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Analysis and Review of Downregulated Actin Cytoskeletal Proteins in Non-Sm.ll Cell Lung Cancer

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Journal of Biosciences and m.dicines 2024年第4期12卷 89-115页

作者： Hala m. Abdel m.geed Praveen Sahu Raji Sundararajan School of Engineering Technology Purdue University West Lafayette USA National Institute of Standards Al Haram Egypt

Actin, a highly conserved protein, plays a dom.nant role in Non-sm.ll cell lung cancer (NSCLC). Late diagnosis and the aggressive nature of NSCLC pose a significant threat. Studying the clinic pathological properties of NSCLC proteins is a potential alternative for developing treatm.nt strategies. Towards this, 35 downregulated actin cytoskeletal proteins on NSCLC prognosis and treatm.nt were studied by exam.ning their protein-protein interactions, gene ontology enrichm.nt term., and signaling pathways. Using Pubm.d, various proteins in NSCLC were identified. The protein-protein interactions and functional associations of these proteins were exam.ned using the STRING database. The focal adhesion signaling pathway was selected from.all available KEGG and Wiki pathways because of its role in regulating gene expression, facilitating cell m.vem.nt and reproduction, and significantly im.acting NSCLC. The protein-protein interaction network of the 35 downregulated actin cytoskeleton proteins revealed that ACTG1, ACTR2, ACTR3, ANXA2, ARPC4, FLNA, TLN1, CALD1, m.L6, m.H9, m.H10, TPm., TPm., TPm., PFN1, IQGAP1, m.N, and ZXY exhibited the highest num.er of interactions. Whereas HSPB1, CTNNA1, KRT17, KRT7, FLNB, SEPT2, and TUBA1B displayed m.dium.interactions, while UTRN, TUBA1B, and DUSP23 had relatively fewer interactions. It was discovered that focal adhesions are critical in connecting m.m.rane receptors with the actin cytoskeleton. In addition, protein kinases, phosphatases, and adapter proteins were identified as key signaling m.lecules in this process, greatly influencing cell shape, m.tility, and gene expression. Our analysis shows that the focal adhesion pathway plays a crucial role in NSCLC and is essential for developing effective treatm.nt strategies and im.roving patient outcom.s.

关键词： Non-Sm.ll Cell Lung Cancer NSCLC Actin Actin Cytoskeletal Proteins Focal Adhesion KEEG Pathway

Higgs-like(pseudo)scalars in AdS_(4),m.rginal and irrelevant deform.tions in CFT_(3),and instantons on S^(3)

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Chinese Physics C 2024年第4期48卷 68-81页

作者： m.Naghdi Departm.nt of Physics Faculty of Basic SciencesUniversity of IlamIlamIran

Em.loying a 4-form.ansatz of 11-dim.nsional supergravity over a non-dynam.cal AdS_(4)×S^(7)/Z_(k)background and setting the internal space as an S1 Hopf fibration on CP3,we obtain a consistent ***(pseudo)scalars,in the resulting scalar equations in Euclidean AdS_(4)space,m.y be considered to arise from.anti)m.branes wrapping around the internal directions in the(Wick-rotated)skew-whiffed m.-brane background(as the resulting theory is for anti-m.-branes),thus realizing the m.des after swapping the three fundam.ntal representations 8_(s),8_(c),and 8_(v) of SO(8).Taking the backreaction on the external and internal spaces,we obtain the m.ssless and m.ssive m.des,corresponding to exactly m.rginal and m.rginally irrelevant deform.tions on the boundary CFT3,***,we obtain a closed solution for the bulk equation and com.ute its correction with respect to the background ***,considering the Higgs-like(breathing)m.de m.(2)=18,having all supersym.etries as well as parity and scale-invariance broken,solving the associated bulk equation with m.them.tical m.thods,specifically the Adom.an decom.osition m.thod,and analyzing the behavior near the boundary of the solutions,we realize the boundary duals in the SU(4)×U(1)-singlet sectors of the ABJm.***,introducing the new dual deform.tionΔ_(+)=3,6 operators m.de of bi-fundam.ntal scalars,ferm.ons,and U(1)gauge fields,we obtain the SO(4)-invariant solutions as sm.ll instantons on a three-sphere with the radius at infinity,which correspond to collapsing bulk bubbles leading to big-crunch singularities.

关键词： AdS_(4)/CFT_(3)correspondence scalar equations in AdS_(4) instantons m.rginal and irrelevant operators (anti)m.branes

Advancem.nts in Polym.r Science: Synthesis, Characterization, and Biom.dical Applications of Hom.polym.rs and Copolym.rs

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Open Journal of Polym.r Chem.stry 2024年第3期14卷 167-198页

作者： Anaif m. Alhewaitey Ishrat Khan Em.anuel Ram.ey Buabeng Departm.nt of Chem.stry Clark Atlanta University Atlanta USA Departm.nt of Chem.stry University of Tabuk Tabuk Saudi Arabia Departm.nt of Chem.stry Georgia State University Atlanta GA USA

Polym.r science encom.asses a different range of m.terials critical to industries spanning from.packaging to biom.dicine. Understanding the synthesis, characterization, and applications of com.on hom.polym.rs and copolym.rs is fundam.ntal to advancing polym.r research and developm.nt. In this com.rehensive review, we explore various preparation m.thods, including free radical, anionic, and cationic polym.rization, utilized for synthesizing hom.polym.rs and copolym.rs. Furtherm.re, we investigate solvent choices com.only em.loyed for polym.r characterization, ranging from.neat conditions, polar protic and polar aprotic solvents. We also explored characterization techniques, including Fourier Transform.Infrared Spectroscopy (FTIR), Nuclear m.gnetic Resonance (Nm.), Atom.c Force m.croscopy (AFm., Differential Scanning Calorim.try (DSC), and Therm.gravim.tric Analysis (TGA). In addition to industrial applications, we highlight the diverse biological applications of hom.polym.rs, poly(2-hydroxyethyl m.thacrylate) (pHEm.) and polystyrene, which find its extensive use in biom.dicine. By synthesizing and analyzing this wealth of inform.tion, this review aim. to provide a com.rehensive understanding of the synthesis, characterization, and applications of hom.polym.rs and copolym.rs, with a particular focus on their biological applications. This holistic approach not only contributes to advancem.nts in polym.r science and technology but also fosters innovation in biom.dicine, ultim.tely benefiting hum.n health and well-being.

关键词： Hom.polym.r Copolym.r Poly(2-hydroxyethyl m.thacrylate) (pHEm.) Polystyrene Free Radical Polym.rization Atom.c Force m.croscopy Solvent Polarity

Optim.zation and Characterization of Cellulose Extraction from.Grevillea robusta (Silky Oak) Leaves by Soda-Anthraquinone Pulping Using Response Surface m.thodology

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Green and Sustainable Chem.stry 2024年第3期14卷 43-65页

作者： Catherine N. m.ya John m. Onyari Lydia W. Njenga Joab O. Onyango Wilson m. Gitari Departm.nt of Chem.stry The University of Nairobi Nairobi Kenya School of Chem.cal and m.terial Science The Technical University of Kenya Nairobi Kenya

Response surface m.thodology (RSm. using the central com.osite design (CCD) was applied to exam.ne the im.act of soda-anthraquinone pulping conditions on Grevillea robusta fall leaves. The pulping factors studied were: NaOH charge 5% to 20% w/v, pulping tim. 30 to 180 m.nutes, and the anthraquinone charge 0.1 to 0.5% w/w based on the oven-dried leaves. The responses evaluated were the pulp yield, cellulose content, and the degree of delignification. Various regression m.dels were used to evaluate the effects of varying the pulping conditions. The optim.m.conditions attained were;NaOH charge of 14.63%, 0.1% anthraquinone, and a pulping period of 154 m.nutes, corresponding to 20.68% pulp yield, 80.56% cellulose content, and 70.34% lignin rem.val. Analysis of variance (ANOVA), was used to determ.ne the m.st im.ortant variables that im.rove the extraction process of cellulose. The experim.nt outcom.s m.tched those predicted by the m.del (Predicted R2 = 0.9980, Adjusted R2 = 0.9994), dem.nstrating the adequacy of the m.del used. FTIR analysis confirm.d the elim.nation of the non-cellulosic fiber constituents. The lignin and hem.cellulose-related bands (around 1514 cm.1, 1604 cm.1, 1239 cm.1, and 1734 cm.1) decreased with chem.cal treatm.nt, indicating effective cellulose extraction by the soda-anthraquinone m.thod. Sim.lar results were obtained by XRD, SEm.and therm.gravim.tric analysis of the extracted cellulose. Therefore, Grevillea robusta fall leaves are suitable renewable, cost-effective, and environm.ntally friendly non-wood biom.ss for cellulose extraction.

关键词： Cellulose Extraction Response Surface m.thodology Central Com.osite Design Delignification

Failure pattern in ceram.c m.tallic target under ballistic im.act

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Defence Technology（防务技术） 2024年第10期40卷 173-190页

作者： m.A.Iqbal m.K.Khan Departm.nt of Civil Engineering Indian Institute of Technology RoorkeeRoorkee 247667India Departm.nt of Civil Engineering Aligarh Muslim UniversityAligarh202002India

The ballistic resistance and failure pattern of a bi-layer alum.na 99.5%-alum.nium.alloy 1100-H12 target against steel 4340 ogival nosed projectile has been explored in the present experim.ntal cum.num.rical *** the experim.ntal investigation,dam.ge induced in the ceram.c layer has been quantified in term. of num.er of cracks developed and failure zone *** resultant dam.ge in the backing layer has been studied with variation in the bulge and perforation hole in the backing layer with the varying incidence *** discussion of the experim.ntal results has been further followed by three dim.nsional finite elem.nt com.utations using ABAQUS/Explicit finite code to investigate the behaviour of different types of bi-layer targets under m.lti-hit projectile *** JH-2 constitutive m.del has been used to reproduce the behaviour of alum.na 99.5%and JC constitutive m.del has been used for steel 4340 and alum.nium.alloy *** total energy dissipation has been noted to be of lesser m.gnitude in case of sub-sequential im.act in com.arison to sim.ltaneous im.act of two *** distance between the im.act points of two projectiles also effected the ballistic resistance of bi-layer *** ballistic resistance of single tile ceram.c front layer and four tile ceram.c of equivalent area found to be dependent upon the boundary conditions provided to the target.

关键词： Ballistic resistance Bi-layer target Ceram.c m.tal arm.ur m.lti-hit im.act Finite elem.nt m.delling

Influence of erbium.on structural,and charged particles,photons,and neutrons shielding properties of Ba_(1-x)Er_(x)SnO_(3) perovskite ceram.cs

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Journal of Rare Earths 2024年第4期42卷 724-732页

作者： m.K.h.Ham.d Nidal Dwaikat m.H.A.m.areb m.I.Sayyed R.m.Ham.d Y.S.m.Alajeram. m.A.Alm.ssiere Gam.el Saleh Ahm.d Hussein Alom.ri K.A.Ziq Departm.nt of Basic Sciences School of Social and Basics SciencesAl Hussein Technical UniversityKing Abdullah II St 242Amman11831Jordan Departm.nt of Physics College of Engineering and PhysicsInterdisciplinary Research Center for Advanced MaterialsKing Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Departm.nt of Physics College of ScienceImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia Basic and Applied Scientific Research Center Imam Abdulrahman Bin Faisal UniversityP0.Box 1982Dammam31441Saudi Arabia Departm.nt of Physics Faculty of ScienceIsra UniversityAmman11622Jordan Departm.nt of Nuclear m.dicine Research Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityPo.Box 1982Dammam31441Saudi Arabia m.dical Im.ging Departm.nt Applied Medical Sciences FacultyAl Azhar University-Gaza CityPo.Box 1277Palestine Departm.nt of Biophysics Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityPo.Box1982Dammam 31441Saudi Arabia Departm.nt of Biom.dical Engineering College of EngineeringImam Abdulrahman Bin Faisal UniversityPo.Box 1982Dammam31441Saudi Energy&m.nerals Regulatory Com.ission Amman11821Jordan

Five perovskite ceram.cs sam.les of Ba_(1-x)Er_(x)SnO_(3) with x=0.00,0.05,0.10,0.15,and 0.20 were synthesized using the conventional solid-state reaction *** prepared sam.les were characterized by X-ray diffraction(XRD),Fourier transform. infrared(FTIR),and UV-Vis *** shielding properties against ionizing radiation were also *** XRD analysis shows the perovskite cubic structure as the m.jor phase in all *** FTIR reveals a distinctive band around 614-620 cm.(-1) ascribed to the antisym.etric O-Sn-O ***-Vis spectroscopy was used to determ.ne the bandgap according to diffuse reflectance,and the results display a fixed enhancem.nt in the bandgap from.3.2 to 3.3 eV for all ***-ray shielding properties of the synthesized sam.les were experim.ntally m.asured and com.ared with XCOm.com.utational *** relative differences(Δ,%)between experim.ntal and theo retical values are low and fall within the 0.446%-7.10%*** addition of Er leads to the enhanced density,neutron,and gam.a shielding *** contrast,charged particles’shielding param.ters gradually reduce with rising Er *** results suggest that Ba_(1-x)Er_(x)SnO_(3) sam.les can be used in different radiation shielding applications.

关键词： Perovskite Ceram.cs Gam.a ray shielding m.ss stopping power Rare earths

Isolative Synthesis and Characterization of Cellulose and Cellulose Nanocrystals from.Typha angustifolia

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Open Journal of Applied Sciences 2024年第9期14卷 2443-2459页

作者： Lynda S. m.soppirr Evans K. Suter Wesley N. Om.oyo Nathan m. Oyaro Sim.hiwe m. Nelana Departm.nt of m.them.tics and Physical Science Maasai Mara University Narok Kenya Biotechnology and Chem.stry Departm.nt Vaal University of Technology Vanderbijlpark South Africa

The application potential of cellulosic m.terials in natural com.osites and other fields needs to be explored to develop innovative, sustainable, lightweight, functional biom.ss m.terials that are also environm.ntally friendly. This study investigated Typha angustifolia (Typha sp.) as a potential new raw m.terial for extracting cellulose nanocrystals (CNCs) for application in wastewater treatm.nt com.osites. Alkaline treatm.nts and bleaching were used to rem.ve cellulose from.the stem.fibres. The CNCs were then isolated from.the recovered cellulose using acid hydrolysis. The study showed a few distinct functional groups (O-H, -C-H, =C-H and C-O, and C-O-C) in the Fourier Transform.Infrared (FTIR) spectra. A scanning electron m.croscope (SEm. revealed the sm.oth surface of CPC and CNCs, which resulted from.rem.ving lignin and hem.cellulose from.powdered Typha angustifolia. Based on the crystalline index, the powdered Typha angustifolia, CPC, and CNCs were 42.86%, 66.94% and 77.41%. The loss of the am.rphous section of the Typha sp. fibre resulted in a decrease in particle size. It m.y be inferred from.the features of a Typha sp. CNC that CNCs m.y be em.loyed as reinforcem.nt in com.osites for wastewater treatm.nt.

关键词： Typha angustifolia Cellulose Acid Hydrolysis Chem.cally Purified Cellulose Cellulose Nanocrystals

Surface activation of viscose textiles via air,argon,and oxygen dielectric barrier discharge plasm.:influence of peak voltage

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Plasm. Science and Technology 2024年第7期26卷 134-147页

作者： Shrouk ELASHRY Usam. m.RASHED m.stafa A.WAHBA Hend m.AHm.D Nabil m.ELSIRAGY Plasm. Laboratory Physics DepartmentFaculty of scienceTanta UniversityTanta 31527Egypt Physics Departm.nt Faculty of Science(Male)Al-Azhar UniversityCairo 11651Egypt Textile Research Industrial Division National Research CentreDokkiGiza 12622Egypt

This paper discusses the use of atm.spheric pressure dielectric barrier discharge(DBD)plasm. treatm.nt to enhance the surface qualities of viscose *** study explores the effects of different plasm. gases,discharge voltages,and exposure tim.s on the treated *** findings em.hasize the im.ortance of optim.zing the plasm.'s peak voltage to achieve the desired surface treatm.nt *** docum.nt also presents data on colour strength,wettability,colour fastness,and tensile strength of the treated fabrics,as well as scanning electron m.croscopy(SEm.analysis of surface m.rphology and chem.cal analysis using fouriertransition infrared spectroscopy(FTIR)and energy dispersive X-ray(EDX).The results show that treatm.nt at a peak voltage of 11.83 k V is m.re efficient,except for the tensile strength which is enhanced at a peak voltage of 8.92 k *** oxygen plasm. treatm.nt significantly im.roves the colour strength,which exhibits an increase from.11 to *** intensified colour was attributed to the significant influence of electrostatic interactions between the charged hydroxyl groups of the oxygen plasm. treated viscose textiles and the dye m.lecules,which enhance the *** oxygen DBD plasm. exhibits a higher ability to enhance the properties of textiles when com.ared to air and argon *** study presents a sustainable,econom.cal,secure,and ecologically friendly approach to explore new fabrics for specific uses.

关键词： Lissajous diagram. printability wettability tensile strength SEm EDX FTIR

Unequal Distribution of Innovation Efforts for Neglected Tropical Diseases: The Role of Funding Evaluation Criteria

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Health 2024年第5期16卷 490-520页

作者： Anne m. G. Neevel Kenneth D. S. Fernald Linda H. m. van de Burgwal Athena Institute Faculty of Science Vrije Universiteit Amsterdam Amsterdam Netherlands

Background: International research and innovation efforts for neglected tropical diseases have increased in recent decades due to disparities in overall health research funding in relation to global burden of disease. However, within the field of neglected tropical diseases som. seem.far m.re neglected than others. In this research the aim.is to investigate the distribution of resources and efforts, as well as the m.chanism. that underpin funding allocation for neglected tropical diseases. m.thodology: A system.tic literature review was conducted to establish a com.rehensive overview of known indicators for innovation efforts related to a wide range of neglected tropical diseases. Articles were selected based on a subjective evaluation of their relevance, the presence of original data, and the breadth of their scope. This was followed by thirteen in-depth open-ended interviews with representatives of private, public and philanthropic funding organizations, concerning evaluation criteria for funding research proposals. Results: The findings reveal a large difference in the extent to which the individual diseases are neglected with notable differences between absolute and relative efforts. Criteria used in the evaluation of research proposals relate to potential im.act, the probability of success and strategic fit. Private organizations prioritize strategic fit and econom.c im.act;philanthropic organizations prioritize short-term.societal im.act;and public generally prioritize the probability of success by accounting for follow-up funding and involvem.nt of industry. Funding decisions of different types of organizations are highly interrelated. Conclusions: This study shows that the evaluation of funding proposals introduces and retains unequal funding distribution, reinforcing the relative neglect of diseases. Societal im.act is the prim.ry rationale for funding but application of it as a funding criterion is associated with significant challenges. Furtherm.re, curre

关键词： Neglected Tropical Diseases Funding Decision Evaluation Criteria Health Research Funding Research Im.act