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Journal of Cancer metastasis and Treatment 2015年第1期1卷 36-38页

作者： Ovidio Fernández Calvo maría eva Pérez López Jesús García Gómez Department of medical Oncology Ourense University Hospital32005 OurenseSpain

Glioblastoma multiforme is the most common type of primary central nervous system tumor and is noted for its short survival and poor response to chemotherapeutic ***,the relapse rate is very high,and there is no reference drug for second-line *** this study,a patient was treated with the Soffi etti *** induction phase was fotemustine 75 mg/m^(2) at day 1 and day 8 and bevacizumab 10 mg/kg at day 1 and day *** maintenance phase was fotemustine 75 mg/m^(2) and bevacizumab 10 mg/kg every 3 weeks for two ***-up magnetic resonance imaging showed post-surgical changes at the left occipital level,without contrast enhancement,and toxic left leuko-encephalopathy post-treatment without mass effect and with no evidence of tumor *** patient then was maintained with bevacizumab monotherapy until it was withdrawn when pulmonary thromboembolism *** tumor regrowth,fotemustine was started again as maintenance *** patient achieved stabilization of his disease until his death due to thromboembolic and infectious complications.

关键词： Bevacizumab brain tumor fotemustine

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空仓螨害的生物防治

国外农学（植物保护） 1992年第3期5卷 21-23页

作者： eva Zdarkova 凌成树

新入仓的粮食,首先遇到上一季仓储中残余螨类的为害,因此,空仓治螨是极为重要的.生物防治相对廉价,而且有效,对环境安全.对捷克斯洛伐克26个农业仓库的螨类区系调查表明:一些螨类存在于所有粮仓,辐螨亚目的螨类在76.9%的粮仓中发现.每10... 详细信息

新入仓的粮食,首先遇到上一季仓储中残余螨类的为害,因此,空仓治螨是极为重要的.生物防治相对廉价,而且有效,对环境安全.对捷克斯洛伐克26个农业仓库的螨类区系调查表明:一些螨类存在于所有粮仓,辐螨亚目的螨类在76.9%的粮仓中发现.每100m^2面积释放普通肉食螨2000～3000头,害螨数量显著减少.

关键词：储藏物螨类生物防治

Prostanoid synthases and receptors in aorta of spontaneously hypertensive rat

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Prostanoid synthases and receptors in aorta of spontaneously...

Female genital schistosomiasis,human papilloma virus infection,and cervical cancer in rural madagascar:a cross sectional study

11th International Vascular Neuroeffector mechanisms and Cardiovascular Pharmacology and medicine Symposia, Shanghai-Suzhou 2006

作者： eva H.C.Tang George P.m.Leung Amy C.Y.Lo Sookja K.Chung Ricky Y.K.man Paul m.Vanhoutte Dept of Pharmacology University of HK Hong Kong Dept of Pharmacology University of HK Hong Kong Dept of Anatomy University of HK Hong Kong Dept of Anatomy University of HK Hong Kong Dept of Pharmacology University of HK Hong Kong Dept of Pharmacology University of HK Hong Kong

Expression pattern of prostanoid synthases on freshly isolated endpthelial cells and its respective receptors on smooth muscle cells of the thoracic aorta of eight-month old Wistar Kyoto rat (WKY) and spontaneously hypertensive rat (SHR) are assessed. Total RNA was isolated, converted into cDNA and used for quantitative real-time polymerase chain reaction (PCR) using SYBR green fluorescent dye to quantify the accumulation of double-stranded PCR

关键词： Prostanoid synthases and receptors in aorta of spontaneously hypertensive rat

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Infectious Diseases of Poverty 2023年第5期12卷 100-100页

作者： Jean-marc Kutz Pia Rausche Tahinamandranto Rasamoelina Sonya Ratefiarisoa Ravo Razafindrakoto Philipp Klein Anna Jaeger Rivo Solotiana Rakotomalala Zoly Rakotomalala Bodo Sahondra Randrianasolo Sandrine mcKay-Chopin Jürgen may Rapahel Rakotozandrindrainy Dewi Ismajani Puradiredja Elisa Sicuri monika Hampl eva Lorenz Tarik Gheit Rivo Andry Rakotoarivelo Daniela Fusco Department of Infectious Disease Epidemiology Bernhard-Nocht Institute for Tropical Medicine (BNITM) Hamburg Germany German Center for Infection Research (DZIF) Hamburg-Borstel-Lübeck-Riems Germany Centre Infectiologie Charles mérieux (CICm) Antananarivo Madagascar Centre Hospitalier Universitaire (CHU) Androva Mahajanga Madagascar Association K’OLO VANONA Antananarivo Madagascar International Agency for Research on Cancer (IARC) Lyon France University medical Center Hamburg-Eppendorf (UKE) Hamburg Germany University of Antananarivo Antananarivo Madagascar Barcelona Institute for Global Health (IS Global) Barcelona Spain Köln-Hohenlind Hospital Cologne Germany University of Fianarantsoa Fianarantsoa Madagascar

Background Women’s health in resource-limited settings can benefit from the integrated management of high-burden diseases,such as female genital schistosomiasis(FGS)and human papilloma virus(HPV)-related cervical *** schistosomiasis-endemic countries such as madagascar,data on FGS and HPV prevalence are lacking as well as preventive measures for both *** study aims to estimate the prevalence of FGS and HPV in rural madagascar,and to examine associated risk factors to identify opportunities for improving women’s *** After initial community outreach activities,interested women aged 18-49 years were recruited consecutively in 2021 at three primary health care centers in the district of *** was detected by *** images were double-blind reviewed by two independent specialists.A Luminex bead-based assay was performed on cervical vaginal lavage specimens for HPV ***(CPR)and adjusted prevalence ratios(APR)of associations between selected factors and FGS and HPV positivity were estimated using univariable and multivariable binary Poisson regression with 95%confidence intervals(CIs).Results Among 500 women enrolled,302 had complete information on FGS and HPV diagnosis,and were thus eligible for *** the sample,189(62.6%,95%CI:56.9-68.1)cases of FGS were detected.A total of 129 women(42.7%,95%CI:37.1-48.5)tested positive for *** total,80 women(26.5%,95%CI:21.6-31.8)tested positive for both *** association was observed between FGS and HPV positivity,while previous pregnancy(APR=0.65,95%CI:0.43-0.78)and older age(APR=0.59,95%CI:0.42-0.81)are showing a negative association with HPV infection compared to no previous pregnancy and younger age *** The results of the study show that FGS and HPV are highly prevalent in rural *** concurrent prevalence of these two conditions requires urgent adaptations of public health strategies to improve women’s health,such as integrated

关键词： Women’s health Female genital schistosomiasis Human papilloma virus Cervical cancer Public health madagascar

Agromorphological Characterization of Introgression Lines Derived from Wild and Exotic Sorghum Germplasm to Climate Change Challenges

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Agricultural Sciences 2021年第10期12卷 1129-1149页

作者： Ouindyam Colette Ouédraogo Nerbéwendé Sawadogo eva Weltzien Baloua Nebie Fred Rattunde Aboubacar Touré Ibrahima Sissoko mahamadou Sawadogo Equipe Génétique et Amélioration des Plantes Laboratoire Biosciences Ecole Doctorale Sciences et Technologies Université Joseph Ki-Zerbo Ouagadougou Burkina Faso International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) Bamako Mali University of Wisconsin-madison Madison WI USA

Sorghum (Sorghum bicolor (L.) moench) is vitally important for food security in semi-arid West Africa. The introgression of wild- and high transpiration efficiency genotypes may contribute genes for abiotic stress tol... 详细信息

Sorghum (m>Sorghum bicolorm> (L.) moench) is vitally important for food security in semi-arid West Africa. The introgression of wild- and high transpiration efficiency genotypes may contribute genes for abiotic stress tolerance or novel traits. Characterizing the introgressed lines can help researchers in the process of varietal improvement. The objectives of this study are (i) To learn if introgression of wild sorghum (CWR) and high transpiration efficiency (HTE) lines into a very early maturing (photoperiod insensitive) local land-race variety can create useful variation for grain yield in drought-prone Sahelian environments, (ii) To determine if grain yield advantages (and putative drought tolerance traits) obtained from introgression of CWR and HTE germplasm are expressed differently in moderately to highly moisture-limited environments, and (iii) To understand the relationship between putative drought tolerance traits. These populations were developed from crosses between the CSm63E (Jakumbe, a high grains quality variety) and two wild parents (accessions) and five high transpiration efficiency (TE) sorghum accessions. Phenotyping was conducted using an alpha lattice design with three replications in two environments for agronomic traits (grain yield and components), flowering time and physiological traits (stay-green, chlorophyll content and lodging). A total of 669 BC1F5 progenies were developed. Genetic variation for grain yield and putative drought tolerant traits were evaluated. Both populations derived from wild parents exhibited in Cinzana a grain yield (>300 g/m2) greater than CSm63E (245 g/m2). In Bema, more than 75% of the progenies of all populations indicated a chlorophyll content at physiological maturity (>30 SPAD) higher than CSm63E (20 SPAD) chlorophyll content. The estimated broad sense heritability was generally high (≥0.50) for all traits. The results also showed a very significant interaction between genotype and e

关键词： Sorghum Transpiration Drought Variability Climate Change

PKR and PP1C Polymorphisms in Alzheimer’s Disease Risk

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Neuroscience & medicine 2011年第3期2卷 226-231页

作者： Ernest Palomer Gerard ILL-Raga marta Tajes eva Ramos-Fernández mònica Bosch-morató Biuse Guivernau Jose J.Galan Jordi Clarimon Carmen Antunez merce Boada Luis m.Real César Fandos Francisco J.munoz Laboratory of molecular Physiology and Channelopathies Department of Experimental and Health SciencesPompeu Fabra University(UPF)BarcelonaSpain NeoCodex SevillaSpain Alzheimer Laboratory Neurology DepartmentSanta Creu and Sant Pau HospitalBiomedical Research Center on Neurodegenerative Diseases(CIBERNED)BarcelonaSpain Fundacion Alzheimur Dementia UnitVirgen de la Arrixaca HospitalMurciaSpain memory Clinic of ACE Foundation Catalan Institute of Applied NeurosciencesBarcelonaSpain Neurology Department Vall d’Hebron Universitary HospitalBarcelonaSpain

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by senile plaques and neurofibrillary tangles. Senile plaques are deposits of amyloid ?-peptide (A?) produced by the cleavage of a transmembrane protein termed Amyloid Precursor Protein (APP). The amyloidogenic cleavage of APP is performed by γ-secretase complex and ?-site APP cleaving enzyme 1 (BACE1), a key enzyme in AD that can be activated by different noxious stimuli. Interestingly, some viruses could activate double-stranded RNA-activated protein kinase (PKR), which phosphorylates Eukaryotic Initiation Factor 2 alpha (eIF2α). This phosphorylation stops global translation to avoid any synthesis of viral infective proteins, but paradoxically up-regulates BACE1 translation. One of the viral mechanisms to circumvent eIF2α phosphorylation is the recruitment of protein phosphatase 1 (PP1), to fully dephosphorylate eIF2α and allow viral protein synthesis. Due to the functional relationship between BACE1, PKR, PP1 and AD we have performed a large (1122 cases and 1191 control individuals) case-control genetic analysis using two biallelic polymorphisms rs2254958 and rs7480390, located within the genes coding for PKR and the catalytic unit A of PP1, respectively. Although a trend to association of the rs2254958 TT genotype with AD risk was found, our results show that neither rs7480390 nor rs2254958 are associated with AD susceptibility.

关键词： Alzheimer’s Disease BACE1 PKR PP1 eIF2α

Cancer Res:HDAC抑制剂可促进单抗药物对HER2阳性肿瘤的治疗效果

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现代生物医学进展 2017年第18期17卷 I0001-I0002页

作者： mikolaj medon eva Vidacs Stephin J Vervoort Jason Li misty R. Jenkins Kelly m. Ramsbottom Joseph A. Trapani mark J. Smyth Phillip K. Darcy Peter W. Atadja michael A. Henderson Ricky W. Johnstone Nicole m. Haynes Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australia.Division of Surgical Oncology Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia. Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australia. Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australia. Bioinformatics Consulting Core Facility Cancer Research Division Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia. Cancer Immunology Research Program Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia.Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia. Cancer Immunology Research Program Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia. Cancer Immunology Research Program Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia.Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia. Immunology in Cancer and Infection Laboratory QIMR Berghofer Medical Research Institute Herston Queensland Australia. Cancer Immunology Research Program Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia.Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia. China Novartis Institute for Biomedical Research Shanghai China. Division of Surgical Oncology Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia. Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australia.Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia. Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australi

最近来自澳大利亚墨尔本的研究人员发现组蛋白去乙酰化酶抑制剂可以发动宿主免疫作为其抗肿瘤效应的一个基础。该研究为增强一些肿瘤免疫治疗药物的杀伤作用提供了新的方向。在这项发表在国际学术期刊Cancer Research上的研究中，研究... 详细信息

最近来自澳大利亚墨尔本的研究人员发现组蛋白去乙酰化酶抑制剂可以发动宿主免疫作为其抗肿瘤效应的一个基础。该研究为增强一些肿瘤免疫治疗药物的杀伤作用提供了新的方向。在这项发表在国际学术期刊Cancer Research上的研究中，研究人员发现组蛋白去乙酰化酶抑制剂panobinostat可以通过宿主免疫增强trastuzumab这种单抗治疗药物的抗肿瘤效果。

关键词：组蛋白去乙酰化酶抑制剂抗肿瘤效应治疗药物治疗效果 HDAC 单抗 Res 阳性

上循环、下循环、再循环——回收原料的有效应用

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国际纺织导报 2022年第2期50卷 1-2,6页

作者： E.Trenz 马昱吉(译) 于俊荣(校) 特吕茨施勒公司(德国) 不详

纺织行业已经把可持续性发展提上了议程.可持续纤维将替代有毒、有害化学物品,从而达到保护环境和资源以及改善人们的工作环境.从生产到回收的处理过程中,有很多方法可以实现这些目标.在设计机械设备时,纺织机械制造商特吕茨施勒公司更... 详细信息

纺织行业已经把可持续性发展提上了议程.可持续纤维将替代有毒、有害化学物品,从而达到保护环境和资源以及改善人们的工作环境.从生产到回收的处理过程中,有很多方法可以实现这些目标.在设计机械设备时,纺织机械制造商特吕茨施勒公司更多地关注于缩短工艺过程,提高原材料利用率和机器部件的耐用性,从而显著提高材料的回收率.

关键词：可持续性聚对苯二甲酸乙二醇酯(PET) 化学回收机械回收

每一座房子都是生活的老师马德里DIDOmESTIC公寓

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室内设计与装修 2014年第8期 111-117页

作者： Uriel Fogué eva Gil Carlos Palacios 许科

西班牙的设计公司Elii从来不缺大胆的设计,尤其在一些小空间的设计上常常有不俗的表现。本案的马德里公寓就是这样一个作品。这个带阁楼的公寓不到60 m2,但在设计师的奇思妙想之下,迸发出超乎想象的能量。

关键词：马德里公寓老师生活房子设计师西班牙小空间

桑给巴尔当地对Chwaka海湾潮汐、季风和海床的认识与实践

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人类环境杂志 1998年第8期27卷 675-682页

作者： eva Tobisson Jessica Andersson Zeninab m.Ngazy Lars Rydberg Ulf Cederlf 胡海瑛斯德哥尔摩大学人类社会学系发展研究部歌德堡大学海洋科学所歌德堡大学海洋学歌德堡大学本科生教学

Chwaka海湾是坦桑尼亚桑给巴尔温古贾岛东岸一个浅的潟湖。春季低水期50%以上海湾地区变得干枯。Chwaka海湾的潮汐、潮速和海床的地貌形态是目前在此处进行的跨领域研究的起始研究对象。研究区集中Chwaka村,此处是斯瓦希里人在海湾区的... 详细信息

Chwaka海湾是坦桑尼亚桑给巴尔温古贾岛东岸一个浅的潟湖。春季低水期50%以上海湾地区变得干枯。Chwaka海湾的潮汐、潮速和海床的地貌形态是目前在此处进行的跨领域研究的起始研究对象。研究区集中Chwaka村,此处是斯瓦希里人在海湾区的7个定居点之一。1997年8月和1998年3～6月进行的调查和观察中收集到Chwaka男子和妇女对海洋和海岸资源利用与管理的资料。研究表明当地居民对:不同的潮汐周期,半日潮、日潮和半月潮;风和降水的季节性变化;海床的地貌形态知识丰富。研究还表明他们利用这些知识对海湾和海湾资源达到最优化利用。Chwaka人民用自己的语言和分类系统描述月亮公转与潮汐周期之间的关系,而这在很大程度上与基础科学命名一致。不仅如此,他们脑海中对海床形态的描画与海湾水流的知识相结合,他们即使在春季极低水位时也能畅游自如。研究表明,自然条件和自然轮回虽然对生产有约束同时也创造了许多机会。文中以事例说明外部影响下有关海洋资源利用与管理机构系统所表现出的优点和弱点。Chwaka实例说明当地居民、研究者和政策制定者之间对话与合作在调查和发展实践中的重要性。

关键词：海湾潮汐季风海就桑给巴尔地区