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Pulse Laser Deposition of HfO_(2)Nanoporous-Like Structure,Physical Properties for Device Fabrication

Journal of Renewable Materials 2022年第11期10卷 2819-2834页

作者： Shams B.Ali Sarmad Fawzi Hamza Alhasan evan T.Salim Forat H.Alsultany Omar S.Dahham Laser and Optoelectronic Engineering Department University of TechnologyBaghdadIraq Applied Science Department University of TechnologyBaghdadIraq Al-Mustaqbal University College Department of Medical PhysicsHillahIraq Center of Excellence Geopolymer and Green Technology Faculty of Engineering TechnologyUniversiti Malaysia PerlisPerlisMalaysia Department of Civil Engineering College of EngineeringCihan University-ErbilKurdistan RegionIraq

The pulsed laser deposition(PLD)technology was used to effectively create conductive nano and micro hafnium oxide with great purity and transparency for(HfO_(2))*** many optoelectronics devices and their applications,the presence of a high dielectric substance like a nano HfO2,between the metal contacts and the substrates was *** used the Pulsed Laser Deposition method to fabricate an Al/HfO_(2)/p-Si Schottky barrier diode where the nanostructured HfO2 films as an intermediate layer and varied substrate *** optical result reveals a high degree of transparency(93%).The optical bandgap of deposited HfO2 films was observed to vary between 4.9 and 5.3 eV,with a value of roughly 5.3 eV at the optimal preparation *** morphology of the surface shows a high homogeneous nano structure with the average values of the roughness about(0.3 nm).With regard to substrate temperature,the produced factor ideality for fabricated diode was determined to be lowering and the associated values of the barrier height rose based on *** regard to substrate temperature,the produced factor ideality for fabricated diode was determined to be lowering and the associated values of the barrier height rose based on I-V *** diode manufactured at 600℃,in particular,had a higher ideality factor value(n=3.2).

关键词： Pulse laser deposition nano films optoelectronics HfO_(2) optical device

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Metformin targets multiple signaling pathways in cancer

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Chinese Journal of Cancer 2017年第7期36卷 289-297页

作者： Yong Lei Yanhua Yi Yang Liu Xia Liu evan T.Keller Chao.Nan Qian Jian Zhang Yi Lu Key Laboratory of Longevity and Ageing.related Diseases Ministry of EducationNanning 530021GuangxiP.R.China Center for Translational Medicine Guangxi Medical University14th FloorPharmacology and Biomedical Sciences BuildingNo.22 Shuangyong RoadNanning 530021GuangxiP.R.China School for International Education Guangxi Medical UniversityNanning 530021GuangxiP.R.China Department of Urology and Pathology School of MedicineUniversity of MichiganAnn ArborMI 48109USA Department of Nasopharyngeal Carcinoma State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Metformin,an inexpensive and well-tolerated oral agent commonly used in the first-line treatment of type 2 diabetes,has become the focus of intense research as a candidate anticancer ***,we discuss the potential of metformin in cancer therapeutics,particularly its functions in multiple signaling pathways,including AMP-activated protein kinase,mammalian target of rapamycin,insulin-like growth factor,c-Jun N-terminal kinase/mitogen-activated protein kinase(p38 MARK),human epidermal growth factor receptor-2,and nuclear factor kappaB *** addition,cutting-edge targeting of cancer stem cells by metformin is summarized.

关键词： Metformin Signaling pathway Cancer stem cell Cancer

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*** of *** enhances prostate cancer chemoresistance via Notch signaling

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Chinese Journal of Cancer 2017年第3期36卷 150-162页

作者： Wenchu Wang Lihui Wang Atsushi Mizokami Junlin Shi Chunlin Zou Jinlu Dai evan T. Keller Yi Lu Jian Zhang Center for Translational Medicine Guangxi Medical University 12th FloorMedical Science Research Building No. 22 Shuangyong Road NanningGuangxi 530021 P. R. China Key Laboratory of Longevity and Ageingrelated Diseases Ministry of Education Nanning Guangxi 530021 P. R. China Department of Urology and Pathology School of Medicine University of Michigan Ann Arbor MI 48109 USA Department of Urology Graduate School of Medical Sciences Kanazawa University Kanazawa 920.1192 Japan Department of Biology and School of Medicine Southern University of Science and Technology Shenzhen Guangdong 518055 P. R. China Department of Urology University of Pittsburgh School of Medicine Pittsburgh PA 15232 USA

Background:The chemoresistance of prostate cancer(PCa)is invariably associated with the aggressiveness and metastasis of this *** emerging evidence indicates that the epithelial-to-mesenchymal transition(EMT)may play pivotal roles in the development of chemoresistance and *** a hallmark of EMT,E-cadherin is suggested to be a key marker in the development of ***,the molecular mechanisms underlying PCa chemoresistance remain *** current study aimed to explore the association between EMT and chemoresistance in PCa as well as whether changing the expression of E-cadherin would affect PCa ***:Parental PC3 and DU145 cells and their chemoresistant PC3-Tx R and DU145-Tx R cells were ***3-Tx R and DU145-Tx R cells were transfected with E-cadherin-expressing lentivirus to overexpress E-cadherin;PC3 and DU145 cells were transfected with small interfering RNA to silence *** of EMT phenotype-related markers and signaling pathways were assessed by Western blotting and quantitative real-time polymerase chain *** cell migration,invasion,and colony formation were then evaluated by wound healing,transwell,and colony formation assays,*** drug sensitivity was evaluated using MTS ***:Chemoresistant PC3-Tx R and DU145-Tx R cells exhibited an invasive and metastatic phenotype that associated with EMT,including the down-regulation of E-cadherin and up-regulation of Vimentin,Snail,and N-cadherin,comparing with that of parental PC3 and DU145 *** E-cadherin was overexpressed in PC3-Tx R and DU145-Tx R cells,the expression of Vimentin and Claudin-1 was down-regulated,and tumor cell migration and invasion were *** particular,the sensitivity to paclitaxel was reactivated in E-cadherin-overexpressing PC3-Tx R and DU145-Tx R *** E-cadherin expression was silenced in parental PC3 and DU145 cells,the expression of Vimentin and Snail was up-regulated,and,pa

关键词： Epithelial-to-mesenchymal transition E-cadherin Chemoresistance Notch signaling Prostate cancer

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Generation of rainfall data series by using the Markov Chain model in three selected sites in the Kurdistan Region,Iraq

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AI in Civil Engineering 2023年第1期2卷 50-62页

作者： evan Hajani Gaheen Sarma Water Resource Engineering Department College of EngineeringUniversity of Duhok38 Zakho StreetKurdistan Region 1006 AJDuhok 42001Iraq

Rainfall forecasting can play a significant role in the planning and management of water resource *** study employs a Markov chain model to examine the patterns,distributions and forecast of annual maximum rainfall(AMR)data collected at three selected stations in the Kurdistan Region of Iraq using 32 years of 1990 to 2021 rainfall data.A stochastic process is used to formulate three states(i.e.,decrease-"d";stability-"s";and increase-"i")in a given year for estimating quantitatively the probability of making a transition to any other one of the three states in the following year(s)and in the long *** addition,the Markov model is also used to forecast the AMR data for the upcoming five years(i.e.,2022-2026).The results indicate that in the upcoming 5 years,the probability of the annual maximum rainfall becoming decreased is 44%,that becoming stable is 16%,and that becoming increased is 40%.Furthermore,it is shown that for the AMR data series,the probabilities will drop slowly from 0.433 to 0.409 in about 11 years,as indi-cated by the average data of the three *** study reveals that the Markov model can be used as an appropri-ate tool to forecast future rainfalls in such semi-arid areas as the Kurdistan Region of Iraq.

关键词： Time series Rainfall Markov chain Forecast Transition Probability

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Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis

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四川生理科学杂志 2022年第12期44卷 2116-2116页

作者： evan S Dellon From the Center for Esophageal Diseases and Swallowing University of North Carolina School of Medicine Chapel Hill (E.S.D.) Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine Cincinnati (M.E.R. M.H.C.) Northwestern University Feinberg School of Medicine Chicago (I.H.) Mount Sinai Center for Eosinophilic Disorders Icahn School of Medicine at Mount Sinai New York (M.C.) and Regeneron Pharmaceuticals Tarrytown (X.S. M.P.K. M.A.K. J.D.H. B.B. E.M. B.A. N.A. W.K.L. M.F.W. M.R. D.R.W. G.D.Y. B.S. J.M. A.G. A.S.) — both in New York Amsterdam University Medical Center Amsterdam (A.J.B.) Hospital General de Tomelloso Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas Madrid and Instituto de Investigación Sanitaria de Castilla–La Mancha Toledo — both in Spain (A.J.L.) Children’s Hospital of Philadelphia Philadelphia (J.M.S.) University of California San Diego La Jolla and Rady Children’s Hospital San Diego — both in California (S.A.) Sanofi Bridgewater NJ (K.P. E.L.) Sanofi Chilly-Mazarin France (L.P.M.) and Sanofi Cambridge MA (N.P.).

Background:Dupilumab,a fully human monoclonal antibody,blocks interleukin-4 and interleukin-13 signaling,which have key roles in eosinophilic ***:We conducted a three-part,phase 3 trial in which patients 12 years of age or older underwent randomization in a 1:1 ratio to receive subcutaneous dupilumab at a weekly dose of 300 mg or placebo(Part A)or in a 1:1:1 ratio to receive 300 mg of dupilumab either weekly or every 2 weeks or weekly placebo(Part B)up to week 24.

关键词： monoclonal placebo weekly

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Immune mediators in the tumor microenvironment of prostate cancer

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Chinese Journal of Cancer 2017年第3期36卷 131-138页

作者： Jinlu Dai Yi Lu Hernan Roca Jill M. Keller Jian Zhang Laurie K. McCauley evan T. Keller Department of Urology and Biointerfaces Institute University of MichiganAnn Arbor MI 48109 USA Center for Translational Medicine Guangxi Medical University Nanning Guangxi 520021 P. R. China Periodontics and Oral Medicine School of Dentistry University of Michigan Ann Arbor MI 48109 USA Department of Urology University of Michigan Ann Arbor MI 48109.8940 USA

Prostate cancer tissue is composed of both cancer cells and host *** milieu of host components that compose the tumor is termed the tumor microenvironment(TME).Host cells can be those derived from the tissue in which the tumor originates(e.g.,fibroblasts and endothelial cells)or those recruited,through chemotactic or other factors,to the tumor(e.g.,circulating immune cells).Some immune cells are key players in the TME and represent a large proportion of non-tumor cells found within the *** cells can have both anti-tumor and pro-tumor *** addition,crosstalk between prostate cancer cells and immune cells affects immune cell *** this review,we focus on immune cells and cytokines that contribute to tumor *** discuss T-regulatory and T helper17 cells and macrophages as key modulators in prostate cancer *** addition,we discuss the roles of interleukin-6 and receptor activator of nuclear factor kappa-B ligand in modulating prostate cancer *** review highlights the concept that immune cells and cytokines offer a potentially promising target for prostate cancer therapy.

关键词： Prostate cancer Tumor microenvironment Macrophage T-regulatory cell Th17 cell Interleukin-6 Receptor activator of nuclear factor kappa-B ligand

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Weave geometry generation avoiding interferences for mesoscale RVEs

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Journal of Materials Science & Technology 2019年第12期35卷 2869-2882页

作者： Daniel Höwer Shengkai Yu Trenton M.Ricks Brett A.Bednarcyk evan J.Pineda Bertram Stier Stefanie Reese Jaan-Willem Simon Institute of Applied Mechanics RWTH Aachen University52074 AachenGermany NASA Glenn Research Center ClevelandOH 44135USA Collier Research and Development Corporation Newport NewsVA 23606USA

An algorithm which allows the generation of representative volume elements(RVEs) for complex woven and warp-interlaced fiber-reinforced composite topologies while avoiding unphysical tow intersections is presented. This is achieved by extending an existing RVE generation strategy in two significant ways:(1) the local cross section shape of the tow is adjusted depending on the local tow curvature in a way that preserves the cross sectional area of the tow, and(2) the elementary crimp interval is separated into a planar and a transition region. The modifications facilitate the generation of a wide range of elaborate textile topologies without tow intersections, which are present without the proposed modifications unless complex tow to tow contact models are introduced. The mechanical properties of plain weaves were predicted based on the topology generated with the proposed algorithm as well as based on RVEs which were constructed based on actual micrographs, i.e. a "digital twin" of the actual microstructure. A comparison of the predicted mechanical properties based on finite element and Multiscale Generalized Method of Cells techniques shows close agreement. However, some differences exist with respect to experimentally determined material parameters due to the finite dimensions of the specimens. Lastly,mechanical properties of multilayered weaves are predicted with the finite element method. The considered material systems are carbon fiber in epoxy matrix as well as C/C-SiC. However, the procedure is applicable to a wide range of material systems.

关键词： RVE generation Multiscale analysis Composites

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Development and validation of a registry-based definition of eosinophilic esophagitis in Denmark

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World Journal of Gastroenterology 2013年第4期19卷 503-510页

作者： evan S Dellon Rune Erichsen Lars Pedersen Nicholas J Shaheen John A Baron Henrik T Sφrensen Mogens Vyberg Center for Esophageal Diseases and Swallowing and Center for Gastrointestinal Biology and DiseaseDivision of Gastroenterology and HepatologyDepartment of MedicineUniversity of North Carolina School of MedicineChapel HillNC 27599-7080United States Center for Gastrointestinal Biology and Disease Division of Gastroenterology and HepatologyDepartment of MedicineUniversity of North Carolina School of MedicineChapel HillNC 27599-7080United States Department of Clinical Epidemiology Aarhus University Hospital8000 AarhusDanmark Institute of Pathology Aalborg HospitalAarhus University Hospital8000 AarhusDanmark

AIM:To develop and validate a case definition of eosinophilic esophagitis(EoE) in the linked Danish health ***:For case definition development,we queried the Danish medical registries from 2006-2007 to identify candidate cases of EoE in Northern *** International Classification of Diseases-10(ICD-10) and prescription codes were obtained,and archived pathology slides were obtained and re-reviewed to determine case *** used an iterative process to select inclusion/exclusion codes,refine the case definition,and optimize sensitivity and *** then re-queried the registries from 2008-2009 to yield a validation *** case definition algorithm was applied,and sensitivity and specificity were ***:Of the 51 and 49 candidate cases identified in both the development and validation sets,21 and 24 had EoE,*** of EoE cases in the development set [mean age 35 years;76% male;86% dysphagia;103 eosinophils per high-power field(eos/hpf)] were similar to those in the validation set(mean age 42 years;83% male;67% dysphagia;77 eos/hpf).Re-review of archived slides confirmed that the pathology coding for esophageal eosinophilia was correct in greater than 90% of *** registrybased case algorithms based on pathology,ICD-10,and pharmacy codes were successfully generated in the development set,one that was sensitive(90%) and one that was specific(97%).When these algorithms were applied to the validation set,they remained sensitive(88%) and specific(96%).CONCLUSION:Two registry-based definitions,one highly sensitive and one highly specific,were developed and validated for the linked Danish national health databases,making future population-based studies feasible.

关键词： Eosinophilic esophagitis Denmark Epidemiology Case definition Sensitivity Specificity

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The Expedition of Humphry Clinker

The Expedition of Humphry Clinker

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作者： Tobias Smollet Edited by evan Gottlieb Oregon State University.

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非光滑表面离心泵叶轮的流动减阻特性

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上海交通大学学报 2016年第2期50卷 306-312页

作者：牟介刚代东顺谷云庆刘剑郑水华 WANG evan 浙江工业大学机械工程学院杭州310014 约瑟夫傅立叶大学格勒诺布尔国立综合理工学院法国格勒诺布尔38031

为了分析非光滑表面对离心泵性能的影响,基于仿生凹坑表面的减阻特性,将凹坑型非光滑单元体排布于离心泵叶片的工作面,建立具有非光滑表面的叶轮离心泵的流动减阻特性分析模型,通过RNGk-ε湍流模型对离心泵内部流场进行数值模拟,分析具... 详细信息

为了分析非光滑表面对离心泵性能的影响,基于仿生凹坑表面的减阻特性,将凹坑型非光滑单元体排布于离心泵叶片的工作面,建立具有非光滑表面的叶轮离心泵的流动减阻特性分析模型,通过RNGk-ε湍流模型对离心泵内部流场进行数值模拟,分析具有非光滑表面叶轮的流动减阻特性,研究不同流量下非光滑表面对叶片近壁面的速度分布、剪应力和离心泵内部流场的影响.结果表明:凹坑型非光滑表面能够降低因黏性阻力产生的叶轮扭矩,其扭矩的最大降幅为5.8%;非光滑表面能够有效控制叶片近壁面边界层的流体流动,减小叶片的壁面剪应力;凹坑型非光滑表面能够降低离心泵叶轮内部流体的湍动程度,减小湍动产生的能量耗散,使叶轮内部的流体流动更加稳定并提高离心泵的效率.

关键词：离心泵非光滑表面减阻边界层

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