检索结果-南通市图书馆

Amyotrophic lateral sclerosis

在线全文

学校读者我要写书评

暂无评论

四川生理科学杂志 2022年第9期44卷 1527-1527页

作者： eva L Feldman Department of Neurology Michigan Medicine University of Michigan Ann Arbor MI USA Department of Neurology Hannover Medical School Hannover Germany ALS Centre Azienda Ospedaliero-Universitaria Maggiore della Carità Novara Italy Department of Neurology University of Piemonte Orientale Novara Italy Sheffield Institute for Translational Neuroscience (SITraN) University of Sheffield Sheffield UK Department of Neurology Aichi Medical University Nagakute Aichi Japan

Amyotrophic lateral sclerosis is a fatal CNS neurodegenerative disease. Despite intensive research, current management of amyotrophic lateral sclerosis remains suboptimal from diagnosis to prognosis. Recognition of the phenotypic heterogeneity of amyotrophic lateral sclerosis, global CNS dysfunction, genetic architecture, and development of novel diagnostic criteria is clarifying the spectrum of clinical presentation and facilitating diagnosis. Insights into the pathophysiology of amyotrophic lateral sclerosis, identification of disease biomarkers and modifiable risks, along with new predictive models, scales, and scoring systems, and a clinical trial pipeline of mechanism-based therapies, are changing the prognostic landscape. Although most recent advances have yet to translate into patient benefit, the idea of amyotrophic lateral sclerosis as a complex syndrome is already having tangible effects in the clinic. This Seminar will outline these insights and discuss the status of the management of amyotrophic lateral sclerosis for the general neurologist, along with future prospects that could improve care and outcomes for patients with amyotrophic lateral sclerosis.

关键词： sclerosis diagnosis translate

The AFB1 auxin receptor controls the cytoplasmic auxin response pathway in Arabidopsis thaliana

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2023年第7期16卷 1120-1130页

作者： Shiv Mani Dubey Soeun Han Nathan Stutzman Michael J.Prigge eva Medvecka Matthieu Pierre Platre Wolfgang Busch Matyas Fendrych Mark Estelle Department of Experimental Plant Biology Faculty of SciencesCharles UniversityPragueCzech Republic Section of Cell and Developmental Biology University of California San DiegoLa JollaCAUSA Plant Molecular and Cellular Biology Laboratory and Integrative Biology Laboratory Salk Institute for Biological StudiesLa JollaCAUSA Department of Biology Chungbuk National UniversityCheongjuKorea

The phytohormone auxin triggers root growth inhibition within seconds via a *** members of the TIR1/AFB auxin receptor family,AFB1 has a primary role in this rapidresponse. However, the unique features that confer this specific function have not been *** we show that the N-terminal region of AFB1, including the F-box domain and residues thatcontribute to auxin binding,is essential and sufficient for its specific role in the rapid response. Substitutionof the N-terminal region of AFB1 with that of TIR1 disrupts its distinct cytoplasm-enriched localizationand activity in rapid root growth inhibition by auxin. Importantly, the N-terminal region of AFB1 isindispensable for auxin-triggered calcium influx, which is a prerequisite for rapid root growth ***, AFB1 negatively regulates lateral root formation and transcription of auxin-induced genes,suggesting that it plays an inhibitory role in canonical auxin signaling. These results suggest that AFB1may buffer the transcriptional auxin response, whereas it regulates rapid changes in cell growth thatcontributeto rootgravitropism.

关键词： gravitropism calcium auxin signaling Arabidopsis lateral root

Linking axon transport to regeneration using in vitro laser axotomy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第3期13卷 410-412页

作者： Bart Nieuwenhuis Richard eva John van Geest Centre for Brain Repair Department of Clinical Neurosciences University of Cambridge Cambridge UK Laboratory for Regeneration of Sensorimotor Systems Netherlands Institute for Neuroscience Royal Netherlands Academy of Arts and Sciences (KNAW) Amsterdam The Netherlands

Spinal cord injury has devastating consequences because adult central nervous system （CNS） neurons do not regenerate their axons after injury. Two key reasons for axon regeneration fail- ure are extrinsic inhibitory factors and a low intrinsic capacity for axon regrowth. Research has therefore focused on overcom- ing extrinsic growth inhibition, and enhancing intrinsic regeneration capacity. Both of these issues will need to be addressed to enable optimal repair of the injured sp＋inal cord.

关键词： CNS ARF Linking axon transport to regeneration using in vitro laser axotomy EFA

Engineering Nannochloropsis oceanica for the production of diterpenoid compounds

在线全文

学校读者我要写书评

暂无评论

mLife 2023年第4期2卷 428-437页

作者： Zhi-Yan Du Wajid W.Bhat Eric Poliner Sean Johnson Conor Bertucci eva Farre Bjoern Hamberger Department of Molecular Biosciences and Bioengineering University of Hawaii at ManoaHonoluluHawaiiUSA Department of Biochemistry and Molecular Biology Michigan State UniversityEast LansingMichiganUSA Department of Plant Biology Michigan State UniversityEast LansingMichiganUSA New England Biolabs Inc. 240 County Roadlpswich01938 MAUSA

Photosynthetic microalgae like Nannochloropsis hold enormous potential as sustainable,light-driven biofactories for the production of high-value natural products such as *** oceanica is distinguished as a particularly robust host with extensive genomic and transgenic resources *** capacity to grow in wastewater,brackish,and sea waters,coupled with advances in microalgal metabolic engineering,genome editing,and synthetic biology,provides an excellent *** the present work,we demonstrate how *** can be engineered to produce the diterpene casbene—an important intermediate in the biosynthesis of pharmacologically relevant macrocyclic *** accumulated after stably expressing and targeting the casbene synthase from Daphne genkwa(DgTPS1)to the algal *** engineered strains yielded production titers of up to 0.12 mg g^(−1) total dry cell weight(DCW)*** overexpression and chloroplast targeting of two upstream rate-limiting enzymes in the 2-C-methyl-d-erythritol 4-phosphate pathway,Coleus forskohlii 1-deoxy-d-xylulose-5-phosphate synthase and geranylgeranyl diphosphate synthase genes,further enhanced the yield of casbene to a titer up to 1.80 mg g^(−1) *** results presented here form a basis for further development and production of complex plant diterpenoids in microalgae.

关键词： casbene microalgae plastid targeting synthetic biology terpene synthase

Colorectal cancer screening and surveillance in patients with inflammatory bowel disease in 2021

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第5期28卷 502-516页

作者： Jose Maria Huguet Luis Ferrer-Barceló Patrícia Suárez eva Sanchez Jose David Prieto Victor Garcia Javier Sempere Department of Digestive Disease General University Hospital of ValenciaValencia 46014Spain

The detection of dysplasia in patients with inflammatory bowel disease(IBD)continues to be important given the increased risk of colorectal cancer in this ***,in 2017,we performed a review and update of the recommendations for the management and follow-up of patients with IBD based on the clinical practice guidelines of various scientific *** present manuscript focuses on new aspects of the detection,follow-up,and management of dysplasia according to the latest studies and *** chromoendoscopy with targeted biopsy continues to be the technique of choice for the screening and detection of dysplasia in IBD,the associated difficulties mean that it is now being compared with other techniques(virtual chromoendoscopy),which yield similar results with less technical ***,the emergence of new endoscopy techniques that are still being researched but seem promising(e.g.,confocal laser endomicroscopy and full-spectrum endoscopy),together with the development of devices that improve endoscopic visualization(e.g.,Endocuff Vision),lead us to believe that these approaches can revolutionize the screening and follow-up of dysplasia in patients with ***,further studies are warranted to define the optimal follow-up strategy in this patient population.

关键词： Colitis surveillance Colitis screening chromoendoscopy Colorectal cancer Inflammatory bowel disease Ulcerative colitis

Giant retroperitoneal liposarcoma treated with radical conservative surgery: A case report and review of literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第19期10卷 6636-6646页

作者： eva Lieto Francesca Cardella Silvia Erario Giovanni Del Sorbo Alfonso Reginelli Gennaro Galizia Fabrizio Urraro Iacopo Panarese Annamaria Auricchio Department of Traslational Medical Sciences University of Campania"L.Vanvitelli"Naples 80128CampaniaItaly Department of Precision Medicine University of Campania"L.Vanvitelli"Naples 80138CampaniaItaly Depatment of Pathology Unit-Menthal Health University of Campania"L.Vanvitelli"Naples 80132CampaniaItaly

BACKGROUND Retroperitoneal liposarcoma(RLPS)is a rare malignant tumor of the connective tissue and usually grows to a large size,*** is currently based on collective findings from clinical examinations and computed tomography(CT)and magnetic resonance imaging,the latter of which show a fat density mass and possible surrounding organ *** resection is the main therapeutic *** efficacy and safety of further therapeutic choices,such as chemotherapy and radiotherapy,are still *** SUMMARY A 61-year-old man presented with complaint of a large left inguinal mass that had appeared suddenly,after a slight *** revealed an omental inguinal *** further clinical examination,an enormous palpable abdominal mass,continuing from the left inguinal location,was *** revealed a giant RLPS,with remarkable mass effect and wide visceral *** multidisciplinary consultation,surgical intervention was *** neoadjuvant chemotherapy and radiotherapy were precluded by the mass’large size and retroperitoneal localization,features typically associated with non-response to these types of ***,the patient underwent conservative treatment via radical surgical *** 1 year,his clinical condition remained good,with no radiological signs of *** Conservative treatment via surgery resulted in a successful outcome for a large RLPS.

关键词： Retroperitoneal liposarcoma Giant sarcoma Sarcoma surgical treatment Sarcoma diagnosis Differentiated liposarcoma Retroperitoneal sarcoma surgical outcome Case report

Microplastic fiber and drought effects on plants and soil are only slightly modified by arbuscular mycorrhizal fungi

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Soil Ecology Letters 2022年第1期4卷 32-44页

作者： Anika Lehmann eva FLeifheit Linshan Feng Joana Bergmann Anja Wulf Matthias C.Rillig Freie Universität Berlin Institut für Biologie14195 BerlinGermany Berlin-Brandenburg Institute of Advanced Biodiversity Research 14195 BerlinGermany Leibniz Centre for Agricultural Landscape Research(ZALF) 15374 MünchebergGermany

Microplastics are increasingly recognized as a factor of global change. By altering soil inherentproperties and processes, ripple-on effects on plants and their symbionts can be ***, interactions with other factors of global change, such as drought, can influence theeffect of microplastics. We designed a greenhouse study to examine effects of polyester microfibers,arbuscular mycorrhizal (AM) fungi and drought on plant, microbial and soil responses. We found thatpolyester microfibers increased the aboveground biomass of Allium cepa under well-watered anddrought conditions, but under drought conditions the AM fungal-only treatment reached the highestbiomass. Colonization with AM fungi increased under microfiber contamination, however, plantbiomass did not increase when both AM fungi and fibers were present. The mean weight diameter ofsoil aggregates increased with AM fungal inoculation overall but decreased when the system wascontaminated with microfibers or drought stressed. Our study adds additional support to themounting evidence that microplastic fibers in soil can affect the plant–soil system by promoting plantgrowth, and favoring key root symbionts, AM fungi. Although soil aggregation is usually positivelyinfluenced by plant roots and AM fungi, and microplastic promotes both, our results show that plasticstill had a negative effect on soil aggregates. Even though there are concerns that microplastic mightinteract with other factors of global change, our study revealed no such effect for drought.

关键词： Arbuscular mycorrhizal fungi Microplastic Soil aggregation Organic matter decomposition Drought Root traits

Presentations,treatment and outcomes of unifocal and multifocal osseous appendicular Langerhans cell histiocytosis lesions in a pediatric population

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatric Surgery 2023年第1期6卷 55-57页

作者： Ekene U Ezeokoli Parker Mitchell eva Schlehr Neritan Borici Nicole Montgomery Department of Orthopedic Surgery Texas Children's HospitalHoustonTexasUSA Oakland University William Beaumont School of Medicine RochesterMichiganUSA Department of Orthopedic Surgery Baylor College of MedicineHoustonTexasUSA Baylor College of Medicine HoustonTexasUSA University at Buffalo Jacobs School of Medicine and Biomedical Sciences BuffaloNew YorkUSA

Langerhans cell histiocytosis(Lch)is a rare disease most commonly presenting in the pediatric population and characterized by neoplastic clonal proliferation of Langerhans dendritic cells with accumulation in various sites,including skeletal and visceral lesions.1 There are three levels of classification per the Histiocyte Society:single-system single-site(SS-s),single-system multiple-site(SS-m),and multisystem(MS).2 SS-s predominantly carries a better prognosis with more conservative treatment while MS requires a more aggressive treatment that is more likely to have an inferior outcome.

关键词： Langerhans lesions treatment

Point-of-care ultrasonography in geriatric medicine: usefulness for approaching infectious endocarditis diagnosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2022年第12期19卷 1001-1002页

作者： Pablo Solla Patricia Cancelo eva López Jesús de la Hera César Morís José Gutiérrez Geriatrics Department Geriatrics Clinical Management AreaHospital Monte NarancoOviedoSpain Health Research Institute of Asturias OviedoSpain Cardiology Department Cardiac AreaHospital Universitario Central de AsturiasOviedoSpain

Infective endocarditis has a high morbimortality rate,and delay in diagnosis and treatment is associated with a higher prevalence of *** clinical presentation is often atypical in older adults,and even when the classic symptoms are present,they may overlap with those of other conditions,making management more *** present the case of a nonagenarian in whom cardiac-centered point-of-care ultrasound facilitated real-time decision making and the diagnosis of mitral endocarditis.

关键词： diagnosis endocarditis mortality