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Source and possible tectonic driver for Jurassic-Cretaceous gold deposits in the West Qinling Orogen, China

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Geoscience Frontiers 2019年第1期10卷 107-117页

作者： Yafei Wu Jianwei Li Katy evans Denis Fougerouse Kirsten Rempel State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan School of Earth and Planetary Sciences The Institute for Geoscience Research (TIGeR) Curtin University School of Earth Resources China University of GeosciencesWuhan State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences

The West Qinling Orogen(WQO) in Central China Orogenic Belt contains numerous metasedimentary rock-hosted gold deposits(>2000 t Au), which mainly formed during two pulses: one previously recognized in the Late Triassic to Early Jurassic(T3 - J1) and one only recently identified in the Late Jurassic to Early Cretaceous(J3 - K1). Few studies have focused on the origin and geotectonic setting of the J3 - K1 gold *** relationships, LA-ICP-MS trace element and sulfur isotope compositions of pyrites in hydrothermally altered T3 dykes within the J3 - K1 Daqiao deposit were used to constrain relative timing relationships between mineralization and pyrite growth in the dykes, and to characterize the source of ore fluid. These results are integrated with an overview of the regional geodynamic setting, to advance understanding of the tectonic driver for J3 - K1 hydrothermal gold systems. Pyrite in breccia-and dykehosted gold ores at Daqiao have similar chemical and isotopic compositions and are considered to be representative of J3 - K1 gold deposits in WQO. Co/Ni and sulfur isotope ratios suggest that ore fluids were derived from underlying Paleozoic Ni-and Se-rich carbonaceous sedimentary rocks. The geochemical data do not support the involvement of magmatic fluids. However, in the EQO(East Qinling Orogen), J3 - K1 deposits are genetically related to magmatism. Gold mineralization in WQO is contemporaneous with magmatic deposits in the EQO and both are mainly controlled by NE-and EWtrending structures produced by changes in plate motion of the Paleo-Pacific plate as it was subducted beneath the Eurasian continent. We therefore infer that the J3 - K1 structural regime facilitated the ascent of magma in the EQO and metamorphic fluids in the WQO with consequent differences in the character of contemporaneous ore deposits. If this is correct, then the far-field effects of subduction along the eastern margin of NE Asia extended 1000's of km into the continental inte

关键词： Pyrite LA-ICP-MS Sulfur isotopes Daqiao gold deposit West Qinling Orogen Paleo-Pacific plate Jurassice Cretaceous

Mosquito-Associated Viruses in China

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Virologica Sinica 2018年第1期33卷 5-20页

作者： Han Xia Yujuan Wang evans Atoni Bo Zhang Zhiming Yuan Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of Virology Chinese Academy of SciencesWuhan 430071 China University of Chinese Academy of Sciences Beijing 100049China

Mosquitoes are classified into approximately 3500 species and further grouped into 41 ***,they are considered to be among the most important disease vectors in the world and they can harbor a wide variety of *** mosquito viruses are considered to be of significant medical importance and can cause serious public health issues throughout the *** viruses are Japanese encephalitis virus(JEV),dengue virus(DENV),chikungunya virus(CHIKV),and Zika virus(ZIKV).Others are the newly recognized mosquito viruses such as Banna virus(BAV)and Yunnan orbivirus(YNOV)with unclear medical *** remaining mosquito viruses are those that naturally infect mosquitoes but do not appear to infect humans or other *** the continuous development and improvement of mosquito and mosquito-associated virus surveillance systems in China,many novel mosquito-associated viruses have been discovered in recent *** review aims to systematically outline the history,characteristics,distribution,and/or current epidemic status of mosquito-associated viruses in China.

关键词： Mosquito associated viruses China - Vector Public health

Impact of delay from transperineal biopsy to radical prostatectomy upon objective measures of cancer control

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Asian Journal of Urology 2022年第2期9卷 170-176页

作者： Liang G.Qu Gregory Jack Marlon Perera Melanie evans Sue evans Damien Bolton Nathan Papa Department of Urology Olivia Newton John Cancer CentreAustin HealthHeidelberg VICAustralia Department of Surgery University of MelbourneMelbourne VICAustralia Department of Epidemiology and Preventive Medicine Monash UniversityMelbourne VICAustralia

Objective:Treatment delays in prostate cancer have been characterised,although not explicitly in men undergoing transperineal prostate *** aimed to determine if delays to radical prostatectomy correlate with adverse outcomes using a contemporary population-based cohort of men diagnosed by transperineal ***:This study analysed men with prostate cancer of the International Society for Urological Pathology grade group≥2,diagnosed by transperineal prostate biopsies who underwent prostatectomy,using the prospectively data from 1 January 2014 to 30 June 2018 Prostate Cancer Outcomes *** were analysed according to stratified demographic and disease *** intervals from biopsy(28,60,90,120,and 270 days)were compared using odds ratios and regression analyses for proportion of upgrading,early biochemical recurrence,pT3 disease at prostatectomy,and positive surgical ***:In total,2008 men were *** were 306(16.7%)men with upgrading,151(8.4%)with biochemical recurrence,1068(54.1%)with pT3 disease,and 464(23.1%)with positive surgical margins(percentages excluded patients with missing data).All adverse outcomes studied were significantly associated with higher prostate-specific antigen and grade at *** of 120-270 days did not adversely alter the incidence of Gleason upgrading,pT3,or ***(most frequent 60-89 days,28%)were associated with positive surgical margins but not *** modelling demonstrated no increased likelihood of most adverse outcomes for up to 270 ***:Men with prostate cancer of grade group≥2 diagnosed through transperineal biopsy may wait up to 270 days for a prostatectomy without a greater likelihood of upgrading,pT3 disease,positive surgical margins,or biochemical recurrence.

关键词： Biopsy Disease progression Prostate cancer Recurrence Treatment delay

Introduction to Simulation and Risk Analysis 2nd ed.

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Introduction to Simulation and Risk Analysis

The management and control of quality 5th ed.

2002年

作者： evans james R

来源：畅想之星图书光盘版（南... 评论

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RNA-based therapies in animal models of Leber congenital amaurosis causing blindness

2001年

作者： evans james R.

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Precision Clinical Medicine 2020年第2期3卷 113-126页

作者： Xia Wang Xianghong Shan Kevin Gregory-evans Cheryl Y.Gregory-evans Department of Ophthalmology and Visual Sciences University of British ColumbiaVancouver BC V5Z 3N9Canada

Leber congenital amaurosis(LCA)is a severe,genetically heterogeneous recessive eye disease in which∼35%of genemutations are in-frame nonsensemutations coding for loss-of-function premature termination codons(PTCs)*** suppression therapy allows read-through of PTCs leading to production of full-length protein.A limitation of nonsense suppression is that nonsense-mediated decay(NMD)degrades PTC-containing RNA *** purpose of this study was to determine whether inhibition of NMD could improve nonsense suppression efficacy in *** a high-throughput approach in the recessive cep290 zebrafish model of LCA(cep290;Q1223X),we first tested the NMD inhibitor Amlexanox in combination with the nonsense suppression drug *** observed reduced retinal cell death and improved visual *** these positive data,we next investigated whether this strategy was also applicable across species in two mammalianmodels:Rd12(rpe65;R44X)and Rd3(rd3;R107X)mouse models of *** the Rd12 model,cell death was reduced,RPE65 protein was produced,and in vivo visual function testing was *** establish for the first time that the mechanism of action of Amlexanox in Rd12 retina was through reduced UPF1 *** the Rd3 model,however,no beneficial effect was observed with Ataluren alone or in combination with *** variation in response establishes that some forms of nonsensemutation LCA can be targeted by RNA therapies,but that this needs to be verified for each *** implementation of precision medicine by identifying better responders to specific drugs is essential for development of validated retinal therapies.

关键词： precision medicine Ataluren Amlexanox nonsense suppression RPE65 CEP290 RD3

Law and government on the net

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Law and government on the net

Genetics of coronary artery disease and myocardial infarction

1998年

作者： evans james (james H.).

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World Journal of Cardiology 2016年第1期8卷 1-23页

作者： Xuming Dai Szymon Wiernek james P evans Marschall S Runge Division of Cardiology University of North Carolina at Chapel Hill Department of Genetics University of North Carolina at Chapel Hill

Atherosclerotic coronary artery disease(CAD) comprises a broad spectrum of clinical entities that include asymptomatic subclinical atherosclerosis and its clinical complications, such as angina pectoris, myocardial infarction(MI) and sudden cardiac death. CAD continues to be the leading cause of death in industrialized society. The long-recognized familial clustering of CAD suggests that genetics plays a central role in its development, with the heritability of CAD and MI estimated at approximately 50% to 60%. Understanding the genetic architecture of CAD and MI has proven to be difficult and costly due to the heterogeneity of clinical CAD and the underlying multi-decade complex pathophysiological processes that involve both genetic and environmental interactions. This review describes the clinical heterogeneity of CAD and MI to clarify the disease spectrum in genetic studies, provides a brief overview of the historical understanding and estimation of the heritability of CAD and MI, recounts major gene discoveries of potential causal mutations in familial CAD and MI, summarizes CAD and MIassociated genetic variants identified using candidate gene approaches and genome-wide association studies(GWAS), and summarizes the current status of the construction and validations of genetic risk scores for lifetime risk prediction and guidance for preventive strategies. Potential protective genetic factors against the development of CAD and MI are also discussed. Finally, GWAS have identified multiple genetic factors associated with an increased risk of in-stent restenosis following stent placement for obstructive CAD. This review will also address genetic factors associated with in-stent restenosis, which may ultimately guide clinical decision-making regarding revascularization strategies for patients with CAD and MI.

关键词： Coronary artery disease Myocardial infarction In-stent restenosis Genetics Heritability Genome-wide association study Atherosclerosis

Influence of a probiotic mixture on antibiotic induced microbiota disturbances

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World Journal of Gastroenterology 2014年第33期20卷 11878-11885页

作者： Sofia Forssten Malkanthi evans Dale Wilson Arthur C Ouwehand Active Nutrition DuPont Nutrition & Health 02460 Kantvik Finland KGK Synergize London ONN6A 5R8 Canada

AIM: To study the effect of probiotic consumption on the faecal microbiota during and after antibiotic exposure.

关键词： Probiotic Antibiotic treatment Amoxicillin/ clavulanate Microbiota Beta-lactamases Lactobacillus acidophilus Bifidobacterium lactis