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Endosonography with linear array instead of endoscopic retrograde cholangiography as the diagnostic tool in patients with moderate suspicion of common bile duct stones

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World Journal of Gastroenterology 2003年第3期9卷 612-614页

作者： Maciej Kohut Andrzej Nowak ewa nowakowska-Dufawa Tomasz Marek Roman Kaczor Gastroenterology Department of Silesian Medical Academy KatowicePoland

AIM: To evaluate the diagnostic efficiency of endoscopic ultrasound (EUS) as the main imaging modality in patients with moderate suspicion of common bile duct stones (CBDS).METHODS: 55 patients with moderate clinical suspicion of CBDS were prospectively included to the study and evaluated with EUS. This study was done in single blind method in the clinical and biochemical data of patients. EUS was done with echo-endoscope Pentax FG 32-UA (f=5-7,5 MHz) and Hitachi EUB 405 ultrasound machine. Patients diagnosed with CBDS by EUS were excluded from this study and treated with ERC. All the other patients were included to the follow up study obtained by mail every 6 months for clinical evaluation (need of ERC or surgery).RESULTS: CBDS was found in 4 patients by EUS. Diagnosis was confirmed in all cases on ERC. The remaining 51 patients without CBDS on EUS were followed up for 6-26 months (meanly 13 months) There were: 40 women, 42cholecystectomized patients, aged: 55 (mean). Biochemical values (mean values) were as follows: bilirubin: 14,9 μmol.L-1,alkaline phosphatase: 95 IU.L-,1 γ-GTP: 131 IU.L-1, ALT: 50IU.L-1, AST: 49 IU.L-1, Only 1 patient was lost for follow *** the remaining 50 patients with follow up, there was only 1 (2 %) patient with persistent biliary symptoms in whom CBDS was finally diagnosed by ERC with ES. All other patients remained symptoms free on follow up and did not require ERC or biliary ***: Vast majority of patients with moderate suspicion of CBDS and no stones on EUS with linear array can avoid invasive evaluation of biliary tree with ERC.

关键词： Aged Cholangiography Endoscopy Endosonography Female Gallstones Humans Male Middle Aged Prospective Studies Single-Blind Method

Potential role of human papilloma virus in the pathogenesis of gastric cancer

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World Journal of Gastroenterology 2014年第21期20卷 6632-6637页

作者： Miroslaw Snietura Dariusz Waniczek Wojciech Piglowski Agnieszka Kopec ewa nowakowska-Zajdel Zbigniew Lorenc Malgorzata Muc-Wierzgon Tumor Pathology Department Maria Sklodowska-Curie Memorial Cancer Center and Institute of OncologyGliwice Branch44-101 GliwicePoland Clinical Department of General Colorectal and Trauma SurgerySilesian Medical University41-200 SosnowiecPoland Department of Internal Diseases Silesian Medical University41-902 BytomPoland

AIM: To demonstrate the presence and biological activity of human papilloma virus (HPV) in gastric cancer (GAC) tissues.

关键词： Gastric cancer Human papilloma virus Quantitative polymerase chain reaction P16INK4a expression

GDF-15 Level Correlates with CMKLR1 and VEGF-A in Tumor-free Margin in Colorectal Cancer

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Current Medical Science 2021年第3期41卷 522-528页

作者： Sylwia Mielcarska Kamila Stopifnska Miriam Dawidowicz Agnieszka Kula Pawel Kicamer Alicja Prawdric Senkowska ewa nowakowska Zajde Katarzyna Walkiewicz Dariusz Waniczek Elzbieta Swietochowska Department of Medical and Molecular Biology Faculry of Medical Sciences in ZabrceMedical University of SilesicaZabrce41-808.Polard Department and Chair of Pathomorphology.Faculty of Medical Sciences in Zabrze Medical University of SilesiaZabrce 41-800Polardl Department of Nutrition Related Disease Prevention Department of Metabolic Disease PreventionSschool of Public Heath inByron.Medical Universiry of SilesiaByrom 41-902Polandd Department of Surgical Nursing cand Ssurgery Propedeutics.Chair of General.Colorectal and Trauma Surgery SHS in Katowice.Medical Universiry of SilesiaBytom 41-902Poland

Colorectal cancer(CRC)is the third most frequently diagnosed cancer worldwide,responsible for over 880000 deaths each ***/differentiation factor 15(GDF-15)is reported to be a promising diagnostic and prognostic factor in *** induces pleiotropic effects in tumor cells:proliferation,sternness,invasion and *** studies indicate that GDF-15 may stimulate angiogenesis in malignant ***,it has not been investigated in CRC *** aim of our study was to determine the level of GDF-15 and the concentrations of hypoxia-inducible factor-la(HIF-1α),VEGF-A and chemokine-like receptor 1(CMKLR1)in tumor and margin specimens of CRC in relation to histological grade and TNM *** study comprised 33 samples of tumor and margin tissues obtained from CRC *** assess the concentration of GDF-15,HIF-1α,VEGF-A and CMKLR1,commercially available enzyme-linked immunosorbent assay(ELISA)kits were *** found significantly increased levels of GDF-15 and CMKLR1 in tumor tissue compared to margin tissue and higher concentrations of HIF-1α and VEGF-A in margin tissue than in tumor *** levels of GDF-15 and HIF-1α were significantly correlated with VEGF-A and CMKLR1 in margin *** CRC,the increased level of GDF-15 might stimulate angiogenesis through upregulation of HIF-1α,VEGF A and CMKLR1 *** study is the first one to reveal the correlation between the levels of GDF-15 and CMKLR1 in *** elevated levels of HIF-1α and VEGF-A in tumor-free margin tissues suggest that noncancer cells in the tumor microenvironment are an important source of proangiogenic factors.

关键词： colorectal cancer growth/differentiation factor 15(GDF-15) chemokine-like receptor 1(CMKLR1) VEGF-A angiogenesis

Specific metabolic biomarkers as risk and prognostic factors in colorectal cancer

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World Journal of Gastroenterology 2014年第29期20卷 9759-9774页

作者： Magorzata Muc-Wierzgoń ewa nowakowska-Zajdel Sylwia Dziegielewska-Gesiak Teresa Kokot Katarzyna Klakla Edyta Fatyga Elzbieta Grochowska-Niedworok Dariusz Waniczek Janusz Wierzgoń Department of Internal Diseases Medical University of Silesia Department of Human Nutrition Medical University of Silesia Department of Gastrointestinal Surgery Medical University of Silesia Department of Oncological and Reconstructive Surgery Center of Oncology Maria Skodowska-Curie Memorial Institute in Warsaw

Advances in genomics,molecular pathology and metabolism have generated many candidate biomarkers of colorectal cancer with potential clinical *** and biological studies suggest a role for adiposity,dyslipidaemia,hyperinsulinemia,altered glucose homeostasis,and elevated expression of insulin-like growth factor(IGF)axis members in the risk and prognosis of *** review discusses some recent past and current approaches being taken by researches in obesity and metabolic *** authors describe three main systems as the most studied metabolic candidates of carcinogenesis:dyslipidemias,adipokines and insulin/IGF ***,each of these components is unsuccessful in defining the diseases risk and progression,while their co-occurrence increases cancer incidence and mortality in both men and women.

关键词： Colorectal cancer Metabolic biomarkers Risk Prognosis Dyslipidemias Adipokines Insulin-like growth factor-system

Alternative prediction methods of protein and energy evaluation of pig feeds

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Journal of Animal Science and Biotechnology 2017年第4期8卷 799-812页

作者： ewa Swiech The Kielanowski Institute of Animal Physiology and Nutrition Polish Academy of SciencesJablonnaPoland

Precise knowledge of the actual nutritional value of individual feedstuffs and complete diets for pigs is important for efficient livestock production. Methods of assessment of protein and energy values in pig feeds have been briefly described. In vivo determination of protein and energy values of feeds in pigs are time-consuming,expensive and very often require the use of surgically-modified animals. There is a need for more simple, rapid,inexpensive and reproducible methods for routine feed evaluation. Protein and energy values of pig feeds can be estimated using the following alternative methods: 1) prediction equations based on chemical composition; 2)animal models as rats, cockerels and growing pigs for adult animals; 3) rapid methods, such as the mobile nylon bag technique and in vitro methods. Alternative methods developed for predicting the total tract and ileal digestibility of nutrients including amino acids in feedstuffs and diets for pigs have been reviewed. This article focuses on two in vitro methods that can be used for the routine evaluation of amino acid ileal digestibility and energy value of pig feeds and on factors affecting digestibility determined in vivo in pigs and by alternative methods. Validation of alternative methods has been carried out by comparing the results obtained using these methods with those acquired in vivo in pigs. In conclusion, energy and protein values of pig feeds may be estimated with satisfactory precision in rats and by the two-or three-step in vitro methods providing equations for the calculation of standardized ileal digestibility of amino acids and metabolizable energy content. The use of alternative methods of feed evaluation is an important way for reduction of stressful animal experiments.

关键词： Energy value In vitro Pig Protein value Rat

Natural Organic Amendments for Improved Phytoremediation of Polluted Soils:A Review of Recent Progress

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Pedosphere 2016年第1期26卷 1-12页

作者： Alina WISZNIEWSKA ewa HANUS-FAJERSKA ewa MUSZYIISKA Krystyna CIARKOWSKA Institute of Plant Biology and Biotechnology Faculty of Biotechnology and HoricultureUniversity of AgricultureKrakow 31-425(Poland) Department of Soil Science and Soil Protection Faculty of Agriculture and EconomicsUniversity of AgricutureKrakow 31-120(Poland)

Environmental pollution caused by metals, radionuclides and organic pollutants affects quality of the biosphere: soil, water and ***, great efforts have been made to reduce, remove or stabilize contaminants in polluted sites. There has been increasing interest in phytoremediation—the use of plants to reduce concentration of pollutants or to render them harmless. This paper provides a brief review of recent progress in the research and practical application of phytoremediation techniques. Improvements in phytoremediation due to utilization of organic amendments, namely, agro- and industrial wastes(such as sugar beet residue, composted sewage sludge or molasses), biochar, humic substances, plant extracts and exudates are discussed, as well as their influences on soil structure and characteristics, plants growth and bioavailability of pollutants. Both plant-assisted phytoremediation and the use of natural materials in the absence of remediating plant are believed to be cost-effective and environmentally friendly approaches for soil cleanup. However,the characterization and quantification of a range of natural materials used in phytoremediation are essential in order to implement these approaches to practice.

关键词： agricultural wastes bioavailability biochar contamination natural chelators toxic elements

Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes

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World Journal of Gastroenterology 2006年第29期12卷 4640-4645页

作者： ewa Cristine Siljevik Ellis Department of Medicine Division of Gastroenterology and Hepatology and the Department of Laboratory MedicineDivision of Clinical ChemistryKarolinska University Hospital at HuddingeKarolinska InstituteStockholmSweden

AIM： It is known that thyroid hormones alter the bile acid metabolism in humans, however the effect on individual enzymes has been difficult to elucidate. This is mainly due to the lack of human liver cell lines producing bile acids. We used cultures of primary human hepatocytes to study the effects of triiodothyronine （T3） on bile acid synthesis.METHODS： Primary hepatocytes were isolated from liver tissue obtained from three different patients undergoing liver resection due to underlying malignancy. The hepatocytes were cultured under serum-free conditions and treated from d 1 to d 5 with culture containing 0.1 - 1000 nmol/L of T3. Bile acid formation and mRNA levels of key enzymes were analysed. RESULTS： The lowest concentration of T3 decreased cholic acid （CA） formation to 43%-53% of controls and chenodeoxycholic acid （CDCA） to 52%-75% of controls on d 5. The highest dose further decreased CA formation to 16%-48% of controls while CDCA formation remained at 50%-117% of controls. Expression of mRNA levels of cholesterol 7α-hydroxylase （CYP7A1） and sterol 12α-hydroxylase （CYPSB1） dose-dependently decreased. Sterol 27-hydroxylase （CYP27A1） levels also decreased, but not to the same extent. CONCLUSION： T3 dose-dependently decreased total bile acid formation in parallel with decreased expression of CYP7A1 and CYP8B1. CA formation is inhibited to a higher degree than CDCA, resulting in a marked decrease in the CA/CDCA ratio.

关键词： Hepatocytes Human Bile acids CYP7A1 CYPSB1 CYP27A1

Unique Factorization of Compositive Hereditary Graph Properties

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Acta Mathematica Sinica,English Series 2012年第2期28卷 267-280页

作者： Izak BROERE ewa DRGAS-BURCHARDT Department of Mathematics University of Johannesburg Department of Mathematics and Applied Mathematics University of PretoriaPretoria0002South Africa Faculty of Mathematics Computer Science and Econometrics University of Zielona Góra

A graph property is any class of graphs that is closed under isomorphisms, A graph property P is hereditary if it is closed under taking subgraphs; it is compositive if for any graphs

关键词： Graph property hereditary compositive property unique factorization minimal forbid-den graphs reducibility

The break-up tendency of long rod projectiles

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Defence Technology（防务技术） 2016年第2期12卷 177-187页

作者： ewa LIDéN Andreas HELTE FOI Swedish Defence Research Agency

A model for the tendency of fragmentation of a long rod projectile subjected to armour components in add-on armours such as reactive armour and active protection systems is presented. The model is based on studies of the interaction between a cylindrical streamlined projectile and moving thin plates(backwards moving like the front plate in a reactive armour panel and forwards moving like the rear plate in a reactive armour panel).The assumption behind the model is that the sliding force, with velocity vslidebetween the projectile and the plate, gives rise to a transverse velocity vtransof the projectile segment it passes, which will deflect the projectile segment. This deflection is assumed to be a major reason for the fractures that can emerge along the projectile. The velocity, geometry and material of the projectile and the plate are of importance for the fragmentation of the projectile and the dimensionless parameterδ? = v trans vslideexpresses how these parameters influence the break-up tendency. Experiments and simulations have verified that the identifiedδ?-parameter predicts an increased amount of fragmentation of the projectile with increasing value of this parameter.

关键词：长杆弹破裂反应装甲趋势模型主动防护系统横向速度无量纲参数附加装甲