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Survival outcome of patients with spontaneously ruptured hepatocellular carcinoma treated surgically or by transarterial embolization

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World Journal of Gastroenterology 2013年第28期19卷 4537-4544页

作者： Young-Joo Jin Jin-Woo Lee Seoung-Wook Park Jung Il Lee Don Haeng Lee Young soo kim soon Gu Cho Yong Sun Jeon Kun Young Lee Seung-Ik Ahn Department of Internal Medicine Inha University Hospital Inha University School of Medicine Incheon 400-711 South Korea Department of Internal Medicine Yonsei University College of Medicine Seoul 120-752 South Korea Department of Internal Medicine and Center for Advanced Medical Education by Brain Korea 21 Project Inha University School of Medicine and Utah-Inha DDS and Advanced Therapeutics Research Center Incheon 400-711 South Korea Department of Radiology Inha University Hospital Inha University School of Medicine Incheon 400-711 South Korea Department of Surgery Inha University Hospital Inha University School of Medicine Incheon 400-711 South Korea

AIM: To evaluate clinical outcomes of patients that underwent surgery, transarterial embolization (TAE), or supportive care for spontaneously ruptured hepatocellular carcinoma (HCC). METHODS: A consecutive 54 patients who diagnosed as spontaneously ruptured HCC at our institution between 2003 and 2012 were retrospectively enrolled. HCC was diagnosed based on the diagnostic guidelines issued by the 2005 American Association for the Study of Liver Diseases. HCC rupture was defined as disruption of the peritumoral liver capsule with enhanced fluid collection in the perihepatic area adjacent to the HCC by dynamic liver computed tomography, and when abdominal paracentesis showed an ascitic red blood cell count of > 50000 mm 3 /mL in bloody fluid. RESULTS: Of the 54 patients, 6 (11.1%) underwent surgery, 25 (46.3%) TAE, and 23 (42.6%) supportive care. The 2-, 4and 6-mo cumulative survival rates at 2, 4 and 6 mo were significantly higher in the surgery (60%, 60% and 60%) or TAE (36%, 20% and 20%) groups than in the supportive care group (8.7%, 0% and 0%), respectively (each, P < 0.01), and tended to be higher in the surgical group than in the TAE group. Multivariate analysis showed that serum bilirubin (HR = 1.09, P < 0.01), creatinine (HR = 1.46, P = 0.04), and vasopressor requirement (HR = 2.37, P = 0.02) were significantly associated with post-treatment mortality, whereas surgery (HR = 0.41, P < 0.01), and TAE (HR = 0.13, P = 0.01) were inversely associated with posttreatment mortality. CONCLUSION: Post-treatment survival after surgery or TAE was found to be better than after supportive care, and surgery tended to provide better survival benefit than TAE.

关键词： Ruptured hepatocellular carcinoma Surgery Transarterial embolization

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间歇曝气脱氮系统的影响因素研究

中国给水排水 2005年第6期21卷 16-19,i001页

作者：金春姬杨海高京淑金秀生中国海洋大学环境科学与工程学院山东青岛266003 佳木斯市自来水公司黑龙江佳木斯154002 韩国东亚大学校

通过观察间歇曝气生物脱氮系统在不同水温、C/N值下的脱氮效率以及好氧/缺氧一周期内的硝化和反硝化过程,分析了温度和缺氧期C/N值对硝化和反硝化速度的影响,探讨了冬季所需外加碳源量。试验结果表明,秋、冬季提高缺氧期C/N值是保障间... 详细信息

通过观察间歇曝气生物脱氮系统在不同水温、C/N值下的脱氮效率以及好氧/缺氧一周期内的硝化和反硝化过程,分析了温度和缺氧期C/N值对硝化和反硝化速度的影响,探讨了冬季所需外加碳源量。试验结果表明,秋、冬季提高缺氧期C/N值是保障间歇曝气脱氮系统运行效率的有效措施;在TN负荷为0.034kg/(kgMLVSS·d),水温为15℃时最适C/N值为7,10℃时最适C/N值为9。为了降低冬季运行费用,有必要寻找廉价的外碳源。

关键词：低C/N 生物脱氮间歇曝气外碳源温度

Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2015年第45期21卷 12787-12799页

作者： Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon kim Yeon Seok Seo Hyung Joon Yim Kwan soo Byun Department of Internal Medicine Korea University College of Medicine

AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) ***: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of ***: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD.

关键词： Nonalcoholic fatty liver disease Nonalcoholic stea

应用重组PDGF—BB或釉基质蛋白衍生物重建人拔牙窝颊侧骨壁缺损

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中国口腔医学继续教育杂志 2013年第4期16卷 209-217页

作者： Marc L. Nevins Marcelo Camelo Peter Schupbach Myron Nevins soo-Woo kim David M. kim 陈欣戬(译) 闫福华(审) 不详福建医科大学附属口腔医院牙周科福州市杨桥中路246号350002 南京大学口腔医学院附属口腔医院南京市鼓楼区中央路30号210008

本研究的目的是评估拔牙窝颊侧骨壁缺损的骨性愈合。试验对象分为4组：A.仅使用矿化胶原骨替代物支架材料（MCBS）;***＋重组人血小板生长因子BB（rhPDGF-BB）．03mg／ml；***＋釉基质蛋白衍生物（EMD）;***与陶瓷化骨替代物联合应用。... 详细信息

本研究的目的是评估拔牙窝颊侧骨壁缺损的骨性愈合。试验对象分为4组：A.仅使用矿化胶原骨替代物支架材料（MCBS）;***＋重组人血小板生长因子BB（rhPDGF-BB）．03mg／ml；***＋釉基质蛋白衍生物（EMD）;***与陶瓷化骨替代物联合应用。光学显微镜，背散射扫描电镜，组织形态测定术检测评估骨质量初期结果。二次手术观察愈合后的骨嵴形态。16名伴有拔牙窝颊侧骨壁缺损的患者随机等分为4个治疗组。拔牙后即刻做移植手术并颊侧瓣前移闭合创口。术后5个月．植入种植体前在种植位点行环钻中心组织穿刺活检术。组织学检测围绕在生物支架材料周围形成的愈合。性新骨。各治疗组未发现统计学意义上的差别。而组织形态测定术检测倾向于B组新骨形成最多．该组具有最佳骨嵴形态而有利于种植体的植入。

关键词：蛋白衍生物骨壁缺损联合应用拔牙窝颊侧 PDGF 基质重组

Dual Channel SIS Receiver of Trao Telescope

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天文研究与技术 1999年第S1期 82-85页

作者： Jong Ae Park 1,2 , Seog Tae Han 1, Tai Seong kim 1, Kwang Dong kim 1, Hyo Ryoung kim 1, Hyun soo Chung 1, Jae Hoon Jung 1, Chang Hoon Lee 1, Se Hyung Cho 1, Jongmann Yang 2 1. Taeduk Radio Astronomy Observatory (TRAO), Hwaam dong,

We have developed the dual channel receiver with 100GHz and 150GHz band, which is used to make the simultaneous observation with two bands. The SIS mixers are used in both bands. The constructed dewar for receiver has the performance with the vacuum of 10 -8 Torr and the temperature of 4 2K. The receiver noise temperature is 50K (DSB) for 100GHz band and 80K (DSB) for 150GHz band ,respectively. In order to achieve the simultaneous observations, the quasioptical system is precisely designed, and also evaluated by the measurement in the laboratory. We have observed the various sources using this receiver since October 1998. The relative pointing offset between two bands is 3″.

关键词： SIS Dual Channel SIS Receiver of Trao Telescope

Surface plasmon excitation in semitransparent inverted polymer photovoltaic devices and their applications as label-free optical sensors

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Light(Science & Applications) 2014年第1期3卷 5-12页

作者： Byoungchoo Park soo Hong Yun Chan Youn Cho Young Chan kim Jung Chul Shin Hong Goo Jeon Yoon Ho Huh Inchan Hwang Ku Youn Baik Young In Lee Han Sup Uhm Guang Sup Cho Eun Ha Choi Department of Electrical and Biological Physics Kwangwoon UniversitySeoul 139-701Republic of Korea Department of Electronic Materials Engineering Kwangwoon UniversitySeoul 139-701Republic of Korea

Herein,we report on surface plasmon(SP)-sensitive semitransparent inverted polymer photovoltaic(PV)devices that are based on multilayered material systems consisting of poly(3-hexylthiophene):fullerene-derivative bulk-heterojunction PV layers and thin gold or silver *** demonstrate that these PV devices allow the simultaneous generation of both electrical power and SPs on their anodes for photoexcitation just above the optical absorption edge of the PV layers,resulting not only in attenuated total reflection,but also in attenuated photocurrent generation(APG)under the SP resonance(SPR)***,we also confirm that the biomolecular interaction of biotin–streptavidin on the PV devices can be precisely detected via apparent SPR angle shifts in the APG spectra,even without the need for complex attenuated total reflection *** highlight our view that APG measurements made using these PV devices show great potential for the development of future generations of compact and highly sensitive SPR-based optical sensors.

关键词： attenuated total reflection optical sensors photocurrent generation polymer photovoltaic devices surface plasmon

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物流业上市公司的盈余管理模式研究

物流技术 2010年第13期29卷 47-50,57页

作者：金炳秀李贞南开大学商学院天津300071

针对中国物流业的发展现状,以分析上市公司盈余管理的动机为起点,对物流业的盈余管理模式进行剖析。

关键词：物流业上市公司盈余管理

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浅析寒地城市公园声环境的存在问题与对策

工业设计 2021年第3期 97-98页

作者：吕海景金秀峰东北农业大学艺术学院 Keimyung University

城市进程的快速发展导致社会的复杂化,噪音问题成为严重影响人们生活的污染问题,城市声环境的问题研究也有一定的进展,对于城市公园内的声环境研究尚在探索中。本文首先阐述了寒地城市公园声环境研究的必要性,然后分析寒地城市公园声环... 详细信息

城市进程的快速发展导致社会的复杂化,噪音问题成为严重影响人们生活的污染问题,城市声环境的问题研究也有一定的进展,对于城市公园内的声环境研究尚在探索中。本文首先阐述了寒地城市公园声环境研究的必要性,然后分析寒地城市公园声环境的存在问题,并提出相应的对策。以期丰富声景观学理论,为当代风景园林设计实践起到指导作用。

关键词：寒地城市公园声环境问题对策

Comparison of a novel bedside portable endoscopy device with nasogastric aspiration for identifying upper gastrointestinal bleeding

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World Journal of Gastroenterology 2014年第25期20卷 8221-8228页

作者： Jong Hwan Choi Jae Hyuk Choi Yoo Jin Lee Hyung Ki Lee Wang Yong Choi Eun soo kim Kyung Sik Park Kwang Bum Cho Byoung Kuk Jang Woo Jin Chung Jae Seok Hwang Division of Gastroenterology and Hepatology Department of Internal Medicine Keimyung University School of MedicineDaegu 700-712South Korea

AIM: To compare outcomes using the novel portable endoscopy with that of nasogastric(NG) aspiration in patients with gastrointestinal ***: Patients who underwent NG aspiration for the evaluation of upper gastrointestinal(UGI) bleeding were eligible for the study. After NG aspiration, we performed the portable endoscopy to identify bleeding evidence in the UGI tract. Then, all patients underwent conventional esophagogastroduodenoscopy as the gold-standard test. The sensitivity, specificity, and accuracy of the portable endoscopy for confirming UGI bleeding were compared with those of NG ***: In total, 129 patients who had GI bleedingsigns or symptoms were included in the study(age 64.46 ± 13.79, 91 males). The UGI tract(esophagus, stomach, and duodenum) was the most common site of bleeding(81, 62.8%) and the cause of bleeding was not identified in 12 patients(9.3%). Specificity for identifying UGI bleeding was higher with the portable endoscopy than NG aspiration(85.4% vs 68.8%, P = 0.008) while accuracy was comparable. The accuracy of the portable endoscopy was significantly higher than that of NG in the subgroup analysis of patients with esophageal bleeding(88.2% vs 75%, P = 0.004). Food material could be detected more readily by the portable endoscopy than NG tube aspiration(20.9% vs 9.3%, P = 0.014). No serious adverse effect was observed during the portable ***: The portable endoscopy was not superior to NG aspiration for confirming UGI bleeding site. However, this novel portable endoscopy device might provide a benefit over NG aspiration in patients with esophageal bleeding.

关键词： Endoscopy Gastrointestinal bleeding Nasogastric as