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Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome

Chinese Medical Journal 2005年第17期118卷 1413-1421页

作者： Loretta YC Yam Alfred YF Chan Thomas MT Cheung eva lh tsui Jane CK Chan Vivian CW Wong Division of Respiratory and Critical Care Medicine Department ofMedicine Pamela Youde Nethersole Eastern Hospital Hong KongChina Division of Respiratory and Critical Care Medicine Department ofMedicine Pamela Youde Nethersole Eastern Hospital Hong KongChina Division of Respiratory and Critical Care Medicine Department ofMedicine Pamela Youde Nethersole Eastern Hospital Hong KongChina Hong Kong Hospital Authority Head Office Hong Kong ChinaHong Kong Hospital Authority Head Office Hong Kong ChinaHong Kong Hospital Authority Head Office Hong Kong China

Severe acute respiratory syndrome is frequently complicated by respiratory failure requiring ventilatory support. We aimed to compare the efficacy of non-invasive ventilation against invasive mechanical ventilation tr... 详细信息

关键词： acute respiratory failure infection control invasive mechanical ventilation non-invasive ventilation severe acute respiratory syndrome

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Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome

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中华医学杂志(英文版) 2005年第17期 7-15页

作者： Loretta YC Yam,Alfred YF Chan,Thomas MT Cheung,eva lh tsui,Jane CK Chan,Vivian CW Wong China Division of Respiratory and Critical Care Medicine Department ofMedicine Pamela Youde Nethersole Eastern Hospital Hong Kong China Hong Kong Hospital Authority Head Office Hong Kong China Hong Kong Hospital Authority Head Office Division of Respiratory and Critical Care Medicine Hong Kong China Hong Kong Hospital Authority Head Office Hong Kong China Department ofMedicine Pamela Youde Nethersole Eastern Hospital Hong Kong China Division of Respiratory and Critical Care Medicine Department ofMedicine Pamela Youde Nethersole Eastern Hospital Hong Kong

Background Severe acute respiratory syndrome is frequently complicated by respiratory failure requiringventilatory support.We aimed to compare the efficacy of non-invasive ventilation against invasive mechanicalventilation treating respiratory failure in this disease.Methods Retrospective analysis was conducted on all respiratory failure patients identified from the HongKong Hospital Authority Severe Acute Respiratory Syndrome Database.Intubation rate, mortality and secondaryoutcome of a hospital utilizing non-invasive ventilation under standard infection control conditions ( NIVHospital) were compared against13 hospitals using solely invasive ventilation (IMVHospitals).Multiple logisticregression analyses with adjustments for confounding variables were performed to test for association betweenoutcomes and hospital groups.Results Both hospital groups had comparable demographics and clinical profiles, but NIV Hospital (42patients) had higher lactate dehydrogenase ratio and worse radiographic score on admission and ribavirin-corticosteroid commencement.Compared to IMV Hospitals (451 patients), NIV Hospital had lower adjustedodds ratios for intubation (0.36, 95% CI 0.164 -0.791,P=0.011) and death (0.235, 95% CI 0.077 -0.716,P=0.011), and improved earlier after pulsed steroid rescue.There were no instances of transmission ofsevere acute respiratory syndrome among health care workers due to the use of non-invasive ventilation.Conclusion Compared to invasive mechanical ventilation, non-invasive ventilation as initial ventilatory supportfor acute respiratory failure in the presence of severe acute respiratory syndrome appeared to be associated withreduced intubation need and mortality.

关键词： acute respiratory failure · infection control · invasive mechanical ventilation · non-invasive ventilation · severe acute respiratory syndrome

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补益中药对老龄雄性大鼠下丘脑神经递质—性腺轴机能作用的研究

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上海医科大学学报 1991年第5期18卷 373-378页

作者：张新民沈自尹王文健张玲娟陈素珍上海医科大学中西医结合研究所

本文通过对3、18和24月龄雄性大鼠下丘脑NE、DA、5-HT、5-HIAA和下丘脑、垂体LRH;垂体、血lh;血E_2、T的测定,研究了老龄大鼠下丘脑神经递质及性腺轴机能的增龄性变化,并在此基础上探讨了补益中药对老龄大鼠下丘脑—垂体—性腺轴机能的... 详细信息

本文通过对3、18和24月龄雄性大鼠下丘脑NE、DA、5-HT、5-HIAA和下丘脑、垂体LRH;垂体、血lh;血E_2、T的测定,研究了老龄大鼠下丘脑神经递质及性腺轴机能的增龄性变化,并在此基础上探讨了补益中药对老龄大鼠下丘脑—垂体—性腺轴机能的作用。结果提示:老龄大鼠下丘脑机能的衰退可能是性腺轴机能衰退的主要原因;补益中药对老龄大鼠性腺轴机能的作用很可能是通过“改善”或“延缓”下丘脑或更高中枢调控机能的老年性变化来实现的。

关键词：补益中药性腺轴机能抗衰老

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