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Polyphenols as potential enhancers of stem cell therapy against neurodegeneration

neural Regeneration Research 2022年第10期17卷 2093-2101页

作者： diana Rodríguez-Vera Antonio Abad-garcía nancy Vargas-Mendoza Rodolfo Pinto-Almazán eunice d.farfán-garcía José A.Morales-González Marvin A.Soriano-Ursúa Sección de Estudios de Posgrado e Investigación.Escuela Superior de Medicina Instituto Politécnico NacionalMéxico CityMéxico Unidad de Investigación Hospital Regional de Alta Especialidad IxtapalucaCarretera Federal México-Puebla km 34.5State of MéxicoMéxico

The potential of polyphenols for treating chronic-degenerative diseases(particularly neurodegenerative diseases)is attractive.However,the selection of the best polyphenol for each treatment,the mechanisms by which they act,and their efficacy are frequently discussed.In this review,the basics and the advances in the field,as well as suggestions for using natural and synthetic polyphenols alone or in a combinatorial strategy with stem cell assays,are compiled and discussed.Thus,stem cells exhibit several responses when polyphenols are added to their environment,which could provide us with knowledge for advancing the elucidation of the origin of neurodegeneration.But also,polyphenols are being included in the innovative strategies of novel therapies for treating neurodegenerative diseases as well as metabolic diseases related to neurodegeneration.In this regard,flavonoid compounds are suggested as the best natural polyphenols due to their several mechanisms for acting in ameliorative effects;but increasing reports are involving other polyphenols.Even if some facts limiting bioactivity prevent them from conventional use,some natural polyphenols and derivatives hold the promise for being improved compounds,judged by their induced effects.The current results suggest polyphenols as enhancers of stem cell therapy against the targeted diseases.

关键词： Alzheimer’s disease chronic degenerative diseases combinatorial therapy metabolism neurodegenerative diseases neuronal damage neuroprotection Parkinson’s disease polyphenols stem cell assays

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Effect of tibolone pretreatment on kinases and phosphatases that regulate the expression and phosphorylation of Tau in the hippocampus of rats exposed to ozone

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neural Regeneration Research 2018年第3期13卷 440-448页

作者： Rodolfo Pinto-Almazán Julia J. Segura-Uribe Marvin A. Soriano-Ursúa eunice d. farfán-garcía Juan M. Gallardo Christian Guerra-Araiza Unidad de Investigación Hospital Regional de Alta Especialidad Ixtapaluca Carretera Federal México-Puebla km 34.5 C.P. 56530. Ixtapaluca State of Mexico Mexico Institute for the developing Mind Children's Hospital Los Angeles Los Angeles CA USA department of Pediatrics Keck School of Medicine University of Southern California Los Angeles CA USA Unidad de Investigación Médica en Enfermedades neurológicas Hospital de Especialidades Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social Av. Cuauhtémoc 330 Col. Doctores. C. P. 06720. Mexico City Mexico Escuela Superior de Medicina Instituto Politécnico Nacional Plan de San Luis y Diaz Mirón Col. Casco de Santo Tomis. C. P. 11340. Mexico City Mexico Unidad de Investigación Médica en Enfermedades nefrológicas Hospital de Especialidades Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social Av. Cuauhtémoc 330 Col. Doctores. C. P. 06720. Mexico City Mexico Unidad de Investigación Médica en Farmacologia Hospital de Especialidades Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social Av. Cuauhtémoc 330 Col. Doctores. C. P. 06720. Mexico City Mexico

Oxidative stress （OS） is a key process in the development of many neurodegenerative diseases, memory disorders, and other pathological processes related to aging. Tibolone （TIB）, a synthetic hormone used as a treatment for menopausal ymptoms, decreases lipoperoxidation levels, prevents memory impairment and learning disability caused by ozone （O3） exposure. However, it is not clear if TIB could prevent the increase in phosphorylation induced by oxidative stress of the microtubule-associated protein Tau. In this study, the effects of TIB at different times of administration on the phosphorylation of Tau, the activation of glycogen synthase kinase-3β （GSK3β）, and the inactivation of Akt and phosphatases PP2A and PTEn induced by O3 exposure were assessed in adult male Wistar rats. Rats were divided into 10 groups： control group （ozone-free air plus vehicle [C]）, control ＋ TIB group （ozone-free air plus TIB 1 mg/kg [C ＋ TIB]）; 7,15, 30, and 60 days of ozone exposure groups [O3] and 7, 15, 30, and 60 days of TIB 1 mg/kg before ozone exposure groups [O3 ＋ TIB]. The effects of O3 exposure and TIB administration were assessed by western blot analysis of total and phosphorylated Tau, GSK3β, Akt, PP2A, and PTEn proteins and oxidative stress marker nitrotyrosine, and superoxide dismutase activity and lipid peroxidation of malondialdehyde by two different spectrophotometric methods （Marklund and TBARS, respectively）. We observed that O3 exposure increases Tau phosphorylation, which is correlated with decreased PP2A and PTEn protein levels, diminished Akt protein levels, and increased GSK3β protein levels in the hippocampus of adult male rats. The effects of O3 exposure were prevented by the long-term treatment （over 15 days） with TIB. Malondialdehyde and nitrotyrosine levels increased from 15 to 60 days of exposure to O3 in comparison to C group, and superoxide dismutase activity decreased. Furthermore, TIB administration limited the changes induced by O3 exposure. Our results suggest a beneficial use of hormone replacement

关键词： tibolone oxidative stress ozone exposure Tau GSK3 hippocampus neuroprotection

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More than boric acid:Increasing relevance of boron in medicine

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World Journal of Translational Medicine 2018年第1期7卷 1-4页

作者： Eunice D Farfán-García Emily L Castillo-garcía Marvin A Soriano-Ursúa department of Physiology Escuela Superior de Medicina Instituto Politécnico Nacional

Although boron has been a chemical element of interest since the ancient times,only a few boron-containing compounds(BCCs)had been used for medicinal purposes before the 21^(st) century.Among these,only boric acid has been explored in multiple therapeutic applications.Hence,it is common to extrapolate from boric acid to all BCCs,supposing a similar biological effect.However,boric acid is just one of dozens of BCCs in nature and thousands available from chemical synthesis.nowadays,there is a boom in research on new BCCs as potential tools in the prevention,diagnosis and therapy of human disease.We herein discuss the new role of BCCs in drug development,with emphasis on the compounds for which a mechanism of action has been proposed or demonstrated.Because of data gathered in recent years,BCCs have expanded beyond the well-known fields of antimicrobial and antineoplastic agents,now being explored for their possible use as enzyme inhibitors,regulators of protein expression and modulators of the immune response,as well as in biomaterials.We suggest that translational medicine can accelerate the medicinal applications of BCCs,which is especially important for the human diseases that are generating a high global burden.

关键词： Boron diagnosis drug development drug targets Immunological processes

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Insights into the structural biology of G-protein coupled receptors impacts drug design for central nervous system neurodegenerative processes

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neural Regeneration Research 2013年第24期8卷 2290-2302页

作者： farfán-garcía eunice dalet Trujillo-Ferrara José Guadalupe Castillo-Hernández María del Carmen Guerra-Araiza Christian Humberto Soriano-Ursúa Marvin Antonio Escuela Superior de Medicina Instituto Politécnico Nacional. Plan de San Luis y Díaz Mirón s/n Col. Casco de Santo Tomas

In the last few years, there have been important new insights into the structural biology of G-protein coupled receptors. It is now known that allosteric binding sites are involved in the affinity and selec- tivity of ligands for G-protein coupled receptors, and that signaling by these receptors involves both G-protein dependent and independent pathways. The present review outlines the physiological and pharmacological implications of this perspective for the design of new drugs to treat disorders of the central nervous system. Specifically, new possibilities are explored in relation to allosteric and or- thosteric binding sites on dopamine receptors for the treatment of Parkinson＇s disease, and on muscarinic receptors for Alzheimer＇s disease. Future research can seek to identify ligands that can bind to more than one site on the same receptor, or simultaneously bind to two receptors and form a dimer. For example, the design of bivalent drugs that can reach homo/hetero-dimers of d2 dopa- mine receptor holds promise as a relevant therapeutic strategy for Parkinson＇s disease. Regarding the treatment of Alzheimer＇s disease, the design of dualsteric ligands for mono-oligomeric mus- carinic receptors could increase therapeutic effectiveness by generating potent compounds that could activate more than one signaling pathway.

关键词： neural regeneration G-Protein coupled receptors structural biology drug design neurodegenera-tive disorders , oligomedzation biased signaling Parkinson＇s disease Alzheimer＇s disease dopa-mine receptors muscarinic receptors grants-supported paper neuroregeneration

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Global longitudinal strain is superior to ejection fraction for detecting myocardial dysfunction in end-stage renal disease with hyperparathyroidism

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World Journal of Cardiology 2022年第4期14卷 239-249页

作者： Maria Fernanda Carrasco-Ruiz Antonio Ruiz-Rivera Marvin A Soriano-Ursúa Carlos Martinez-Hernandez Leticia Manuel-Apolinar Carmen Castillo-Hernandez Gustavo Guevara-Balcazar Eunice D Farfán-García Ana Mejia-Ruiz Ivan Rubio-Gayosso Teresa Perez-Capistran department of Physiology Escuela Superior de MedicinaInstituto Politécnico NacionalCiudad de México 11340Mexico department of Cardiology Instituto Mexicano del Seguro SocialCiudad de México 06720Mexico Endocrine Research Unit Instituto Mexicano del Seguro SocialCiudad de México 06720Mexico department of Cardiovascular Pharmacology Instituto Politécnico NacionalCiudad de México 11340Mexico department of Biochemistry Escuela Superior de MedicinaInstituto Politécnico NacionalCiudad de México 11340Mexico Education Research Comisión Nacional Para la Mejora Continua de la EducaciónCiudad de México 03900Mexico Postgraduate Studies and Research Section Escuela Superior de MedicinaInstituto Politécnico NacionalCiudad de México 11340Mexico department of Physiology Instituto Politécnico NacionalMexico City 11340Ciudad de MéxicoMexico

BACKGROUnd The estimation of left ventricular ejection fraction(LVEF)by 2d echocardiography(2d-ECHO)is the most used tool to assess LV systolic function(LVSF).Global longitudinal strain(GLS)has recently been suggested as a superior method for several evaluations.This study explored the association and prevalence of LV systolic dysfunction(LVSd)by using these methods in patients with end-stage renal disease(ESRd)and severe hyperparathyroidism(SHPTH);both associated with cardiovascular events(CEs).AIM To evaluate the myocardial function in patients with ESRd and SHPTH by using the GLS and LVEF measured through conventional 2d-ECHO.METHOdS In 62 patients with ESRd and SHPTH,asymptomatic,and without a history of CEs,LVSF was evaluated by 2d-ECHO,obtaining the EF,by the Simpson biplane method,and GLS by speckle tracking.RESULTS The total patients with ESRd had a preserved LVEF(>50%)but abnormal GLS(dditionally,multivariate analysis showed an independent association of GLS and serum parathyroid hormone(PTH),LV mass index,and hemoglobin.Also,PTH was independently associated with lateral e'wave and tricuspid regurgitation velocity.COnCLUSIOn In patients with SHPTH linked to ESRd,the use of GLS by 2d-ECHO is a more sensitive tool than LVEF for detecting LVSd.

关键词： Left ventricular hypertrophy Systolic dysfunction Global longitudinal strain End-stage renal disease Parathormone

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Scope of translational medicine in developing boroncontaining compounds for therapeutics

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World Journal of Translational Medicine 2017年第1期6卷 1-9页

作者： Ana Karen garcía-ávila eunice dalet farfán-garcía Juan Alberto Guevara-Salazar José Guadalupe Trujillo-Ferrara Marvin Antonio Soriano-Ursúa department of Biochemistry and Section of Post Graduate Studies and Research Escuela Superior de MedicinaInstituto Politécnico Nacional department of Physiology and Section of Post Graduate Studies and Research Escuela Superior de MedicinaInstituto Politécnico Nacional

The ubiquitousness of naturally occurring boron-containing compounds(BCCs) has led to their constant contact with humankind.Recently,many synthetic BCCs have been elaborated for a broad spectrum of purposes,especially boric,boronic and borinic acids.Although BCCs were once employed primarily as antiseptics and later as antibiotics,they have become an increasingly relevant therapeutic tool.nevertheless,this potential of BCCs has been drastically limited due to some unfortunate intra-hospital accidents in the 1940 s and 1950 s.The increasing use of BCCs as insecticides,antimicrobials,and other agents is providing new insights into their role in the physiology of several living species and in the pathophysiology of humans.It is becoming clear that BCCs act through a wide range of mechanisms,as do their corresponding boron-free counterparts.When comparing BCCs and similar boron-free compounds,in many cases the former show advantages in the medical field.The current minireview focuses on how BCCs have been developed by means of translational medicine,a process connecting biomedical research with clinical applications.This process of discovery is currently in an exponential stage.

关键词： Boron Boron-containing compounds drug development Toxicity Medicinal chemistry Pharmacology

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Boron-containing compounds as labels,drugs,and theranostic agents for diabetes and its complications

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World Journal of diabetes 2024年第6期15卷 1060-1069页

作者： Marvin A Soriano-Ursúa R Ivan Cordova-Chávez eunice d farfan-garcía George Kabalka department of Physiology Escuela Superior de MedicinaInstituto Politécnico NacionalCiudad de México 11340Mexico department of Physiology Instituto Politécnico NacionalMexico City 11340Mexico department of Biochemistry Instituto Politécnico NacionalMexico City 11340Mexico department of Chemistry The University of TennesseeKnoxvilleTN 37996United States

diabetes is a disease with a high global burden.Current strategies have failed to limit the advancement and impact of the disease.Successful early diagnosis and treatment will require the development of new agents.In this sense,boroncontaining compounds have been reported as agents with the ability to reduce glycemia and lipidemia.They have also been used for labeling and measuring carbohydrates and other molecules linked to the initial stages of diabetes and its progression.In addition,certain boron compounds bind to molecules related to diabetes development and their biological activity in the regulation of elevated glycemia.Finally,it should be noted that some boron compounds appear to exert beneficial effects on diabetes complications such as accelerating wound healing while ameliorating pain in diabetic patients.

关键词： Boron Carbohydrates Metabolism diabetes Boronodipyrromethene

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Modifi cation of sleep architecture in an animal model of experimental cirrhosis

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World Journal of Gastroenterology 2009年第41期15卷 5176-5180页

作者： Anabel Jiménez-Anguiano Vanessa díaz-Medina Blanca Eugenia farfán-Labonne Gloria Giono-Chiang david Kersenobich Mario garcía-Lorenzana Maria Concepción Gutiérrez-Ruiz Javier Velázquez-Moctezuma Area of neuroscience department of Biology of Reproduction Universidad Autónoma Metropolitana-Iztapalapa CP 09340 Mexico City Mexico Cell Physiology Laboratory Department of Health Sciences Universidad Autónoma Metro-politana-Iztapalapa CP 09340 Mexico City Mexico Unit of Liver Pancreas and Motility Faculty of Medicine Universidad Nacional Autónoma de México Mexico City D.F CP 09340 Mexico

AIM: To analyze the polygraphic sleep patterns during cirrhosis progression in a rat model by repeated CCl4 administration. METHOdS: Male Wistar rats received three weekly injections of CCl4 for 11 wk, and were analyzed before and during the induction of cirrhosis. Rats were implanted with electrodes to record their sleep patterns. Polygraph recordings were made weekly over 11 wk for 8 h, during the light period. After a basal recording, rats received three weekly injections of CCl4. Histological conf irmation of cirrhosis was performed after 11 wk.RESULTS: The results showed a progressive decrease in total wake time that reached statistical signif icance from the second week of treatment. In addition, there was an increase in total time of slow wave sleep (SWS) and rapid eye movement sleep (REM sleep) in most of the 11 wk. SWS showed no signif icant variations.during the final weeks, a significant increase in REM sleep frequency was also observed. Histological analyses of the livers showed unequivocal signs of cirrhosis. COnCLUSIOn: These data suggest that hepatic failure produced by CCl4 administration is capable of modifying the sleep pattern even after only a few doses.

关键词：睡眠模式肝硬化动物模型结构改造实验性 Wistar大鼠慢波睡眠大鼠模型

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视线聚焦2019中国国际大学生时装周 751d·PARK“爆炸式”上演青春活力

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时尚北京 2019年第7期 154-157页

作者： eunice

时尚是什么?每个人都对时尚有不同理解,没有人能给出一个标准答案。服装设计师们总是可以将自己的理解通过面料、色彩、线条等方式展示出设计风格,将自己的抽象情绪用具象的方式表达出来。在刚结束的尚坤塬·2019中国国际大学生时装周... 详细信息

时尚是什么?每个人都对时尚有不同理解,没有人能给出一个标准答案。服装设计师们总是可以将自己的理解通过面料、色彩、线条等方式展示出设计风格,将自己的抽象情绪用具象的方式表达出来。在刚结束的尚坤塬·2019中国国际大学生时装周秀场上,年轻一代设计师发展学校的特点,采用新奇的创想展现着对时尚的重新定义,跟随小编一起回顾学生设计们带来的精彩瞬间。

关键词：时装周湖北美术学院中国美术学院浙江理工大学服装学院线聚焦青春活力

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Power Tensor Theory and Continuous Wavelet Transform

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American Journal of Computational Mathematics 2012年第2期2卷 130-135页

作者： Eduardo Antonio Cano-Plata Armando Jaime Ustariz-farfán Luis Fernando díaz-Cadavid departmentof Electrical Electronic and Computer Engineering National University of Colombia Manizales Colombia

A model for the definition of electrical Power is presented, which retrieves the concepts of homomorphism from the geometrical tensor approximation at the wavelet approach. Their definition here is nevertheless different in that it considers both tensor algebra and wavelet operators, solving thus most of the problems usually associated with the numerical methods.

关键词： Wavelets Tensor Electrical Power Power Electronic Power Quality

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