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Tumor necrosis f.ctor receptor superf.mily member 9 is upregulated in the endothelium and tumor cells in melanoma brain metastasis

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Neuroimmunology and Neuroinf.ammation 2014年第1期1卷 135-140页

作者： Patrick N.Harter Anna-eva Blank Benjamin Weide Rudi Beschorner Simon Bernatz Peter Baumgarten Anne KBraczynski Elke Hattingen Michael WRonellenf.tsch Herbert Schwarz michel Mittelbronn Institute of.Neurology(Edinger Institute) Goethe University60528 FrankfurtGermany German Cancer Consortium(DKTK) 69120 HeidelbergGermany German Cancer Research Center(DKf.) 69120 HeidelbergGermany Department of.Neuropediatrics University of Frankfurt60590 FrankfurtGermany Department of.Dermatology Eberhardt-Karls University72076 TuebingenGermany Department of.Neuropathology Institute of Pathology and NeuropathologyEberhardt-Karls University72076 TuebingenGermany Department of.Neurosurgery Goethe University60528 FrankfurtGermany Department of.Neuroradiology University of Frankfurt am Main60258 FrankfurtGermany Dr.Senckenberg Institute of.Neurooncology University of Frankfurt am Main60258 FrankfurtGermany Department of.Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117456Singapore

Aim:The cytokine receptor tumor necrosis f.ctor receptor superf.mily member 9(TNf.Sf.)is mainly considered to be a co-stimulatory activation marker in hematopoietic *** preclinical models have shown a dramatic benef.cial ef.ect of.treatment approaches targeting TNf.Sf. with agonistic ***,preliminary clinical phase I/II studies were stopped af.er the occurrence of.several severe deleterious side *** a previous study,it was demonstrated that TNf.Sf. was strongly expressed by reactive astrocytes in primary central nervous system(CNS)tumors,but was largely absent f.om tumor or inf.ammatory *** aim of.the present study was to address the cellular source of.TNf.Sf. expression in the setting of.human melanoma brain metastasis,a highly immunogenic tumor with a prominent tropism to the ***:Melanoma brain metastasis was analyzed in a cohort of.78 patients by immunohistochemistry f.r TNf.Sf. and its expression was correlated with clinicopathological parameters including sex,age,survival,tumor size,number of.tumor spots,and BRAf.V600E expression ***:Tumor necrosis f.ctor receptor superf.mily member 9 was f.equently expressed independently on both melanoma and endothelial *** addition,TNf.Sf. was also present on smooth muscle cells of.larger vessels and on a subset of.lymphomonocytic tumor *** association between TNf.Sf. expression and patient survival or other clinicopathological parameters was *** note,several cases showed a gradual increase in TNf.Sf. expression on tumor cells with increasing distance f.om blood vessels,an observation that might be linked to hypoxia-driven TNf.Sf. expression in tumor ***:The f.ndings indicate that the cellular source of.TNf.Sf. in melanoma brain metastasis largely exceeds the lymphomonocytic pool,and theref.re f.rther caref.l(re-)assessment of.potential TNf.Sf. f.nctions in cell types other than hematopoietic cells is ***,the hypothesis of

关键词： 4-1BB brain metastasis CD137 melanoma tumor necrosis f.ctor receptor superf.mily member 9

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Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway

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Horticulture Research 2021年第1期8卷 2949-2961页

作者： Camille Chalvin Stephanie Drevensek f.ançoise Gilard Caroline Mauve Christel Chollet Halima Morin Edith Nicol eva Heripre Lucie Kriegshauser Bertrand Gakiere michel Dron Abdelhaf.d Bendahmane Adnane Boualem Universite Paris-Saclay CNRSINRAEUniv EvryInstitute of Plant Sciences Paris-Saclay(IPS2)91405 OrsayFrance Molecular Chemistry Laboratory(LCM) UMR 9168CNRSEcole PolytechniqueInstitut Polytechnique de ParisRoute de Saclay91128 Palaiseau CedexFrance Laboratory of.Mechanics of.Soils Structures and Materials(MSSMAT)UMR 8579CNRSEcole CentraleSupelecUniversite Paris-SaclayBâtiment Eiffel8-10 rue Joliot-Curie91190 Gif-Sur-YvetteFrance

Sclareol,an antif.ngal specialized metabolite produced by clary sage,Salvia sclarea,is the starting plant natural molecule used f.r the hemisynthesis of.the perf.me ingredient *** is mainly produced in clary sage f.ower calyces;however,the cellular localization of.the sclareol biosynthesis remains *** elucidate the site of.sclareol biosynthesis,we analyzed its spatial distribution in the clary sage calyx epidermis using laser desorption/ionization mass spectrometry imaging(LDI–f.ICR-MSI)and investigated the expression prof.le of.sclareol biosynthesis genes in isolated glandular trichomes(GTs).We showed that sclareol specif.cally accumulates in GTs’gland cells in which sclareol biosynthesis genes are strongly *** next isolated a glabrous beardless mutant and demonstrate that more than 90%of.the sclareol is produced by the large capitate *** experiments,using 1-13 C-glucose,and specif.c enzyme inhibitors f.rther revealed that the methylerythritol-phosphate(MEP)biosynthetic pathway is the main source of.isopentenyl diphosphate(IPP)precursor used f.r the biosynthesis of.*** f.ndings demonstrate that sclareol is an MEP-derived diterpene produced by large capitate GTs in clary sage emphasing the role of.GTs as biof.ctories dedicated to the production of.specialized metabolites.

关键词： oxide. starting synthesis

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PGR5-PGRL1-Dependent Cyclic Electron Transport Modulates Linear Electron Transport Rate in Arabidopsis thaliana

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Molecular Plant 2016年第2期9卷 271-288页

作者： Marjaana Suorsa f.bio Rossi Luca Tadini Mathias Labs Monica Colombo Peter Jahns Martin M. Kater Dario Leister Giovanni f.nazzi eva-Mari Aro Roberto Barbato Paolo Pesaresi Molecular Plant Biology Department of Biochemistry University of Turku 20014 Turku Finland Dipartimento di Bioscienze Unlversit~ degli studi di Milano 20133 Milano Italy Plant Molecular Biology (Botany) Department Biology I Ludwig-Maximilians-Universit~t MSnchen 82152 Planegg-Martinsded Germany Centro Ricerca e Innovazione Fondazione Edmund Mach 38010 San Michele all'Adige Italy Plant Biochemistry Heinrich-Heine-University Dusseldorf Universitstsstrasse 140225 Dusseldorf Germany Laboratoire de Physiologie Cellulaire & Vegetale Unite Mixte de Recherche 5168 Centre National de la Recherche Scientifique 38054 Grenoble France Dipartimento di Scienze dell'Ambiente e della Vita Universita del Piemonte Orientale viale Teresa Michel 11 15121 Alessandria Italy These authors contributed equally to this article

Plants need tight regulation of.photosynthetic electron transport f.r survival and growth under environ- mental and metabolic conditions. f.r this purpose, the linear electron transport （LET） pathway is supple- mented by a number of.alternative electron transf.r pathways and valves. In Arabidopsis, cyclic electron transport （CET） around photosystem I （PSI）, which recycles electrons f.om f.rrodoxin to plastoquinone, is the most investigated alternative route. However, the interdependence of.LET and CET and the relative importance of.CET remain unclear, largely due to the dif.iculties in precise assessment of.the contribution of.CET in the presence of.LET, which dominates electron f.ow under physiological conditions. We there- f.re generated Arabidopsis mutants with a minimal water-splitting activity, and thus a low rate of.LET, by combining knockout mutations in Psb01, PsbP2, PsbQ1, PsbQ2, and PsbR loci. The resulting 45 mutant is viable, although mature leaves contain only ~20% of.wild-type naturally less abundant Psb02 protein. 45 plants compensate f.r the reduction in LET by increasing the rate of.CET, and inducing a strong non-photochemical quenching （NPQ） response during dark-to-light transitions. To identif. the molecular origin of.such a high-capacity CET, we constructed three sextuple mutants lacking the qE component of.NPQ （45 npq4-1）, NDH-mediated CET （45 crr4-3）, or PGR5-PGRLl-mediated CET （45 pgrS）. Their analysis revealed that PGR5-PGRLl-mediated CET plays a major role in ~pH f.rmation and induction of.NPQ in C3 plants. Moreover, while pgr5 dies at the seedling stage under f.uctuating light conditions, 45 pgr5 plants are able to survive, which underlines the importance of.PGR5 in modulating the intersystem electron transf.r.

关键词： Arabidopsis Photosynthesis Linear Electron Transport Cyclic Electron Transport Oxygen EvolvingComplex PGR5

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PET/CT与增强CT诊断头颈肿瘤颈淋巴结转移的对比研究

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现代肿瘤医学 2007年第11期15卷 1555-1557页

作者：陆海杰 Lydia RIBERE-BRUGEL Emmanuel ITTI eva evaNGELISTA 王安宇朱小东 michel MEIGNAN Henri Mondora医院核医学科法国巴黎94000 Intercommunal de Creteil医院头颈外科法国巴黎94000 广西医科大学附属肿瘤医院放疗科广西南宁530021

目的:探讨18f.脱氧葡萄糖(f.G)PET/CT显像与螺旋CT增强扫描检测头颈肿瘤淋巴结转移的临床价值。方法:13个头颈肿瘤病人在颈部手术前,行PET/CT和增强CT检查。术后病理结果作为参考标准,PET/CT与增强CT的发现以左、右颈侧为记录单位进行... 详细信息

目的:探讨18f.脱氧葡萄糖(f.G)PET/CT显像与螺旋CT增强扫描检测头颈肿瘤淋巴结转移的临床价值。方法:13个头颈肿瘤病人在颈部手术前,行PET/CT和增强CT检查。术后病理结果作为参考标准,PET/CT与增强CT的发现以左、右颈侧为记录单位进行比较。结果:在21个颈侧清扫(8个双侧,5个单侧)中,共清扫出440个淋巴结,其中的45个颈部淋巴结转移癌分布在14个颈侧。PET/CT检测颈淋巴结转移的敏感性、特异性和准确性分别为86%、100%和90%,增强CT分别为79%、86%和81%,PET/CT诊断的敏感性和准确性均显著高于增强CT(P<0.05)。结论:PET/CT在头颈肿瘤淋巴结转移的诊断中优于增强CT。本文结果为PET/CT在临床和放射影像诊断为颈部淋巴结阴性病人中发现转移的研究提供了可行性依据。

关键词：头颈肿瘤颈淋巴结转移体层摄影术发射型正电子

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Geochronology and isotope analysis of.the Late Paleozoic to Mesozoic granitoids f.om northeastern Vietnam and implications f.r the evolution of.the South China block

Geochronology and isotope analysis of the Late Paleozoic to ...

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中国科学院地质与地球物理研究所2014年度（第14届）学术年会

作者： Zechao Chen Wei Lin michel f.ure Claude Lepvrier Nguyen Van Vuong Vu Van Tich State Key Laboratory of.Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of Sciences Graduate University of.Chinese Academy of.Sciences Institut des Sciences de la Terre d’Orléans (ISTO) UMR CNRS 6113Université d’Orléans Institut des Sciences de la Terre de Paris (iste P) UMR CNRS 7193Case 129Université Pierre & Marie Curie f.culty of.Geology Hanoi University of Science

In northeastern Vietnam,Late Paleozoic and Permo-Triassic granitic plutons are widespread,but their tectonic signif.cance is *** order to understand the regional magmatism and crustal evolution processes of.the South China block(SCB),this study reports integrated in situ U–Pb,Hf.O and Sr–Nd isotope analyses of.granitic rocks f.om f.ve plutons in northeastern *** SIMS U–Pb ages of.six granitic samples cluster around in two groups 255–228 Ma and 90 ***-rock eNd(t)ranges f.om 11to 9.7,suggesting that continental crust materials were involved in their granitic *** situ zircon Hf.O isotopic measurements f.r the granitic samples yield a mixing trend between the mantle-and supracrustal-derived *** is suggested that the granitic rocks were f.rmed by re-melting of.the continental *** new data are compared with the Paleozoic and Mesozoic granitic rocks of.South *** argue that northeastern Vietnam belongs to the South China *** still speculated,an ophiolitic suture between NE Vietnam and South China,so-called Babu ophiolite,appears *** Late Paleozoic to Mesozoic magmatism in the research area provides new insights f.r the magmatic evolution of.the South China block.

关键词： Northeastern Vietnam South China block Triassic orogen Zircon SIMS dating Hf.O isotopes Eastern Paleotethys

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