检索结果-南通市图书馆

Secondary protective control for mitigation of protection misoperations in electric power systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2016年第3期4卷 427-439页

作者： N.eva WU Qiu QIN Department of Electrical and Computer Engineering Binghamton UniversityBinghamtonNY 13902USA

This paper investigates the feasibility of a selective secondary protective control strategy proposed to maximize the likelihood of recovery from misoperations of the existing(primary) protection in a power system. A scalable stochastic discrete-state model is established, taking into consideration of the processes of protection misoperations and their mitigations. Such misoperations have been a main culprit of cascading failures in modern power systems. The likelihood of recovery from protection misoperations is quantified by a set of security indices that formally incorporate the uncertain knowledge of the continuous-state of rotor angles/speed deviations of synchronous generators and that of the discretestate of equipment faults and primary protection misoperations. The proposed secondary protection leverages on the ever more available time-synchronized samples of networked sensors for diagnosis and fault-tolerant control to cost effectively improving power system reliability without altering the existing protection system. The technology readiness for implementing the secondary protective control is examined through a three-area test system.

关键词： Availability and security Fault-tolerance Fault-coverage and fault-diagnosis Hybrid modeling and

Time for a Nuclear Meeting： Protein Trafficking and Chromatin Dynamics Intersect in the Plant Circadian System

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2012年第3期5卷 554-565页

作者： eva Herrero Seth J. Davis Max Planck Institute for Plant Breeding Research Carl-von-Linne＇weg 10 50829 Cologne Germany Present address： MRC National Institute for Medical Research The Ridgeway Mill Hill NW7 1AA London UK

Circadian clocks mediate adaptation to the 24-h world. In Arabidopsis, most circadian-clock components act in the nucleus as transcriptional regulators and generate rhythmic oscillations of transcript accumulation. In this review, we focus on post-transcriptional events that modulate the activity of circadian-clock components, such as phosphorylation, ubiquitination and proteasome-mediated degradation, changes in cellular localization, and protein-protein interactions. These processes have been found to be essential for circadian function, not only in plants, but also in other circadian systems. Moreover, light and clock signaling networks are highly interconnected. In the nucleus, light and clock compo- nents work together to generate transcriptional rhythms, leading to a general control of the timing of plant physiological processes.

关键词： circadian light signaling chromatin cellular dynamics ubiquitin/proteasome-mediated proteolysis

Highlights of ASS234: a novel and promising therapeutic agent for Alzheimer’s disease therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第1期15卷 30-35页

作者： Alejandro Romero JoséMarco-Contelles eva Ramos Department of Pharmacology&Toxicology Faculty of Veterinary MedicineComplutense University of MadridMadridSpain Laboratory of Medicinal Chemistry Institute of General Organic Chemistry(CSIC)MadridSpain

There is no effective treatment to face Alzheimer’s disease *** molecules are a good approach against the multiple physiopathological events associated with its development and *** this context,N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine(ASS234)has been tested achieving promising ***234 has demonstrated to cross the blood-brain barrier in vivo,and a good in silico safety profile being less toxic than ***,ASS234 reversibly inhibits human acetyl-and butyryl-cholinesterase,and irreversibly inhibits human monoamine oxidase A and ***,this multitarget molecule has antioxidant and neuroprotective properties,and inhibitsΑβ1–42 andΑβ1–40 *** about the mechanism of action,several signaling pathways related to Alzheimer’s disease had been explored showing that ASS234 induces the wingless-type MMTV integration site(Wnt)family and several members of the heat shock proteins family and moreover counteracts neuroinflammatory and oxidative stress-related genes promoting the induction of several key antioxidant ***,in vivo experiments with ASS234 in C57BL/6J mice displayed its ability to reduce amyloid plaque burden and gliosis in the cortex and hippocampus,ameliorating scopolamine-induced learning *** we gather the information regarding ASS234 evaluated so far,showing its ability to face different targets,necessary to counteract a neurodegenerative disease as complex as the Alzheimer’s disease.

关键词： AChE BuChE gene expression heat shock proteins inflammation in silico toxicology MAO A/B neuroprotection oxidative stress Wnt signaling

SPINOPHILIN: A multiplayer tumor suppressor

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第1期10卷 187-198页

作者： eva M.Verdugo-Sivianes Amancio Carnero Instituto de Biomedicina de Sevilla IBISHospital Universitario Virgen del RocioConsejo Superior de Investigaciones CientificasUniversidad de SevillaSeville 41013Spain CIBERONC Instituto de Salud Carlos IlMadrid 28029Spain

SPINOPHILIN(SPN,PPP1R9B or NEURABIN-2)is a multifunctional protein that regulates protein-protein interactions in different cell signaling *** is also one of the regulatory subunits of protein phosphatase 1(PP1),implicated in the dephosphorylation of retinoblastoma protein(pRB)during cell *** SPN gene has been described as a tumor suppressor in different human tumor contexts,in which low levels of SPN are correlated with a higher grade and worse *** addition,mutations of the SPN protein have been reported in human ***,an oncogenic mutation of sPN,A566V,was described,which affects both the SPN-PP1 interaction and the phosphatase activity of the holoenzyme,and promotes p53-dependent tumorigenesis by increasing the cancer stem cell(CsC)pool in breast ***,the loss or mutation of SPN could be late events that promotes tumor progression by increasing the CSC pool and,eventually,the malignant behavior of the tumor.

关键词： Cancer therapy Phosphatase PP1 SPINOPHILIN Tumor suppressor Tumorigenesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

护理领域证据临床实施障碍因素的研究进展

中华护理杂志 2024年第18期59卷 2290-2296页

作者：杨福娜徐晓霞石红英何家欣邾萍王慧琳郑州大学附属肿瘤医院/河南省肿瘤医院护理部郑州市450008 郑州大学附属肿瘤医院/河南省肿瘤医院院长办公室郑州市450008 香港理工大学护理学院中国香港江苏省肿瘤医院肿瘤内科中国医学科学院北京协和医学院肿瘤医院早诊早治办公室

护理工作作为全球卫生健康事业的重要组成部分,护理学科开展实施性研究任重而道远。如何减少证据与护理实践之间的差距,将证据传播和应用到护理实践中,是护理领域亟需解决的问题。该研究基于实施科学视角,梳理了护理领域证据临床实施现... 详细信息

护理工作作为全球卫生健康事业的重要组成部分,护理学科开展实施性研究任重而道远。如何减少证据与护理实践之间的差距,将证据传播和应用到护理实践中,是护理领域亟需解决的问题。该研究基于实施科学视角,梳理了护理领域证据临床实施现状、临床实施障碍因素的理论框架、临床实施障碍因素分析的研究方法及具体内容,并提出相关建议,以期为进一步推动护理领域证据的实施提供指导。

关键词：实施科学护理学证据实施障碍因素综述

Ethylene and Cytokinin:Partners in Root Growth Regulation

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2019年第10期12卷 1312-1314页

作者： Christina Artner eva Benkova Institute of Science and Technology Austria Am Campus 1KlosterneuburgAustria

Ethylene and cytokinin,two plant hormones with essential functions throughout the plant's life cycle,contribute to a wide spectrum of physiological,biochemical,and developmental *** the last decades,the molecular mechanisms underlying their biosynthesis and metabolism as well as pathways mediating their perception and signal transduction have been *** machineries controlling the activities of these two central hormonal regulators appear robust and autonomous,in the ever-changing environmental conditions that plants face,survival is dependent on their tight communication and mutually balanced activities.A recent work by Zdarska et al.(2019)is trying to address the challenging question regarding the mechanisms underlying the cytokinin and ethylene *** study reveals an intriguing,multilayered nature of hormonal interaction,in which the EHYLENE RESISTANT 1(ETR1)receptor upon perceiving an ethylene signal activates a multistep phosphorelay(MSP)cytokinin transduction cascade,integrating ethylene and cytokinin in the control of root apical meristem *** parallel,activation of canonical ethylene signaling adjusts the responsiveness of the cytokinin pathway by transcriptional upregulation of one of its key signaling components,the ARR10 response regulator(Figure 1).Importantly,unlike the canonical ethylene transduction machinery,ethylene input into the MSP is dependent on histidine kinase activity of ETR1 receptor.

关键词： Ethylene Root metabolism

MINIMIZING EXCITATION LIGHT LEAKAGE AND MAXIMIZING MEASUREMENT SENSITIVITY FOR MOLECULAR IMAGING WITH NEAR-INFRARED FLUORESCENCE

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2011年第3期4卷 301-307页

作者： BANGHE ZHU eva M.SEVICK-MURACA Center for Molecular Imaging The Brown Foundation Institute of Molecular Medicine The University of Texas Health Science Center at Houston Houston TX 77030USA

Near-infraredfluorescence(NIRF)imaging involves the separation of weakfluorescence signals from backscattered excitation *** measurement sensitivity of current NIRF imaging systems is limited by the excitation light leakage through *** this contribution,the authors demonstrate that the excitation light leakage can be suppressed upon using appropriatefilter combination and *** excitation light leakage and measurement sensitivity were assessed and compared in this study by computing the transmission ratios of excitation to emission light collected and the signal-to-noise ratios in well-controlled phantom studies with differentfilter combinations and *** appropriatefilter combinations and permutations,we observe as much as two orders of magnitude reduction in the transmission ratio and higher signal-to-noise ratio.

关键词： Molecular imaging fluorescence opticalfilter excitation light leakage noise floor

The many faces of cGAS:how cGAS activation is controlled in the cytosol,the nucleus,and during mitosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第8期6卷 2261-2263页

作者： Anna-Maria Herzner Martin Schlee eva Bartok Department of Cancer Immunology and Immune Modulation Boehringer Ingelheim Pharma GmbH&Co.KGBiberach an der RiBGermany lnstitute of Clinical Chemistry and Clinical Pharmacology University HospitalUniversity of BonnBonnGermany Unit of Experimental Immunology Department of Biomedical SciencesInstitute of Tropical MedicineAntwerpBelgium

In their recently published study in Science,Li et al.1 unravel how hyperphosphorylation and chromatin-tethering of the double-stranded(dsDNA)sensor cGAMP synthase(cGAS)prevent self DNA recognition during mitosis(Fig.1);providing important insight into how this innate immune sensor balances its essential function for pathogen defense against potential autoinflammation.

关键词： activation sensor insight

Subcellular Distribution of Glutathione Precursors in Arabidopsis thaliana

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2011年第12期53卷 930-941页

作者： Barbara eva Koffler Romana Maier Bernd Zechmann University of Graz Institute of Plant Sciences 8010 Graz Austria Graz University of Technology Institute for Electron Microscopy and Fine Structure Research 8010 Graz Austria

Glutathione is an important antioxidant and has many important functions in plant development, growth and defense. Glutathione synthesis and degradation is highly compartment-specific and relies on the subcellular availability of its precursors, cysteine, glutamate, glycine and γ-glutamylcysteine especially in plastids and the cytosol which are considered as the main centers for glutathione synthesis. The availability of glutathione precursors within these cell compartments is therefore of great importance for successful plant development and defense. The aim of this study was to investigate the compartmentspecific importance of glutathione precursors in Arabidopsis thaliana. The subcellular distribution was compared between wild type plants （Col-0）, plants with impaired glutathione synthesis （glutathione deficient pad2-1 mutant, wild type plants treated with buthionine sulfoximine）, and one complemented line （OE3） with restored glutathione synthesis. Immunocytohistochemistry revealed that the inhibition of glutathione synthesis induced the accumulation of the glutathione precursors cysteine, glutamate and glycine in most cell compartments including plastids and the cytosol. A strong decrease could be observed in γ-glutamylcysteine （γ-EC） contents in these cell compartments. These experiments demonstrated that the inhibition of γ-glutamylcysteine synthetase （GSH1） - the first enzyme of glutathione synthesis - causes a reduction of γ-EC levels and an accumulation of all other glutathione precursors within the cells.

关键词： Arabidopsis cysteine glutamate glutathione glycine.