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Hepatobiliary & Pancreatic Diseases International 2016年第2期15卷 122-124页

作者： Kwang Yeol Paik eung kook kim Department of Surgery Yeouido St.Mary’s Hospital The Catholic University of Korea College of Medicine

Hepatocellular carcinoma （HCC） is one of the most frequent complications in patients with .liver cirrhosis. HCC without cirrhosis is rareand obviously a different entity. Treatment depends on tumor stage, liver function and general performance. Results of locoregional treatment, resection or liver transplantation are superior to those of medical therapy. Surgical approaches are potentially curative. Underlying cirrhosis is usually the limiting factor for the extent of resection and persists after resection. Liver transplantation eliminates both cirrhosis and, potentially, the tumor. Whereas surgery （functional liver capacity provided） may be performed even in advanced tumors, liver transplantation is advocated in less advanced （T2） tumors in order to keep the rate of recurrent tumor low. Responsible use of scarce grafts requires sticking to this rule.

关键词： recurrence cirrhosis preoperative frequent extrahepatic cirrhotic dissemination potentially metastases necrotic

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Optimal Center-of-Mass Pivot Effect of Spinal Motion in Feline Galloping

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Journal of Bionic Engineering 2020年第5期17卷 970-977页

作者： Young kook kim Dongwon Yun LV R&D team Electro-technology R&D CenterLS ELECTRIC Co.LtdCheongju 28437South Korea Department of Robotics Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988South Korea

In this paper,we studied the acceleration behavior of a quadruped animal during a galloping *** the development of many quadruped robotic systems has been focused on dynamic movements,it is obvious that guidance from the dynamic behavior of quadruped animals is needed for robotics *** fulfill this demand,this paper deals with analysis of the galloping motions of a domestic cat,which is well known for its excellent acceleration performance among four-legged *** on the planar motion capture environment,the movement data of a galloping feline was acquired and the dynamic motions were estimated using a spring-mass *** particular,the effects of the position and angle of the center-of-mass of the cat,angular displacement of the spine,and angular velocity of the spine were analyzed and are discussed *** this process,it was possible to understand the dynamic movement characteristics of the cat,and to understand the relationships between,and the influences of,these *** this analysis,we provide significant data applicable to the design of joint movements in quadruped robot systems.

关键词： quadrupedalism feline galloping domestic cat center-of-mass

The westward intrusion of south Pacific water at the western tip of the New Guinea Island

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Acta Oceanologica Sinica 2013年第1期32卷 24-31页

作者： kim eung JEON Dongchull Hadikusumah Ocean Circulation & Climate Research Division Korea Institute of Ocean Science and Technology Physical Oceanography Laboratory Indonesian Institute of Sciences-Research Center for Oceanography

From the eastern Indonesian cruise from November 14 to 23, 2007, CTD （conductivity, temperature, depth profiler）/ADCP （acoustic Doppler current profiler）casting and seawater sampling were done at 25 stations around Waigeo Island near New Guinea Island. It was found overall westward intrusion of the south Pacific waters into the Seram Sea and southward spreading of the north and south Pacific waters into the Seram Sea. There is westward residual flow along the channel between Waigeo and New Guinea within upper 200 m with the maximum speed up to 50 cm/s, and much weaker eastward flow in the lower layer （〈 10 cm/s） due to blocking by the shallow sill at the west of the Dampier Strait. The abrupt change of bottom topography induces active horizontal and vertical mixing which results in a three-layered current system with a major through-flow of-0.99 Sv （Sv = 106 ma/s） into the Seram Sea; the transports in the upper and the lower layers are -1.14 Sv and -0.24 Sv （westward）, respectively, and in the middle there is a return flow with the transoort of ＋0.39 Sv （eastward）.

关键词： a three-layered system New Guinea coastal undercurrent south Pacific tropical water (SPTW),south Pacific intermediate water (SP1W) vertical mixing

Biomimetic Quadruped Robot with a Spinal Joint and Optimal Spinal Motion via Reinforcement Learning

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Journal of Bionic Engineering 2021年第6期18卷 1280-1290页

作者： Young kook kim Woojin Seol Jihyuk Park LV R&D Team Electro-technology R&D CenterLS Electric Co.LtdCheongju28437Republic of Korea Digital Innovation Unit Korea Hydro&Nuclear Power Co.Ltd1312-gil YuseongdaeroYusung-guDaejeon34101Republic of Korea Department of Automotive Engineering College of Mechanical and IT EngineeringYeungnam University280 Daehak-roGyeongsanGyeongbuk38541Republic of Korea

Feline animals can run quickly using spinal joints as well as the joints that make up their four *** paper describes the development of a quadruped robot including a spinal joint that biomimics feline *** developed robot platform consists of four legs with a double 4-bar linkage type and one simplified rotary *** addition,Q-learning,a type of machine learning,was used to find the optimal motion profile of the spinal *** bounding gait was implemented on the robot system using the motion profile of the spinal joint,and it was confirmed that using the spinal joint can achieve a faster Center of Mass(CoM)forward speed than not using the spinal *** the motion profile obtained through Q-learning did not exactly match the spinal angle of a feline animal,which is more multiarticular than that of the developed robot,the tendency of the actual feline animal spinal motion profile,which is sinusoidal,was similar.

关键词： Quadruped robot system Bioinspired methods Legged robots Machine learning Q-learning

Comparison of the impact of endoscopic retrograde cholangiopancreatography between pre-COVID-19 and current COVID-19 outbreaks in South Korea:Retrospective survey

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World Journal of Clinical Cases 2021年第28期9卷 8404-8412页

作者： kook Hyun kim Sung Bum kim Division of Gastroenterology and HepatologyDepartment of Internal Medicine Yeungnam UniversityCollege of MedicineDaegu 42415South Korea

BACKGROUND The coronavirus disease 2019(COVID-19)outbreak has markedly influenced the endoscopic *** retrograde cholangiopancreatography(ERCP)is an essential technique for pancreatobiliary disease but increases the risk of exposure to the virus-containing body fluid;however,the impact of COVID-19 on ERCP is *** To compare the number of endoscopic activities and to analyze the clinical outcomes of ERCPs before and during the COVID-19 outbreak in Daegu,South *** This retrospective cohort study included patients aged≥18 years who underwent ERCP between February 18 and March 28,2020,at a tertiary *** indications and endoscopic details were compared with those from the same period in 2018 and 2019 as control *** Of the 269 ERCP procedures,113(42.0%)cases were performed as emergency *** number of ERCP procedures in 2018 and 2019 decreased by 20.2%and 56.6%,respectively,compared with that in 2020(P<0.01);among the 113 emergency ERCPs,the observed numbers in 2018(n=42)and 2019(n=55)dramatically dropped by 61.9%and 70.9%,respectively,compared with that in 2020(n=16).Of the 16 cases in 2020,stone removal was performed in five,biliary stenting in five,sphincterotomy in five,and nasobiliary drainage in *** case of ERCP-related infection in medical workers or other patients has been *** The COVID-19 outbreak significantly reduced the number of ERCPs;however,there is no difference in the indications and endoscopic interventions before and during the COVID-19 outbreak.

关键词： Coronavirus disease 2019 Coronavirus Endoscopic retrograde cholangi-opancreatography Emergency endoscopic retrograde cholangiopancreatography Endoscopy

Endoscopic papillary large balloon dilation in patients with periampullary diverticula

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World Journal of Gastroenterology 2013年第41期19卷 7168-7176页

作者： kook Hyun kim Tae Nyeun kim Division of Gastroenterology and Hepatology Department of Internal medicineYeungnam University College of MedicineDaegu 705-717South Korea

AIM:To evaluate the safety and effectiveness of endoscopic papillary large balloon dilation(EPLBD)for bile duct stone extraction in patients with periampullary ***:The records of 223 patients with large common bile duct stones(≥10 mm)who underwent EPLBD(12-20 mm balloon diameter)with or without limited endoscopic sphincterotomy(ES)from July 2006to April 2011 were retrospectively *** these patients,93(41.7%)had periampullary diverticula(PAD),which was categorized into three *** clinical variables of EPLBD with limited ES(EPLBD+ES)and EPLBD alone were analyzed according to the presence of ***:Patients with PAD were significantly older than those without(75.2±8.8 years vs 69.7±10.9years,P=0.000).The rates of overall stone removal and complete stone removal in the first session were not significantly different between the PAD and nonPAD groups,however,there was significantly less need for mechanical lithotripsy in the PAD group(3.2%vs 11.5%,P=0.026).Overall stone removal rates,complete stone removal rates in the first session and the use of mechanical lithotripsy were not significantly different between EPLBD+ES and EPLBD alone in patients with PAD(96.6%vs 97.1%;72.9%vs 88.2%;and 5.1%vs 0%,respectively).No significant differences with respect to the rates of pancreatitis,perforation,and bleeding were observed between EPLBD+ES and EPLBD alone in the PAD group(3.4%vs 14.7%,P=0.095;0%vs 0%;and 3.4%vs 8.8%,P=0.351,respectively).CONCLUSION:EPLBD with limited ES and EPLBD alone are safe and effective modalities for common bile duct stone removal in patients with PAD,regardless of PAD subtypes.

关键词： Endoscopic papillary large balloon dilation Endoscopic sphincterotomy Periampullary diverticula

A novel electrospinning method for self-assembled tree-like fibrous scaffolds:Microenvironment-associated regulation of MSC behavior and bone regeneration

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Journal of Materials Science & Technology 2022年第20期115卷 52-70页

作者： Jeong In kim Ju Yeon kim Sung-Ho kook Jeong-Chae Lee Cluster for Craniofacial Development and Regeneration Research Institute of Oral Biosciences and School of DentistryJeonbuk National UniversityJeonju 54896Republic of Korea Department of Bionanosystem Engineering Jeonbuk National UniversityJeonju 54896Republic of Korea Department of Bioactive Material Sciences Research Center of Bioactive MaterialsJeonbuk National UniversityJeonju 54896Republic of Korea

Numerous studies highlight advantages of electrospun scaffolds in bone tissue engineering,in which cellular behavior is tightly affected by fiber topographical cues of ***,the classic electrospinning setup limits a desired presentation of biomimetic fibrous microenvironments that sense mechanosignaling and regulate stem cell *** aims of this study were to fabricate advanced asspun scaffolds presenting tree-like microfiber/nanonet networks and to evaluate their regulatory potentials on behavior of human mesenchymal stem cells(h MSCs)and bone *** we developed a novel electrospinning setup that allowed the presentation of patterned Trunk microfibers(TMF)and/or branched nanonet fibers(BNn Fs)in biomimetic fibrous *** the cellular mechanisms,anisotropichierarchical topography of TMF controlled behavior of h MSCs through focal adhesion formation and Yesassociated protein(YAP)induction,whereas BNn F disturbed such mechanosensing responses in the *** fiber microenvironment-related expression and nuclear localization of YAP *** correlated with the potentials of as-spun scaffolds to enhance osteogenic differentiation of the h MSCs and alveolar bone defect healing in an animal ***,this study provides an advanced approach of the modified electrospinning setup for presentation of biomimetic fibrillar microenvironments in as-spun scaffolds along with their application in stem cell behavior regulation and regenerative tissue engineering.

关键词： Electrospinning Advanced biomimetic scaffolds Stem cell behavior Mechanosensing Bone tissue engineering

The Role of Relative Spinal Motion during Feline Galloping for Speed Performance

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Journal of Bionic Engineering 2014年第4期11卷 517-528页

作者： Young kook kim Jongwon Park Byungho Yoon Kyung-Soo kim Soohyun kim Robotics Program Korea Advanced Institute of Science and Technology (KAIST) Daejeon 305-701 Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 305-701 Republic of Korea

Felines use their spinal column to increase their running speed at rapid locomotion performance. However, its motion profile behavior during fast gait locomotion has little attention. The goal of this study is to examine the relative spinal motion profile during two different galloping gait speeds. To understand this dynamic behavior trend, a dynamic motion of the feline animal （Felis catus domestica） was measured and analyzed by motion capture devices. Based on the experiments at two different galloping gaits, we observed a significant increase in speed （from 3.2 m.s-1 to 4.33 m.s-1） during the relative motion profile synchronization between the spinal （range： 118.86~ to 168.00~） and pelvic segments （range： 46.35~ to 91.13~） during the hindlimb stance phase （time interval： 0.495 s to 0.600 s）. Based on this discovery, the relative angular speed profile was applied to understand the possibility that the role of the relative motion match during high speed locomotion generates bigger ground reaction force.

关键词： feline galloping galloping gait pattern relative spinal motion speed performance phase match

Changes in endoscopic patterns before and during COVID-19 outbreak:Experience at a single tertiary center in Korean

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World Journal of Clinical Cases 2021年第15期9卷 3576-3585页

作者： kook Hyun kim Sung Bum kim Tae Nyeun kim Division of Gastroenterology and Hepatology Department of Internal MedicineYeungnam University College of MedicineDaegu 42415South Korea

BACKGROUND The surge of coronavirus disease 2019(COVID-19)patients has markedly influenced the treatment policies of tertiary hospitals because of the need to protect medical staff and contain viral transmission,but the impact COVID-19 had on emergency gastrointestinal endoscopies has not been *** To compare endoscopic activities and analyze the clinical outcomes of emergency endoscopies performed before and during the COVID-19 outbreak in Daegu,the worst-hit region in South *** This retrospective cohort study was conducted on patients aged≥18 years that underwent endoscopy from February 18 to March 28,2020,at a tertiary hospital in ***,laboratory findings,types and causes of emergency endoscopies,and endoscopic reports were reviewed and compared with those obtained for the same period in 2018 and *** From February 18 to March 28,a total of 366 emergent endoscopic procedures were performed:Upper endoscopy(170,50.6%),endoscopic retrograde cholangiopancreatography(113,33.6%),and colonoscopy with sigmoidoscopy(53,15.8%).The numbers of procedures performed in 2018 and 2019 dropped by 48.8%and 54.8%,respectively,compared with those in *** the COVID-19 outbreak,the main indications for endoscopy were melena(36.7%),hematemesis(30.6%),and hematochezia(10.2%).Of the endoscopic abnormalities detected,gastrointestinal bleeding was the most common:39 cases in 2018,51 in 2019,and 35 in *** The impact of COVID-19 is substantial and caused dramatic reductions in endoscopic procedures and changes in patient ***-term follow-up studies are required to determine the effects of COVID-19 induced changes in the endoscopy field.

关键词： COVID-19 Coronavirus Endoscopy Emergency endoscopy

Landscape pattern and its effect on ecosystem functions in Seoul Metropolitan area:Urban ecology on distribution of the naturalized plant species

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Journal of Environmental Sciences 2003年第2期15卷 199-204页

作者： Sun-Kee Hong In-Ju Song Hyun-Ok kim eung-Kyong Lee Environmental Planning Institute Seoul National UniversitySeoul Development InstituteTechnical University BerlinEnvironmental Planning Institute Seoul National University Seoul 151-742 Korea Seoul 100-250 KoreaGermanySeoul 151-742 Korea

During land transformation process in the human history, naturalized plants were introduced to several land use patterns by the different ways of plant itself. Including some naturalized plants that had been contribute to land restoration, many naturalized plants have been invaded to original habitat or landscape for native plants. Once the plants were colonized, they extend their area and population size. Urban developed areas often give an important role of source habitat for naturalized plants and expanding their population size. In recent, this situation is appearing as one of environmental problems about the urban landscape management controlling the naturalized plants that invaded in the developed area and conserving the native vegetation. This paper is focusing on relationships between distribution of habitat of naturalized plants and landscape patch in urban area in Seoul. Gangdong-Gu, one of the administrative areas in Seoul was selected for this study. We examined the recent land use change using LANDSAT TM data and spreading of the representative naturalized plants (Robinia pseudoacacia and Eupatorium rugosum) by Seoul Biotope Mapping Project and field survey in 1999. As a result, these two species were often occurred in the same habitat and distributed in forest edge disturbed by man. Their distribution patterns were related to landscape indices (patch size and shape) in the forest edge.

关键词： biotope mapping ecosystem management human impact landscape pattern naturalized plants urban ecology