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Melatonin:a multitasking indoleamine to modulate hippocampal neurogenesis

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Neural Regeneration Research 2023年第3期18卷 503-505页

作者： Alejandro Romero JoséÁngel Morales-García eva Ramos Department of Pharmacology and Toxicology Faculty of Veterinary MedicineComplutense University of Madrid Institute for Biomedical Research“A.Sols”(CSIC-UAM) Spanish Center for Networked Biomedical Research on Neurodegenerative Diseases(CIBERNED Department of Cellular Biology School of MedicineComplutense University of MadridMadridSpain

Neurodegeneration affects a large number of cell types including neurons,astrocytes or oligodendrocytes,and neural stem *** stem cells can generate new neuronal populations through proliferation,migration,and *** neurogenic potential may be a relevant factor to fight neurodegeneration and *** the last years,we can find growing evidence suggesting that melatonin may be a potential modulator of adult hippocampal *** lack of therapeutic strategies targeting neurogenesis led researchers to explore new *** preclinical studies with melatonin observed how melatonin can modulate and enhance molecular and signaling pathways involved in *** made a special focus on the connection between these modulation mechanisms and their implication in neurodegeneration,to summarize the current knowledge and highlight the therapeutic potential of melatonin.

关键词： adult hippocampal neurogenesis aging melatonin neural stem cell neurodegeneration neuroprotection signaling pathway therapeutic strategy

All Roads Lead to Auxin: Post-translational Regulation of Auxin Transport by multiple Hormonal Pathways

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Plant Communications 2020年第3期1卷 1-19页

作者： Hana Semeradova Juan Carlos Montesinos eva Benkova Institute of Science and Technology Austria 3400 KlosterneuburgAustria

Auxin is a key hormonal regulator,that governs plant growth and development in concert with other hormonal *** unique feature of auxin is its polar,cell-to-cell transport that leads to the formation of local auxin maxima and gradients,which coordinate initiation and patterning of plant *** molecular machinery mediating polar auxin transport is one of the important points of interaction with other *** hormonal pathways converge at the regulation of auxin transport and form a regulatory network that integrates various developmental and environmental inputs to steer plant *** this review,we discuss recent advances in understanding the mechanisms that underlie regulation of polar auxin transport by multiple hormonal ***,we focus on the post-translational mechanisms that contribute to fine-tuning of the abundance and polarity of auxin transporters at the plasma membrane and thereby enable rapid modification of the auxin flow to coordinate plant growth and development.

关键词： plant hormones polar auxin transport(PAT) post-translational regulation trafficking PINs abiotic stress

Aerial pollutants on a pig farm in peri-urban Beijing,China

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International Journal of Agricultural and Biological Engineering 2013年第1期6卷 36-47页

作者： Roxana Mendoza Huaitalla eva Gallmann Liu Xuejun Eberhard Hartung Institute of Agricultural Engineering University of HohenheimStuttgart70599Germany College of Agricultural Resources and Environmental Sciences China Agricultural UniversityBeijing 100094China Institute of Agricultural Engineering Christian-Albrechts-University KielKiel24098Germany

The study was carried out to evaluate the airborne gases and suspended particulate matter concentrations in the pig barns of a commercial pig farm situated in the peri-urban area of Beijing,*** measurements followed the natural pig life-stages namely:gestation,farrowing,weaning,and *** order to accomplish these objectives,three different measurement devices were employed:(i)color diffusion tubes,(ii)a portable gas measuring device,and(iii)a dust measuring *** to the rotation of the devices in the different sampling places,the measurements were performed at different time periods during the months of the summer and winter season in *** pig farm had a capacity of 15000 pigs per year and the manurial system was identified as“gan qing fen”or dry cleaning of the *** main by-products generated by the farm were irrigation water and small-scale biogas *** dust concentrations were identified in the pig barns,especially during the feeding and manure cleaning events inside the farrowing and weaning barns with slatted *** dust ranged from 0 mg/m3 to 12.45 mg/m3,while the allowable dust ranged from 0 mg/m3 to 9.62 mg/*** concentration ranged from 0 ppm to 20 ppm(1 ppm=1 cm3/m3),and the carbon dioxide concentration ranged from 300 ppm to 8000 *** highest ammonia concentration was recorded in the fattening barn during the summer season,while the highest carbon dioxide concentration was reported in the weaning barn during the summer *** results of this study were similar to the results of studies performed on pig farms under natural and mechanical ventilation *** the other hand,the problems encountered during the gas measurements on the pig farm were directly related to the inadequate housing layout due to the obstruction of windows,fans and air channels for indoor ventilation,and thus the measurement devices faced harsh working ***,it is recommended that the housing system s

关键词： pig farm aerial pollutant barn China gases dust

A short climatology of black and brown carbon and their sources at a suburban site impacted by smoke in Brazil

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Journal of Environmental Sciences 2024年第2期136卷 498-511页

作者： Admir Creso Targino Patricia Krecl Gabriel Yoshikazu Oukawa eva Maria Mollinedo Graduate Program in Environmental Engineering Federal University of TechnologyAv.Pioneiros 3131LondrinaPR 86036-370Brazil Department of Environmental Engineering Federal University of TechnologyAv.Pioneiros 3131LondrinaPR 86036-370Brazil

Emissions from biomass burning challenge efforts to curb air pollution in cities downwind of fire-prone regions,as they contribute large amounts of brown carbon(Br C)and black carbon(BC)*** investigated the patterns of Br C and BC concentrations using Aethalometer data(atλ=370 and 880 nm,respectively)spanning four years at a site impacted by the outflow of *** data required to be post processed for the shadowing effect since,without correction,concentrations would be between 29%and 35%*** Br C concentrations were consistently higher than the BC concentrations,indicating the prevalence of aerosols from biomass *** results were supported by the Angstrom coefficient(A_(370/880)),with values predominantly larger than 1(mean±standard deviation:1.25±0.31).A_(370/880)values below 1 were more prevalent during the wet season,which suggests a contribution from fossil fuel *** observed sharp Br C and BC seasonal signals,with mean minimum concentrations of 0.40μg/m^(3)and 0.36μg/m^(3),respectively,in the wet season,and mean maximum concentrations of 2.05μg/m^(3)and 1.53μg/m^(3)in the dry *** largest concentrations were observed when northerly air masses moved over regions with a high density of fire *** burning of residential solid waste and industrial combustion caused extreme Br C and BC concentrations under favourable wind *** neither pollutant is included in any ambient air quality standards,our results suggest that transboundary smoke may hamper efforts to meet the World Health Organization guidelines for fine particles.

关键词： Light-absorbing carbonaceous matter Black carbon Wildfires Biomass burning Aethalometer

Perspectives for delivery of therapeutics by extravasation of biodegradable microspheres in the brain

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Neural Regeneration Research 2024年第5期19卷 969-970页

作者： Anne-eva van der Wijk Ed VanBavel Amsterdam UMC location University of Amsterdam Department of Biomedical Engineering and PhysicsAmsterdamThe Netherlands Amsterdam Neuroscience Neurovascular Disorders ProgramAmsterdamThe Netherlands Amsterdam Cardiovascular Sciences Microcirculation ProgramAmsterdamThe Netherlands

Development of therapeutics for brain diseases has remained challenging,in particular due to the difficulty of passing the blood-brain *** a result,the current arsenal of therapeutics targeting the brain is limited to small,lipid-soluble drugs and there is a lack of options for treating neuroblastomas,Alzheimer’s disease,and many other devastating *** the advances in strategies for crossing the blood-brain barrier such as the use of nanoparticles(Hersh et al.,2022;Duan et al.,2023),such delivery systems have not yet reached clinical ***,novel platforms for the transport of therapeutics across the blood-brain barrier remain highly *** specifically holds for large molecules such as monoclonal antibodies and recombinant proteins,as well as nucleotide-based therapeutics and cell *** efforts in this field are increasing exponentially,with thousands of publications in the last few years.

关键词： therapeutics holds spite

Environmental correlates of sedentary behaviors and physical activity in Chinese preschool children:A cross-sectional study

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Journal of Sport and Health Science 2022年第5期11卷 620-629页

作者： Congchao Lu Tong Shen Guowei Huang eva Corpeleijn School of Public Health Tianjin Medical UniversityTianjin 300070China Department of Epidemiology University Medical Center GroningenUniversity of GroningenGroningen9700 RBthe Netherlands Tianjin Key Laboratory of Environment Nutrition and Public HealthCenter for International Collaborative Research on EnvironmentNutrition and Public HealthTianjin 300070China Tianjin University Kindergarten Tianjin UniversityTianjin 300072China Department of Nutrition and Food Science School of Public HealthTianjin Medical UniversityTianjin 300070China

Objective:This cross-sectional study examined environmental correlates of sedentary behavior(SB) and physical activity(PA) in preschool children in the urban area of Tianjin,***:Data were collected from the Physical Activity and Health in Tianjin Chinese Children study,involving healthy children 3-6 years old and their *** all children(n=980),leisure-time SB(LTSB) and leisure-time PA(LTPA) were reported in min/day by *** a subgroup(n=134),overall sedentary time,light PA,and moderate-to-vigorous PA(MVP A) were objectively measured using ActiGraph accelerometry(>3 days,>10 h/day).Environmental correlates were collected using a questionnaire that included home and neighborhood characteristics(e.g.,traffic safety,presence of physical activity facilities) and children’s *** correlates were identified using linear regression ***:multiple linear regression analysis showed that "having grandparents as primary caregivers"(βs and 95% confidence intervals(95%CIs)for overall sedentary time:29.7(2.1-57.2);LTSB(In):0.19(0.11-0.28)) and "having a television(for LTSB(In):0.13(0.00-0.25)) or computer(for LTSB(ln):0.13(0.03-0.23) in the child’ s bedroom" were both associated with higher ***, "having grandparents as primary caregivers" was associated with less MVPA(β(95%CI):-7.6(-14.1 to-1.2)),and "active commuting to school by walking" correlated with more MVPA(β(95%CI):9.8(2.2-17.4)).The path model showed that "more neighborhood PA facilities close to home" was indirectly related to higher LTPA(In),which was partly mediated by "outdoor play"(path coefficients(95%CI):0.005(0.002-0.008)) and "going to these facilities more often"(path coefficients(95%CI):0.013(0.008-0.01 8)).Traffic safety was not a ***:Family structure and media exposure in the home maybe important factors in shaping preschoolers’ PA *** environmental correlates could indirectly influence preschoolers’ LTPA through parental h

关键词： Active commuting Built environment Family structure Media exposure Traffic safety

A Cross-Cultural Reflection on Shusterman＇s Suggestion of the ＂Transactional＂ Body

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Frontiers of Philosophy in China 2015年第2期10卷 181-191页

作者： eva Kit Wah Man Department of Humanities and Creative Writing Hong Kong Baptist University Hong KongChina

This short article explores the meaning of Shusterman＇s ＂transactional body,＂ derived from his statement that the will is not a purely mental affair that is independent of physical modality but is always an interaction with its environment. While he appreciates the Deweyan interaetional model, he develops the ＂transactional mode,＂ which he implies should expand the body-mind unity to the level of social and cultural conditions. Shusterman finds similar integrations and transactions among the mental, psychophysical and physical levels in Asian philosophical traditions. This article conducts a comparative study between his theory and Mencius＇ understanding of the body. Within the discussion, the analysis of aesthetic experience explicated by Dewey and Shusterman is reviewed as the link to the comparison.

关键词： Richard Shusterman body cross-cultural transactional interactional,heaven aesthetic experience

Nanofluid based on 1-dodecylpyridinium chloride for enhanced oil recovery

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Petroleum Science 2023年第1期20卷 600-610页

作者： Akram Al-Asadi Alba Somoza Alberto Arce eva Rodil Ana Soto CRETUS.Department of Chemical Engineering Universidade de Santiago de CompostelaE-15782Santiago de CompostelaSpain Chemical and Petrochemical Techniques Eng.Department Basra Engineering Technical CollegeSothern Technical UniversityMinistry of Higher Education and Scientific ResearchIraq School of Engineering Universidade de A CorunaE-15403FerrolSpain

The use of nanoparticles is considered promising for enhanced oil recovery(EOR),especially when they are combined with ***,the combination of nano-sized material with surface-active ionic liquids(SAILs)is an unexplored EOR *** this work,the advantages of mixing Al2O3 nanoparticles with the SAIL 1-dodecylpyridinium chloride were *** nanofluids in brine could only be achieved using the polymer polyvinylpyrrolidone(PVP)as a stabilizing *** was found that the addition of nanoparticles(and PVP)to the surfactant formulation helped to:slightly increase its viscosity,enhance its water-oil interfacial tension(IFT)reduction capacity,and reduce the adsorption on carbonate rocks(adsorption on sandstone was found to be excessive).IFT was selected as target property to minimize for the design of EOR *** flooding tests were carried out with surfactant(0.5 wt%[C_(12)py]Cl),surfactant-polymer(0.5 wt%[C_(12)py]Cl,1.0 wt%PVP)and nanofluid(0.05 wt%Al_(2)O_(3),1.0 wt%PVP,0.5 wt%[C12py]Cl)formulations in brine(0.5 wt%NaCl).Additional oil recoveries of 3.4%,7.4%and 12.0%OOIP were achieved,respectively,the nanofluid formulation being the most promising for the ***,it was found capable of changing the wettability of carbonate rocks from oilwet to *** significance of this work lies in showing the new possibilities resulting from the combination of SAILs and nanoparticles for EOR,specifically the combination of[C_(12)py]Cl with Al_(2)O_(3).

关键词： Nanofluid Viscosity Interfacial tension Adsorption Wettability EOR

Morphological aspects of small-duct cholangiopathies:A minireview

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World Journal of Hepatology 2023年第4期15卷 538-553页

作者： eva Sticova Ondrej Fabian Clinical and Transplant Pathology Centre Institute for Clinical and Experimental MedicinePrague 14021Czech Republic Department of Pathology The Third Faculty of MedicineCharles University and University Hospital Kralovske VinohradyPrague 10000Czech Republic Department of Pathology and Molecular Medicine The Third faculty of MedicineCharles University and Thomayer University HospitalPrague 14059Czech Republic

The biliary system consists of intrahepatic and extrahepatic bile ducts lined by biliary epithelial cells(cholangiocytes).Bile ducts and cholangiocytes are affected by a variety of disorders called cholangiopathies,which differ in aetiology,pathogenesis,and *** of cholangiopathies is complex and reflects pathogenic mechanisms(immune-mediated,genetic,drug-and toxininduced,ischaemic,infectious,neoplastic),predominant morphological patterns of biliary injury(suppurative and non-suppurative cholangitis,cholangiopathy),and specific segments of the biliary tree affected by the disease *** the involvement of large extrahepatic and intrahepatic bile ducts is typically visualised using radiology imaging,histopathological examination of liver tissue obtained by percutaneous liver biopsy still plays an important role in the diagnosis of cholangiopathies affecting the small intrahepatic bile *** increase the diagnostic yield of a liver biopsy and determine the optimal therapeutic approach,the referring clinician is tasked with interpreting the results of histopathological *** requires knowledge and understanding of basic morphological patterns of hepatobiliary injury and an ability to correlate microscopic findings with results obtained by imaging and laboratory *** minireview describes the morphological aspects of small-duct cholangiopathies pertaining to the diagnostic process.

关键词： Bile duct Cholangiocytes Cholangiopathy Cholangitis Liver biopsy Histopathology