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西部皮革 2013年第22期 35-39页

作者： evren Türker Ahmet Aslan Yesim zcan Ceren Türkcan Sinan Akg 刘萌四川大学制革清洁技术国家工程实验室

在传统的软化工序中,为了除去无用残留物,通常使用从猪或牛胰腺中分离提取的的胰酶。一般来说,软化工序结束后,浴液的酶不能重复利用,被排放到废水中。由于这些错误,软化工序增加了额外的废水处理费用。纳米粒子有较大的表面积和较自己... 详细信息

在传统的软化工序中,为了除去无用残留物,通常使用从猪或牛胰腺中分离提取的的胰酶。一般来说,软化工序结束后,浴液的酶不能重复利用,被排放到废水中。由于这些错误,软化工序增加了额外的废水处理费用。纳米粒子有较大的表面积和较自己的体重高数百倍的结合容量。他们也可以通过染料载体使用非纤维蛋白的吸附。通过这种方式,我们研究了染料亲和纳米颗粒代替酶软化过程。在这项研究中,p(HEMA)(2-羟基乙基甲基丙烯酸酯)纳米颗粒通过表面活性剂乳液自由聚合产生。P(HEMA)纳米粒子的特性通过傅里叶变换红外光谱(FTIR)和扫描电子显微镜(SEM)表征。三嗪染料活性红120通过化学方法附加到p(HEMA)纳米粒子。这些染料包含p(HEMA)-活性红120具有亲和力的纳米颗粒,用于在水溶液中非纤维蛋白质的吸附。此外优化了p(HEMA)-活性红120在间歇反应器的实验条件和其吸附容量。结果证明了纳米颗粒的可重用性和其作为软化剂的有效性。因此,和软化工序中的酶相比,p(HEMA)-活性红120纳米粒子是一种环境友好的、廉价的、可重复使用的材料。

关键词：纳米级粒子 p(PMEA) 活性红120 皮革软化废水非纤维蛋白质

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Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study

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Journal of Clinical and Translational Hepatology 2021年第6期9卷 818-827页

作者： Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu evrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi CHESS Center Institute of Portal HypertensionThe First Hospital of Lanzhou UniversityLanzhouGansuChina CHESS Center The Sixth People’s Hospital of ShenyangShenyangLiaoningChina Department of Infectious Disease Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Microbiology and Infec-tious Disease Center School of Basic Medical SciencesPeking University Health Science CenterBeijingChina Depart-ment of Radiology Zhongda HospitalMedical School of Southeast UniversityNanjingJiangsuChina Istanbul Health and Technology University Zytinburnu/İstanbulTurkey CHESS Working Party Xingtai People’s HospitalXingtaiHebeiChina Department of Hepatobiliary Surgery The Third People’s Hospital of ShenzhenShenzhenGuangdongChina Department of Radiology Fifth Medical Center of PLA General HospitalBeijingChina Department of Gastroenterol-ogy Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandongChina Department of Radiology IRCCS Azienda Ospedaliero-Universitaria di BolognaUniversity of BolognaItaly Department of Radiology Ankara University School of MedicineAnkaraTurkey Department of Gastroenterology Ankara University School of MedicineAnkaraTurkey Department of Hepatobiliary Surgery People’s Hospital of Ningxia Hui Autonomous RegionYinchuanNingxiaChina

Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in ***:In this international multicenter,diagnostic study(***,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November *** segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface ***:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,*** area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,*** intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,***:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive ***,this score could be used to detect CSPH in patients with cirrhosis.

关键词： Liver cirrhosis Advanced chronic liver disease Hepatic venous pressure gradient Liver surface nodularity Imaging

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