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门诊使用米索前列醇促宫颈成熟而非引产的一项随机试验

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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 52-52页

作者： mckenna D.S. Ester J.B. Proffitt M. Waddell K.R. 张会孝 Department of Obstetrics Mt. Area Health Education Center 900 Hendersonville Road Ashev ille NC 28803 United States Dr.

OBJECTIVE: To estimate the effect of outpatient administration of a single d os e of vaginal misoprostol at term on the interval to delivery in women with unfav orable cervices. METHODS: Randomized, double blind, placebo-controlled trial co mparing a single 25-μg outpatient intravaginal dose of misoprostol to placebo in pregnant women with Bishop scores less than 9 at 40 weeks or greater. After p lacement of the study medication, subjects were permitted to go into spontaneous labor unless an indication for induction developed. Analysis was by intent to t reat. The interval to delivery, defined as the time from medication placement to delivery, was compared by Student t test and by survival analysis with the log -rank test. RESULTS: Thirty-three women were randomly assigned to receive miso prostol, and 35 were assigned to receive placebo. The mean interval to delivery was significantly less in the misoprostol group, 4.2 ±.4.1 compared with 6.1 ± .3.6 days, P = .04. The interval to delivery for only the nulliparous patients w as significantly less in the misoprostol group, 4.2 ±.4.0 compared with 7.2 ±. 3.7 days, P = .02. The survival curves for the interval to delivery were signifi cantly different (P = .04 by log-rank test) with 4.1 days median interval to de livery for misoprostol compared with 9.2 days for placebo. There were no adverse outcomes in either group. CONCLUSION: A single 25-μg outpatient intravaginal dose of misoprostol is effective in decreasing the interval to delivery in women with unfavorable cervices at term.

关键词：宫颈成熟宫颈条件随机试验生存分析安慰剂 Bishop 初产妇生存曲线自然分娩统计分析

A history of high-power laser research and development in the United Kingdom

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High Power Laser Science and Engineering 2021年第2期9卷 41-126页

作者： Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul mckenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone AWE Aldermaston ReadingUK Oxford Centre for High Energy Density Science Department of PhysicsClarendon LaboratoryUniversity of OxfordOxfordUK Centre for Intertial Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Formerly of Electrox LetchworthUK Formerly of Central Laser Facility Rutherford LaboratoryDidcotUK Formerly of Ferranti Defence Systems LincolnUK Leonardo EdinburghUK Retired AWEReadingUK Formerly of AWE ReadingUK Formerly of Laser Lines Ltd BanburyUK Formerly of Optilas Ltd Milton KeynesUK Retired Pro-Lite TechnologyCranfieldUK Specialised Imaging Ltd PitstoneUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK Magna-Power Electronics Ltd ReadingUK DeBe Lasers Needham Laser TechnologiesWhitchurchUK Blackett Laboratory Imperial College LondonLondonUK SPIE Europe CardiffUK Professor Emeritus(Physics) University of HullKingston upon HullUK Kentech Instruments Ltd WallingfordUK Department of Physics Clarendon LaboratoryUniversity of OxfordOxfordUK Professor Emeritus Department of PhysicsUniversity of StrathclydeGlasgowUK Department of Physics Durham UniversityDurhamUK Professor Emeritus(Photonics) Heriot-Watt UniversityEdinburghUK Professor Emeritus University of SouthamptonSouthamptonUK Optical Surfaces Ltd KenleyUK JEH Lasers Ltd RugbyUK Scottish Universities Physics Alliance Department of PhysicsUniversity of StrathclydeGlasgowUK ITER Organization Saint-Paul-lez-DuranceFrance Manx Precision Optics Ltd BallasallaUK Laser Lines Ltd BanburyUK Elliot Scientific Ltd MetroTest Scientific GroupHarpendenUK Centre for Plasma Physics Queen’s University BelfastBelfastUK Retired Founderand former MDRofin-Sinar UK LtdHullUK Heraeus Noblelight Ltd CambridgeUK Mirli Books ChelmsfordUK M Squared Lasers Ltd GlasgowUK University of Hertfordshire HatfieldUK E&EO UK Ltd Barton-upon-HumberUK Department of Physics University of YorkYorkUK IC Optical Systems Ltd BeckenhamUK Laser Micromachining Ltd St AsaphUK MBDA UK Ltd Brist

The first demonstration of laser action in ruby was made in 1960 by *** of Hughes Research Laboratories,*** laboratories worldwide began the search for lasers using different materials,operating at different *** the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of *** historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years.

关键词： high-power lasers history United Kingdom

Versatile tape-drive target for high-repetition-rate laser-driven proton acceleration

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High Power Laser Science and Engineering 2023年第4期11卷 59-69页

作者： N.Xu M.J.V.Streeter O.C.Ettlinger H.Ahmed S.Astbury M.Borghesi N.Bourgeois C.B.Curry S.J.D.Dann N.P.Dover T.Dzelzainis V.Istokskaia M.Gauthier L.Giuffrida G.D.Glenn S.H.Glenzer R.J.Gray J.S.Green G.S.Hicks C.Hyland M.King B.Loughran D.Margarone O.McCusker P.mckenna C.Parisuaña P.Parsons C.Spindloe D.R.Symes F.Treffert C.A.J.Palmer Z.Najmudin John Adams Institute for Accelerator Science Blackett LaboratoryImperial College LondonLondonUK School of Maths and Physics Queen’s University BelfastBelfastUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK SLAC National Accelerator Laboratory Menlo ParkUSA ELI Beamlines Centre Institute of PhysicsCASDolni BrezanyCzech Republic Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in PraguePragueCzech Republic Department of Physics SUPAUniversity of StrathclydeGlasgowUK Department of Mechanical Engineering Stanford UniversityStanfordUSA Department of Applied Physics Stanford UniversityStanfordUSA Department of Electrical and Computer Engineering University of AlbertaEdmontonCanada Institut für Kernphysik Technische Universität DarmstadtDarmstadtGermany

We present the development and characterization of a high-stability,multi-material,multi-thickness tape-drive target for laser-driven acceleration at repetition rates of up to 100 *** tape surface position was measured to be stable on the sub-micrometre scale,compatible with the high-numerical aperture focusing geometries required to achieve relativistic intensity interactions with the pulse energy available in current multi-Hz and near-future higher repetition-rate lasers(>kHz).Long-term drift was characterized at 100 Hz demonstrating suitability for operation over extended *** target was continuously operated at up to 5 Hz in a recent experiment for 70,000 shots without intervention by the experimental team,with the exception of tape replacement,producing the largest data-set of relativistically intense laser–solid foil measurements to *** tape drive provides robust targetry for the generation and study of high-repetitionrate ion beams using next-generation high-power laser systems,also enabling wider applications of laser-driven proton sources.

关键词： high-repetition-rate laser target laser-plasma acceleration proton generation tape-drive target