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Wireless capsule endoscopy in the investigation of patients with chronic renal failure and obscure gastrointestinal bleeding (preliminary data)

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World Journal of Gastroenterology 2006年第32期12卷 5182-5185页

作者： Stephanos Karagiannis Spyros Goulas Georgios Kosmadakis Petros Galanis Dimitrios Arvanitis John Boletis evangelos georgiou Christos Mavrogiannis Academic Department of Gastroenterology Faculty of Nursing Athens UniversityGeneral Hospital of Athens "Helena Venizelou"Greece Department of Nephrology and Transplantation Center Laiko General Hospital AthensGreece Department of Nephrology A. Fleming General Hospital AthensGreece Medical Physics Department Medical School Athens UniversityGreece

AIM： To investigate the role of wireless capsule endoscopy （WCE） in detection of small bowel （SB） pathology in patients with chronic renal failure （CRF） and obscure bleeding. METHODS： Consecutive CRF patients with obscure bleeding were prospectively studied. Patients with normal renal function and obscure bleeding, investigated during the same period with WCE, were used for the interpretation of results. RESULTS： Seventeen CRF patients （11 overt, 6 occult bleeding） and 51 patients （33 overt, 18 occult bleeding） with normal renal function were enrolled in this study. Positive SB findings were detected in 70.6% of CRF patients and in 41.2% of non-CRF patients （P〈0.05）. SB angiodysplasia was identified in 47% of CRF patients and in 17.6% of non-CRF patients. Univariate logistic regression revealed CRF as a significant predictive factor for angiodysplasia （P〈0.05）. Therapeutic measures were undertaken in 66% of the patients with the positive findings. CONCLUSION： According to our preliminary results, SB angiodysplasia was found in an increased prevalence among CRF patients with obscure bleeding. WCE is useful in diagnosis of gastrointestinal pathologies and in planning appropriate therapeutic intervention and, therefore, should be included in the work-up of this group of patients.

关键词： Chronic renal failure Obscure gastrointestinalbleeding Wireless capsule endoscopy Angiodysplasia

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Exploring the useful exposure range limits of three intraoral image receptors for various tube potential, tube current and exposure time settings

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Health 2011年第5期3卷 292-299页

作者： Elli Katsoni Ioannis A. Tsalafoutas Panagiotis Gritzalis Evripides Stefanou evangelos georgiou Emmanouel Yakoumakis 不详

Objectives: To determine the useful exposure range limits of three intraoral image receptors of different technology when exposed to different X-ray beam spectra, dose and dose rate levels. Study Design: A dental X-ray unit offering a wide range of tube potential, tube current and exposure time settings was used to expose a dental quality control phantom. The receptors that were used to capture the radiographic images of the phantom were: the Kodak Insight, the Kodak RVG-6000 and the Duerr Vistascan system. The images that were produced over a wide range of exposure factor settings were evaluated in terms of diagnostic quality by three experienced radiologists. Results: The number of images with acceptable diagnostic quality was in total 1257;310 with Insight, 331 with RVG 6000 and 616 with Vistascan. At 60 kV, diagnosable images were produced with doses ranging from 0.44-1.56 mGy for the Insight film 0.44-2.82 mGy for the RVG 6000 and 0.22-4.93 mGy for the Vistascan system. At 70 kV, the respective ranges were 0.39-1.28 mGy for the Insight film 0.31-2.55 mGy for the RVG6000 and 0.30-3.46 mGy for the Vistascan system. Conclusions: The Vistascan exhibited the widest useful exposure range and required the least exposure to produce a diagnosable image at almost all tube potential settings. The RVG 6000 exhibited a slightly wider useful exposure range than the Insight film, with almost the same dose requirements especially in higher Kv settings.

关键词： Radiography Dental Digital Dosage

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Performance comparison between three intraoral image receptors of different technology at a variety of tube potential, tube current and exposure time settings using a stepwedge phantom

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Health 2011年第1期3卷 56-65页

作者： Elli Katsoni Ioannis A. Tsalafoutas Panagiotis Gritzalis Evripidis Stefanou evangelos georgiou Emmanuel Yakoumakis Department of Medical Physics Medical School University of Athens Athens Greece Department of Oral Diagnosis and Radiology Dental School University of Athens Athens Greece Medical Physics Department Agios Savvas Hospital Athens Greece

Purpose: To comparatively evaluate the per-formance of three intraoral image receptors of different technology when exposed to different X-ray beam spectra, dose and dose rate levels using a stepwedge phantom. Materials and methods: The intraoral radiographic receptors evaluated were: the Kodak Insight F speed class film, the Kodak RVG 6000, and the Duerr Vis-tascan Combi PSP system. A dental quality control phantom made of Plexiglas, containing an aluminium stepwedge with 12 steps and 7 holes drilled in each step was radiographed using a dental X-ray unit offering a wide range of tube potential, tube current and exposure time settings. The visibility of the holes in the images produced with each one of the three receptors was assessed by three independent observers. For each image the total image quality score (TS) was derived from the summation of the number of visible holes in each step. The numbers of perceptible holes in each experimental condition (TSs) were statistically analyzed through use of analysis of variance. Intraobserver and interobserver agree-ment was also measured. Results: Vistascan ex-hibited the most extended useful exposure range, followed by RVG 6000 and Insight. RVG 6000 exhibited the largest TS values in all tube potential settings except 70 kV where the Vistascan performed better. Insight performed better than Vistascan only at 60 and 63 kV. Vistascan performed better at 66 and 70 kV, Insight at 60 and 66 kV, whereas RVG performed equally well at all tube potential settings, except than at 52 and 70 kV. For the Insight the largest TS values were obtained with the smallest ESAK values whereas with the Vistascan the largest TS were obtained with ESAK values that where the largest observed. Conclusions: The performance of all receptors tested was greatly dependent on the exposure parameters and mainly on the kV settings. Overall, the RVG 6000 offered the best image quality at doses somewhere in between those required by the Insight and the Vi

关键词： Radiography Dental Digital Dosage

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Congenital Nephrotic Syndrome of the Finnish Type: A Greek Case Report

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Health 2014年第12期6卷 1436-1439页

作者： Sofia Melina Stasinou George Valasoulis Ioannis georgiou Kyrgiou Maria evangelos Paraskevaidis Nikolaos Plachouras Department of Obstetrics & Gynaecology University Hospital of Ioannina Ioannina Greece Genetics and IVF Unit Department of Obstetrics & Gynaecology University Hospital of Ioannina Ioannina Greece Queen Charlotte’s and Chelsea Hospital Hammersmith London UK

Congenital Nephrotic Syndrome Type 1 (Congenital Nephrotic Syndrome of the Finnish Type—CNF) is an autosomal recessive disorder encoding by nephrin gene mutation which is a (transmembrane protein 1-homolog—NPHS1) structural component of the slit diaphragm responsible for the proper functioning of the renal filtration barrier. In NPHS1 kidneys there is an effacement of the foot processes of the podocytes and impaired glomerular filtration barrier leading to antenatal manifestations and end-renal stage of disease after birth. We present a case of this disease where sonographic appearance of the fetal kidneys had alerted the experts for further genetic investigation for congenital nephrotic syndrome.

关键词： NPHS1 Gene Congenital Nephrotic Syndrome Kidney Ultrasound Findings

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Mesenchymal stromal cell delivery as a potential therapeutic strategy against COVID-19:Promising evidence from in vitro results

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World Journal of Biological Chemistry 2022年第2期13卷 47-65页

作者： Panagiotis Mallis Theofanis Chatzistamatiou Zetta Dimou Eirini-Faidra Sarri Eleni georgiou Maria Salagianni Vasiliki Triantafyllia evangelos Andreakos Catherine Stavropoulos-Giokas Efstathios Michalopoulos Hellenic Cord Blood Bank Biomedical Research Foundation Academy of AthensAthens 11527Greece Laboratory of Immunobiology Center for ClinicalExperimental Surgery and Translational ResearchBiomedical Research Foundation Academy of AthensAthens 11527Greece

BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is responsible for the coronavirus disease 2019(COVID-19)pandemic,which was initiated in December ***-19 is characterized by a low mortality rate(<6%);however,this percentage is higher in elderly people and patients with underlying ***-19 is characterized by mild to severe ***,several therapeutic strategies are evaluated,such as the use of anti-viral drugs,prophylactic treatment,monoclonal antibodies,and *** cellular therapies are also investigated,thus representing an additional therapeutic tool for *** stromal cells(MSCs),which are known for their immunoregulatory properties,may halt the induced cytokine release syndrome mediated by SARS-CoV-2,and can be considered as a potential stem cell *** To evaluate the immunoregulatory properties of MSCs,upon stimulation with COVID-19 patient *** MSCs derived from the human Wharton’s Jelly(WJ)tissue and bone marrow(BM)were isolated,cryopreserved,expanded,and defined according to the criteria outlined by the International Society for Cellular ***,WJ and BM-MSCs were stimulated with a culture medium containing 15%COVID-19 patient serum,1%penicillin-streptomycin,and 1%L-glutamine for 48 *** quantification of interleukin(IL)-1 receptor a(Ra),IL-6,IL-10,IL-13,transforming growth factor(TGF)-β1,vascular endothelial growth factor(VEGF)-a,fibroblast growth factor(FGF),platelet-derived growth factor(PDGF),and indoleamine-2,3-dioxygenase(IDO)was performed using commercial ELISA *** expression of HLA-G1,G5,and G7 was evaluated in unstimulated and stimulated WJ and ***,the interactions between MSCs and patients’macrophages were established using co-culture *** Thawed WJ and BM-MSCs exhibited a spindle-shaped morphology,successfully differentiated to“osteocytes”,“adipocytes”,and“chondrocytes”,and in flow cytometric analysis were characte

关键词： SARS-CoV-2 COVID-19 MSCs Stem cell therapy Cytokine storm Immunomodulation

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