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1981至1997年丹麦精神分裂症患者自杀率的变化:巢式病例对照研究

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英国医学杂志中文版 2005年第3期8卷 194-194页

作者： Merete Nordentoft Thomas Munk Laursen Esben Agerbo Ping Qin eyd hansen hyer Preben Bo Mortensen 朱丽琳

目的：研究精神分裂症及相关疾病患者自杀率的变化。设计：对相关资料进行巢式病例对照设计。资料来源：丹麦的4个纵向登记材料。研究对象：病例组包括1981至1997年的18 744名自杀者，其年龄均小于75岁，每名自杀者设置20名对照与之匹... 详细信息

目的：研究精神分裂症及相关疾病患者自杀率的变化。设计：对相关资料进行巢式病例对照设计。资料来源：丹麦的4个纵向登记材料。研究对象：病例组包括1981至1997年的18 744名自杀者，其年龄均小于75岁，每名自杀者设置20名对照与之匹配。结果：在此期间，研究发现这些精神分裂症及其他相关精神异常患者自杀率的下降幅度与普通人群相似(发生率比为1.00，95%可信区间为0.98～1.03)。其他相关精神疾病患者自杀率的下降比普通人群快。在住院的精神分裂症患者中，入院后第一年的自杀风险最高，年轻者的自杀风险更高，自杀风险随着年龄的增长逐年下降。结论：精神分裂症及相关疾病患者的自杀率已经下降。这可能是由于心理治疗水平的提高、自杀手段的限制或者患者试图自杀后治疗的改进。

关键词：巢式病例对照研究精神分裂症患者自杀率 1997年丹麦疾病患者

Assembling the RNA therapeutics toolbox

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Medical Review 2024年第2期4卷 110-128页

作者： Mona Teng Ziting Judy Xia Nicholas Lo Kashif Daud housheng hansen he Department of Medical Biophysics Temerty Faculty of MedicineUniversity of TorontoTorontoONCanada Princess Margaret Cancer Centre University Health NetworkTorontoONCanada Department of Medical Biophysics Temerty Faculty of MedicineUniversity of TorontoToronto M2J 4A6ONCanada Princess Margaret Cancer Centre University Health NetworkToronto M2J 4A6ONCanada

From the approval of COVID-19 mRNA vaccines to the 2023 Nobel Prize awarded for nucleoside base modifications,RNA therapeutics have entered the spotlight and are transforming drug *** the term“RNA therapeutics”has been used in various contexts,this review focuses on treatments that utilize RNA as a component or target RNA for therapeutic *** summarize the latest advances in RNA-targeting tools and RNA-based technologies,including but not limited to mRNA,antisense oligos,siRNAs,small molecules and RNA *** focus on the mechanisms of current FDA-approved therapeutics but also provide a discussion on the upcoming *** clinical utility of RNA-based therapeutics is enabled not only by the advances in RNA technologies but in conjunction with the significant improvements in chemical modifications and delivery platforms,which are also briefly discussed in the *** summarize the latest RNA therapeutics based on their mechanisms and therapeutic effects,which include expressing proteins for vaccination and protein replacement therapies,degrading deleterious RNA,modulating transcription and translation efficiency,targeting noncoding RNAs,binding and modulating protein activity and editing RNA sequences and *** review emphasizes the concept of an RNA therapeutic toolbox,pinpointing the readers to all the tools available for their desired research and clinical *** the field advances,the catalog of RNA therapeutic tools continues to grow,further allowing researchers to combine appropriate RNA technologies with suitable chemical modifications and delivery platforms to develop therapeutics tailored to their specific clinical challenges.

关键词： RNA therapeutics delivery of nucleic acids chemical modifications

An Overview of Quality Management of Therapeutic Vaccines in Clinical Trials in China

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Asian Journal of Social Pharmacy 2024年第1期19卷 50-57页

作者： Lin hansen Tian Lijuan School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To provide suggestions and a reference for improving the quality management system of clinical trials of therapeutic vaccines and promoting the development of therapeutic vaccines in *** Literature research,case study and comparative study were used to analyze the quality management system of clinical trials of therapeutic *** and Conclusion From the perspective of the sponsor,investigators and the thirdparty technical service company,the problems such as the low efficiency of clinical trial sample preparation and the lax implementation of the protocol by hospital departments in the quality management of clinical trials of therapeutic vaccines in China were ***,the optimization plan for the quality management of clinical trials of therapeutic vaccines is proposed,including optimizing the preparation process of therapeutic vaccines and strengthening the training of hospital department personnel.

关键词： therapeutic vaccine clinical trial quality management good clinical practice(GCP)

Identific tion of quantitative trait loci and associated candidate genes for pregnancy success in Angus–Brahman crossbred heifers

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Journal of Animal Science and Biotechnology 2024年第1期15卷 162-170页

作者： Quinn A.hoorn Gabriel A.Zayas Eduardo E.Rodriguez Laura M.Jensen Raluca G.Mateescu Peter J.hansen Department of Animal Sciences Donald Henry Barron Reproductive and Perinatal Biology Research Programand the Genetics InstituteUniversity of FloridaGainesvilleFLUSA School of Applied Systems Biology La Trobe UniversityBundooraVIC 3083Australia

Background In beef cattle, more than 50% of the energy input to produce a unit of beef is consumed by the female that produced the calf. Development of genomic tools to identify females with high genetic merit for reproductive function could increase the profitability and sustainability of beef *** Genome-wide association studies(GWAS) were performed using a single-step genomic best linear unbiased prediction approach on pregnancy outcome traits from a population of Angus–Brahman crossbred heifers. Furthermore, a validation GWAS was performed using data from another farm. heifers were genotyped with the Bovine GGP F250 array that contains 221,077 SNPs. In the discovery population, heifers were bred in winter breeding seasons involving a single round of timed artificial insemination(AI) followed by natural mating for 3 months. Two phenotypes were analyzed: pregnancy outcome to first-service AI(PAI;n = 1,481) and pregnancy status at the end of the breeding season(PEBS;n = 1,725). The heritability was estimated as 0.149 and 0.122 for PAI and PEBS, respectively. In the PAI model, one quantitative trait locus(QTL), located between 52.3 and 52.5 Mb on BTA7, explained about 3% of the genetic variation, in a region containing a cluster of γ-protocadherin genes and SLC25A2. Other QTLs explaining between 0.5% and 1% of the genetic variation were found on BTA12 and 25. In the PEBS model, a large QTL on BTA7 was synonymous with the QTL for PAI, with minor QTLs located on BTA5, 9, 10, 11, 19, and 20. The validation population for pregnancy status at the end of the breeding season were Angus–Brahman crossbred heifers bred by natural mating. In concordance with the discovery population, the large QTL on BTA7 and QTLs on BTA10 and 12 were *** In summary, QTLs and candidate SNPs identified were associated with pregnancy outcomes in beef heifers, including a large QTL associated with a group of protocadherin genes. Confirmation of these associations

关键词： Beef cattle Fertility GWAS QTL

Perspective: Dimensions of Environment and health in Arctic Communities

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Environment & health 2024年第1期2卷 3-10页

作者： Rainer Lohmann Bonita Beatty Jessica Graybill Elena Grigorieva Ketil Lenert hansen Anu Soikkeli Graduate School of Oceanography University of Rhode IslandNarragansettRhode Island 02882United States College of Arts and Sciences University of SaskatchewanSaskatoonSaskatchewan S7N 5A2Canada Jessica Graybill−Colgate UniversityHamiltonNew York 13346United States Geographisches Institut Humboldt UniversitätBerlin 10099Germany Regional Centre for Child Youth Mental Health and Child Welfare North(RKBU Nord)UiT The Arctic University of NorwayTromsø9037Norway Oulu School of Architecture University of OuluOulu 90014Finland

In the Arctic,environment and health are linked in myriad ways.A key emphasis has been on numerous long-lived contaminants in traditional foods,particularly marine mammals,and their well-documented impacts on human,animal and environmental health(“One health approach”).More recent concerns for Indigenous communities focus on the(side)effects of the switch to a modern,processed diet,which is accompanied by a loss of tradition and emerging health ***,the availability of traditional foods is increasingly threatened by the impacts of climate change,which also causes the emergence and spread of new and old diseases,such as *** change,including thawing permafrost and new forest fire regimes,threatens the built environment and *** particular,well-built,planned,and healthy housing is urgently needed,given that much time is spent *** care,particularly for remote and Indigenous communities,is sparse,and often ignores traditional knowledge and local *** communities in the Arctic continue to suffer from marginalization,resource colonization/extraction,and the impacts of *** examples of the green energy transition,such as in Norway,continue a pattern of ignoring Indigenous rights and ***,the connection between environment and health in the Arctic is multifaceted and complex,and investigations and solutions ought to embrace an interdisciplinary and holistic approach toward improving Environmental and human health in the region.

关键词： Climate change Indigenous Infrastructure Permafrost housing health care Well-being Green transition

Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

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Bone Research 2024年第1期12卷 180-198页

作者： Morten S.hansen Kaja Madsen Maria Price Kent Søe Yasunori Omata Mario M.Zaiss Caroline M.Gorvin Morten Frost Alexander Rauch Molecular Endocrinology Laboratory(KMEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of Metabolism and Systems Research(IMSR)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for Membrane Proteins and Receptors(COMPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of Molecular Medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal Medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(SSTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enhanced osteoclast formation,while activating SSTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

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浅析混凝土的冻融破坏机理

混凝土 2024年第6期 12-18页

作者：任旭刘志超 WILL hansen 武汉理工大学硅酸盐建筑材料国家重点实验室湖北武汉430070 密歇根大学土木与环境工程学院安娜堡48109美国

混凝土耐久性决定了建筑结构的安全性与稳定性,并在长期服役过程中起到重要作用,影响其使用寿命。耐久性与混凝土所处的环境密切相关,寒冷地区正负温交变引起的混凝土冻融破坏是导致混凝土耐久性不足的重要原因之一。介绍了混凝土冻融... 详细信息

混凝土耐久性决定了建筑结构的安全性与稳定性,并在长期服役过程中起到重要作用,影响其使用寿命。耐久性与混凝土所处的环境密切相关,寒冷地区正负温交变引起的混凝土冻融破坏是导致混凝土耐久性不足的重要原因之一。介绍了混凝土冻融耐久性的两种典型破坏形式,即内部冻胀开裂和表面盐冻剥蚀,包括冻融破坏的特征、常用表征手段以及劣化机理。同时针对非引气混凝土和引气混凝土,普通混凝土和高性能混凝土的冻融破坏机理进行了比较和分析,并针对性介绍了高性能混凝土的冻融破坏特性。

关键词：混凝土冻融冻胀开裂盐冻剥蚀破坏机理

Glycerol Electrooxidation over Precision-Synthesized Gold Nanocrystals with Different Surface Facets

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Precision Chemistry 2024年第3期2卷 103-111页

作者： hansen Mou Fang Lu Zechao Zhuang Qiaowan Chang Lihua Zhang Xiaobo Chen Yugang Zhang Jingguang G.Chen Department of Chemical Engineering Columbia UniversityNew YorkNew York 10027United States School of Chemical Engineering and Bioengineering Washington State UniversityPullmanWashington 99164United States Center for Functional Nanomaterials Brookhaven National LaboratoryUptonNew York 11973United States Materials Science and Engineering Program State University of New York at BinghamtonBinghamtonNew York 13902United States Chemistry Division Brookhaven National LaboratoryUptonNew York 11973United States

Electrochemical glycerol oxidation(EGO)emerges as a promising route to valorize glycerol,an underutilized byproduct from biodiesel production,into value-added *** study employed three types of gold(Au)nanocrystals with controlled shapes to elucidate the facet-dependent electrocatalytic behavior in ***,rhombic dodecahedral,and cubic Au nanocrystals with{111},{110},and{100}facets,respectively,were precisely synthesized with uniform size and *** dodecahedra exhibited the lowest onset potential for EGO due to facile AuOh formation,while octahedra showed enhanced electrochemical activity for glycerol oxidation and resistance to ***-situ FTIR analysis revealed that Au{111}surfaces selectively favored C_(2) products,whereas Au{100}surfaces promoted C_(3) product formation,highlighting the significant effect of facet orientation on EGO performance and informing catalyst design.

关键词： Electrochemical glycerol oxidation Precision synthesis Shaped nanocrystals Au nanocrystals SAXS In-situ FTIR

fRAP 2.0:a community engagement method applied to cervical cancer disparities among hispanic women

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Family Medicine and Community health 2024年第S2期12卷 44-57页

作者： Autumn M Kieber-Emmons Susan E hansen Michael Topmiller Jaskaran Grewal Carlos Roberto Jaen Benjamin F Crabtree William L Miller Department of Family Medicine Lehigh Valley Health NetworkAllentownPennsylvaniaUSA College of Medicine USFTampaFloridaUSA Lehigh Valley health Network AllentownPennsylvaniaUSA American Academy of Family Physicians-health Landscape CincinattiOHUSA Lafayette College EastonPennsylvaniaUSA UT health San Antonio San AntonioTexasUSA Rutgers Robert Wood Johnson Medical School PiscatawayNew JerseyUSA Cancer Institute of New Jersey New BrunswickNew JerseyUSA

focused Rapid Assessment Process(fRAP)2.0 is a community engagement approach combining geospatial mapping with rapid qualitative assessment in cyclical fashion within communities to capture multifactorial and multilevel features impacting primary care *** 2.0 offers primary care researchers a methodology framework for exploring complex community features that impact primary healthcare delivery and *** fRAP 2.0 study design expands the fRAP from a sequential design to a cyclical process of geospatial mapping and rapid qualitative assessment in search of modifiable contextual *** participants are stakeholders from various socioecological levels whose perspectives inform study outcomes that they may use to then become the agents of change for the very problems they helped ***,we present a proof-of-concept study for fRAP 2.0 examining disparities in cervical cancer mortality rates among hispanic women in *** primary outcomes of interest are features at the community level,medical health system level and regional government policy levels that offer opportunities for collaborative interventions to improve cervical cancer *** this study,geospatial mapping of county and ZIP code-level variables impacting postdiagnosis cervical cancer care at community,medical and policy levels were created using publicly available data and then overlaid with maps created with Texas Cancer Registry data for cervical cancer cases in three of the largest population *** disparate areas were then qualitatively explored using participant observation and ethnographic field work,alongside 39 key informant *** discussion groups and stakeholder engagement existed at every phase of the *** the fRAP 2.0 method,we created an action-oriented roadmap of next steps to improve cervical cancer care disparities in the three Texas counties with emphasis on the high disparity *** identified local change

关键词： cervical qualitative policy