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Superinsulating BNNS/PVA Composite Aerogels with High Solar Reflectance for Energy-Efficient Buildings

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Nano-Micro Letters 2022年第3期14卷 292-307页

作者： Jie Yang Kit‑Ying Chan Harun Venkatesan eunyoung kim Miracle Hope Adegun Jeng‑Hun Lee Xi Shen Jang‐Kyo kim Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongPeople’s Republic of China Department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongPeople’s Republic of China

With the mandate of worldwide carbon neutralization,pursuing comfortable living environment while consuming less energy is an enticing and unavoidable *** composite aerogels with super thermal insulation and high sunlight reflection are developed for energy-efficient buildings.A solvent-assisted freeze-casting strategy is used to produce boron nitride nanosheet/polyvinyl alcohol(BNNS/PVA)composite aerogels with a tailored alignment channel *** effects of acetone and BNNS fillers on microstructures and multifunctional properties of aerogels are *** acetone in the PVA suspension enlarges the cell walls to suppress the shrinkage,giving rise to a lower density and a higher porosity,accompanied with much diminished heat conduction throughout the whole *** addition of BNNS fillers creates whiskers in place of disconnected transverse ligaments between adjacent cell walls,further ameliorating the thermal insulation transverse to the cell wall *** resultant BNNS/PVA aerogel delivers an ultralow thermal conductivity of 23.5 mW m^(−1) K^(−1) in the transverse *** superinsulating aerogel presents both an infrared stealthy capability and a high solar reflectance of 93.8%over the whole sunlight wave-length,far outperforming commercial expanded polystyrene foams with reflective *** anisotropic BNNS/PVA composite aerogel presents great potential for application in energy-saving buildings.

关键词： Boron nitride nanosheets Solvent-assisted freeze-casting Thermally insulating aerogel Solar reflectance Energy-saving buildings

Anisotropic,Wrinkled,and Crack-Bridging Structure for Ultrasensitive,Highly Selective Multidirectional Strain Sensors

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Nano-Micro Letters 2021年第8期13卷 121-135页

作者： Heng Zhang Dan Liu Jeng-Hun Lee Haomin Chen eunyoung kim Xi Shen Qingbin Zheng Jinglei Yang Jang-Kyo kim Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongPeople’s Republic of China School of Science and Engineering The Chinese University of Hong KongShenzhen 518172GuangdongPeople’s Republic of China

Flexible multidirectional strain sensors are crucial to accurately determining the complex strain states involved in emerging sensing *** considerable efforts have been made to construct anisotropic structures for improved selective sensing capabilities,existing anisotropic sensors suffer from a trade-off between high sensitivity and high stretchability with acceptable ***,an ultrasensitive,highly selective multidirectional sensor is developed by rational design of functionally different anisotropic *** bilayer sensor consists of an aligned carbon nanotube(CNT)array assembled on top of a periodically wrinkled and cracked CNT-graphene oxide *** transversely aligned CNT layer bridge the underlying longitudinal microcracks to effectively discourage their propagation even when highly stretched,leading to superior sensitivity with a gauge factor of 287.6 across a broad linear working range of up to 100%*** wrinkles generated through a pre-straining/releasing routine in the direction transverse to CNT alignment is responsible for exceptional selectivity of 6.3,to the benefit of accurate detection of loading directions by the multidirectional *** work proposes a unique approach to leveraging the inherent merits of two cross-influential anisotropic structures to resolve the trade-off among sensitivity,selectivity,and stretchability,demonstrating promising applications in full-range,multi-axis human motion detection for wearable electronics and smart robotics.

关键词： Anisotropic strain sensor Wrinkle Aligned carbon nanotube Stretchability Complex motion detection

Comparative efficacy and optimal duration of first-line antibiotic regimens for acute otitis media in children and adolescents:a systematic review and network meta-analysis of 89 randomized clinicaltrials

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World Journal of Pediatrics 2024年第3期20卷 219-229页

作者： Min Seo kim Jae Han kim Seohyun Ryu Seung Won Lee Dong Keon Yon eunyoung kim Ai Koyanagi Elena Dragioti Jae Il Shin Lee Smith Samsung Advanced Institute forHealth Sciences&Technology(SAIHST) Samsung Medical CenterSungkyunkwan UniversitySeoulRepublic of Korea Yonsei University Collegeof Medicine SeoulRepublicof Korea Department of Precision Medicine Sungkyunkwan University School of MedicineSuwonRepublic of Korea Center for Digital Health Medical Science Research InstituteKyung Hee University College of MedicineSeoulRepublic of Korea Evidence-Based Research Laboratory Department of Clinical Pharmacy and Pharmaceutical CareCollege of PharmacyChung-Ang UniversitySeoulRepublic of Korea Parc Sanitari Sant Joan de Deu/CIBERSAM/ISCIII Universitat de BarcelonaFundacio Sant Joan de Déu.Sant Boi de LlobregatBarcelonaSpain ICREA Pg.Lluis Companys 23BarcelonaSpain Pain and Rehabilitation Centre and Department of Medical and Health SciencesLinkoping University58185 LinkopingSweden Department of Pediatrics Yonsei University College of MedicineYonsei-ro 50Seodaemun-gu8044Seoul 03722Republic of Korea Centre for Health Performanceand WellbeingAnglia Ruskin UniversityCambridge CB11PTUK Research Laboratory Psychology of Patients Families&Health ProfessionalsDepartment of NursingSchool of Health SciencesUniversity of IoanninaIoannina 45500Greece

Introduction Antibiotic use for acute otitis media(AOM)is one of the major sources of antimicrobial ***,the effective minimal antibiotic duration for AOM remains ***,guidelines often recommend broad ranges(5-10 days)of antibiotic use,yet the clinical impact of such a wide window has not been *** We systematically searched PubMed/MEDLINE,Embase,Scopus,Web of Science,and Cochrane Library from database inception to 6 October *** meta-analysis was conducted on randomized controlled trials that assessed antibiotic treatment for AOM in children(PROSPERO CRD42020196107).Results For amoxicillin and amoxicillin-clavulanate,7-day regimens were noninferior to 10-day regimens in clinical responses[amoxicillin:risk ratio(RR)0.919(95%CI 0.820-1.031),amoxicillin-clavulanate:RR 1.108(0.957-1.282)],except for≤2 *** the third-generation cephalosporins,7-day and 10-day regimens had similar clinical responses compared to placebo[7-day:RR 1.420(1.190-1.694),10-day:RR 1.238(1.125-1.362)compared to placebo].However,5-day regimens of amoxicillin-clavulanate and third-generation cephalosporins were inferior to 10-day *** to amoxicillin,a shorter treatment duration was tolerable with *** Our findings indicated that 1O days of antibiotic use may be unnecessarily long,while the treatment duration should be longer than 5 ***,5-day regimens would be sufficient for a modest treatment *** findings revealed that the current wide range of recommended antibiotic durations may have influenced the clinical outcome of AOM,and a narrower antibiotic duration window should be re-established.

关键词： Amoxicillin-potassium Amoxicillin Antibacterial agents Cephalosporins Duration of therapy

Workshop design for enhancing the appropriateness of idea generation using analogical thinking

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International Journal of Innovation Studies 2017年第2期1卷 134-143页

作者： eunyoung kim Human Life Design Area School of Knowledge ScienceJapan Advanced Institute of Science and Technology1-1 AsahidaiNomiIshikawa 923Japan

As technologies advance and replace human labor in a variety of settings,we focus our attention on human creativity for generating new *** organizations,more than ever,recognize that they need employees who think creatively to maintain their competitive ***,there is a lack of research assessing new ideas and influential factors in generating innovative *** aim of this study is to identify the factors that influence the creation of innovative *** conducted two different types of workshops with 22 subjects and 23 subjects *** the first workshop,subjects were asked to generate new business ideas through analogical *** a result,half of the participants generated appropriate ideas,and three influential factors were determined:categorization skill,deliberation,and trial and *** second workshop was designed to facilitate participants to enhance these three *** a result,70%of the participants could generate appropriate *** identifying influential factors,this paper suggests a procedure for designing an innovationworkshop that enables the creation of appropriate ideas.

关键词： Analogical thinking Appropriateness in ideas generated Trial and error Categorization Deliberation

Molecules “buckle up” to drive layered hybrid perovskites into single-crystal nanowires in water

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Science China Chemistry 2025年第1期68卷 3-4页

作者： Seokhyoung kim Department of Chemistry Michigan State University

Layered 2D metal halide perovskites (MHPs) are one of the most exciting candidates for next-generation light sources owing to their outstanding optoelectronic properties. These properties are readily tunable by controlling the halide composition, number of inorganic layers, and the chemistry of organic cations. Another key element that can substantially impact the materials’ functionalities is crystal morphology [1].

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Role of glutathione transferase in phase separation of FUS and TAF15 in neurons

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Neural Regeneration Research 2025年第7期20卷 1999-2000页

作者： Kiyoung kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disorder characterized by the degeneration of motor neurons in the brain and spinal cord,leading to muscle weakness,paralysis,and ultimately death(Cleveland and Rothstein,2001).Frontotemporal lobar degeneration(FTLD)is a neurodegenerative disease affecting the frontal and temporal lobes of the brain,leading to changes in behavior,personality,and language(Van Langenhove et al.,2012).Both ALS and FTLD are classified as proteinopathies in which abnormal protein aggregation and accumulation in neurons contribute to the disease *** in sarcoma(FUS)is a DNA/RNA-binding protein involved in various cellular processes,including transcriptional regulation,RNA splicing,and DNA *** in the FUS gene have been linked to familial ALS,highlighting the importance of FUS in the disease pathogenesis(Vance et al.,2009).In ALS and FTLD,aberrant post-translational modifications(PTMs)of FUS,such as phosphorylation,acetylation,and methylation,have been implicated in the promotion of FUS aggregation and neurotoxicity(Choi et al.,2023).Therefore,understanding the regulatory mechanisms of FUS PTMs is crucial for developing targeted therapies against these diseases.

关键词： degeneration FUS aggregation

Carboplatin restores neuronal toxicity in FUS-linked amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第8期20卷 2319-2320页

作者： Kiyoung kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS),also known as Lou Geh rig's disease,is a progressive neurodegenerative disorder that affects motor neurons in the brain and spinal *** leads to muscle weakness,paralysis,and ultimate... 详细信息

关键词： paralysis sclerosis respiratory

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal Sharma Sehwan kim Hyemi Eo Sang Ryong kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim Bum Jun kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration