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Altered thermal sensitivity in facial skin in chronic whiplash-associated disorders

International Journal of Oral Science 2013年第3期5卷 150-154页

作者： Birgitta Hggman-Henrikson ewa Lampa Erik Nordh Department of Odontology Clinical Oral Physiology Umea University Department of Pharmacology and Clinical Neurosciences Division of Clinical Neurophysiology Ume University

There is a close functional relationship between the jaw and neck regions and it has been suggested that trigeminal sensory impairment can follow whiplash *** of manageable routines for valid assessment of the facial sensory capacity is thus needed for comprehensive evaluations of patients exposed to such *** present study investigated facial thermal thresholds in patients with chronic whiplash-associated disorders（WADs）with both a qualitative method and quantitative sensory testing（QST）.Ten women with pain and dysfunction following a whiplash injury were compared to 10 healthy age-matched *** detection thresholds were assessed by qualitative chair-side testing and by QST according to the *** test sites in the facial skin（overlying each trigeminal branch bilaterally,and the midpoint of the chin）were *** detection warm and cold thresholds were defined as the mean values of 10 individual *** the WAD patients,the qualitative assessment demonstrated both reduced and increased sensitivity compared to the healthy,whereas QST systematically showed significantly higher detection thresholds（i.e.,decreased sensitivity）for both cold and warm *** the individuals who were assessed as having increased sensitivity in the qualitative assessment,the QST displayed either normal or higher thresholds,i.e.,decreased *** results suggest that QST is more sensitive for detecting thermal sensory disturbances in the face than a qualitative *** impaired thermal sensitivity among the patients corroborates the notion of altered thermal detection capacity induced by WAD-related pain.

关键词： jaw neck quantitative sensory testing thermal thresholds trigeminal whiplash injury

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The Application of Cellulose Nanocrystals Modified with Succinic Anhydride under the Microwave Irradiation for Preparation of Polylactic Acid Nanocomposites

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Journal of Renewable Materials 2021年第6期9卷 1127-1142页

作者： ewa Szefer Agnieszka Leszczyńska Edyta Hebda Krzysztof Pielichowski Department of Chemistry and Technology of Polymers Cracow University of TechnologyKrakow31-155Poland

The aim of this work was to use cellulose nanocrystals that were obtained by hydrolysis in phosphoric acid solution and further modified with succinic anhydride in the microwave field for PLA reinforcement.A series of allbionanocomposites containing unmodified and surface modified cellulose nanocrystals with CNC content in the range of 1–3%_(w.t.) were obtained by melt blending and tested by XRD,SEM,DSC and DMA to investigate the effect of surface esterification of CNCs on the structure,morphology,dynamic mechanical properties of bionanocomposites,as well as phase transitions of PLA in the presence of cellulosic *** investigations showed the highest increase of storage modulus by ca.7%(335 MPa at 25℃)in the glassy state of PLA for 2%_(w.t.)of unmodified ***,addition of 2%_(w.t.)of succinylated CNCs caused the highest increase of the onset of glass transition temperature(by 6.2℃)thus widening the temperature range of biocomposite *** increase of glass transition temperature indicates the strongest interfacial interactions due to improved miscibility of surface modified nanocrystals and thus good dispersion of additive in PLA matrix providing high interface.

关键词： Cellulose nanocrystals CNC whiskers surface modification succinic anhydride PLA polylactic acid nanocomposites

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Specific and Selective Bacteriophages in the Fight against Multidrug-resistant Acinetobacter baumannii

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Virologica Sinica 2019年第4期34卷 347-357页

作者： Natalia Baginska Anna Pichlak Andrzej Gorski ewa Jonczyk-Matysiak Bacteriophage Laboratory Hirszfeld Institute of Immunology and Experimental TherapyPolish Academy of Sciences53-114 WroclawPoland Phage Therapy Unit Hirszfeld Institute of Immunology and Experimental TherapyPolish Academy of Sciences53-114 WroclawPoland Department of Clinical Immunology Transplantation InstituteMedical University of Warsaw53-114 WarsawPoland

Acinetobacter baumannii causes serious infections especially in immunocompromised and/or hospitalized *** *** strains are multidrug resistant and infect wounds,bones,and the respiratory *** studies are focused on finding new effective agents against *** therapy is a promising means to fight this bacterium and many studies on procuring and applying new phages against *** are currently being *** shown in animal models,phages against multidrug-resistant *** may control bacterial infections caused by this pathogen and may be a real hope to solve this dangerous health problem.

关键词： Acinetobacter baumannii Bacteriophages Phage therapy Multidrug resistance(MDR)

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Financialisation in emerging economies:a systematic overview and comparison with Anglo-Saxon economies

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Economic and Political Studies 2017年第1期5卷 60-86页

作者： ewa Karwowski Engelbert Stockhammer School of Social and Behavioural Sciences Kingston UniversityLondonUK

Financialisation research has originally focussed on the US experience,but the concept is now increasingly applied to emerging economies(EMEs).There is a rich literature stressing peculiarities of individual country experiences,but little systematic comparison across *** paper fills this gap,providing an overview of the debate and identifying six financialisation interpretations for *** different interpretations stress(1)financial deregulation,(2)foreign financial inflows,(3)asset price volatility,(4)the shift from bank-based to market-based finance,(5)business debt,and(6)household *** construct and compare measures of the six financialisation interpretations across a sample of 17 EMEs from Latin America,emerging Europe,Africa and Asia,contrasting them with the US and UK,two financialised *** find considerable variation in financialisation experiences of *** price volatility is found across the *** has been more exposed to capital inflows,stock markets have gained importance and private sector debt has *** emerging Europe financial deregulation has been more pronounced with lower levels but strong increases in household *** picture is similar in South Africa,the African EME in the sample,where household debt is comparatively *** in Latin America is weaker according to our measures.

关键词： Financialisation emerging markets financial instability asset price volatility heterodox economics

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Poly(phenylene oxide) and Renewable Polyamide 11 Blends Compatibilized by Ethylene-n-Octene Copolymer

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Journal of Renewable Materials 2018年第7期6卷 772-783页

作者： Regina Jeziorska Agnieszka Abramowicz Agnieszka Szadkowska Anna Pasnik ewa Spasowka Department of Polymer Technology and Processing Industrial Chemistry Research InstituteRydygiera 801-793 WarsawPoland

Poly(phenylene oxide)/renewable polyamide 11 (PPO/PA11 20/80) blends toughened with glycidylmethacrylate grafted ethylene-n-octene copolymer (GEOC) were prepared in a co-rotating twin-screwextruder. The reaction between GEOC and PPO/PA11 blend was analyzed by gel content tests. Themorphology of PPO/PA11/GEOC blends was observed by scanning electron microscope. The SEMresults showed that PPO formed the continuous phase, though it is a minority component of blends. Withincreasing GEOC content from 5 to 15 wt% the morphology of the blends transformed from droplet-matrix toco-continuous structure, in which both PA11 and PPO phases are continuous. The blend with co-continuousmorphology had better mechanical properties than those with droplet-matrix morphology. The impactstrength of the PPO/PA11/GEOC blends was much higher compared to the one without GEOC as well asPA11 due to the compatibilizing effect, which was also proved by DSC analysis, rheological behavior (MFR,DMTA) and tensile properties.

关键词： Compatibilization elastomer PPO/PA11 blends toughening

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From infections to autoimmunity:Diagnostic challenges in common variable immunodeficiency

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World Journal of Clinical Cases 2020年第18期8卷 3942-3955页

作者： ewa Więsik-Szewczyk Karina Jahnz-Różyk Department of Internal Medicine PulmonologyAllergy and Clinical ImmunologyCentral Clinical Hospital of the Ministry of National DefenseMilitary Institute of MedicineWarsaw 04-141Poland

Common variable immunodeficiency(CVID)is the most common clinically significant primary antibody deficiency diagnosed in *** early symptoms are not *** include common infections,mainly of the respiratory tract,caused by typical microorganisms,so cases can be missed in primary *** the majority of patients increased susceptibility to infections coexists with signs or symptoms of autoimmunity,inflammation or polyclonal lymphoproliferation,which can divert diagnosis from immune *** overall incidence of malignancy is increased in CVID and certain cancers are significantly more *** and gastric carcinoma are the most frequently reported malignancies in CVID,so a high index of suspicion is *** delay in CVID is seen *** main goal of this paper is to increase the awareness about CVID among health care *** aim to present features which can be helpful in CVID diagnosis in order to shorten the“latency”of proper management of CVID *** review clinical symptoms,complications and laboratory abnormalities of *** replacement therapy is regarded as the cornerstone of pharmacological *** modes of Ig application,mainly subcutaneously and via the hyaluronidase-facilitated subcutaneous route,help to adjust therapy to patients’needs and *** there remain unmet *** remains to be seen whether CVID complications can be avoided by earlier diagnosis,treatment and thorough monitoring in the context of increased risk of *** of patient tailored protocols depending on the clinical phenotype and risk factors might be more *** most important consideration is to diagnose suspected cases and stratify patients in a precise and timely *** is needed to define features predictive of unfavorable prognosis.

关键词： Primary antibody deficiency Recurrent respiratory tract infections Complications Immunoglobulin replacement Adults Early diagnosis

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Esophageal duplication cysts:Endosonographic findings in asymptomatic patients

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World Journal of Gastroenterology 2012年第11期18卷 1270-1272页

作者： Anna Wiechowska-Kozlowska ewa Wunsch Marek Majewski Piotr Milkiewicz Department of Endoscopy Ministry of Internal Affairs Hospital Liver Unit Pomeranian Medical University

Esophageal duplication cysts are rare inherited lesions usually diagnosed in early childhood. Most of them are found in the mediastinum and manifest themselves as separate masses along or in continuity with the native esophagus. Their prevalence remains unknown and they are treated either surgically or endoscopically. In this report we describe a series of four adult patients in whom esophageal duplication cysts were Iocalised intramurally as masses pressing on the esophageal lumen and who were diagnosed with endoscopic ultrasonography. All patients were initially referred to other centres for upper gastroduodenoscopy due to nonspecific dyspeptic symptoms. After finding suspicious lesions in the esophagus their endoscopists referred them for endoscopic ultrasound examination at our centre. In two of the cases lesions mimicked esophageal varices and the other two submucosal tumours. In all four patients endoscopic ultrasonography has shown esophageal duplication cysts. Patients had no symptoms suggesting disease of the esophagusand required no treatment. As the true prevalence of esophageal cysts is unknown, it is very likely that in many patients, like in these four described by us, they may cause no symptoms, remain undetected and require no intervention. Increasing availability of new diagnostic modalities such as endoscopic ultrasonography may change the current view regarding the prevalence of esophageal duplication cysts and prove that they may1 in fact, not be such rare findings.

关键词： Esophageal cyst Endoscopic ultrasonogra-phy Endovascular surgery

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Polarization effect in tip-enhanced infrared nanospect- roscopy studies of the selective Y5 receptor antagonist Lu AA33810

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Nano Research 2018年第8期11卷 4401-4411页

作者： Natalia Piergies ewa Pinta Czestawa Paluszkiewicz Helena Domin Wojciech M.Kwiatek Institute of Nuclear Physics Polish Academy of Sciences PL-31342 Krakow Poland Institute of Pharmacology Polish Academy of Sciences Department of Neurobiology 31-343 Krakow Smetna Street 12 Poland Natalia Piergies and ewa Pieta contributed equally to this work.

A novel approach of combining conventional infrared spectroscopy （IR） and atomic force microscopy （AFM） is presented to better understand the behavior of a drug adsorbed on a metal substrate at the nanoscale level. Tip-enhanced infrared nanospectroscopy （TEIRA） was used for the first time to investigate Lu AA33810, a selective brain-penetrating Y5 receptor antagonist, after immobilization on gold nanopartides （GNPs）. Here, a gold coated AFM tip and gold substrate were used to obtain the near-field electromagnetic field trapping effect. Because of the huge signal enhancement, it was possible to obtain the spectral information regarding the self-assembled monolayer of the investigated molecule. The effect of two orthogonal polarizations （p- and s-polarization modulations） of the excitation laser beam on the spectral patterns is also discussed. The results show that there is a strong relationship between the state of polarization of the incident radiation and the relative infrared band intensities. Another factor affecting the observed spectral differences is the topology of the metal substrate, which may result in the induction of a cross-polarization effect. The performed analysis indicates that the C--C bond from the cyclohexyl group is oriented almost parallel to the metal surface. Conversely, the p- and s-polarized spectral variations suggest that the O=S---O angle is high enough to enable the simultaneous interaction of both oxygen atoms with the GNPs.

关键词： tip-enhanced infrared nanospectroscopy polarization modulation Y5 receptor antagonist gold nanoparticles adsorption

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Impact of diet on long-term decline in gastric cancer incidence in Poland

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World Journal of Gastroenterology 2011年第1期17卷 89-97页

作者： Mirosaw Jarosz Wodzimierz Sekua ewa Rychlik Katarzyna Figurska Department of Dietetics and Nutrition in Hospitals with Clinic of Metabolic Diseases and Gastroenterology National Food and Nutrition Institute02-903 WarsawPoland Independent Laboratory of the Economics of Food and Nutrition National Food and Nutrition Institute02-903 WarsawPoland

AIM:To examine the relationship between the trends in food consumption and gastric cancer morbidity in ***:The study was based on gastric cancer incidence rates and consumption of vegetables,fruit,vitamin C and salt in Poland between 1960 and *** consumption data were derived from the national food balance sheets or household budget *** correlation coefficients were used to estimate the relationship between the ***:A negative correlation was found between vegetables(-0.70 both for men and women;P < 0.0001),fruit(-0.65 and-0.66;P < 0.0001) and vitamin C(-0.75 and-0.74;P < 0.0001) consumption and stomach cancer incidence *** same applied to the availability of refrigerators in the household(-0.77 and-0.80;P < 0.0001).A decline in these rates could also be linked to reduction in salt ***:The decline of gastric cancer incidence probably resulted from increased consumption of vegetables,fruit and vitamin C and a decrease in salt consumption.

关键词： Vegetables Fruit Vitamin C Salt Gastric cancer

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Glycoprotein fucosylation is increased in seminal plasma of subfertile men

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Asian Journal of Andrology 2015年第2期17卷 274-280,I0010页

作者： Beata Olejnik ewa M Kratz Mariusz Zimmer Mirostawa Ferens-Sieczkowska Department of Chemistry and Immunochemistry Medical University of Wrociaw Wroclaw Poland Department and Clinic of Gynecology and Obstetrics Medical University of Wrodaw Wrodaw Poland.

Fucose, the monosaccharide frequent in N- and O-glycans, is a part of Lewis-type antigens that are known to mediate direct sperm binding to the zona pellucida. Such interaction was found to be inhibited in vitro by fucose-containing oligo- and polysaccharides, as well as neoglycoproteins. The objective of this study was to screen seminal plasma proteins of infertile/subfertile men for the content and density of fucosylated glycoepitopes, and compare them to samples of fertile normozoospermic subjects. Seminal proteins were separated in polyacrylamide gel electrophoresis and blotted onto nitrocellulose membrane and probed with fucose-specific Aleuria aurantia lectin （AAL）. Twelve electrophoretic bands were selected for quantitative densitometric analysis. It was found that the content, and especially the density of fucosylated glycans, were higher in glycoproteins present in seminal plasma of subfertile men. No profound differences in fucosylation density were found among the groups of normozoospermic, oligozoospermic, asthenozoospermic, and oligoasthenozoospermic subfertile men. According to the antibody probing, AAL-reactive bands can be attributed to male reproductive tract glycoproteins, including prostate-specific antigen, prostatic acid phosphatase, glycodelin and chorionic gonadotropin. Fibronectin, a1-acid glycoprotein, a1-antitrypsin, immunoglobulin G and antithrombin III may also contribute to this high fucosylation. It is suggested that the abundant fucosylated glycans in the sperm environment could interfere with the sperm surface and disturb the normal course of the fertilization cascade.

关键词： fucose glycosylation infertility seminal plasma

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