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Long-term outcomes of endoscopic submucosal dissection and surgery for undifferentiated intramucosal gastric cancer regardless of size

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World Journal of Gastroenterology 2022年第8期28卷 840-852页

作者： Gil Ho lee eunyoung lee Bumhee Park Jin Roh Sun Gyo Lim Sung Jae Shin Kee Myung lee Choong-Kyun Noh Department of Gastroenterology Ajou University School of MedicineSuwon 16499South Korea Department of Biomedical Informatics Ajou University School of MedicineSuwon 16499South Korea Department of Pathology Ajou University School of MedicineSuwon 16499South Korea

BACKGROUND The clinical outcomes of endoscopic submucosal dissection(ESD)for undifferentiated(UD)intramucosal early gastric cancer(EGC)compared with those of surgery,regardless of lesion size,are not well ***,there is a concern regarding the treatment plan before and after ESD in cases of UD intramucosal EGC within expanded *** To evaluate clinical outcomes of ESD compared with those of surgery in UD intramucosal EGC patients regardless of tumor *** We enrolled patients with UD intramucosal EGC after ESD with complete resection or surgery from January 2005 to August 2020 who met the within or beyond expanded indications with lesion size>2 cm(the only non-curative factor).Overall,123 and 562 patients underwent ESD and surgery,*** propensity-score matching,clinical and long-term outcomes,i.e.,recurrencefree survival(RFS)and overall survival(OS),were *** multivariable Cox proportional hazard model with treatment modality and ESD indication was used to evaluate the recurrence *** After matching,119 patients each were finally enrolled in the ESD and surgery *** median length of hospital stay was shorter in the ESD group than surgery group(4.0 vs 9.0 days,P<0.001).Four cases of recurrence after ESD were local recurrences,all of which occurred within 1 *** recurrence was seven(5.9%)and two(1.7%)in the ESD and surgery groups,*** difference was observed between the two groups with respect to OS(P=0.948).However,the ESD group had inferior RFS compared with the surgery group(P=0.031).ESD was associated with the risk of recurrence after initial treatment in all enrolled patients(hazard ratio,5.2;95%confidence interval:1.0-25.8,P=0.045).CONCLUSION Although OS was similar between the two groups,surveillance endoscopy was important for the ESD than for the surgery group because RFS was inferior and local recurrence was an issue.

关键词： Early gastric cancer Undifferentiated cancer Expanded indication Endoscopic submucosal dissection Surgery

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A Test Case Prioritization through Correlation of Requirement and Risk

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Journal of Software Engineering and Applications 2012年第10期5卷 823-835页

作者： Miso Yoon eunyoung lee Mikyoung Song Byoungju Choi Department of Computer Science Ewha Womans University Seoul Korea

Test case prioritization techniques have been focused on regression testing which is conducted on an already executed test suite. In fact, the test case prioritization for new testing is also required. In this paper, we propose a method to prioritize new test cases by calculating risk exposure value for requirements and analyzing risk items based on the calculation to evaluate relevant test cases and thereby determining the test case priority through the evaluated values. Moreover, we demonstrate effectiveness of our technique through empirical studies in terms of both APFD and fault severity.

关键词： Test Case Priority Risk-Based Testing Requirement Analysis Risk Exposure

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Variation Patterns of NLR Clusters in Arabidopsis thaliana Genomes

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Plant Communications 2020年第4期1卷 129-143页

作者： Rachelle R.Q.lee eunyoung Chae Department of Biological Sciences National University of SingaporeSingapore 117558Singapore

The nucleotide-binding domain and leucine-rich repeat(NLR)gene family is highly expanded in the plant lineage with extensive sequence and structure *** survey the landscape of NLR expansion,we mined the published long-read data generated by the resistance gene enrichment sequencing of 64 diverse Arabidopsis thaliana *** found that the hot spots of massive multi-gene NLR cluster expansion did not typically span the whole cluster;instead,they were restricted to a handful of,or only one,dominant radiation(s).All sequences in such a radiation were distinct from other genes in the cluster but not from each other in the clade,making it difficult to assign trustworthy reference-based orthologies when multiple reference genes were present in the ***,NLR genes can be broadly divided into two types:radiating or high-fidelity,where high-fidelity genes are well conserved and well separated from other clades.A similar distinction could be made for NLR clusters,depending on whether cluster size was determined primarily by extensive radiation or the presence of numerous high-fidelity *** also identified groups of well-conserved NLR clades that were missing from the Columbia-0 reference *** suggests that the classification of NLRs using gene IDs from a single reference accession can rarely capture all major paralogs in a cluster accurately and representatively and that a referenceagnostic perspective is required to properly characterize these additional ***,we present a quantitative visualization method for differentiating these situations in a given clade of interest.

关键词： NLR cluster evolution phylogenetics disease resistance plant immunity

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PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

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Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles

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Bioactive Materials 2022年第2期7卷 20-34页

作者： Donghyun lee Soonmin Kwon Seok-young Jang eunyoung Park Yeeun lee Heebeom Koo Department of Medical Life Sciences Department of Biomedicine&Health Sciencesand Catholic Photomedicine Research InstituteCollege of MedicineThe Catholic University of Korea222 Banpo-daeroSeocho-guSeoul06591Republic of Korea

Photodynamic therapy(PDT)has been applied in clinical treatment of tumors for a long ***,insufficient supply of pivotal factors including photosensitizer(PS),light,and oxygen in tumor tissue dramatically reduces the therapeutic efficacy of *** have received an influx of attention as drug carriers,and recent studies have demonstrated their promising potential to overcome the obstacles of PDT in tumor *** optimization for passive targeting,ligand modification for active targeting,and stimuli-responsive release achieved efficient delivery of PS to tumor *** trials using upconversion NPs,two-photon lasers,X-rays,and bioluminescence have provided clues for efficient methods of light delivery to deep *** have been made to overcome unfavorable tumor microenvironments via artificial oxygen generation,Fenton reaction,and combination with other chemical *** this review,we introduce these creative approaches to addressing the hurdles facing PDT in *** particular,the studies that have been validated in animal experiments are preferred in this review over proof-of-concept studies that were only performed in cells.

关键词： Photodynamic therapy Nanoparticle Tumor-targeting Drug delivery Tissue penetration

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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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Genus Polynomials of Cycles with Double Edges

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Acta Mathematica Sinica,English Series 2011年第3期27卷 595-606页

作者： eunyoung BAEK Jongyook PARK Department of Mathematics Pohang University of Science and Technology Pohang 790-784 Korea

Two cellular embeddings i ： G→S and j ： G → S of a connected graph G into a closed orientable surface S are equivalent if there is an orientation-preserving surface homeomorphism h ： S → S such that hi = j. The genus polynomial of a graph G is defined by g[G]（x）=∞∑g=0agx^g, where ag is the number of equivalence classes of embeddings of G into the orientable surface Sg with g genera. In this paper, we compute the genus polynomial of a graph obtained from a cycle by replacing each edge by two multiple edges.

关键词： Embedding genus genus distribution genus polynomial

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Nucleocytoplasmic trafficking during immunity

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Molecular Plant 2021年第10期14卷 1612-1614页

作者： Baptiste Castel eunyoung Chae Department of Biological Sciences National University of SingaporeSingapore 117558Singapore

Major signaling components in the plant immune system have been discovered via genetic *** use of ethylmethane sulfonate or fast-neutron mutagenesis has generated a myriad of mutants with a hyper-or hypoactivated immune system,which led to the discovery that nucleotide-binding(NB),leucine-rich repeat(LRR)proteins(NLRs)are the major intracellular immune receptors and that NLRs require core signaling components such as EDS1 and NDR1.

关键词： system methane immunity

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New strategy for reversal tolerant anode for automotive polymer electrolyte fuel cell

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Chinese Chemical Letters 2019年第6期30卷 1186-1189页

作者： Chanho Pak Seung Woo lee Chaekyung Baik Bong Ho lee Dae Jong You eunyoung You Graduate Program of Energy Technology School of Integrated Technology Institute of Integrated Technology Gwangju Institute of Science and Technology Gwangju 61005 Republic of Korea Fuel Cell Engineering Core Technology Team Division of Electric Powertrain Hyundai Mobis Co. Ltd. Yongin Gyeonggi-do 16891 Republic of Korea

Since the commercialization of the fuel cell electric vehicles (FCEVs), the polymer electrolyte membrane fuel cell system has been actively improved as a powertrain for ultimate environment-friendly vehicle. During the FCEV operation, various transient conditions such as start-up/shut-down and fuel starvation occur irregularly, which deteriorates the durability of the membrane electrode assembly. In particular, when fuel starvation occurs, the carbon support in the anode is oxidized within few minutes, thus the mitigation of this phenomenon is essential for securing the durability. This short review introduces the concept of reversal tolerant anode (RTA), which is a mitigation method using an oxygen evolution catalyst and reviews some previous reports. In addition, new approach for RTA suggested by authors recently, which is the replacement of Pt anode catalyst by multifunctional IrRu alloy catalyst that simultaneously exhibits the activities for the hydrogen oxidation reaction and the oxygen evolution reaction is introduced.

关键词： Multifunctional IrRu alloy catalyst Reversal tolerant anode Hydrogen oxidation reaction catalyst Oxygen evolution reaction catalyst Cell reversal durability Polymer electrolyte membrane fuel cell

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