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Plasma Accumulations of Vitamin B6 from an Oral Dose in a new Reversible Model for Mouse Gut Injury and Regeneration

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Food and nutrition Sciences 2013年第9期4卷 908-917页

作者： Pilar Jiménez Damián Cordoba-Diaz Patricia Cabrero Mónica Aracil Manuel J. Gayoso Manuel Garrosa Manuel Cordoba-Diaz Tomás Girbés Biología Celular Histología y Farmacología Facultad de Medicina and INCYL (Instituto de Neurociencias de Castilla y León) Universidad de Valladolid Valladolid Spain. Farmacia y Tecnología Farmacéutica Facultad de Farmacia and IUFI (Instituto Universitario de Farmacia Industrial) Universidad Complutense de Madrid Madrid Spain nutrición y Bromatología Facultad de Medicina and CINAD (Centro de Investigación en Nutrición Alimentación y Dietética- Edificio LUCIA-Parque Científico) Universidad de Valladolid Valladolid Spain

Chemically based rodent models are used to assess the positive effects promoted by foods and gut microbiota on gut health. Lectins with enzymatic activity, such as type 2 ribosome-inactivating proteins, might also prove useful for exploring these issues. Sub-lethal doses of the lectin nigrin from Sambucus nigra L. to mice promoted reversible derangement of gut epithelium by induction of apoptosis of transit amplifying cells of the small intestine crypts in a time-dependent course. The present work seeks to study vitamin B6 accumulation in plasma from an oral bolus in a mouse nigrin model. 24 h after sub-lethal nigrin b treatment, there was clear body weight reduction associated to a notable increase in evan’s blue stain accumulation in excised small intestine, an increase in myeloperoxidase activity, and a near 50% reduction in plasma accumulation of vitamin B6. Histological analysis of small intestine sections of nigrin b-treated animals also revealed significant derangement of intestinal crypts. Seventy two hours after nigrin b treatment, stain uptake decreased and vitamin B6 accumulation was almost restored despite villi derangement. Large intestine crypts were scarcely or not at all affected. Eight days after nigrin b treatment, vitamin B6 uptake and intestinal crypt structure had fully recovered. The nigrin b mice model supports the view that, under these conditions, the carrier-mediated vitamin B6 uptake component of the small intestine crypts is probably the most active when the vitamin is administered orally as a bolus. The findings provide insights into the suitability of the present mice model for nutritional or drug absorption studies in conditions of partially altered or injured intestinal mucosa.

关键词： Vitamin B6 nigrin b Ribosome-Inactivating Protein Sambucus Ricin Intestines Mice Model

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Views of South Asian Physicians on Climate Related Health Effects: A Multinational Cross-Sectional Pilot Study

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American Journal of Climate Change 2023年第1期12卷 58-79页

作者： Tehzeeb Zulfiqar Hina Jawaid Abdul Jalil Khan n. Waseem Ahmed Asif Rehman Muhammad Hassam Khan Kinley Bhutti Md. Ferdous Rahman Saadia Mustafa Husnulmaab Ali Tariq Aziz Health Services Academy Islamabad Pakistan University of Health Sciences Lahore Pakistan Khyber Medical University Peshawar Pakistan Department of Diabetes Gem Hospital & Research Centre Chennai Tamilnado India Peshawar Medical College Peshawar Pakistan PARO General Hospital Paro Bhutan International Centre for Diarrheal Disease Research Dhaka Bangladesh

Background: South Asian populations are vulnerable to poor health outcomes associated with climate due to the region’s complex topography, poverty, lack of education, and population density. Physicians, being highly trusted members of society, can help mitigate climate change effects in their countries. Objectives: The present study assessed perceptions of physicians from four South Asian countries (Bangladesh, Bhutan, India, and Pakistan). We hypothesized that physicians from these countries will be aware and knowledgeable about health effects of climate change. Methods: We conducted a cross-sectional online survey of physicians between March and July 2022. Data of 201 physicians was analyzed using the Kruskal-Wallis test and dunn’s post hoc method. Results: Physicians from four South Asian countries were attuned to the health risks associated with climate change. A majority of physicians (86.6%) believed that climate change would make health conditions in their countries more severe or frequent (Bangladesh 83.3%;Bhutan 70%;India 91% and Pakistan 90.8%). The most common health effect related to climate change was illnesses related to reduced outdoor air quality (54.3%). Common barriers to discuss climate change with patients from all four countries were physicians’ lack of knowledge (strongly agree, 13.8%;agree 47.7%) in how to approach the issue with patients, lack of time (strongly agree, 12%;agree, 48%) and their perception that patients were not interested in knowing about climate change (strongly agree, 8.6%;agree, 42.6%). More than half (56.2%) of the physicians reported no training (Bangladesh, 51.7%;Bhutan, 80%;India, 44.6%;Pakistan, 63.1%) and approximately 30% reported less than 20 hours of training (Bangladesh, 28.3%;Bhutan, 15.0%;India, 39.3%;Pakistan, 27.7%) in climate-change-related health effects. Conclusion: While additional large-scale research is needed to understand the trends observed in our pilot study, our findings identify the need to introdu

关键词： Climate Change Health Physicians South Asia

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肺炎链球菌溶血素致脑损伤中细胞凋亡及凋亡诱导因子的变化及意义

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中华神经医学杂志 2011年第10期10卷 1009-1013页

作者：王越王怀立禚志红李国栋田培超罗强郑州大学第一附属医院儿内科郑州450052

目的探讨肺炎链球菌溶血素（PLY）致感染性脑损伤中细胞凋亡及凋亡诱导因子（AIF）的表达及意义。方法SD大鼠80只按随机数字表法分为PLY组颈内动脉注射0．2mL（7μg）PLY]和生理盐水（nS）组（颈内动脉注射等体积nS），每组40只。每组... 详细信息

目的探讨肺炎链球菌溶血素（PLY）致感染性脑损伤中细胞凋亡及凋亡诱导因子（AIF）的表达及意义。方法SD大鼠80只按随机数字表法分为PLY组颈内动脉注射0．2mL（7μg）PLY]和生理盐水（nS）组（颈内动脉注射等体积nS），每组40只。每组按观察时间点分为6h、12h、24h、48h4个亚组，每亚组10只，其中5只注射EB，甲酰胺法测定脑组织EB含量判断血脑屏障（BBB）的破坏程度。5只不注射EB，取脑组织切片，应用免疫组化和TUnEL染色分别检测脑组织神经元特异性烯醇化酶（nSE）、胶质纤维酸性蛋白（GFAP）、AIF蛋白含量和细胞凋亡。结果与nS组比较，造模后各时间点PLY组大鼠脑组织EB、nSE、GFAP、AIF蛋白含量均较高。细胞凋亡较多，差异均有统计学意义（P〈0．05）；PLY组大鼠脑组织凋亡细胞数与AIF蛋白的表达呈正相关关系（r=0．959，P=0．000）。结论细胞凋亡参与了PLY诱导的脑损伤的发展过程，A1F可能介导了神经细胞的凋亡。

关键词：肺炎链球菌溶血素感染性脑损伤细胞凋亡凋亡诱导因子

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髋臼软骨厚度测量:尸体多层CT三维重组关节成像的准确性研究

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国际医学放射学杂志 2010年第4期 376-376页

作者： B.C.Allen C.L.Peters n.A.T.Brown A.E.Anderson 李宁 Department of Orthopaedics Harold K.Dunn Orthopaedic Research LaboratoryUniversity of Utah590 Wakara WayRoom A100Salt Lake CityUT 84108USA

目的以直接物理测量的髋臼软骨厚度作为参考标准,前瞻性量化研究多层CT(MDCT)关节扫描中分段3D表面重组在髋臼软骨厚度测量中的准确性。材料与方法获得2名年龄分别为43岁及46岁的男性

关键词：髋臼软骨厚度测量 CT MDCT 关节运动器官尸体

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