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SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

Cellular & Molecular Immunology 2021年第12期18卷 2676-2678页

作者： Daniel Perez-Zsolt Jordana muñoz-Basagoiti Jordi Rodon Marc Elosua-Bayes Dàlia Raïch-Regué Cristina Risco Martin Sachse Maria Pino Sanjeev Gumber Mirko Paiardini Jakub Chojnacki Itziar Erkizia Xabier muñiz-Trabudua Ester Ballana eva riveira-muñoz Marc Noguera-Julian Roger Paredes Benjamin Trinité Ferran Tarrés-Freixas Ignacio Blanco Victor Guallar Jorge Carrillo JuliàBlanco Amalio Telenti Holger Heyn Joaquim Segalés Bonaventura Clotet Javier Martinez-Picado Júlia Vergara-Alert Nuria Izquierdo-Useros IrsiCaixa AIDS Research Institute 089BadalonaSpain IRTA Centre de Recerca en Sanitat Animal(CReSAIRTA-UAB)Campus de la UAB08193Bellaterra(Cerdanyola del Vallès)Spain CNAG-CRG Centre for Genomic Regulation(CRGBarcelona Institute of Science and Technology(BIST)08028BarcelonaSpain Centro Nacional de Biotecnología CSIC28049MadridSpain Division of Microbiology and Immunology Yerkes National Primate Research CenterEmory UniversityAtlantaGAUSA Department of Pathology and Laboratory Medicine School of MedicineEmory UniversityAtlantaGeorgiaUSA Division of Pathology Yerkes National Primate Research CenterEmory UniversityAtlantaGeorgiaUSA Germans Trias i Pujol Research Institute(IGTP) Can Ruti Campus089BadalonaSpain Barcelona Supercomputing Center(BSC) 08034BarcelonaSpain Catalan Institution for Research and Advanced Studies(ICREA) 08010BarcelonaSpain University of Vic-Central University of Catalonia(UVic-UCC) Vic08500Spain Department of Integrative Structural and Computational Biology Scripps ResearchLa JollaCA92037USA Universitat Pompeu Fabra(UPF) BarcelonaSpain UAB CReSA(IRTA-UAB)Campus de la UAB08193Bellaterra(Cerdanyola del Vallès)Spain Departament de Sanitat i Anatomia Animals Facultat de VeterinàriaUAB08193Bellaterra(Cerdanyola del Vallès)Spain

Antigen-presenting cells(APCs)may be resistant to SARS-CoV-2 infection but still contribute to viral *** such as sialic acid-binding Ig-like lectin 1(Siglec-1/CD169)mediate the attachment of viruses to ***,we show that APCs effectively capture SARS-CoV-2 within compartments via recognition of *** receptor interacts with sialylated gangliosides on membranes of SARS-CoV-2 variants.

关键词： infection Antigen media

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Author Correction to: SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

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Cellular & Molecular Immunology 2022年第8期19卷 965-966页

作者： Daniel Perez-Zsolt Jordana muñoz-Basagoiti Jordi Rodon Marc Elosua-Bayes Dàlia Raïch-Regué Cristina Risco Martin Sachse Maria Pino Sanjeev Gumber Mirko Paiardini Jakub Chojnacki Itziar Erkizia Xabier muñiz-Trabudua Ester Ballana eva riveira-muñoz Marc Noguera-Julian Roger Paredes Benjamin Trinité Ferran Tarrés-Freixas Ignacio Blanco Victor Guallar Jorge Carrillo JuliàBlanco Amalio Telenti Holger Heyn Joaquim Segalés Bonaventura Clotet Javier Martinez-Picado Júlia Vergara-Alert Nuria Izquierdo-Useros IrsiCaixa AIDS Research Institute 08916 Badalona Spain IRTA Centre de Recerca en Sanitat Animal (CReSA IRTA-UAB) Campus de la UAB 08193 Bellaterra (Cerdanyola del Vallès) Spain CNAG-CRG Centre for Genomic Regulation (CRG) Barcelona Institute of Science and Technology (BIST) 08028 Barcelona Spain Centro Nacional de Biotecnología CSIC 28049 Madrid Spain Division of Microbiology and Immunology Yerkes National Primate Research Center Emory University Atlanta GA USA Department of Pathology and Laboratory Medicine School of Medicine Emory University Atlanta GA USA Division of Pathology Yerkes National Primate Research Center Emory University Atlanta GA USA Germans Trias i Pujol Research Institute (IGTP) Can Ruti Campus 08916 Badalona Spain Barcelona Supercomputing Center (BSC) 08034 Barcelona Spain Catalan Institution for Research and Advanced Studies (ICREA) 08010 Barcelona Spain University of Vic—Central University of Catalonia (UVic-UCC) Vic 08500 Spain Department of Integrative Structural and Computational Biology Scripps Research La Jolla CA 92037 USA Universitat Pompeu Fabra (UPF) Barcelona Spain UAB CReSA (IRTA-UAB) Campus de la UAB 08193 Bellaterra (Cerdanyola del Vallès) Spain Departament de Sanitat i Anatomia Animals Facultat de Veterinària UAB 08193 Bellaterra (Cerdanyola del Vallès) Spain

Correction to:Cellular&Molecular Immunology https://***/10.1038/s41423-021-00794-6,published online 15 November 2021 In the version of this correspondence initially published,one of the SARS-CoV-2 variants used in Fig.1B,which was originally described in the article as the SARS-CoV-2 variant‘B.1.***.248.2 Gamma’,is actually the‘P.2 Zeta’SARS-CoV-2 variant of *** GISAID accession ID EPI_ISL_1831696 provided is correct。

关键词： interaction media initially

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Depressant effects of Agastache mexicana methanol extract and one of major metabolites tilianin

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Asian Pacific Journal of Tropical Medicine 2015年第3期8卷 185-190页

作者： María eva González-Trujano Hilda Ponce-muoz Sergio Hidalgo-Figueroa Gabriel Navarrete-Vázquez Samuel Estrada-Soto Laboratorio de Neurofarmacologia de Productos Naturales de la Directión de Investigaciones en Neurociencias.Instituto National de Psiquiatria "Ramón de la Fuente muiz" México D.F.14370México Facultad de Farmacia Universidad Autonoma del Estado de MorelosCuernavaca.Morelos.México

Objective:To determine the depressant-like effects and the possible mechanism of action of tilianin isolated from active methanol extract of Agastache mexicana(***).Also,to establish the pharmacophoric requirements of tilianin,as a possible ligand of GABA_A/BZD receptor,by the alignment of ***-9896 and diindole,using a previously described pharmacophoric ***:Tilianin(30 to 300 mg/*** 300 mg/kg,pa.) and methanol crude extract(10 to 300 mg/kg,*** 300 mg/kg po.) from *** were evaluated for potential sedative and anxiolytic-like response drugs by using open-field,hole-board,cylinder of exploration,plus-maze and sodium pentobarbital-induced hypnosis mice ***:Methanol extract and tilianin showed anxiolytic-like activity from a dosage of 30 mg/kg,*** 300 mg/kg,*** were less potent than diazepam 0.1 mg/kg.a reference anxiolytic drug ***,depressant activity of both potentiates sodium pentobarbital(SP)-induced sleeping *** anxiolytic-like effect of 30 mg/kg *** for the extract and tilianin,by using the plus-maze model,was partially prevented in the presence of flumazenil(a GABA_A/BZD antagonist,5 mg/kg ip.) but not in the presence of WAY100635(a selective 5-HT_(1A) receptor antagonist,0.32 mg/***.).Pharmacophoric modeling alignments of three agonist of GABA_A/BZD allow identify seven chemical *** contains six of the seven features previously ***:Results indicate that tilianin is one of the bioactive metabolites in the anxiolytic-like activity of *** its central nervous system uses,where GABA_A/BZD,but not 5-HT_(1A),receptors are partially involved.

关键词： Agastache mexicana Anxiety Benzodiazepine Central nervous system Sedative Tilianin

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Genome-wide QTL analysis of tomato fruit cuticle deposition and composition

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Horticulture Research 2021年第1期8卷 1443-1457页

作者： Rida Barraj Barraj Patricia Segado Rocio Moreno-Gonzalez Antonio Heredia Rafael Fernandez-munoz eva Dominguez Instituto de Hortofruticultura Subtropical y Mediterranea La Mayora Universidad de Malaga-Consejo Superior de Investigaciones CientificasDepartamento de Mejora Genetica y BiotecnologiaEstacion Experimental La MayoraAlgarrobo-CostaE-29750 MalagaSpain Instituto de Hortofruticultura Subtropical y Mediterranea La Mayora Universidad de Malaga0Consejo Superior de Investigaciones CientificasDepartamento de Biologia Molecular y BioquimicaUniversidad de MalagaE-29071 MalagaSpain Departament de Bioquimica i Fisiologia and Institut de Recerca en Nutricioi Seguretat Alimentaria(INSA-UB) Universitat de Barcelona(UB)E-08028 BarcelonaSpain

Genetics of traits related to fruit cuticle deposition and composition was studied in two red-fruited tomato *** mapping populations derived from the cross between the cultivated tomato(Solanum lycopersicum L.)and its closest relative wild species Solanum pimpinellifolium *** employed to conduct a QTL analysis.A combination of fruit cuticle deposition,components and anatomical traits were investigated and the individual effect of each QTL evaluated.A total of 70 QTLs were identified,indicating that all the cuticle traits analyzed have a complex polygenic nature.A combination of additive and epistatic interactions was observed for all the traits,with positive contribution of both parental lines to most of *** of QTLs for various traits uncovered novel genomic regions producing extensive changes in the *** density emerges as an important trait since it can modulate cuticle thickness and invagination thus providing a strategy for sustaining mechanical strength without compromising *** genomic regions,located in chromosomes 1 and 12,are responsible for the negative interaction between cuticle waxes and phenolics identified in tomato *** candidate genes,including transcription factors and structural genes,are postulated and their expression analyzed throughout development.

关键词： cultivated traits additive

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Management of incidentally discovered appendiceal neuroendocrine tumors after an appendicectomy

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World Journal of Gastroenterology 2022年第13期28卷 1304-1314页

作者： JoséLuis muñoz de Nova Jorge Hernando Miguel Sampedro Núñez Greissy Tibisay Vázquez Benítez eva María Triviño Ibáñez María Isabel del Olmo García Jorge Barriuso Jaume Capdevila Elena Martín-Pérez Department of General and Digestive Surgery Hospital Universitario de La PrincesaMadrid 28006Spain Department of Surgery Universidad Autónomade MadridMadrid 28029Spain Gastrointestinal and Endocrine Tumor Unit Medical Oncology DepartmentVall d´Hebron University HospitalVall d´Hebron Institute of OncologyBarcelona 08035Spain Department of Endocrinology and Nutrition Hospital Universitario de La PrincesaMadrid 28006Spain Department of Pathology Hospital Universitario Puerta de HierroMadrid 28222Spain Department of Pathology Universidad Autónoma de MadridMadrid 28029Spain Department of Nuclear Medicine Virgen de las Nieves University HospitalGranada 18014Spain Department of Endocrinology and Nutrition Hospital Universitario i Politècnic La FeValencia 46023Spain Division of Cancer Sciences School of Medical SciencesFaculty of BiologyMedicine and HealthUniversity of ManchesterManchester M139PLUnited Kingdom Department of Medical Oncology The Christie NHS Foundation TrustManchester M204BXUnited Kingdom

Appendiceal neuroendocrine tumors(aNETs)are an uncommon neoplasm that is relatively indolent in most *** are typically diagnosed in younger patients than other neuroendocrine tumors and are often an incidental finding after an *** there are numerous clinical practice guidelines on management of a NETs,there is continues to be a dearth of evidence on optimal *** of these tumors is stratified according to risk of locoregional and distant ***,there is a lack of consensus regarding tumors that measure 1-2 *** these cases,some histopathological features such as size,tumor grade,presence of lymphovascular invasion,or mesoappendix infiltration must also be *** tomography or magnetic resonance imaging scans are recommended for evaluating the presence of additional disease,except in the case of tumors smaller than 1 cm without additional risk *** receptor scintigraphy or positron emission tomography with computed tomography should be considered in cases with suspected residual or distant *** main point of controversy is the indication for performing a completion right hemicolectomy after an initial appendectomy,based on the risk of lymph node *** main factor considered is tumor size and 2 cm is the most common threshold for indicating a *** factors such as mesoappendix infiltration,lymphovascular invasion,or tumor grade may also be *** the other hand,potential complications,and decreased quality of life after a hemicolectomy as well as the lack of evidence on benefits in terms of survival must be taken into *** this review,we present data regarding the current indications,outcomes,and benefits of a colectomy.

关键词： Neuroendocrine tumors Carcinoid tumor Appendiceal neoplasms Colectomy Neoplasm grading Treatment outcome

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Language Education Optimization: A New Human-Based Metaheuristic Algorithm for Solving Optimization Problems

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Computer Modeling in Engineering & Sciences 2023年第8期136卷 1527-1573页

作者： Pavel Trojovsky Mohammad Dehghani eva Trojovská eva Milkova Department of Mathematics Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Department of Applied Cybernetics Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic

In this paper,based on the concept of the NFL theorem,that there is no unique algorithm that has the best performance for all optimization problems,a new human-based metaheuristic algorithm called Language Education Optimization(LEO)is introduced,which is used to solve optimization *** is inspired by the foreign language education process in which a language teacher trains the students of language schools in the desired language skills and *** is mathematically modeled in three phases:(i)students selecting their teacher,(ii)students learning from each other,and(iii)individual practice,considering exploration in local search and exploitation in local *** performance of LEO in optimization tasks has been challenged against fifty-two benchmark functions of a variety of unimodal,multimodal types and the CEC 2017 test *** optimization results show that LEO,with its acceptable ability in exploration,exploitation,and maintaining a balance between them,has efficient performance in optimization applications and solution *** efficiency in optimization tasks is compared with ten well-known metaheuristic *** of the simulation results show that LEO has effective performance in dealing with optimization tasks and is significantly superior andmore competitive in combating the compared *** implementation results of the proposed approach to four engineering design problems show the effectiveness of LEO in solving real-world optimization applications.

关键词： Optimization language education exploration exploitation metaheuristic algorithm

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Interstitial lung disease in rheumatoid arthritis:Current concepts in pathogenesis,diagnosis and therapeutics

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World Journal of Rheumatology 2015年第1期5卷 1-22页

作者： eva M Olivas-Flores David Bonilla-Lara Jorge I Gamez-Nava Alberto D Rocha-muoz Laura Gonzalez-Lopez Hospital General Regional 180 Instituto Mexicano del Seguro Social (IMSS) Centro Universitario de Ciencias de la Salud (CUCS) Universidad de Guadalajara Hospital de Especialidades Centro Medico Nacional de Occidente Instituto Mexicano del Seguro Social (IMSS) Hospital General Regional 110 Departamento de Medicina Interna-Reumatologia Instituto Mexicano del Seguro Social (IMSS)

Rheumatoid arthritis(RA) is the most common chronic autoimmune inflammatory joint disease. RA-associated interstitial lung disease(RA-ILD) is a major extraarticular complication and causes symptoms that lead to a deterioration in the quality of life, high utilization of health resources, and an increased risk of earlier mortality. Early in the course of RA-ILD, symptoms are highly variable, making the diagnosis difficult. Therefore, a rational diagnostic strategy that combines an adequate clinical assessment with the appropriate use of clinical tests, including pulmonary function tests and high-resolution computed tomography, should be used. In special cases, lung biopsy or bronchioalveolar lavage should be performed to achieve an early diagnosis. Several distinct histopathological subtypes of RA-ILD are currently recognized. These subtypes also have different clinical presentations, which vary in therapeutic response and prognosis. This article reviews current evidence about the epidemiology of RA-ILD and discusses the varying prevalence rates observed in different studies. Additionally, aspects of RA-ILD pathogenesis, including the role of cytokines and other molecules such as autoantibodies, as well as the evidence linking several drugs used to treat RA with lung damage will be discussed. Some aspects of the clinical characteristics of RA-ILD are noted, and diagnostic strategies are reviewed. Finally, this article analyzes current treatments for RA-ILD, including immunosuppressive therapies and biologic agents, as well as other therapeutic modalities. The prognosis of this severe complication of RA is discussed. Additionally, this paper examines updated evidence from studies identifying an association between drugs used for the treatment of RA and the development of ILD.

关键词： Rheumatoid arthritis Interstitial lung disease Pathogenesis Diagnosis Therapeutic

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Antimicrobial impacts of selected Lamiaceae plants on bacteria isolated from vegetables and their application in edible films

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Food Bioscience 2023年第1期51卷 618-624页

作者： eva Gyorgy eva Laslo Bernadette Salamon Sapientia Hungarian University of Transylvania(Cluj-Napoca Romania)Faculty of EconomicsSocio-Human Sciences and EngineeringDepartment of Food ScienceMiercurea CiucRomania

Fresh vegetables can be contaminated with spoilage and food-borne pathogenic bacteria during cultivation,harvesting,transport and further *** essential oils seem a promising solution for preserving vegetables incorporated in edible *** the study it was determined the prevalence of allochthonous bacteria on some fresh vegetables with classical cultivation and molecular biology *** evaluation of the antibacterial effect of Thymus vulgaris,Origanum vulgare,Mentha piperita and Melissa officinalis essential oils against identified bacteria from vegetables and on some standard foodborne pathogenic bacteria was realized with agar diffusion *** prevalence of allochthonous bacteria in the examined vegetables was *** some cases,high contamination level could be detected reaching the level of 104 colony forming units/*** identified bacteria belong to different genera like Bacillus,Enterobacter,Pseudomonas *** the tested plant essential oils,the most pronounced antibacterial effect was detected in the case of thyme and oregano,with over 30 mm inhibition *** isolated bacteria from vegetables showed higher resistance to the used essential *** results suggest that edible films containing thyme and oregano essential oils possess efficient antibacterial effect against mesophilic aerobic bacteria and Staphylococcus *** findings seem a promising solution for preserving vegetables with natural antimicrobial containing edible films.

关键词： Essential oils Antimicrobial activity Fresh vegetables Allochthonous bacteria Food-borne pathogens

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Promoting axon regeneration in the central nervous system by increasing PI3-kinase signaling

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Neural Regeneration Research 2022年第6期17卷 1172-1182页

作者： Bart Nieuwenhuis Richard eva John van Geest Center for Brain Repair Department of Clinical NeurosciencesUniversity of CambridgeCambridgeUK

much research has focused on the PI3-kinase and PTEN signaling pathway with the aim to stimulate repair of the injured central nervous *** in the central nervous system fail to regenerate,meaning that injuries or diseases that cause loss of axonal connectivity have life-changing *** 2008,genetic deletion of PTEN was identified as a means of stimulating robust regeneration in the optic *** is a phosphatase that opposes the actions of PI3-kinase,a family of enzymes that function to generate the membrane phospholipid PIP_(3) from PIP_(2)(phosphatidylinositol(3,4,5)-trisphosphate from phosphatidylinositol(4,5)-bisphosphate).Deletion of PTEN therefore allows elevated signaling downstream of PI3-kinase,and was initially demonstrated to promote axon regeneration by signaling through *** recently,additional mechanisms have been identified that contribute to the neuron-intrinsic control of regenerative *** review describes neuronal signaling pathways downstream of PI3-kinase and PIP3,and considers them in relation to both developmental and regenerative axon *** briefly discuss the key neuron-intrinsic mechanisms that govern regenerative ability,and describe how these are affected by signaling through *** highlight the recent finding of a developmental decline in the generation of PIP_(3) as a key reason for regenerative failure,and summarize the studies that target an increase in signaling downstream of PI3-kinase to facilitate regeneration in the adult central nervous ***,we discuss obstacles that remain to be overcome in order to generate a robust strategy for repairing the injured central nervous system through manipulation of PI3-kinase signaling.

关键词： axon cytoskeleton axon regeneration axon transport cell signaling central nervous system growth cone neuroprotection PI3-kinase PI3K PTEN trafficking transcription translation

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Utilization of fly ash from coal-fired power plants in China

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第5期9卷 681-687页

作者： eva SELIC Jan-Dirk HERBELL Waste Management Engineering Department of Mechanical Engineering University of Duisburg-Essen Duisburg 47057 Germany

The rapidly increasing demand for energy in China leads to the construction of new power plants all over the country. Coal, as the main fuel resource of those power plants, results in increasing problems with the disposal of solid residues from combustion and off gas cleaning. This investigation describes chances for the utilization of fly ash from coal-fired power plants in China. After briefly comparing the situation in China and Germany, the status of aluminum recycling from fly ash and the ad- vantages for using fly ash in concrete products are introduced. Chemical and physical analyses of Chinese fly ash samples, e.g., X-ray diffraction (XRD), ICP (Inductive Coupled Plasma) and particle size analysis, water requirement, etc. are presented. Rea- sonable amounts of aluminum were detected in the samples under investigation, but for recovery only sophisticated procedures are available up to now. Therefore, simpler techniques are suggested for the first steps in the utilization of Chinese fly ash.

关键词： Fly ash utilization Aluminum recycling Concrete Chemical and physical analyses

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