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戴安娜:悲剧王妃

新民周刊 2022年第23期 50-51页

作者： eva 不详

戴妃离婚和死亡,一度令英国王室的形象受到重击。1961年7月1日,戴安娜·弗兰西斯·斯宾塞出生于英格兰东部诺福克附近桑德林厄姆的帕克庄园。对这个女儿的出生,双亲没有展现出多少喜悦。斯宾塞小姐才6岁的时候,父母就离婚了。16岁,她与... 详细信息

戴妃离婚和死亡,一度令英国王室的形象受到重击。1961年7月1日,戴安娜·弗兰西斯·斯宾塞出生于英格兰东部诺福克附近桑德林厄姆的帕克庄园。对这个女儿的出生,双亲没有展现出多少喜悦。斯宾塞小姐才6岁的时候,父母就离婚了。16岁,她与查尔斯初次相遇,彼时他正跟她的姐姐交往。三年后,因蒙巴顿公爵之死倍感抑郁的王储,突然觉得姑娘挺傻白甜、挺不错,遂开始时断时续的追求。没多久,她欣然应允做他的王妃。

关键词：戴安娜欣然应允英国王室斯宾塞弗兰西斯蒙巴顿诺福克英格兰

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国产动画连续剧:青春力量与成长的烦恼

新民周刊 2022年第39期 50-53页

作者： eva 不详

ACG文化的滋养,塑造了他们的共同记忆。纵浪与弹幕齐飞,情怀共创新一色。你以为的国产动画连续剧,还是《喜羊羊与灰太狼》《熊出没》之类让人看了产生原地转圈眩晕感的“低幼向”?跟不上时代潮流了。光阴似箭,岁月如梭。魔童神兽在长大... 详细信息

ACG文化的滋养,塑造了他们的共同记忆。纵浪与弹幕齐飞,情怀共创新一色。你以为的国产动画连续剧,还是《喜羊羊与灰太狼》《熊出没》之类让人看了产生原地转圈眩晕感的“低幼向”?跟不上时代潮流了。光阴似箭,岁月如梭。魔童神兽在长大,中二之魂/怀春之心要燃烧。

关键词：岁月如梭国产动画《熊出没》《喜羊羊与灰太狼》成长的烦恼连续剧共同记忆时代潮流

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Kinetic study of phytotoxicity induced by foliar lead uptake for vegetables exposed to fine particles and implications for sustainable urban agriculture

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Journal of Environmental Sciences 2016年第8期28卷 16-27页

作者： TianTian Xiong Annabelle Austruy Antoine Pierart Muhammad Shahid eva Schreck Stéphane Mombo Camille Dumat Université de Toulouse Institut National Polytechnique de Toulouse-Ecole Nationale Supérieure Agronomique de Toulouse (INP-ENSAT) Centre National de la Recherche Scientifique Institut Ecocitoyen Centre de Vie la Fossette RD 268 Department of Environmental Sciences COMSATS Institute of Information Technology Géosciences Environnement Toulouse (GET) Observatoire Midi Pyrénées Université de Toulouse Centre d'Etude et de Recherche Travail Organisation Pouvoir (CERTOP) UMR5044 Universite J. Jaurès - Toulouse II

At the global scale, foliar metal transfer occurs for consumed vegetables cultivated in numerous urban or industrial areas with a polluted atmosphere. However, the kinetics of metal uptake, translocation and involved phytotoxicity was never jointly studied with vegetables exposed to micronic and sub-micronic particles（PM）. Different leafy vegetables（lettuces and cabbages） cultivated in RHIZOtest？ devices were, therefore, exposed in a greenhouse for 5, 10 and 15 days to various Pb O PM doses. The kinetics of transfer and phytotoxicity was assessed in relation to lead concentration and exposure duration. A significant Pb accumulation in leaves（up to 7392 mg/kg dry weight（DW） in lettuce） with translocation to roots was observed. Lead foliar exposure resulted in significant phytotoxicity, lipid composition change, a decrease of plant shoot growth（up to 68.2% in lettuce） and net photosynthesis（up to 58% in lettuce）. The phytotoxicity results indicated plant adaptation to Pb and a higher sensitivity of lettuce in comparison with cabbage. Air quality needs, therefore, to be considered for the health and quality of vegetables grown in polluted areas, such as certain megacities（in china, Pakistan, Europe, etc.） and furthermore, to assess the health risks associated with their consumption.

关键词： Metallic particles Vegetables Foliar uptake Transfer kinetics and phytotoxicity

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5-Azacytidine induces changes in electrophysiological properties of human mesenchymal stem cells

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Cell Research 2006年第12期16卷 949-960页

作者： Bartosz Balana Cecilia Nicolett Ihor Zahanich eva M Graf Torsten christ Sabine Boxberger Department of Pharmacology and Toxicology Medical Clinic I Medical FacultyDresden University of TechnologyFetscherstr.74D-01307 DresdenGermany

Previously,mouse bone marrow-derived stem cells（MSC）treated with the unspecific DNA methyltransferase inhibi-tor 5-azacytidine were reported to differentiate into *** aim of the present study was to investigate theefficiency of a similar differentiation strategy in human mononuclear cells obtained from healthy bone marrow *** 1-3 passages,cultures were exposed for 24 h to 5-azacytidine（3μM）followed by 6 weeks of further *** treatment did not induce expression of myogenic marker MyoD or cardiac markers Nkx2.5 and GATA-4 and didnot yield beating cells during *** patch clamp experiments,approximately 10-15% of treated and untreatedcells exhibited L-type Ca2+ *** all cells showed outwardly rectifying K+currents of rapid or slow *** current amplitude at +60 mV doubled after 6 weeks of treatment compared with time-matched *** capacitance of treated cells was significantly larger than in controls 2 weeks after treatment and remained highafter 6 *** levels ofmRNAs for the K+channels Kv1.1,Kv1.5,Kv2.1,Kv4.3 and KCNMA1 and for theCa2+ channel Cav1.2 were not affected by *** with potassium channel blockers tetraethylammoniumand clofilium at concentrations shown previously to inhibit rapid or slowly activating K+currents of hMSC inhibitedproliferation of these *** results suggest that despite the absence of differentiation of hMSC into cardiomyocytes,treatment with 5-azacytidine caused profound changes in current density.

关键词： human mesenchymal stem cells 5-azacytidine cardiac differentiation outward K~+ currents

Real-life multi-center retrospective analysis on nivolumab in difficult-to-treat patients with advanced hepatocellular carcinoma

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World Journal of Hepatology 2022年第8期14卷 1608-1620页

作者： Nika De Wilde Luisa Vonghia Sven Francque Thomas De Somer Ali Bagdadi eva Staub Jasper Lambrechts Ana-Maria Bucalau Gontran Verset christophe Van Steenkiste Department of Internal Medicine University Hospital GhentGhent 9000Belgium Department of Gastroenterology and Hepatology University Hospital AntwerpAntwerp 2650Belgium Department of Gastroenterology and Hepatology Maria Middelares HospitalGhent 9000Belgium Department of Psychiatry UniversitéLibre de BruxellesBrussels 1050Belgium Department of Orthopedics University of GhentGhent 9000Belgium Department of Gastroenterology Hepatopancreatology and Digestive OncologyCUB Erasme HospitalUniversitéLibre de BruxellesBrussels 1070Belgium Department of Gastroenterology AZ Maria MiddelaresGhent 9000Belgium Department of Gastroenterology University AntwerpAntwerp 2650Belgium

BACKGROUND Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related death *** landscape of the systemic treatment for advanced HCC is changing quickly,and recently,the standard of care became either atezolizumab plus bevacizumab or tremelimumab plus durvalumab in the single tremelimumab regular interval durvalumab *** monotherapy has proven to be effective sometimes for advanced HCC and could be a valuable treatment option for patients outside current treatment indications and reimbursement criteria for the standard of *** is a particular population of *** To evaluate the real-world effectiveness of nivolumab monotherapy in patients with advanced HCC who are not eligible for other *** We conducted a retrospective,multicentric study including 29 patients with advanced HCC from 3 Belgian tertiary *** patients had had prior chemotherapy or were intolerant or ineligible for *** study subjects received nivolumab 3 mg/kg in monotherapy,administered once every two weeks *** continued until disease progression,severe adverse events or *** were retrieved from patients'medical *** outcome parameters such as radiological response according to response evaluation criteria in solid tumors(RECIST)criteria,the biological response through the evolution of the alpha-fetoprotein(AFP)level,and clinical response considering both the child–Pugh(CP)score and the World Health Organization(WHO)performance status(PS)were reported.A safety profile was also *** analysis was performed using the SPSS Statistics 27 statistical software *** The radiological overall response rate(defined as complete or partial response according to the immune RECIST and modified RECIST criteria)to nivolumab monotherapy was 24.1%.The biological overall response rate(defined as a decrease of≥25%in AFP blood level)was 20.7%.Radiological and biological responses w

关键词： Advanced hepatocellular carcinoma Systemic treatment Immunotherapy Nivolumab Difficult-to-treat patients Real-life setting

Finding a fairy in the forest： ELF4, a novel and critica element of type I interferon responses

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Cellular & Molecular Immunology 2014年第3期11卷 218-220页

作者： Attila Szabo eva Rajnavolgyi Department of Immunology Medical and Health Science Centre University of Debrecen Debrecen Hungary

Type I interferon （IFN） production is a key event during innate *** early and prompt mechanism is mediated by multiple factors that involve various pattern recognition receptors （PRRs）, adaptor proteins, kinases and transcription factors. Stimulator of IFN genes （STING） is an important transmembrane adaptor protein that plays a role in the activation of downstream transcription factors,

关键词：蛋白质类干扰素Ⅰ型干扰素类基因磷酸转移酶类胰岛素猪繁殖和呼吸综合征转录因子

Assay of ghrelin concentration in infant formulas and breast milk

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World Journal of Gastroenterology 2011年第15期17卷 1971-1975页

作者： Francesco Savino Elisa Petrucci Maria Maddalena Lupica Giuliana eva Nanni Roberto Oggero Department of Pediatrics "Regina Margherita" Children's Hospital Piazza Polonia 94-10126 Turin Italy

AIM: To test if total ghrelin is present in infant formulas. METHODS: Using a radioimmunoassay, we measured total ghrelin concentrations in 19 samples of commercial infant formulas and in 20 samples of human milk. We also determined ghrelin concentration in the serum of infants and lactating mothers. RESULTS: Ghrelin concentrations were significantly higher in artificial milk (2007.1 ± 1725.36 pg/mL) than in human milk (828.17 ± 323.32 pg/mL) (P = 0.005). The mean ghrelin concentration in infant serum (n = 56) was 1115.86 ± 42.89 pg/mL, and was significantly higher (P = 0.023) in formula-fed infants (1247.93 ± 328.07 pg/mL) than in breast-fed infants (1045.7 ± 263.38 pg/mL). The mean serum ghrelin concentration (mean ± SD) in lactating mothers (n = 20) was 1319.18 ± 140.18 pg/mL. CONCLUSION: This study provides evidence that total ghrelin is present in infant formulas. This findingraises diverse questions regarding the uptake, absorption and metabolic effects of this hormone.

关键词： ghrelin 婴儿配方奶粉浓度母乳放射免疫分析法 Ghrelin 哺乳期血清

Structural damage response of lanthanum and yttrium aluminate crystals to nuclear collisions and electronic excitation:Threshold assessment of irradiation damage

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Journal of Materials Science & Technology 2021年第31期90卷 95-107页

作者： Yong Liu Xinqing Han Qing Huang Miguel L.Crespillo Peng Liu eva Zarkadoula Xuelin Wang Institute of Frontier and Interdisciplinary Science and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityQingdao 266237China Shanghai Institute of Applied Physics Chinese Academy of Sciences(CAS)Shanghai 201800China Department of Materials Science&Engineering University of TennesseeKnoxvilleTN 37996United States Materials Science&Technology Division Oak Ridge National LaboratoryOak RidgeTN 37831United States

A comparative analysis is performed on the structural damage response and associated mechanisms in lanthanum aluminate and yttrium aluminate crystals under various irradiation conditions by a combination of experimental and theoretical *** low-energy Au~+irradiation,the damage accumulation curve shows a higher damage rate for LaAlO_(3)crystals than YAlO_(3)*** relatively low irradiation tolerance of LaAlO_(3)to the action of nuclear collisions is ascribed to the large amorphization cross-section and effective cross-section for defect-stimulated *** swift Ar^(12+),Ni^(19+)and Kr^(17+)irradiation with different ion energies and velocities,the formed highly-disordered/amorphous latent tracks with different morphologies in pristine and predamaged crystals are discussed,and the corresponding electronic energy loss and lattice temperature thresholds are quantitatively *** to YAlO_(3),LaAlO_(3)exhibits lower sensitivity and higher damage tolerance to the electronic energy loss process,attributing to its relatively high recrystallization efficiency during the rapid quenching ***,the introduction of lattice defects into LaAlO_(3)and YAlO_(3)crystals considerably enhances the sensitivity and intensity of thermal spike response to the electronic energy loss,and the induced effective modification of track morphologies demonstrates the synergistic effect between the electronic energy loss and pre-existing defects created by nuclear *** this case,even under the action of electronic energy loss below the threshold,the lattice temperature in the nuclear-collision damaged crystalline system could still meet the criterion for track *** irradiation energy deposited to atoms and induced lattice temperature evolution discussed in this work provide a deeper insight into the complex processes involved in irradiation-induced latent track behaviors.

关键词： Nuclear energy loss Electronic energy loss Synergistic effect Irradiation damage Latent ion track

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