Medina Ignacio Gasparri Eugenio Alvarez Arnesi María Paula Barral Axel von Müller Norberto M.Pahr Josefina Uribe Echevarria Pedro Fernández Marina Morsucci Dardo López Juan Manuel Cellini Leandro Alvarez Ignacio Barberis Hernán Colomb Ludmila La Manna Sebastián Barbaro Cecilia Blundo Ximena Sirimarco Laura Cavallero Gualberto Zalazar Guillermo Martínez Pastur Instituto Nacional de Tecnología Agropecuaria (INTA) Universidad Nacional de la Patagonia Austral (UNPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Luján Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Grupo de Estudio de Agroecosistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) CCT San Luis Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IANIGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Cuyo Instituto de Investigaciones en Biodiversidad y Medioambiente (INIBIOMA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto de Investigaciones en Energía No Convencional CCT Salta-JujuyConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Dirección Nacional de Bosques Ministerio de Ambiente y Desarrollo Sostenible de la Nación Instituto de Ecología Regional Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )Universidad Nacional de Tucumán Universidad Nacional de Rosario Instituto de Investigaciones en Ciencias Agrarias de Rosario Centro Científico Tecnológico CONICET Grupo de Estudio de Agroecosistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Investigaciones en Maderas (LIMAD) Universidad Nacional de La Plata (UNLP) Administración de Parques Nacionales (APN) Parque Nacional Los Alerces Centro de Estudios Ambientales Integrados (CEAI) Universidad Nacional de la Patagonia San Juan Bosco (UNPASJB) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Background The nationally determined contribution（NDC） presented by Argentina within the framework of the Paris Agreement is aligned with the decisions made in the context of the United Nations Framework Conven-tion on Climate Change（UNFCCC） on the reduction of emissions derived from deforestation and forest degradation, as well as forest carbon conservation（REDD+）. In addition, climate change constitutes one of the greatest threats to forest biodiversity and ecosystem services. However, the soil organic carbon（SOC） stocks of native forests have not been incorporated into the Forest Reference Emission Levels calculations and for conservation planning under cli-mate variability due to a lack of information. The objectives of this study were:（i） to model SOC stocks to 30 cm of native forests at a national scale using climatic, topographic and vegetation as predictor variables, and（ii） to relate SOC stocks with spatial–temporal remotely sensed indices to determine biodiversity conservation concerns due to threats from high inter-annual climate *** We used 1040 forest soil samples（0–30 cm） to generate spatially explicit estimates of SOC native forests in Argentina at a spatial resolution of approximately 200 m. We selected 52 potential predictive environmental covari-ates, which represent key factors for the spatial distribution of SOC. All covariate maps were uploaded to the Google Earth Engine cloud-based computing platform for subsequent modelling. To determine the biodiversity threats from high inter-annual climate variability, we employed the spatial–temporal satellite-derived indices based on Enhanced Vegetation Index（EVI） and land surface temperature（LST） images from Landsat *** SOC model（0–30 cm depth） prediction accounted for 69% of the variation of this soil property across the whole native forest coverage in Argentina. Total mean SOC stock reached 2.81 Pg C（2.71–2.84 Pg C with a probability of 90%） for a total area of 460,790 km2,

关键词： Soil organic carbon Biodiversity Native forest Climate change mitigation Modelling Resilience

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Targeted therapy for capillary-venous malformations

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon Charles Bayard Marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag Jean-Paul Duong Sophie Kaltenbach Estelle balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique Minard-Colin Caroline Chopinet Michael Dussiot Denise MAdams Tristan Mirault Laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance Department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous

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Initial failures of anti-tau antibodies in Alzheimer’s disease are reminiscent of the amyloid-βstory

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Neural Regeneration Research 2023年第1期18卷 117-118页

作者： Bruno P.Imbimbo Claudia balducci Stefania Ippati Mark Watling Department of Research&Development Chiesi FarmaceuticiParmaItaly Department of Neuroscience Istituto di Ricerche Farmacologiche“Mario Negri”IRCCSMilanItaly San Raffaele Scientific Institute San Raffaele HospitalMilanItaly CNS&Pain Department TranScrip Ltd.ReadingUK

Tau is an important protein of the central nervous system formed by 352-441 amino acids and encoded by the MAPT(microtubule-associated protein tau)gene on chromosome 17 which generates 6 *** is located in axons,dendrites,nucleus,cell membrane,and synapses of *** protein is also expressed to a lesser extent in astrocytes and oligodendrocytes,although its role in these cells has been little *** protein is also present in the interstitial fluid and can cross into the cerebrospinal fluid(CSF)and reach the systemic circulation.

关键词： tau Alzheimer cerebrospinal

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Multiple giant diverticula of the foregut causing upper gastrointestinal obstruction

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World Journal of Gastroenterology 2008年第20期14卷 3259-3261页

作者： Genoveffa balducci Mario Dente Giulia Cosenza Paolo Mercantini Pier Federico Salvi Departments of Surgery ⅡSchool of Medicine University of Rome "La Sapienza" Sant'Andrea Hospital Departments of Surgery ⅡSchool of Medicine University of Rome "La Sapienza" Sant’Andrea Hospital

Small bowel diverticulosis represents an uncommon disorder (except for Meckel diverticulum) often misdiagnosed since it causes non-specific gastroin- testinal symptoms. Most of times the diagnosis is carried out in case of related complications, such as diverticulitis, hemorrhage, perforation or obstruction. Intestinal obstruction can be caused by inflammatory stenosis due to repeated episodes of diverticulitis, volvulus, intussusception or jejunal stones. Herein we report a case of multiple jejunal diverticula causing chronic gastrointestinal obstruction.

关键词： Jejunal diverticula Chronic symptoms Gastrointestinal obstruction Jejunal resection

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Pulmonary administration of functionalized nanoparticles significantly reduces beta-amyloid in the brain of an Alzheimer＇s disease murine model

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Nano Research 2016年第7期9卷 2190-2201页

作者： Giulio Sancini Roberta Dal Magro Francesca Ornaghi Claudia balducci Gianluigi Forloni Marco Gobbi Mario Salmona Francesca Re Nanomedicine Center School of Medicine and Surgery University of Milano-Bicocca via Cadore 48 20900 Monza (MB) Italy Department ofNeuroscience IRCCS-Istituto di Ricerche Farmacologiche Mario Negri via La Masa 19 20159 Milano Italy Department of Biochemistry and Molecular Pharmacology IRCCS-Istituto di Ricerche Farmacologiche Mario Negri via La Masa 19 20159 Milano Italy

Treatment options for Alzheimer＇s disease （AD） are limited because of the inability of drugs to cross the blood-brain barrier （BBB）. A promising strategy to overcome this obstacle is the use of nanoparticles （NPs）. Previously, we showed that intraperitoneal administration of liposomes functionalized with phosphatidic acid and an ApoE-derived peptide （mApoE-PA-LIP） reduces brain beta-amyloid （A） burden and ameliorates impaired memory in AD mice. Here, we investigated lung administration as an alternative, non-invasive NP delivery route for reaching the brain. Our results show that mApoE-PA-LIP were able to cross the pulmonary epithelium （[C]-PA permeability = 6.5 ＋ 2.0 × 10^4 cm/min） in vitro and reach the brain （up to 0.6 μg PA/g brain） following in vivo intratracheal instillations. Lung administration of mApoE-PA-LIP to AD mice significantly decreased total brain Aβ （-60%; p 〈 0.05） compared to untreated mice. These results suggest that pulmonary administration could be exploited for brain delivery of NPs designed for AD therapy.

关键词： ApoE-derived peptide lung administration nanoparticles Alzheimer's disease liposomes

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Event Scenario Analysis for the Design of Rockslide Countermeasures

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Journal of Mountain Science 2014年第6期11卷 1521-1530页

作者： GIGLI Giovanni INTRIERI Emanuele LOMBARDI Luca NOCENTINI Massimiliano FRODELLA William balducci Marco VENANTI Luca Domenico CASAGLI Nicola Department of Earth Science University of Studies of Florence Area Progetto Associati Studio Geologi Associati

The Torgiovannetto quarry(Assisi municipality,central Italy) is an example of a site where the natural equilibrium was altered by human activity,causing current slope instability phenomena which threaten two roadways important for the local *** quarry front,having a height of about 140 m,is affected by a 182,000 m3 rockslide developed in intensely fractured limestone and is too large to be *** 2003 some tension cracks were detected in the vegetated area above the quarry upper *** then on,several monitoring campaigns were carried out by means of different instrumentations(topographic total station,extensometers,inclinometers,ground-based interferometric radar,laser scanner and infrared thermal camera),allowing researchers to accurately define the landslide area and *** latter's major displacements are localized in the eastern *** deformational field appears to be related to the seasonal *** landslide hazard associated with the worst case scenario was evaluated in terms of magnitude,intensity and triggering *** the definition of the possible runout process the DAN 3D code was *** simulation results were used in order to design and construct a retaining ***,in order to preserve both the safety of the personnelinvolved in its realization and of the roadways users,an early warning system was *** early warning system is based on daily-averaged displacement velocity *** alarm level is reached if the prediction based on the methods of Saito(1969) and Fukuzono(1985) forecasts an imminent rupture.

关键词： Risk scenarios Risk management Landslides Monitoring Rock avalanche

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Evidence based medicine and surgical approaches for colon cancer: Evidences, benefits and limitations of the laparoscopic vs open resection

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World Journal of Gastroenterology 2014年第13期20卷 3680-3692页

作者： Laura Lorenzon Marco La Torre Vincenzo Ziparo Francesco Montebelli Paolo Mercantini Genoveffa balducci Mario Ferri Department of Translational Medicine Sant’Andrea HospitalFaculty of Medicine and Psychology University of Rome "La Sapienza"00189 RomeItaly

AIM: To report a meta-analysis of the studies that compared the laparoscopic with the open approach for colon cancer resection.

关键词： Laparoscopy Colon resection Colon cancer Meta-analysis Evidence-based medicine

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Quality in Healthcare: The New Frontier of“Patient-Centered Care Approach” in Day Clinics

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Journal of Civil Engineering and Architecture 2020年第3期14卷 160-167页

作者： Michele Di Sivo1 Claudia balducci2 Department of Engineering of Energy SystemsTerritory and ConstructionUniversity of PisaPisa 56122Italy Department of Architecture G.D’Annunzio University of Chieti-PescaraPescara 65100Italy

This article aims to study methodologically hospital buildings and, in particular, the design of day clinics in the recovery area. The definition of design guidelines to improve and qualify the day clinic, enhancing their performance, takes into account the fact that the established requirements of medical protocols must be accompanied by those new requirements related to the massive evolution in health organizations. Changes in medicine, culture and society have necessarily led to a new formulation of the hospital model and the introduction of the theme of the humanization of the curing process has conditioned the morphological-space configuration and the presence of new relationships and spatial functions in the hospitals. The research of this article attempts, therefore, to explore the use of technology to improve the quality of day clinics’ design, formulating strategies that contribute on one side to facilitating the efficiency of service, and on the other side to making the user feel at ease in a welcoming and comfortable environment.

关键词： Quality in healthcare day clinics patient-centered care approach technology healthcare structures healthcare outcomes

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Congenital Cardiac Defects, Such as Eustachian Valve, May Increase the Risk of Cryptogenic Stroke: A Case Report

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World Journal of Cardiovascular Diseases 2020年第6期10卷 379-384页

作者： Chiara Bandinelli Giovanni Maria Puddu Anna balducci Giampaolo Bianchi Marco Zoli U.O. Stroke Unit Policlinico di Sant’Orsola Bologna Italy U.O. Cardiologia Pediatrica e dell’Età Evolutiva Policlinico di Sant’Orsola Bologna Italy

Eustachian valve is an embryonic endocardial heart structure;after birth it becomes an embryogenic residue and its persistance in adult life is unusual. The literature reports some cases of association between Eustachian valve and PFO and is known that the prominent Eustachian valve can represent a way facilitating systemic embolism.Several studies also investigated the role of Eustachian valve in the pathophysiology of both migraine and cerebral embolism. In addiction is known how Eustachian valve may increase the risk of endocarditis, which mostly affects intravenous drug abusers or those with implanted medical devices or central venous catheters. The most commonly identified organism is Staphylococcus aureus (approximately 53% of cases). We present a case of a 46-year-old woman with known migraine. She was hospitalized in Stroke Unit for a cryptogenic stroke with a right-to-left shunt detected with transcranial doppler ultrasound with “bubble test” and a patent foramen ovale with right-to-left shunt with a fenestration of atrial septum and a voluminous Eustachian valve detected with transesophageal echocardiography;she developed fever with a blood cultures positive for methicillin-resis- tant Staphylococcus aureus (MRSA), even if without evidence of endocarditis vegetations.

关键词： Eustachian Valve Cryptogenic Stroke Patent Foramen Ovale PFO Endocarditis Staphylococcus aureus Transesophageal Echocardiography Migraine

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饮食,致癌作用与衰老

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国外医学(老年医学分册) 1987年第3期 107-110页

作者： balducci L 于哲夫

由于已确认在人类致癌作用中饮食因素的作用,现正在研究防止癌肿发展的营养方案。问题在于对较长期间暴露于环境致癌物的老年人,这些预防措施是否可能取得成功。为回答这一问题,本文集中综述饮食因素、致癌作用与衰老互相作用问题。复... 详细信息

由于已确认在人类致癌作用中饮食因素的作用,现正在研究防止癌肿发展的营养方案。问题在于对较长期间暴露于环境致癌物的老年人,这些预防措施是否可能取得成功。为回答这一问题,本文集中综述饮食因素、致癌作用与衰老互相作用问题。复习了化学致癌作用的机理,发现通过调节饮食可逆转癌发生过程。已证实改变饮食可预防癌肿发生,因为某些特殊营养物对癌的发生有影响。最后,本文还探讨了饮食致癌物对老年人的易损性和老年人饮食预防癌的可能效果。化学的致癌作用在动物实验中,化学物质诱发癌肿是一多阶段的过程。从Berenblum和Shubik1947年倡导的理论中所引伸的概念是化学致癌作用可分为起动和促进两个阶段。近代的概念

关键词：饮食致癌物哺乳类细胞致癌作用致癌性腌制食品癌肿老年人

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