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Simulation of Solid Particle Interactions Including Segregated Lamination by Using MPS Method

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Computer Modeling in Engineering & Sciences 2018年第7期116卷 11-29页

作者： kyung Sung Kim Moo-Hyun Kim Hakun jang Hee Chen Cho Tongmyong University BusanRepublic of Korea Texas A&M University College StationTXU.S.A Mississippi State University MSU.S.A

A new MPS(Moving Particle Semi-implicit)method is developed to simulate the behaviors and interactions of multiple fine solid particles as a *** fluid particles are affected by viscosity,so solid particles are affected by *** solid particle dynamics for landslides,dumping,and gravity sorting *** can be difficult to simulate using conventional MPS methods,are modeled in this paper using the developed multi-solid-particle MPS method that benefits from drawing comparisons with the corresponding fluid particle *** present MPS results for dumping solid particles are verified against the corresponding DEM(Discrete Element Method)*** shape and angle of repose for solid particles are shown to be highly dependent on the friction coefficient between *** peculiar phenomenon of segregated lamination(gravity sorting)among grains of different densities has been successfully reproduced using the multi-solid-particle MPS *** quality is found to be dependent on the densities and frictional coefficients of the constituent *** behavior of heterogeneous mixtures of multiple solid and liquid particles are also compared and *** newly developed tool offers a window into the physical dynamics of sedimentology that the broader geoscience community might benefit from.

关键词： Fine solid particle MPS(Moving Particle Semi-implicit) friction force land sliding dumping segregated lamination heterogeneous multiple particles gravity sorting

Pancreatic fistula after pancreaticoduodenectomy:A comparison between the two pancreaticojejunostomy methods for approximating the pancreatic parenchyma to the jejunal seromuscular layer:Interrupted vs continuous stitches

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World Journal of Gastroenterology 2007年第40期13卷 5351-5356页

作者： Seung eun Lee Sung Hoon Yang Jin-Young jang Sun-Whe Kim Department of Surgery Seoul National University College of Medicine28 Yongon-dongChongno-guSeoul 110-744Korea

AIM： The purpose of this study is to find a better operative technique by comparing interrupted stitches with continuous stitches for the outer layer of the pancreaticojejunostomy, i.e. the stitches between the stump parenchyma of the pancreas and the jejunal seromuscular layer, and other risk factors for the incidence of pancreatic leakage.METHODS： During the period January 1997 to October 2004, 133 patients have undergone the end-to-side and duct-to-mucosa pancreaticojejunostomy reconstruction after pancreaticoduodenectomy with interrupted suture for outer layer of the pancreaticojejunostomy and 170 patients with a continuous suture at our institution by one surgeon.RESULTS： There were no significant differences between the two groups in the diagnosis, texture of the pancreas, use of octreotide and pathologic stage. Pancreatic fistula occurred in 14 patients （11%） among the interrupted suture cases and in 10 （6%） among the continuous suture cases （P = 0.102）. Major pancreatic leakage developed in three interrupted suture patients （2%） and zero continuous suture patients （P = 0.026）. In multivariate analysis, soft pancreatic consistency （odds ratio, 5.5; 95% confidence interval 2.3-13.1） and common bile duct cancer （odds ratio, 3.7; 95%CI 1.6-8.5） were＇predictive of pancreatic leakage.CONCLUSION： Pancreatic texture and pathology are the most important factors in determining the fate of pancreaticojejunal anastomosis and our continuous suture method was performed with significantly decreased occurrence of major pancreatic fistula. In conclusion, the continuous suture method is more feasible and safer in performing duct-to-mucosa pancreaticojejunostomy.

关键词： Pancreaticoduodenectomy Pancreaticojejunostomy Pancreatic fistula

N-terminal pro-B-type natriuretic peptide as prognostic marker for patients of non ST-segment elevation myocardial infarction

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Journal of Central South University 2013年第8期20卷 2226-2232页

作者： SHON Ho Sun HWANG kyung Kuk BAE jang Whan KIM kyung Ah LEE Jong Yun RYU Keun Ho Database and Bioinformatics Laboratory School of Electrical & Computer Engineering also PSM of School of Medicine Chungbuk National University Department of Medicine School of Medicine Chungbuk National University Department of Biomedical Engineering School of Medicine Chungbuk National University Department of Informatics and Convergence Chungbuk National University Cheongju

In this work, we analyzed only the patients of the NSTEMI (non ST-segment elevation myocardial infarction) who arrived at the hospital within 12 h after symptoms started. Using NSTEMI follow-up data within, the characteristics of the clinical data, the risk factor, and the blood tested in the hospital visit were analyzed for MACE (major adverse cardiac events) patients. MACE includes cardiac death, MI (myocardial infarction), Re-PCI, and CABG (coronary artery bypass graft). As a result, from the NSTEMI patients which can be followed up for over 12 m, NT-ProBNP (p=0.014) and age (p=0.045) are found to be the independent risk factors related to MACE. Accordingly, they can be useful for the diagnosis and prognosis for NSTEMI patients as a biomarker.

关键词： non ST-segment elevation myocardial infarction NT-ProBNP cardiovascular disease

Characteristics and biological control functions of Bacillus ***8313 as a host-associated probiotic in red sea bream(Pagrus major)aquaculture

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Animal Nutrition 2023年第1期12卷 20-31页

作者： Won Je jang kyung-Bon Lee Mi-Hyeon Jeon Su-Jeong Lee Sang Woo Hur Seunghan Lee Bong-Joo Lee Jong Min Lee Kang-Woong Kim eun-Woo Lee Department of Biotechnology Pukyong National UniversityBusan48513South Korea Department of Biology Education College of Education Chonnam National UniversityGwangju61186South Korea Biopharmaceutical Engineering Major Division of Applied BioengineeringDong-Eui UniversityBusan47340South Korea Aquafeed Research Center National Institute of Fisheries SciencePohang37517South Korea Department of Smart Fisheries Resources College of Industrial SciencesKongju National UniversityYesan32439South Korea

Host-associated probiotics(HAPs)are bacteria originally isolated from rearing water or the host's gastrointestinal tract in order to enhance the host's growth and *** study investigated the HAP potential of Bacillus ***8313,isolated from wild red sea bream(Pagrus major),through characterization and feeding *** based on in vitro tests showed that PM8313 is safe,confirming its hemolytic,cytotoxic,and antibiotic *** addition,PM8313 showed advantages as a probiotic with high viability in the gastrointestinal model and a high cell adhesion ***-genome sequencing demonstrated that PM8313 has a 4,615,871 bp single circular chromosome and a guaninecytosine content of 45.25%.It also showed the absence of genes encoding virulence factors,such as cytotoxin,enterotoxin,hemolysin,sphingomyelinase,and *** the feeding trial,a supplemental diet of 1×10^(8)CFU/g PM8313 positively altered the weight gain,digestive enzyme activity,and intestinal microbiota composition of red sea *** of nonspecific immune parameters and immune-related gene expression,and a challenge test showed that PM8313 supplementation increases immunity and pathogenic bacteria *** findings suggest that PM8313 should be considered for application as a novel HAP to red sea bream aquaculture.

关键词： Host-associated probiotics Immunity Microbiota Probiotics Red sea bream

Interplay between ABA and GA Modulates the Timing of Asymmetric Cell Divisions in the Arabidopsis Root Ground Tissue

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Molecular Plant 2016年第6期9卷 870-884页

作者： Shin Ae Lee Sejeong jang eun kyung Yoon Jung-Ok Heo Kwang Suk Chang Ji Won Choi Souvik Dhar Gyuree Kim Jeong-eun Choe Jae Bok Heo Chian Kwon Jae-Heung Ko Yong-Sic Hwang Jun Lim Department of Systems Biotechnology Konkuk University Seour 05029 Korea Department of Molecular Biotechnology Dong-A University Busan 49201 Korea Department of Molecular Biology Dankook University Yongin 16890 Korea Department of Plant and Environmental New Resources Kyung Hee University Yongin 17104 Korea These authors contributed equally to this article. Present address: The Sainsbury Laboratory University of Cambridge Cambridge CB2 1LR United Kingdom Present address: Department of Life Science Research Institute for Natural Sciences Hanyang University Seoul 04763 Korea

In multicellular organisms, controlling the timing and extent of asymmetric cell divisions （ACDs） is crucial for correct patterning. During post-embryonic root development in Arabidopsis thaliana, ground tissue （GT） maturation involves an additional ACD of the endodermis, which generates two different tissues： the endo- dermis （inner） and the middle cortex （outer）. It has been reported that the abscisic acid （ABA） and gibberellin （GA） pathways are involved in middle cortex （MC） formation. However, the molecular mechanisms under- lying the interaction between ABA and GA during GT maturation remain largely unknown. Through transcriptome analyses, we identified a previously uncharacterized C2H2-type zinc finger gene, whose expression is regulated by GA and ABA, thus named GAZ （GA- AND ABA-RESPONSIVE ZINC FINGER）. Seedlings ectopically overexpressing GAZ （GAZ-OX） were sensitive to ABA and GA during MC formation, whereas GAZ-SRDX and RNAi seedlings displayed opposite phenotypes. In addition, our results indicated that GAZ was involved in the transcriptional regulation of ABA and GA homeostasis. In agreement with pre- vious studies that ABA and GA coordinate to control the timing of MC formation, we also confirmed the unique interplay between ABA and GA and identified factors and regulatory networks bridging the two hor- mone pathways during GT maturation of the Arabidopsis root.

关键词： ABA GA GRAS ground tissue root development transcription factor

Intraductal papillary mucinous carcinoma with atypical manifestations:Report of two cases

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World Journal of Gastroenterology 2007年第10期13卷 1622-1625页

作者： Seung eun Lee Jin-Young jang Sung Hoon Yang Sun-Whe Kim Department of Surgery Seoul National University College of MedicineSeoulKorea

Intraductal papillary mucinous neoplasms （IPMNs） are a well-characterized group of rnucin-producing cystic neoplasms of the clear malignant potential type. We report here two cases of intraductal papillary mucinous carcinoma （IPMC） with atypical manifestations. In one case, we discussed a pseudomyxoma peritonei caused by a ruptured IPMC. In the other case we discussed the fistulization of IPMC into the stomach and duodenum. These two cases suggest that IPMN can either spontaneously rupture causing mucinous materials to spill into the free abdominal cavity or directly invade adjacent organs resulting in fistula development.

关键词： Intraductal papillary mucinous neoplasm Intraductal papillary mucinous carcinoma Pseudomyxoma peritonei Fistula

Oral TNF-αsiRNA delivery via milk-derived exosomes for effective treatment of inflammatory bowel disease

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Bioactive Materials 2024年第4期34卷 138-149页

作者： Geonhee Han Hyosuk Kim Hochung jang eun Sun Kim Sun Hwa Kim Yoosoo Yang KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea Medicinal Materials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and TechnologySeoul02792Republic of Korea Department of Internal Medicine Korea University College of MedicineSeoul02841Republic of Korea

Oral administration facilitates the direct delivery of drugs to lesions within the small intestine and colon,making it an ideal approach for treating patients with inflammatory bowel ***,multiple physical barriers impede the delivery of oral RNA drugs through the gastrointestinal ***,we developed a novel oral siRNA delivery system that protects nucleic acids in extreme environments by employing exosomes derived from milk to encapsulate tumor necrosis factor-alpha(TNF-α)siRNA *** remarkable structural stability of milk-derived exosomes(M-Exos),as opposed to those from HEK293T cells,makes them exceptional siRNA *** demonstrate that milk exosomes loaded with TNF-αsiRNA(M-Exo/siR)can effectively inhibit the expression of TNF-α-related inflammatory ***,given that milk exosomes are composed of unique lipids with high bioavailability,orally administered M-Exo/siR effectively reach colonic tissues,leading to decreased TNF-αexpression and successful alleviation of colitis symptoms in a dextran sulfate sodium-induced inflammatory bowel disease murine ***,milk-derived exosomes carrying TNF-αsiRNA can be effectively employed to treat inflammatory bowel ***,using exosomes naturally derived from milk may shift the current paradigm of oral gene delivery,including siRNA.

关键词： Milk-derived exosome Oral gene delivery siRNA Inflammatory bowel disease TNF-α

Prognostic role of plasma level of angiopoietin-1,angiopoietin-2,and vascular endothelial growth factor in hepatocellular carcinoma

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World Journal of Gastroenterology 2021年第27期27卷 4453-4467页

作者： Gwang Hyeon Choi eun Sun jang Jin-Wook Kim Sook-Hyang Jeong Department of Internal Medicine Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam 13620South Korea

BACKGROUND Most hepatocellular carcinomas(HCCs)are hypervascular,with characteristic features of hepatic arterial supply to the *** factors involved in tumor angiogenesis include angiopoietin-1(Ang-1),angiopoietin-2(Ang-2),and vascular endothelial growth factor(VEGF).AIM To investigate the profiles of plasma levels of angiogenesis markers in patients with HCC and evaluate their roles in predicting overall survival(OS)and progression-free survival(PFS).METHODS Plasma samples from 240 prospectively enrolled HCC patients in the very early to advanced stages were used to measure the levels of Ang-1,Ang-2,and *** associations with clinical characteristics,OS,and PFS were *** The median plasma levels of Ang-1,Ang-2,and VEGF were 3216 pg/mL,1684 pg/mL,and 26.5 pg/mL,*** plasma level of Ang-2 showed a significant increase from early stage[Barcelona clinic liver cancer(BCLC)A]to intermediate(BCLC B)and advanced stage HCC(BCLC C/D),whereas Ang-1,VEGF,and alpha-fetoprotein(AFP)levels in the plasma did not show any such *** analysis,propensity score-matched analysis,and timedependent receiver operating curve analysis revealed that Ang-2 levels had the highest predictive power for OS and *** Ang-1 nor VEGF was significantly associated with OS or *** neutrophil-to-lymphocyte ratio was an independent factor for OS and *** The plasma levels of Ang-2 correlated with liver function,tumor stage,and tumor invasiveness,showing better performance in predicting OS and PFS than AFP,Ang-1,or VEGF.

关键词： Hepatocellular carcinoma Angiogenesis Biomarker Prognosis Survival

Calcium-dependent proteasome activation is required for axonal neurofilament degradation

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Neural Regeneration Research 2013年第36期8卷 3401-3409页

作者： Joo Youn Park So Young jang Yoon kyung Shin Duk Joon Suh Hwan Tae Park Department of Physiology Mitochondria Hub Regulation Center College of Medicine Dong-A University

Even though many studies have identified roles of proteasomes in axonal degeneration, the mo- lecular mechanisms by which axonal injury regulates proteasome activity are still unclear. In the present study, we found evidence indicating that extracellular calcium influx is an upstream regulator of proteasome activity during axonal degeneration in injured peripheral nerves. In degenerating axons, the increase in proteasome activity and the degradation of ubiquitinated proteins were sig- nificantly suppressed by extracellular calcium chelation. In addition, electron microscopic findings revealed selective inhibition of neurofilament degradation, but not microtubule depolymerization or mitochondrial swelling, by the inhibition of calpain and proteasomes. Taken together, our findings suggest that calcium increase and subsequent proteasome activation are an essential initiator of neurofilament degradation in Wallerian degeneration.

关键词： neural regeneration peripheral nerve injury neurofilament degradation sciatic nerve calcium calpain mitochondria microtubule depolymerization axon axon degeneration neuroregeneration