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Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

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Neural Regeneration Research 2025年第8期20卷 2218-2230页

作者： Rahul Mittal Keelin McKenna Grant Keith evan McKenna Joana R.N.Lemos Jeenu Mittal Khemraj Hirani Diabetes Research Institute University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

Prostate cancer cells metastasize to the hematopoietic stem cell niche in bone

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Asian Journal of Andrology 2011年第4期13卷 622-623页

作者： evan T Keller Departments of UroJogy and Pathology University of Michigan Ann Arbor MI 48109 USA

The majority of men with advanced prostate cancer develop bone metastases as opposed to metastases at other sites. It has been unclear why prostate cancer selectively metastasizes to and proliferates in bone. Recently, Shiozawa et al. delineated a mechanism that may account for the establishment of prostate cancer in bone. Specifically, they identified that prostate cancer cells compete with hematopoietic stem cells （HSC） for the osteoblast in the HSC niche of the bone. Defining the mechanisms through which prostate cancer cells establish themselves in bone is critical towards developing effective therapeutic strategies to prevent or target bone metastases.

关键词： Biological sciences Cell biology Microbiology

Predicting the synthesizability of crystalline inorganic materials from the data of known material compositions

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npj Computational Materials 2023年第1期9卷 733-743页

作者： evan R.Antoniuk Gowoon Cheon George Wang Daniel Bernstein William Cai evan J.Reed Materials Science Division Physical and Life Sciences DirectorateLawrence Livermore National LaboratoryLivermoreCAUSA Department of Chemistry Stanford UniversityStanfordCAUSA Department of Applied Physics Stanford UniversityStanfordCAUSA Google Research Mountain ViewCAUSA Department of Physics Stanford UniversityStanfordCAUSA Department of Mathematics Stanford UniversityStanfordCAUSA Department of Computer Science Stanford UniversityStanfordCAUSA Department of Materials Science and Engineering Stanford UniversityStanfordCAUSA

Reliably identifying synthesizable inorganic crystalline materials is an unsolved challenge required for realizing autonomous materials *** this work,we develop a deep learning synthesizability model(SynthNN)that leverages the entire space of synthesized inorganic chemical *** reformulating material discovery as a synthesizability classification task,SynthNN identifies synthesizable materials with 7×higher precision than with DFT-calculated formation *** a head-to-head material discovery comparison against 20 expert material scientists,SynthNN outperforms all experts,achieves 1.5×higher precision and completes the task five orders of magnitude faster than the best human ***,without any prior chemical knowledge,our experiments indicate that SynthNN learns the chemical principles of charge-balancing,chemical family relationships and ionicity,and utilizes these principles to generate synthesizability *** development of SynthNN will allow for synthesizability constraints to be seamlessly integrated into computational material screening workflows to increase their reliability for identifying synthetically accessible materials.

关键词： inorganic crystalline utilize

A Group of Cu(Zr)-based BMGs with Critical Diameter in the Range of 12 to 18 mm

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Journal of Materials Science & Technology 2008年第2期24卷 149-152页

作者： Yong SHEN evan MA Jian XU Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Department of Materials Science and Engineering The Johns Hopkins University Baltimore Maryland 21218 USA

A group of Cu（Zr）-based bulk metallic glasses （BMGs） with critical diameter （De） in the 12 to 18 mm range have been obtained using copper mould casting. In the Cu-Zr-Y-Al quaternary system, a new record of Dc=14 mm was established for Cu-based compositions, and 16 mm for compositions based on equi-atomic CuZr. Additional partial substitution of Hf for Zr further elevated the Dc to 18 mm at Cu42Zr43Hf1.5Y3.5Al10.

关键词： Bulk metallic glasses Glass-forming ability Copper Zirconium

SPDEF： a molecular switch for E-cadherin expression that promotes prostate cancer metastasis

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Asian Journal of Andrology 2013年第5期15卷 584-585页

作者： Mary Osisami evan T Keller Department of Urology University of Michigan AnnArbor M148105 USA

In order to design effective therapies for prostate cancer, a clear understanding of mechanisms that contribute to various components of prostate cancer progression is necessary. Study of metastasis suppressor genes, i.e., genes that can inhibit metastasis, is an important field of study that can lead to identification of therapeutic targets to diminish metastasis.

关键词： SPDEF a molecular switch metastasis

China’s transitioning class identity

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China Finance and Economic Review 2016年第1期5卷 71-87页

作者： evan Osborne Department of Economics Wright State University

China’s rapid economic transformation is similar in some ways to those that have occurred in other East Asian *** the changing structure of perceived class identity that occurs in many rapidly growing economies is found to be absent in China,and in fact as China has continued to grow such change as has occurred is found to be downward,despite the immense material improvement *** data on income distribution in China do not explain this phenomenon,but anomalies in China’s urban real-estate market might.

关键词： Housing market class identity middle class social effects of economic growth

Beyond first-line chemotherapy for advanced pancreatic cancer:An expanding array of therapeutic options?

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World Journal of Gastroenterology 2014年第9期20卷 2224-2236页

作者： evan J Walker Andrew H Ko University of California Helen Diller Family Comprehensive Cancer Center San Francisco CA 94115 United States

While an increasing number of therapeutic options are now available for the first-line treatment of locally advanced or metastatic pancreatic cancer,the optimal choice for treatment in the second-line setting and beyond is less well defined.A variety of cytotoxic agents,either alone or in combination,have been evaluated,although primarily in the context of small single-arm or retrospective *** regimens have been associated with median progression-free survival rates in the range of 2-4 mo and overall survival rates between 4-8mo,highlighting the very poor prognosis of patients who are candidates for such *** therapies studied in this chemotherapy-refractory setting,meanwhile,have produced even worse efficacy *** the current article,we review the clinical evidence for treatment of refractory disease,primarily in patients who have progressed on front-line gemcitabine-based *** the process,we highlight the limitations of the available data to date as well as some of the challenges in designing appropriate clinical trials in this salvage setting,including how to select an appropriate control arm given the absence of a wellestablished reference standard,and the importance of incorporating predictive biomarkers and quality of life measures whenever possible into study design.

关键词： Pancreatic cancer Refractory Second-line chemotherapy Gemcitabine

Cascade of care for children and adolescents with chronic hepatitis C

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World Journal of Gastroenterology 2021年第12期27卷 1117-1131页

作者： Michael evan Rogers William F Balistreri Department of Pediatrics Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

Chronic hepatitis C virus(HCV)infection presents a significant global public health *** 2015,over 400000 deaths worldwide were attributed to HCV *** led the World Health Organization(WHO)in 2016 to set the ambitious goal of eliminating HCV by ***-centered guidelines have been established in order to provide direction for healthcare professionals,allowing integration of the newest screening policies and therapeutic strategies into their ***,for children and adolescents,HCV is a significant,unrecognized public health *** infection rates in the United States in women of childbearing age and those who are pregnant have increased in parallel with the rising opioid *** estimated 29000 women with HCV infection gave birth each year from 2011 to 2014 in the United States,with approximately 1700 of their infants being infected with *** HCV-specific therapeutics,namely direct acting antivirals(DAA),has brought a new and highly successful approach to treatment of hepatitis *** studies have confirmed similar levels of effectiveness and safety of DAA therapies in the pediatric ***,an enhanced cascade of care,which should include the population under 18 years of age,can help achieve the WHO goal by focusing on elimination in the youngest *** review will present an overview of the natural history,clinical features,and management of HCV in children and adolescents.

关键词： Hepatitis C virus Hepatitis C education Hepatitis C elimination

Improved skin regeneration with acellular fish skin grafts

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Engineered Regeneration 2020年第1期1卷 95-101页

作者： Gabriella Fiakos Zeming Kuang evan Lo Stony Brook University Biomedical Engineering100 Nicolls RdStony BrookNew York 11794United States

Fish skin graft,a novel skin substitute,has seen a widespread clinical application since the approval for wound coverage by the *** to its properties in promoting wound healing and its efficient cost in manufacturing,fish skin grafts are a potential alternative to allograft and xenograft sources including,but not limited to cadaver and porcine grafts in a variety of ***,fish skin grafts show promising results in treating diabetic foot ulcers(DFUs),venous leg ulcers(VLUs)and some evidence worthy of further exploration in treating a host of other acute and chronic *** we summarize the material and biological properties of fish skin *** this graft compares to other prevailing skin substitutes on the market for different wound types was also *** skin grafts have many uses in clinical applications of the future.

关键词： Wound healing Chronic wounds Burn wounds Skin xenografts Omega-3 polyunsaturated fatty acid