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Rumen microbial degradation of bromoform from red seaweed(Asparagopsis taxiformis)and the impact on rumen fermentation and methanogenic archaea

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Journal of Animal Science and Biotechnology 2024年第1期15卷 412-426页

作者： Pedro Romero Alejandro Belanche Elisabeth Jiménez Rafael Hueso eva ramos-morales Joan King Salwen Ermias Kebreab David R.Yáñez-Ruiz Estacion Experimental del Zaidin Consejo Superior de Investigaciones Cientificas(CSIC)Profesor Albareda 1Granada 18008Spain Department of Animal Production and Food Sciences University of ZaragozaMiguel Servet 177Saragossa 50013Spain Blue Ocean Barns Inc. Redwood CityCAUSA Department of Animal Science University of CaliforniaDavisCA 95618USA

Background The red macroalgae Asparagopsis is an effective methanogenesis inhibitor due to the presence of halogenated methane(CH_(4))analogues,primarily bromoform(CHBr_(3)).This study aimed to investigate the degradation process of CHBr3 from A taxiformis in the rumen and whether this process is *** in vitro batch culture system was used according to a 2×2 factorial design,assessing two A taxiformis inclusion rates[0(CTL)and 2%DM diet(AT)]and two diets[high-concentrate(HC)and high-forage diet(HF)].Incubations lasted for 72 h and samples of headspace and fermentation liquid were taken at 0,0.5,1,3,6,8,12,16,24,48 and 72 h to assess the pattern of degradation of CHBr_(3) into dibromomethane(CH_(2)Br_(2))and fermentation ***,an in vitro experiment with pure cultures of seven methanogens strains(Methanobrevibacter smithii,Methanobrevibacter ruminantium,Methanosphaera stadtmanae,Methanosarcina barkeri,Methanobrevibacter millerae,Methanorhermobacter wolfei and Methanobacterium mobile)was conducted to test the effects of increasing concentrations of CHBr3(0.4,2,10and 50μmol/L).Results The addition of AT significantly decreased CH_(4) production(P=0.002)and the acetate:propionate ratio(P=0.003)during a 72-h *** concentrations of CHBr_(3) showed a rapid decrease with nearly 90%degraded within the first 3 h of *** the contrary,CH_(2)Br_(2) concentration quickly increased during the first 6 h and then gradually decreased towards the end of the *** CHBr_(3) degradation nor CH_(2)Br_(2) synthesis were affected by the type of diet used as substrate,suggesting that the fermentation rate is not a driving factor involved in CHBr_(3)*** in vitro culture of methanogens showed a dose-response effect of CHBr3 by inhibiting the growth of ***,***,***,***,***,***,and *** The present work demonstrated that CHBr_(3) from *** is quickly degrad

关键词： Bromoform metabolism Dibromomethane metabolism Methane mitigation Methanogens Rumen microbiota Seaweed

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Melatonin:a multitasking indoleamine to modulate hippocampal neurogenesis

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Neural Regeneration Research 2023年第3期18卷 503-505页

作者： Alejandro Romero JoséÁngel morales-García eva ramos Department of Pharmacology and Toxicology Faculty of Veterinary MedicineComplutense University of Madrid Institute for Biomedical Research“A.Sols”(CSIC-UAM) Spanish Center for Networked Biomedical Research on Neurodegenerative Diseases(CIBERNED Department of Cellular Biology School of MedicineComplutense University of MadridMadridSpain

Neurodegeneration affects a large number of cell types including neurons,astrocytes or oligodendrocytes,and neural stem *** stem cells can generate new neuronal populations through proliferation,migration,and *** neurogenic potential may be a relevant factor to fight neurodegeneration and *** the last years,we can find growing evidence suggesting that melatonin may be a potential modulator of adult hippocampal *** lack of therapeutic strategies targeting neurogenesis led researchers to explore new *** preclinical studies with melatonin observed how melatonin can modulate and enhance molecular and signaling pathways involved in *** made a special focus on the connection between these modulation mechanisms and their implication in neurodegeneration,to summarize the current knowledge and highlight the therapeutic potential of melatonin.

关键词： adult hippocampal neurogenesis aging melatonin neural stem cell neurodegeneration neuroprotection signaling pathway therapeutic strategy

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Highlights of ASS234: a novel and promising therapeutic agent for Alzheimer’s disease therapy

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Neural Regeneration Research 2020年第1期15卷 30-35页

作者： Alejandro Romero JoséMarco-Contelles eva ramos Department of Pharmacology&Toxicology Faculty of Veterinary MedicineComplutense University of MadridMadridSpain Laboratory of Medicinal Chemistry Institute of General Organic Chemistry(CSIC)MadridSpain

There is no effective treatment to face Alzheimer’s disease *** molecules are a good approach against the multiple physiopathological events associated with its development and *** this context,N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine(ASS234)has been tested achieving promising ***234 has demonstrated to cross the blood-brain barrier in vivo,and a good in silico safety profile being less toxic than ***,ASS234 reversibly inhibits human acetyl-and butyryl-cholinesterase,and irreversibly inhibits human monoamine oxidase A and ***,this multitarget molecule has antioxidant and neuroprotective properties,and inhibitsΑβ1–42 andΑβ1–40 *** about the mechanism of action,several signaling pathways related to Alzheimer’s disease had been explored showing that ASS234 induces the wingless-type MMTV integration site(Wnt)family and several members of the heat shock proteins family and moreover counteracts neuroinflammatory and oxidative stress-related genes promoting the induction of several key antioxidant ***,in vivo experiments with ASS234 in C57BL/6J mice displayed its ability to reduce amyloid plaque burden and gliosis in the cortex and hippocampus,ameliorating scopolamine-induced learning *** we gather the information regarding ASS234 evaluated so far,showing its ability to face different targets,necessary to counteract a neurodegenerative disease as complex as the Alzheimer’s disease.

关键词： AChE BuChE gene expression heat shock proteins inflammation in silico toxicology MAO A/B neuroprotection oxidative stress Wnt signaling

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Confounding response of macrofauna from a confluence of impacts: brine and sewage pollution

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Acta Oceanologica Sinica 2013年第10期32卷 74-81页

作者： Rodrigo Riera Fernando Tuya Myriam Rodríguez óscar Monterroso eva ramos Centro de Investigaciones Medioambientales del Atlántico (CIMA SL) Arzobispo Elías Yanes 4438206 La LagunaTenerifeCanary IslandsSpain BIOGES University of Las Palmas de G.C.35017 Las Palmas de Gran CanariaCanary IslandsSpain

Throughout the shores of the world, a confluence of different sources of pollution is common, e.g., through outlets releasing brine, industrial, and domestic sewage. In this study, we assessed whether a combined disposal of domestic sewage and brine altered the patterns of abundance and assemblage structure of sub- tidal macrofauna inhabiting sandy seabeds on the south coast of Gran Canaria （Canary Islands, NE Atlantic Ocean）. Samples were collected in two surveys （May 2008 and January 2009） at three distances （0, 15, and 30 m） away from the discharge point. Macrofaunal abundances showed different patterns with varying proximity from the disposal point in the two surveys. In May 2008, lower abundances were observed at 0 m （53.89±46.82 ind.） than at 15 m （120±91.7 ind.） and 30 m （283.89±189.33 ind.） away from the dis- posal point. In January 2009, however, higher abundances were observed at 0 m （131.33±58.69 ind.） than at 30 m （100±24.44 ind.） and 15 m （84.78±58.39 ind.） away from the disposal point. Significant differ- ences in macrofaunal assemblage structure were found with varying proximity from the discharge point in both surveys. The effect of proximity from the disposal point was confounded by changes in sedimen- tary composition between surveys, which contributed to explain differences in macrofaunal abundances and assemblage structure with varying proximity from the discharge point. As a result, confounding driver- s of macrofaunal assemblage structure, here, changes in sediment composition, accounted for changes in macrofaunal abundances and assemblage structure with varying proximity from a combined disposal point of brine and sewage.

关键词： macrofauna amphipoda polychaeta brine sewage Canary Islands

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Macrofaunal communities of threatened subtidal maёrl seabeds on Tenerife (Canary Islands, north-east Atlantic Ocean) in summer

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Acta Oceanologica Sinica 2012年第1期31卷 98-105页

作者： Rodrigo Riera Juan Domingo Delgado Myriam Rodríguez Óscar Monterroso eva ramos Centro de Investigaciones Medioambientales del Atlántico(CIMA SL) C/Arzobispo Elías Yanes Área de Ecología Departamento de Sistemas FísicosQuímicos y Naturales.Facultad de Ciencias ExperimentalesUniversidad Pablo de Olavide

This study contributes with the first data on physical and taxonomical structure of macrofaunal assemblages of maerl beds from the Canary Islands. Maerl beds and Cymodocea nodosa meadows of the Canary Islands are considered biodiversity hot-spots in terms of taxonomic and functional biodiversity with a broad geographical and depth ranges. The authors have studied the structure of the macrofaunal assemblages on different habitat types （Cymodocea, Caulerpa, sabellid field, garden eel and maerl beds）. Samples were taken at a range of depths between 14 and 46 m. Correlations were performed among abiotic variables （granulometry, organic matter, nitrogen and phosphates） and the most abundant taxa. Similarity analysis was performed to explore the patchiness of seabeds at a local scale. Significant differences were found in macrofaunal assemblages among seabed types, with highest abundances and lowest biodiversity in sabellid fields, where the sabellid Bispira viola dominated. The polychaetes Aponuphis bilineata and Chone filicauda and the mollusc Turritella brochii were the most abundant taxa on maerl beds. The mosaic of granulometric conditions would explain the associated macroinfaunal community structure and contribute to the creation of diversity on these relatively well preserved seabeds at a local scale.

关键词： Macrofauna Polychaetes Amphipods Molluscs soft-bottoms subtidal Tenerife Canary Islands

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Are assemblages of the fireworm Hermodice carunculata enhanced in sediments beneath offshore fish cages?

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Acta Oceanologica Sinica 2014年第4期33卷 108-111页

作者： Rodrigo Riera Oscar Pérez Myriam Rodríguez eva ramos óscar Monterroso Centro de Investigaciones Medioambientales del Atlántico (CIMA SL) Department of Biodiversity Qatar Environment and Energy Research Institute (QEERI)

Abundances of the fireworm Hermodice carunculata were counted through a monitoring assessment study of fish cages in Barranco Hondo（NE Tenerife）. Seven campaigns were conducted from November 2007 to June 2010 and temporal variations were found, as well as differences among sampling stations. The polychaete H. carunculata obtained its highest abundance in sediments beneath fish cages throughout the study period. Thus, the assemblages of this omnivorous species were favoured by the presence of fish cages.

关键词： aquaculture organic enrichment environmental impact Polychaeta Hermodice carunculata Tenerife Canary Islands Atlantic Ocean

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Quantification of the Mixture of Hydrothermal and Fresh Water in Tectonic Valleys

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Journal of Earth Science 2020年第5期31卷 1007-1015页

作者： Janete Moran-Ramirez Jose Ivan morales-Arredondoc Maria Aurora Armienta-Hernandez Jose Alfredo ramos-Leal National Council of Science and Technology National Autonomous University of MexicoInstitute of GeophysicsScientific Research CircuitUniversity CityCoyoacan 04150Mexico CityMexico National Autonomous University of Mexico Institute of GeophysicsUniversity CampusMexico CityMexico Potosino Institute for Scientific and Technological Research 78216 San Luis PotosiS.L.P.Mexico

This study was conducted to identify the origin, hydrogeochemical processes and evolution of groundwater in a tectonic valley. This study was carried out with the aim of quantifying the proportions of groundwater flows contributing to the water chemistry abstracted in a zone of convergence favored by the presence of active faults. The study area is located in the Trans-Mexican Volcanic Belt. End members methodology was applied to identify the mixing of hydrothermal with fresh groundwater, where changes in the aquifer geology result in distinct groundwater chemical signatures. Ternary mixing was quantified using conservative elements. Moreover, other evolutionary processes, such as ion exchange and silicate weathering occur due to changes in the geology of the area. In ternary mixing, each of the end members is associated with the lithology through which it circulates. The local flow contributes 70% of the water to the system, the intermediate flow contributes 14%, and the regional flow contributes 16%. Three types of water are produced: Na-HCO3, due to the interaction of water with volcanic rocks of rhyolitic composition, Na-Mg-HCO3, due to the interaction of water with volcanic rocks of basaltic-andesite composition, and Ca-HCO3, due to the interaction of water with sedimentary calcareous rocks.

关键词： hydrogeochemistry ternary mixing end members conservative elements local flow Mexico

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Reuse of port industrial heritage in tourist cities:Shipyards as case studies

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Frontiers of Architectural Research 2024年第1期13卷 164-183页

作者： María J.Andrade Eduardo Jiménez-morales Rachel Rodríguez-ramos Pablo Martínez-Ramírez Department of Art and Architecture School of ArchitectureMalaga UniversityMalaga 29013Spain

The progressive deindustrialisation of many western cities since the 1980s has led to many industrial zones linked to port activities being abandoned or falling into *** such as Barcelona,Naples,Lisbon,Amsterdam,and Hamburg have port industrial complexes of high tangible and intangible heritage value that could totally or partially disappear,resulting in an irreparable loss of their scientific,architectural,social,technological,and historical *** that in mind,Adaptive Reuse(AR)of the built heritage allows the industrial memory of the ports to be preserved by turning them into new functional centres within the existing urban *** occurs in the context of the contemporary challenges of those cities,such as touristification,the circular economy and climate change,while guaranteeing the life cycle of those *** article analyses two case studies—the Nederlandsche Scheepsbouw Maatschappij(NDSM)and the Rotterdamsche Droogdok Maatschappij(RDM)shipyards,both in the Netherlands—in order to contribute to the knowledge of AR of Port Industrial *** are two examples of good practices in port industrial heritage interventions,where the factors behind their acclaim can be easily highlighted.A multi-scale methodology is therefore used and tailored to the case of port industrial heritage,based on analysing previous studies of the heritage in different spheres and on different scales.A relationship matrix tool is thus *** enables a comparative study to be conducted,using key variables and indicators,and considering qualitative and quantitative *** provides extensive output information for each case study,which is summarised in the most favourable factors for the success of the AR of this port industrial heritage.

关键词： Industrial heritage Port-city Adaptive reuse Best practices Circular economy HUL Touristification

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ECIEN-2020 study:the effect of COVID-19 on admissions for non-COVID-19 diseases

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World Journal of Pediatrics 2021年第1期17卷 85-91页

作者： Beatriz ramos-Lacuey Mercedes Herranz Aguirre Clara Calderón Gallego Andrea Ilundain López de Munain eva Gembero Esarte Laura Moreno-Galarraga Department of Pediatrics CHNComplejo Hospitalario de NavarraServicio Navarro de SaludC/Irunlarrea 331080 PamplonaSpain Pediatric Infectious Diseases Department CHNComplejo Hospitalario de NavarraServicio Navarro de SaludPamplonaSpain Pediatric Hospitalization Department of PediatricsCHNComplejo Hospitalario de NavarraServicio Navarro de SaludPamplonaSpain IdiSNA Navarra Institute for Health ResearchPamplonaSpain Department of Preventive Medicine and Public Health School of MedicineUniversity of NavarraPamplonaSpain Pediatric Pulmonology Department of PediatricsCHNComplejo Hospitalario de NavarraServicio Navarro de SaludPamplonaSpain

Background The pandemic caused by severe acute respiratory coronavirus 2(SARS-CoV-2)has had great effects on health systems worldwide,not only in relation to coronavirus disease 2019(COVID-19)cases but also affecting patients with other *** ECIEN-2020 is an observational study conducted in a tertiary referral hospital in Navarra,*** describes the effects of COVID-19 pandemic and the preventive measures adopted,in pediatric admissions for non-COVID-19 *** during March-June 2020(first wave of the COVID-19 pandemic in Spain)are described and compared with the same quarter in 2019.A sub-analysis was performed delving into *** characteristics(age,sex,past medical history),disease characteristics(symptoms,duration of symptoms,previous consultation in Primary Care Health Center),and admission characteristics(place and average stay)were *** A 33% reduction in the number of pediatric hospital admissions was observed,decreasing from 529 hospitaliza-tions in 2019 to 353 in 2020(P<0.001).This highlights a 48% reduction in patients admitted for pulmonary *** were no significant changes in average hospital-stay,percentage of intensive care unit admissions,or in admissions for other *** of patients admitted among those seen in the emergency department rose from 5.1%in 2019 to 10.9% in 2020,whereas the total number of consultations in the emergency department decreased by 68%.Conclusion The pandemic and the measures adopted due to SARS-CoV-2 have significantly decreased pediatric admissions for non-COVID-19 diseases,especially due to a reduction in the hospitalization for respiratory diseases.

关键词： Admission COVID-19 Hospitalization SARS-CoV-2

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Clinical characteristics and surgical treatment of schwannomas of the esophagus and stomach: A case series and systematic review

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World Journal of Gastrointestinal Oncology 2019年第9期11卷 750-760页

作者： Jesús morales-Maza Francisco Ulises Pastor-Sifuentes Germán E Sánchez-morales Emilio Sanchez-Garcia ramos Oscar Santes Uriel Clemente-Gutiérrez Adriana Simoneta Pimienta-Ibarra Heriberto Medina-Franco Department of Surgery Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

BACKGROUND Gastrointestinal schwannomas are slow-growing benign mesenchymal neoplasms that originate from Schwann cells of the nerve sheath of Auerbach′s plexus or less frequently from Meissner′s *** main differential diagnosis of gastric schwannomas are the gastrointestinal stromal tumors(GISTs),which are classified by their *** treatment of choice for gastric schwannomas is surgery where laparoscopy plays an important *** resection,subtotal or total gastrectomy can be *** its counterpart,esophageal schwannomas are benign tumors of the esophagus that are very uncommon since they comprise less than 2%of all esophageal *** main differential diagnosis is the leiomyoma which corresponds to the most common benign esophageal tumor,followed by *** treatment consists on tumoral enucleation or *** To review the available literature about gastrointestinal schwannomas;especially lesions from de stomach and esophagus,including diagnosis,treatment,and follow up,as well as,reporting our institutional *** A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes *** following databases were used for reviewing process:Pub Med,Ovid,MEDLINE,and *** English language manuscripts were *** gastrointestinal schwannomas specifically located in the esophagus and stomach were *** that did not report long-term follow-up were *** Gastric localization showed a higher prevalence in both,the literature review and our institution:94.95%(n=317)and 83%(n=5)*** a follow-up with disease-free survival greater than 36 mo in most cases:62.01%(n=80)vs66.66%(n=4).In both groups,the median size was>4.1 *** treatment is curative in most cases CONCLUSION Schwannoma must be taken into account in the differential diagnosis of gastrointestinal mesenchymal *** has a good prognosis,and most are benig

关键词： Schwannoma Esophagus Stomach Surgery Systematic review

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