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Characterization of Newly Developed Wheat/Barley Introgression Lines in Respect of Aluminium Tolerance

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American Journal of Plant Sciences 2012年第10期3卷 1462-1469页

作者： eva Darko Beáta Barnabás márta molnár-Láng Cell Biology Department of Agricultural Institute Centre for Agricultural Research Hungarian Academy of Sciences Martonvásár Hungary Department of Plant Genetic Resources and Organic Breeding of Agricultural Institute Centre for Agricultural Research Hungarian Academy of Sciences Martonvásár Hungary

The Al tolerance of newly developed wheat/barley disomic addition, substitution and translocation lines carry chromosomes of three different barley cultivars was evaluated by comparing the root growth in solution containing 75 μm AlCl3 at pH 4.0 to that of known Al-tolerant and sensitive wheat genotypes. The wheat Asakaze komugi, barley manas cultivars and their hybrid derivatives were found to have high levels of Al tolerance. The wheat line mv9kr1, barley cultivar Igri and progenies of the hybrids were sensitive to Al. In most cases, the Al tolerance of the wheat/barley introgression lines derived from Al-sensitive wheat mv9kr1 and barley Betzes with moderate Al tolerance was similar to that of the wheat parents, but the 2DS.2DL-1HS translocation line of mv9kr1/Betzes exhibited more intensive root growth, while accumulating less Al than the parental lines. This indicates that either the lack of the distal part of chromosome 2DL or the presence of the distal part of 1HS improved the Al tolerance level.

关键词： Aluminium Tolerance Barley Introgression Line Wheat

On the study of ricochet and penetration in sand,water and gelatin by spheres,7.62 mm APm2,and 25 mm projectiles

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Defence Technology（防务技术） 2016年第2期12卷 159-170页

作者： John F.mOXNES ∅yvind FR∅YLAND Stian SKRIUDALEN Anne K.PRYTZ Jan A.TELAND eva FRIIS Gard ∅DEGARDSTUEN Land Systems Division Norwegian Defence Research EstablishmentP.O.Box 25N0-2027 KjellerNorway Nammo Raufoss AS P.O.Box 162N0-2831 RaufossNorway

We examine the ricochet and penetration behavior in sand, water and gelatin by steel spheres, 7.62 mm APm2 and 25 mm projectiles. A threshold impact angle(critical angle) exists beyond which ricochet cannot occur. The Autodyn simulation code with the smooth particle hydrodynamic(SPH) method and Impetus Afea Solver with the corpuscular model are used and the results are compared with experimental and analytical results. The resistance force in sand for spheres was proportional to a term quadratic in velocity plus a term linear in velocity. The drag coefficient for the quadratic term was 0.65. The Autodyn and Impetus Afea codes simulate too large penetration due to the lack of a linear velocity resistance force. Critical ricochet angles were consistent with analytical results in the literature. In ballistic gelatin at velocities of 50–850 m/s a drag coefficient of 0.30 fits the high speed camera recordings if a linear velocity resistance term is included. However, only a quadratic velocity resistance force with drag coefficient that varies with the Reynolds number also fits the measurements. The simulation of a sphere in water with Autodyn showed too large drag coefficient. The 7.62 mm APm2 core simulations in sand fit reasonable well for both codes. The 25 mm projectile ricochet simulations in sand show consistency with the high speed camera recordings. Computer time was reduced by one to two orders of magnitudes when applying the Impetus Afea Solver compared to Autodyn code due to the use of the graphics processing units(GPU).

关键词：明胶微球渗透行为炮弹光滑粒子流体动力学阻力系数模拟显示高速摄像机砂

Fitness and health benefits of team handball training for young untrained women--A cross-disciplinary RCT on physiological adaptations and motivational aspects

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Journal of Sport and Health Science 2018年第2期7卷 139-148页

作者： Therese Hornstrup Johan m.Wikman Bjorn Fristrup Susana Povoas eva W.Helge Signe H.Nielsen Jorn W.Helge Jesper L.Andersen Lars Nybo Peter Krustrup Department of Nutrition Exercise and Sports University of Copenhagen Copenhagen N 2200 Denmark Research Center in Sports Sciences Health Sciences and Human Development CIDESD University Institute of Maia ISMAI Maia 4475-690 Portugal Center of Healthy Aging Department of Biomedical Sciences University of Copenhagen Copenhagen N 2200 Denmark Institute of Sports medicine Copenhagen Bispebjerg Hospital Copenhagen NV 2400 Denmark Department of Sports Science and Clinical Biomechanics SDU Sport and Health Sciences Cluster (SHSC) University of Southern Denmark Odense 3450 Denmark Sport and Health Sciences University of Exeter Exeter EX1 2LU UK

Purpose: The present study evaluated the effects of regular participation in small-sided team handball training on body composition, osteogenic response, physical performance, and cardiovascular risk factors, as well as well-being and motivation, in young untrained ***: Twenty-eight untrained 20- to 30-year-old women were randomized to a handball training group(HG; n = 14, height 170 ± 5 cm, weight 73 ± 11 kg, VO_(2peak) 37.7 ± 4.1 mL/min/kg) that trained 1.7 ± 0.3 times per week over 12 weeks(70 min 4 v 4 handball sessions) or an inactive control group(CG; n = 14, 169 ± 5 cm, 71 ± 12 kg, 38.1 ± 3.7 mL/min/kg). Physiological and psychological and motivational training adaptations were assessed pre-and post-intervention by dual-energy X-ray Absorptiometry(DXA) scans, blood sampling, physical tests, and ***: The average heart rate(HR) over all training sessions was equal to 85% ± 6% HR_(max). Between-group intervention effects were observed in favor of HG for muscle mass(2.1%, p = 0.024), proximal femur bone mineral density(0.8%, p = 0.041), Yo-Yo IE1 intermittent endurance test level 1(IE1) performance(35%, p mental treadmill test performance(11.5%, p = 0.003), but not total fat mass(p = 0.176),mean arterial blood pressure(p = 0.328), resting HR(p = 0.219), or blood lipids(p = 0.298—0.854). In CG, no changes were observed in any of the measured physiological variables after the training period. Compared to CG, HG had an increase in intrinsic motivation(p m handball training organized as small-sided games has marked beneficial effects on physical performance, musculoskeletal fitness, well-being, and motivation in untrained young women.

关键词：物理测试类脂化合物测试水平物理性能肉质量训练健康心血管

Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in murine model

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Chinese Journal of Integrative medicine 2020年第11期26卷 812-818页

作者： Juan Luis Santiago eva maria Galan-moya Jose Ramon munoz-Rodriguez miguel Angel de la Cruz-morcillo Francisco Javier Redondo-Calvo Ignacio Gracia-Fernandez Peter m.Elias Jose manuel Perez-Ortiz mao-Qiang man Dermatology Service Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Research Unit Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Oncology Laboratory Centro Regional de Investigaciones BiomedicasUniversidad de Castilla-La ManchaAlbacete(02008)Spain Instituto de Tecnologia Quimica y medioambiental Universidad de Castilla-La ManchaCiudad Real(13004)Spain Dermatology Service Vetera ns Affairs Medical Centerand Department of DermatologyUniversity of CaliforniaSan FranciscoCA(94121)USA Dermatology Hospital Southern Medical UniversityGuangzhou(510091)China

Objective To determine whether topical applications of thiosulfinate-enriched Allium sativum extract(TASE)can accelerate acute cutaneous wound healing(WH)in a murine *** Keratinocyte viability and in vitro wound closure were assessed in keratinocyte *** of topical TASE(0.5μg/mL of allicin in 97%ethanol)on acute cutaneous WH were determined in a murine model of acute cutaneous *** mice were alternately assigned to the vehicle-and TASE-treated groups(n=6 per group).Expression levels of mRNA for keratinocyte differentiation marker-related proteins(filaggrin,loricrin and involucrin)and lipid synthetic enzymes(elongation of very long chain fatty acids protein 4(ELOVL4),fatty acid synthase(FA2H),3-hydroxy-3-methyl-glutaryl-coenzyme A reductase(HmGCoA),and serine palmitoyltransferase(SPT))were assessed using real-time quantitative polymerase chain reaction on day 3 and 8 after wounding,while transepidermal water loss(TEWL)rates were measured in wounded *** TASE accelerated WH both in vivo(40%vs.22%reduction in wound area,Pmoreover,topical applications of TASE upregulated the expression levels of epidermal mRNA for ELOVL4,HmGCoA,SPT,filaggrin,loricrin and involucrin(Pmparison with vehicle alone on day 8(33.06±2.09 g/(m^2·h)vs.24.60±2.04 g/(m^2·h),Pmulated keratinocyte proliferation and formation of epidermal permeability barrier function,leading to acceleration of acute cutaneous *** products containing TASE could be used to manage acute cutaneous WH.

关键词： Allium sativum thiosulfinate wound healing permeability barrier keratinocytes proliferation

Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma

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World Journal of Gastroenterology 2011年第34期17卷 3899-3911页

作者： Borja Hernández-Breijo Jorge monserrat Sara Ramírez-Rubio eva P Cuevas Diana Vara Inés Díaz-Laviada m Dolores Fernández-moreno Irene D Román Javier P Gisbert Luis G Guijarro molecular Hepatic Toxicology Unit Biochemistry and Molecular Biology Department University of Alcalá Networked Biomedical Research Center of Hepatic and Digestive Diseases (CIBEREHD) medicine Department University of Alcalá Neuroendocrinology of Cannabinoid/Vanilloid System Unit Biochemistry and Molecular Biology Department University of Alcalá Gastroenterology Unit Hospital de la Princesa Institute of Health Research Princesa Networked Biomedical Research Center of Hepatic and Digestive Diseases (CIBEREHD)

AIm: To evaluate the efficacy and the safety of azathioprine (AZA) and buthionine sulfoximine (BSO) bylocalized application into HepG2 tumor in ***: Different hepatoma and colon carcinoma cell lines (HepG2, HuH7, Chang liver, LoVo, RKO, SW-48, SW-480) were grown in minimal essencial medium supplemented with 10% fetal bovine serum and 1% antibiotic/antimycotic solution and maintained in a humidified 37 ℃ incubator with 5% CO2. These cells were pretreated with BSO for 24 h and then with AZA for different times. We examined the effects of this combination on some proteins and on cellular death. We also studied the eff icacy and the safety of AZA (6 mg/kg per day) and BSO (90 mg/kg per day) in HepG2 tumor growth in vivo using athymic mice. We measured safety by serological markers such as aminotransferases and creatine ***: The in vitro studies revealed a new mechanism of action for the AZA plus BSO combination in the cancer cells compared with other thiopurines (6-mercaptopurine, 6-methylmercaptopurine, 6-thioguanine and 6-methylthioguanine) in combination with BSO. The cytotoxic effect of AZA plus BSO in HepG2 cells resulted from necroptosis induction in a mitochondrial-dependent manner. From kinetic studies we suggest that glutathione (GSH) depletion stimulates c-Jun amino-terminal kinase and Bax translocation in HepG2 cells with subsequent deregulation of mitochondria (cytochrome c release, loss of membrane potential), and proteolysis activation leading to loss of membrane integrity, release of lactate dehydrogenase and DNA degradation. Some of this biochemical and cellular changes could be reversed by N-acetylcysteine (a GSH replenisher). In vivo studies showed that HepG2 tumor growth was inhibited when AZA was combined with ***: Our studies suggest that a combination of AZA plus BSO could be useful for localizedtreatment of hepatocellular carcinoma as in the currently used transarterial chemoembolization method.

关键词：硫唑嘌呤结肠癌肝癌 HepG2细胞评价亚砜肿瘤生长临床

Review on laboratory preparation processes of polymer modified asphalt binder

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Journal of Traffic and Transportation Engineering(English Edition) 2023年第2期10卷 159-184页

作者： m.A.Dalhat Khaleel Al-Adham Transportation and Traffic Engineering Department College of EngineeringImam Abdulrahman Bin Faisal UniversityDammam 31451Saudi Arabia Shibh Al-Jazira Contracting Company Dammam 32257Saudi Arabia

Several previous studies have documented the progress in polymer modified asphalt binder with respect to materials'types and ***,limited or no effort was made to document findings on the laboratory preparation practices of polymer modified asphalt *** and clear disclosure of asphalt blend preparation method is necessary for research continuity,reproducibility,and accurate adaptation by future studies for analogy and reliable *** laboratory preparation processes of various modified asphalt binders have been reviewed in this *** affecting the optimal mixing of asphalt-polymer blends were *** optimal mixing conditions associated with different asphalt modifiers were *** in the literature on the current practice for the preparation and reporting of various modified asphalt binder was *** include styrene butadiene styrene(SBS),polyethylene(PE),waste tire rubber or crumb rubber(CR),ethylene vinyl acetate(eva),sulfur,polyphosphoric acid(PPA),epoxy,polyurethane,nano-materials,***,there is lack of modern innovative approached in the preparation of modified asphalt towards better *** is no clear standardized definition of term associated with asphalt binder preparation *** the limited and common types of polymers utilized for the modification of asphalt binder,it is possible to standardize the mixing procedure for several *** so could ease research continuity and facilitates accurate comparison of new studies with earlier ones.

关键词： Pavement engineering Polymer modified asphalt SBS PE Waste tire rubber

Nanovesicles Are Secreted during Pollen Germination and Pollen Tube Growth： A Possible Role in Fertilization

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molecular Plant 2014年第3期7卷 573-577页

作者： Noela Prado Juan de Dios Alche Juan Casado-Vela Salvador mas mayte Villalba Rosalia Rodriguez eva Batanero Departamento de Bioquimica y Biologia molecular Facultad de Qu[mica Universidad Complutense de Madrid 28040 Madrid Spain Departamento de Bioquimica Biologia Celular y Molecular de Plantas Estacion Experimental de1Zaidin (CSIC) E-18080 Granada Spain Spanish National Research Council (CSIC) Spanish National Centre for Biotechnoiogy (CNB) Darwin 3 Cantoblanco 28049 Madrid Spain

Dear Editor, During recent decades, a novel mechanism of secretion has been identified in a wide range of mammalian cells. It involves the release of bioactive membrane nanovesicles （30-100 nm）, termed exosomes, upon the fusion of multivesicular bodies with the plasma membrane （Thery et al., 2009）. Exosomes are implicated in diverse functions, such as scavenging of archaic proteins, intercellular messengers delivering cell-specific signals, and vehicles for transmissible pathogens. Exosomes have also been described in other organisms such as bacte- ria, Drosophila, and fungi.

关键词： OLIVE POLLEN ARABIDOPSIS EXPRESSION PROTEINS ALLERGEN PECTIN

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《发展心理语言学》介绍

当代语言学 2012年第1期14卷 95-98页

作者： Irina A.Sekerina eva m.Fernndez Harald Clahsen 姚岚中国计量学院外国语学院

2006年3月在美国纽约城市大学举办了一次“儿童语言加工的在线研究方法研讨会”。2008年John Benjamins出版社出版了《发展心理语言学——儿童语言加工的在线研究方法》（Developmental Psycholinguistics：On—line methods in Childre... 详细信息

2006年3月在美国纽约城市大学举办了一次“儿童语言加工的在线研究方法研讨会”。2008年John Benjamins出版社出版了《发展心理语言学——儿童语言加工的在线研究方法》（Developmental Psycholinguistics：On—line methods in Children＇s Language Processing）。

关键词：发展心理语言学 Language 语言加工 2008年城市大学出版社在线儿童

Depressant effects of Agastache mexicana methanol extract and one of major metabolites tilianin

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Asian Pacific Journal of Tropical medicine 2015年第3期8卷 185-190页

作者： maría eva González-Trujano Hilda Ponce-muoz Sergio Hidalgo-Figueroa Gabriel Navarrete-Vázquez Samuel Estrada-Soto Laboratorio de Neurofarmacologia de Productos Naturales de la Directión de Investigaciones en Neurociencias.Instituto National de Psiquiatria "Ramón de la Fuente muiz" méxico D.F.14370México Facultad de Farmacia Universidad Autonoma del Estado de MorelosCuernavaca.Morelos.México

Objective:To determine the depressant-like effects and the possible mechanism of action of tilianin isolated from active methanol extract of Agastache mexicana(***).Also,to establish the pharmacophoric requirements of tilianin,as a possible ligand of GABA_A/BZD receptor,by the alignment of ***-9896 and diindole,using a previously described pharmacophoric ***:Tilianin(30 to 300 mg/*** 300 mg/kg,pa.) and methanol crude extract(10 to 300 mg/kg,*** 300 mg/kg po.) from *** were evaluated for potential sedative and anxiolytic-like response drugs by using open-field,hole-board,cylinder of exploration,plus-maze and sodium pentobarbital-induced hypnosis mice ***:methanol extract and tilianin showed anxiolytic-like activity from a dosage of 30 mg/kg,*** 300 mg/kg,*** were less potent than diazepam 0.1 mg/kg.a reference anxiolytic drug ***,depressant activity of both potentiates sodium pentobarbital(SP)-induced sleeping *** anxiolytic-like effect of 30 mg/kg *** for the extract and tilianin,by using the plus-maze model,was partially prevented in the presence of flumazenil(a GABA_A/BZD antagonist,5 mg/kg ip.) but not in the presence of WAY100635(a selective 5-HT_(1A) receptor antagonist,0.32 mg/***.).Pharmacophoric modeling alignments of three agonist of GABA_A/BZD allow identify seven chemical *** contains six of the seven features previously ***:Results indicate that tilianin is one of the bioactive metabolites in the anxiolytic-like activity of *** its central nervous system uses,where GABA_A/BZD,but not 5-HT_(1A),receptors are partially involved.

关键词： Agastache mexicana Anxiety Benzodiazepine Central nervous system Sedative Tilianin