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Efficacy of the new therapeutic approach in curing malignant neoplasms on the model of human glioblastoma

Cancer Biology & Medicine 2021年第3期18卷 910-930页

作者： evgeniya V.Dolgova Oleg M.Andrushkevich Polina E.Kisaretova Anastasia S.Proskurina Genrikh S.Ritter Tatyana D.Dubatolova Margarita V.Romanenko Oleg S.Taranov Yaroslav R.Efremov evgeniy l.zavyalov Alexandr V.Romaschenko Sergey V.Mishinov Svetlana S.Kirikovich evgeniy V.levites Ekaterina A.Potter Alexandr A.Ostanin Elena R.Chernykh Stanislav Yu.Roshchin Anatoliy V.Bervitskiy Galina I.Moysak Jamil A.Rzaev Sergey S.Bogachev Institute of Cytology and Genetics SB RAS Novosibirsk 630090Russia A.I.Evdokimov Moscow State University of Medicine and Dentistry Moscow 127473Russia Institute of Molecular and Cellular Biology Novosibirsk 630090Russia Novosibirsk State University Novosibirsk 630090Russia The State Research Center of Virology and Biotechnology"Vector" KoltsovoNovosibirsk 630559Russia First Department of Neurosurgery Ya.L.Tsivian Novosibirsk Research Institute of Traumatology and OrthopaedicsNovosibirsk 630091Russia Institute of Fundamental and Clinical immunology Novosibirsk 630099Russia Sklifosovsky Research Institute of Emergency Medicine Moscow 129010Russia Federal Center of Neurosurgery Novosibirsk 630048Russia

Objective:Glioma is a highly invasive tumor,frequently disposed in essential areas of the brain,which makes its surgical excision extremely difficult;meanwhile adjuvant therapy remains quite ***:In the current report,a new therapeutic approach in curing malignant neoplasms has been performed on the U87 human glioblastoma *** approach,termed"Karanahan",is aimed at the eradication of cancer stem cells(CSCs),which were recently shown to be capable of internalizing fragments of extracellular double-stranded *** being internalized,these fragments interfere in the process of repairing interstrand cross-links caused by exposure to appropriate cytostatics,and such an interference results either in elimination of CSCs or in the loss of their tumorigenic *** of the approach requires a scheduled administration of cytostatic and complex composite double-stranded DNA ***:U87 cells treated in vitro in accordance with the Karanahan approach completely lost their tumorigenicity and produced no grafts upon intracerebral transplantation into immunodeficient *** SCID mice with developed subcutaneous grafts,the treatment resulted in reliable slowing down of tumor growth rate(Pl transplantation of U87 cells followed by surgical excision of the developed graft and subsequent therapeutic treatment,the Karanahan approach was shown to reliably slow down the tumor growth rate and increase the median survival of the mice twofold relative to the ***:The effectiveness of the Karanahan approach has been demonstrated both in vitro and in vivo in treating developed subcutaneous grafts as well as orthotopic grafts after surgical excision of the tumor.

关键词： Glioblastoma U87 cell line mytomycin C cancer stem cells TAMRA

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A new karst-dwelling bent-toed gecko (Squamata： Gekkonidae Cyrtodactylus) from Xiangkhoang Province, northeastern laos

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Zoological Research 2018年第3期39卷 202-219页

作者： Roman A. Nazarov Olivier S.G. Pauwels evgeniy l. Konstantinov Anatoliy S. Chulisov Nikolai l. Orlov Nikolay A. Poyarkov, Jr. Zoological Museum Moscow State University Moscow 125009 Russia Royal Belgian Institute of Natural Sciences Brussels B-1000 Belgium Institute of Natural Sciences Kaluga State University named after K.I. Tsiolkovskii Kaluga 248023 Russia Zoological Institute Russian Academy of Sciences St. Petersburg 199034 Russia Department of Vertebrate Zoology Biological Faculty Lomonosov Moscow State University Moscow 119234 Russia Joint Russian-Vietnamese Tropical Research and Technological Center 63 Nguyen Van Huyen Road Nghia Do Cau Giay Hanoi Vietnam

We describe a new karst-dwelling Cyrtodactylus from Ban Thathom, Xiangkhoang Province, northeastern laos. The new species can be distinguished from other congeners by having four dark dorsal bands between limb insertions, a discontinuous nucha~ loop, 10 precloacal pores in males or 10-12 precloacal pits （females） separated by a diastema from a series of enlarged femoral scales bearing 18 or 19 pores （male） or 8-10 pits （females） along each femur, 14-18 dorsal tubercle rows at midbody, no precloacal groove, 30-36 midbody scale rows across belly between ventrolateral skin folds, transversely enlarged subcaudal plates, and a maximal known snout-vent length of 75.5 mm. Our description brings to 22 the number of Cyrtodactylus species recorded from laos.

关键词： Indochinese region Karst limestone Herpetology Taxonomy New species

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liver transplantation in a patient with primary antiphospholipid syndrome and Budd-Chiari syndrome

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World Journal of Hepatology 2015年第19期7卷 2229-2236页

作者： Tatiana M Reshetnyak Natalia V Seredavkina Maria A Satybaldyeva evgeniy l Nasonov Vasiliy I Reshetnyak VA Nasonova Research Institute of Rheumatology Kashirskoye Shosse Russian Medical Academy of Post-graduate Education VA Negorovsky Research Institute of General Reanimatology

The antiphospholipid syndrome(APS) is an acquired thrombophilic disorder in which autoantibodies are produced to a variety of phospholipids determinants of cell membranes or phospholipid binding proteins. There are few reports about association between antiphospholipid antibodies and development of BuddChiari syndrome(BCS). We report the case of BCS development in young Russian male with primary APS. The patient underwent orthotopic liver transplantation on August 26, 2012. At present time his state is good, the blood flow in the liver restored and its function is not impaired. We report about the first time the successful use of dabigatran etexilate for prolonged anticoagulation therapy in APS patient with BCS. In addition patient is managed with immunosuppressive drugs.

关键词： Budd-Chiari syndrome Antiphospholipid syndrome Inh

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Cu/TiO_(2) Photocatalysts for CO_(2) Reduction: Structure and Evolution of the Cocatalyst Active Form

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Transactions of Tianjin University 2024年第2期30卷 140-151页

作者： Andrey A.Saraev Anna Yu.Kurenkova Denis D.Mishchenko Alexandr l.Trigub evgeniy Yu.Gerasimov Ekaterina A.Kozlova Boreskov Institute of Catalysis Lavrentieva Ave 5Novosibirsk 630090Russia Synchrotron Radiation Facility SKIF Boreskov Institute of CatalysisNikol’skiy Ave 1Kol’tsovo 630559Russia National Research Center “Kurchatov Institute”Kurchatova Sq 1Moscow 123182Russia

Extensive work on a Cu-modified TiO_(2) photocatalyst for CO_(2) reduction under visible light irradiation was conducted. The structure of the copper cocatalyst was established using UV-vis diff use refl ectance spectroscopy, high-resolution transmis- sion electron microscopy, X-ray absorption spectroscopy, and X-ray photoelectron spectroscopy. It was found that copper exists in different states (Cu 0 , Cu^(+) , and Cu^(2+) ), the content of which depends on the TiO_(2) calcination temperature and copper loading. The optimum composition of the cocatalyst has a photocatalyst based on TiO_(2) calcined at 700℃ and modified with 5 wt% copper, the activity of which is 22 μmol/(h·g cat ) (409 nm). Analysis of the photocatalysts after the photocatalytic reaction disclosed that the copper metal on the surface of the calcined TiO_(2) was gradually converted into Cu_(2) O during the photocatalytic reaction. Meanwhile, the metallic copper on the surface of the noncalcined TiO_(2) did not undergo any trans- formation during the reaction.

关键词： Photocatalysis Photocatalytic CO_(2)conversion Visible light Titanium dioxide Copper Copper oxides Methane formation Photocatalyst transformation

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Hydrogel scaffolds based on blood plasma cryoprecipitate and collagen derived from various sources: Structural, mechanical and biological characteristics

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Bioactive Materials 2019年第1期4卷 334-345页

作者： Marfa N.Egorikhina Diana Ya Aleynik Yulia P.Rubtsova Grigory Ya levin Irina N.Charykova ludmila l.Semenycheva Marina l.Bugrova evgeniy A.Zakharychev Federal State Budgetary Educational Institution of Higher Education«Privolzhsky Research Medical University»of the Ministry of Health of the Russian Federation Nizhny NovgorodRussian Federation lobachevsky State University of Nizhny Novgorod Nizhny NovgorodRussian Federation

At present there is a growing need for tissue engineering products,including the products of *** hydrogel scaffolds have a number of advantages and are increasingly being used to provide means of cell transfer for therapeutic treatments and for inducing tissue *** work presents original hydrogel biopolymer scaffolds based on a blood plasma cryoprecipitate and collagen and formed under conditions of enzymatic *** differently originated collagens were used for the scaffold *** this work the structural and mechanical characteristics of the scaffold were *** was found that,depending on the origin of collagen,scaffolds possess differences in their structural and mechanical *** types of hydrogel scaffolds have good biocompatibility and provide conditions that maintain the three-dimensional growth of adipose tissue stem ***,scaffolds based on such a blood plasma cryoprecipitate and collagen have good prospects as cell carriers and can be widely used in regenerative medicine.

关键词： Biopolymers Blood plasma cryoprecipitate Collagen Hydrogel scaffolds Stem cells

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Counting stripes:revision of the lipinia vittigera complex(Reptilia, Squamata, Scincidae) with description of two new species from Indochina

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Zoological Research 2019年第5期40卷 358-393页

作者： Nikolay A. Poyarkov Jr. Peter Geissler Vladislav A. Gorin evgeniy A. Dunayev Timo Hartmann Chatmongkon Suwannapoom Department of Vertebrate Zoology Biological Faculty Lomonosov Moscow State University Moscow 119991 Russia Joint Russian-Vietnamese Tropical Research and Technological Center Nghia Do Cau Giay Hanoi Vietnam Museum Natur und Mensch Freiburg 79098 Germany Zoological Museum Moscow State University Moscow 125009 Russia Zoological Research Museum Alexander Koenig Bonn 53113 Germany School of Agriculture and Natural Resources University of Phayao Phayao 56000 Thailand

We provide an integrative taxonomic analysis of the lipinia vittigera species complex from mainland Southeast Asia. Based on examination of external morphology, color pattern, and 681 base pairs of the cytochrome oxidase subunit I (COI) mitochondrial gene, we demonstrate the presence of four morphologically distinct lineages of lipinia in Vietnam, Cambodia, Thailand, and Malaysia, showing a sequence divergence ranging 15.5%–20.4%. All discovered lineages are discretely diagnosable from one another by a combination of scalation traits and color patterns. A review of the published distribution data and a re-examination of available type material revealed the following results:(1) distribution of l. vittigera (Boulenger, 1894) sensu stricto is restricted to Sundaland and the Thai-Malay Peninsula south of the Isthmus of Kra;(2) l. microcercus (Boettger, 1901) stat. nov. is elevated to full species rank;the species has a wide distribution from central and southern Vietnam across Cambodia to eastern Thailand;we regard lygosoma vittigerum kronfanum Smith, 1922 and leiolopisma pranensis Cochran, 1930 as its junior synonyms;(3) lipinia trivittata sp. nov. occurs in hilly areas of southern Vietnam, Cambodia, and eastern Thailand;and (4) lipinia vassilievi sp. nov. is currently known only from a narrow area along the Vietnamese-Cambodian border in the foothills of the central Annamite Mountain Range. We further provide an identification key for lipinia occurring in mainland Southeast Asia.

关键词： lipinia microcercus stat. nov. lipinia trivittata sp. nov. lipinia vassilievi sp. nov. Vietnam, Thailand, Cambodia Biogeography mtDNA COI-barcoding

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Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice

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World Journal of Diabetes 2020年第12期11卷 596-610页

作者： Vadim V Klimontov Anton I Korbut Iuliia S Taskaeva Nataliya P Bgatova Maksim V Dashkin Nikolai BOrlov Anna S Khotskina Evgenii l.zavyalov Thomas Klein laboratory of Endocrinology Research Institute of Clinical and Experimental Lymphology–Branch of the Institute of Cytology and GeneticsSiberian Branch of Russian Academy of Sciences(RICEL–Branch of IC&G SB RAS)Novosibirsk 630060Russia laboratory of Ultrastructural Research Research Institute of Clinical and Experimental Lymphology–Branch of the Institute of Cytology and GeneticsSiberian Branch of Russian Academy of Sciences(RICEL–Branch of IC&G SB RAS)Novosibirsk 630060Russia laboratory of Clinical Immunogenetics Research Institute of Clinical and Experimental Lymphology–Branch of the Institute of Cytology and GeneticsSiberian Branch of Russian Academy of Sciences(RICEL–Branch of IC&G SB RAS)Novosibirsk 630060Russia Center for Genetic Resources of laboratory Animals Institute of Cytology and GeneticsSiberian Branch of Russian Academy of SciencesNovosibirsk 630090Russia Department of Cardiometabolic Diseases Research Boehringer Ingelheim Pharma GmbHBiberach 88397Germany

BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGlT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney ***,the mechanisms underlying the renal protective effect of SGlT2 inhibitors are not fully *** of podocytes and nephrin expression in glomeruli in db/db diabetic *** We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 ***-matched male db/+mice were included as non-diabetic *** of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were *** evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,*** nephrin and transforming growth factor beta(TGF-β)were assessed by *** Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were *** expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated *** was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were *** decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of *** These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney *** anti-albuminuric effect of EMPA could be attributed to mitigation o

关键词： Diabetes Chronic kidney disease Albuminuria Podocyte Sodium-glucose transporter 2 inhibitors Empagliflozin

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Creation of Mesostructural Material with Nanocrystalline Inclusions of Titanium Diboride by Quasidynamic Method

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材料科学与工程（中英文版） 2010年第3期4卷 52-56页

作者： Mariya Petrovna Bondar evgeniy Viktorovich Karpov Mikhail Alekseevich Korchagin evgeniy Semionovich Obodovskyt Yaroslav l. lukyanov lavrentyev Institute of Hydrodynamics Siberian Branch of the Russian Academy of Sciences Novosibirsk 630090 Russia Institute of Solid State Chemistry and Mechanochemistry Siberian Branch of the Russian Academy of Sciences Novosibirsk630090 Russia

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Improving the Efficiency of Induction Heating in the Air Gap of the Magnetic Circuit

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Journal of Electronic Research and Application 2020年第4期4卷 1-4页

作者： Vladimir l.lanin evgeniy Ratnikau Alexander D.Hatskevich Electronic Technique and Technology Department Belarus State University of Informatics and RadioelectronicsMinskBelarus

Improving the efficiency of induction heating of parts in the air gap of the magnetic circuit is associated with the use of surface and edge *** modeling in ANSYS Electromagnetics Suite 19.2 and experimental studies identified patterns of edge effect in the heated *** ensure the uniformity of induction heating of small parts and reduce the soldering time,the electrical switch of soldered parts is used,which with the help of device controller forms a secondary circuit with low electrical resistance and high density of eddy currents.

关键词： Induction heating The gap of the magnetic circuit Edge effect Secondary circuit

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Fine-needle aspiration technique under endoscopic ultrasound guidance:A technical approach for RNA profiling of pancreatic neoplasms

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2663-2672页

作者： Sabina Sherafedinovna Seyfedinova Olga Aleksandrovna Freylikhman Polina Sergeevna Sokolnikova Konstantin Aleksandrovich Samochernykh Anna Aleksandrovna Kostareva Olga Viktorovna Kalinina evgeniy Gennadievich Solonitsyn Research laboratory of Digestive Cancer Almazov Medical Research CentreSaint-Petersburg 197341Russia Research laboratory of Molecular and Cellular Modeling and Gene Therapy Almazov Medical Research CentreSaint-Petersburg 197341Russia Head of Russian Neurosurgical Institute Named after Prof.A.l.Polenova Russian Neurosurgical Institute Named after Prof.A.L.PolenovaSaint-Petersburg 191014Russia Head of Institute of Molecular Biology and Genetics Almazov National Medical Research CentreSaint-Petersburg 197341Russia Research laboratory of Autoimmune and Autoinflammatory Diseases Almazov National Medical Research CentreSaint-Petersburg 197341Russia

BACKGROUND Early diagnosis of pancreatic ductal adenocarcinoma(PDAC)has been a longstanding *** prognosis of patients with PDAC depends on the stage at *** is necessary to identify biomarkers for the detection and differentiation of pancreatic tumors and optimize PDAC sample preparation procedures for DNA and RNA *** molecular studies are done using paraffin-embedded blocks;however,the integrity of DNA and RNA is often compromised in this ***,RNA isolated from human pancreatic tissue samples is generally of low quality,in part,because of the high concentration of endogenous pancreatic RNAse activity *** To assess the potential of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA)to obtain specimens from pancreatic neoplasms for subsequent RNA molecular profiling,including next-generation sequencing(NGS).METHODS Thirty-four EUS-FNA samples were included in this study:PDAC(n=15),chronic pancreatitis(n=5),pancreatic cysts(n=14),mucinous cysts(mucinous cystic neoplasia/intraductal papillary mucinous neoplasia)n=7,serous cystic neoplasms n=5,and pseudocysts n=*** material consisted of cyst fluid and cyst wall samples obtained by through-the-needle biopsy(TTNB).Samples were stored at -80℃ until *** purity(A260/230,A260/280 ratios),concentration,and integrity(RIN)were ***-time polymerase chain reaction was conducted on all samples,and small RNA libraries were prepared from solid mass *** RNA was successfully extracted from 29/34(85%)EUS-FNA samples:100% pancreatic adenocarcinoma samples,100% chronic pancreatitis samples,70% pancreatic fluid cyst samples,and 50%TTNB *** relative expression of GAPDH and HPRT were obtained for all successfully extracted RNA samples(n=29)including lowquality RNA *** concentration and nonoptimal RIN values(no less than 3)of RNA extracted from EUS-FNA samples did not prevent NGS library *** suitability of cyst fluid samples

关键词： Endoscopic ultrasound-guided,fine-needle aspiration Pancreatic cancer Pancreatic cysts RNA extraction Through-the-needle biopsy Next-generation sequencing

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