检索结果-南通市图书馆

DA-9601, a standardized extract of Artemisia asiatica, blocks TNF-α-induced IL-8 and CCL20 production by inhibiting p38 kinase and NF-κ-B pathways in human gastric epithelial cells

引用

World Journal of Gastroenterology 2006年第30期12卷 4850-4858页

作者： Suck-Chei choi eun-ju choi Hyun-Mee Oh SungGa Lee Jeong-Kun Lee Meung-Su Lee Yong-Il Shin Suck-jun choi Jeong-Ryong Chae Kang-Min Lee Won-jung Lee Jae-Sik Park Chang-Yell Shin Tae-Young Oh Chang-Duk jun Digestive Disease Research Institute Wonkwang University School of Medicine Iksan Chonbuk 570-749 Korea Department Physical Education Kunsan National University Chonbuk 573-701 Korea Department of Life Science Gwangju Institute of Science and Technology Gwangju 500-712 Korea Department of Leisure Sports Wonkwang Health Science College Iksan Chonbuk 570-749 Korea Division of Biological Sciences College of Natural Science Chonbuk National University Jeonju Chonbuk 561-756 Korea Department of Physiology Kyungpook National University School of Medicine Taegu 700-422 Korea Research Institute Dong-A Pharmaceutical Co. Ltd. Yongin 449-905 Korea

AIM: To investigate whether, or how, DA-9601, which is a new gastroprotective agent, inhibits TNF-α-induced inflammatory signals in gastric epithelial AGS cells. METHODS: Cell viability was determined by MTT assay. IL-8 and CCL20 promoter activities were determined by a luciferease reporter gene assay. NF-κB-dependent transcriptional activity was determined by I-κBαdegradation, NF-κB p65 nuclear translocation and a luciferase activity assay. IL-8 and CCL20 gene expression and protein secretion were determined by RT-PCR and an enzymelinked immunosorbent assay (ELISA). Total and phos-phorylated forms of mitogen-activated protein kinases (MAPKs) were determined by Western blot. RESULTS: Treatment of AGS cells with DA-9601 reduced TNF-α-induced IL-8 and CCL20 promoter activities, as well as their gene expression and protein release. TNF-αalso induced NF-κB-dependent transcriptional activity in AGS cells. In contrast, in cells treated with DA-9601, TNF-α-induced NF-κB activity was significantly blocked. Although all three MAP kinase family members were phosphorylated in response to TNF-α, a selective inhibitor of p38 kinase SB203580 only could inhibit both NF-κB-dependent transcriptional activity and IL-8 and CCL20 production, suggesting a potential link between p38 kinase and NF-κB-dependent pathways in AGS cells. Interestingly, DA-9601 also selectively inhibited p38 kinase phosphorylation induced by TNF-α. CONCLUSION: DA-9601 blocked TNF-α-mediated inflammatory signals by potentially modulating the p38 kinase pathway and/or a signal leading to NF-κBdependent pathways in gastric epithelial cells.

关键词： CCL20 IL-8 Artemisia asiatica DA-9601 TNF-α p38 kinase NF-κB

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

引用

Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-Ho choi Keun-Young Kim Yury I.Miller Won-Kyu ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways

引用

International Journal of Oral Science 2022年第2期14卷 192-200页

作者： Bongkun choi Ji-eun Kim Si-On Park eun-Young Kim Soyoon Oh Hyuksu choi Dohee Yoon Hyo-Jin Min Hyung-Ryong Kim eun-ju Chang Department of Biomedical Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Stem Cell Immunomodulation Research Center Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Pharmacology College of DentistryJeonbuk National UniversityJeonjuKorea Department of Biochemistry and Molecular Biology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

Sphingosine-1-phosphate(S1P)is an important lipid mediator that regulates a diverse range of intracellular cell signaling pathways that are relevant to tissue engineering and regenerative ***,the precise function of S1P in dental pulp stem cells(DPSCs)and its osteogenic differentiation remains *** here investigated the function of S1P/S1P receptor(S1PR)-mediated cellular signaling in the osteogenic differentiation of DPSCs and clarified the fundamental signaling *** results showed that S1P-treated DPSCs exhibited a low rate of differentiation toward the osteogenic phenotype in association with a marked reduction in osteogenesis-related gene expression and AKT *** note,both S1PR1/S1PR3 and S1PR2 agonists significantly downregulated the expression of osteogenic genes and suppressed AKT activation,resulting in an attenuated osteogenic capacity of *** importantly,an AKT activator completely abrogated the S1P-mediated downregulation of osteoblastic markers and partially prevented S1P-mediated attenuation effects during ***,the pro-inflammatory TNF-αcytokine promoted the infiltration of macrophages toward DPSCs and induced S1P production in both DPSCs and *** findings indicate that the elevation of S1P under inflammatory conditions suppresses the osteogenic capacity of the DPSCs responsible for regenerative endodontics.

关键词： pulp hinder precise

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Massive hemothorax following internal jugular vein catheterization under ultrasound guidance:A case report

引用

World Journal of Clinical Cases 2022年第17期10卷 5776-5782页

作者： Hyun Kang Soo Young Cho eun Ha Suk Wan ju Joon Yong choi Department of Anesthesiology and Pain Medicine Kwangju Christian HospitalGwangju 61661South Korea

BACKGROUND Hemothorax is a rare but life-threatening complication of central venous *** reports suggest that ultrasound guidance may reduce complications however,it does not guarantee safety CASE SUMMARY A 75-year-old male patient was admitted for laparoscopic radical *** ultrasound guidance,right internal jugular vein catheterization was successfully achieved after failure to aspirate blood from the catheter in the first *** hypotension developed after surgical positioning and persisted until the end of the operation,lasting for about 4 *** the recovery room,a massive hemothorax was identified on chest radiography and computed *** patient recovered following chest tube drainage of 1.6 L *** Hemothorax must be suspected when unexplained hemodynamic instability develops after central venous catheterization despite ultrasound *** the proper use of ultrasound is important.

关键词： Central venous catheterization Hemothorax Ultrasound guidance Internal jugular vein Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CoolVox:Advanced 3D convolutional neural network models for predicting solar radiation on building facades

引用

Building Simulation 2022年第5期15卷 755-768页

作者： jung Min Han eun Seuk choi Ali Malkawi Harvard University Graduate School of Design CambridgeUSA Harvard Center for Green Buildings and Cities CambridgeUSA Harvard John A.Paulson School of Engineering and Applied Sciences CambridgeUSA

Data-driven models have become increasingly prominent in the building,architecture,and construction *** area ideally suited to exploit this powerful new technology is building performance ***-based models have traditionally been used to estimate the energy flow,air movement,and heat balance of ***,physics-based models require many assumptions,significant computational power,and a considerable amount of time to output *** neural networks(ANNs)with prefabricated or simulated data are likely to be a more feasible option for environmental analysis conducted by designers during the early design *** ANNs require fewer inputs and shorter computation times and offer superior performance and potential for data augmentation,they have received increased attention for predicting the surface solar radiation on ***,ANNs can provide innovative and quick design solutions,enabling designers to receive instantaneous feedback on the effects of a proposed change to a building's *** research introduces deep learning methods as a means of simulating the annual radiation intensities and exposure level of buildings without the need for physics-based *** propose the CoolVox model to demonstrate the feasibility of using 3D convolutional neural networks to predict the surface radiation on building *** CoolVox model accurately predicted the radiation intensities of building facades under different boundary conditions and performed better than ARINet(with average mean square errors of 0.01 and 0.036,respectively)in predicting the radiation intensity both with(validation error=0.0165)and without(validation error=0.0066)the presence of boundary buildings.

关键词： artificial neural networks 3D convolutional neural networks solar radiation simulation building performance simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electrochemical processing of spent nuclear fuels:An overview of oxide reduction in pyroprocessing technology

引用

Progress in Natural Science:Materials International 2015年第6期25卷 572-582页

作者： eun-Young choi Sang Mun Jeong Korea Atomic Energy Research Institute Department of Chemical Engineering Chungbuk National University

The electrochemical reduction process has been used to reduce spent oxide fuel to a metallic form using pyroprocessing technology for a closed fuel cycle in combination with a metal-fuel fast *** the electrochemical reduction process,oxides fuels are loaded at the cathode basket in molten LiO–LiCl salt and electrochemically reduced to the metal *** approaches based on thermodynamic calculations and experimental studies have been used to understand the electrode reaction and efficiently treat spent *** factors that affect the speed of the electrochemical reduction have been determined to optimize the process and scale-up the electrolysis *** addition,demonstrations of the integrated series of processes(electrorefining and salt distillation) with the electrochemical reduction have been conducted to realize the oxide fuel *** overview provides insight into the current status of and issues related to the electrochemical processing of spent nuclear fuels.

关键词： Pyroprocessing Electrochemical reduction Electrorefining Molten salt Spent oxide fuel

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Antioxidant and anticancer activity of Artemisia princeps *** extract in HepG2 and Hep3B hepatocellular carcinoma cells

引用

Chinese Journal of Cancer Research 2013年第5期25卷 536-543页

作者： eun-Jeong choi Gun-Hee Kim Plant Resources Research Institute Duksung Women's University

Objective：The aim of the present study was to investigate antioxidant and the anticancerigen activity of a methanol extract from Artemisia princeps *** （APME）,a well-known traditional herbal medicine in Asia,in hepatocellular cancer ***：To evaluate the antioxidant activity of APME,reactive oxygen species （ROS） and the antioxidant enzymes,superoxide dismutase （SOD） and catalase were investigated in HepG2 cells exposed to APME （5,100,and 200 μg/mL） for 72 ***,to evaluate the anticancer activity of APME,we investigated the proliferation and apoptosis induction of HepG2 and Hep3B cells exposed to APME （1-200 μg/mL） for 24,48,and 72 ***：APME dose-dependently reduced the generation of ROS in the presence of H2O2 compared with control ***,it increased catalase and SOD ***,APME inhibited cell proliferation in a dose-and time-dependcnt manner,but at concentrations lower than 100 μg/mL,the inhibition was less dose-dependent than ***2 and Hep3B cells exposed to 5,100,and 200 μg/mL APME for 72 h underwent cell cycle arrest and *** to APME resulted in a significant increase in the number of cells in G1 phase and a decrease in the G2/M phase cell *** addition,APME induced P53 expression of HepG2 cells in a dose-dependent manner,and played a role in the downregulation of Bcl-2 and upregulation of Bax in both HepG2 and Hep3B ***：These results indicate the potential role of APME as an antioxidant and anticancerigen agent in hepatocarcinoma cell lines.

关键词： Artemisia princeps var.orientalis antioxidant anticancer hepatocellular carcinoma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of optical emission spectroscopy data during silicon etching in SF_(6)/O_(2)/Ar plasma

引用

Plasma Science and Technology 2021年第12期23卷 117-127页

作者： Dong Hwan KIM Jeong eun choi Sang Jeen HONG Department of Electronics Engineering Myongji University116 Myongji-roYongin-siGyeonggi-doRepublic of Korea

Silicon etching is an essential process in various applications,and a major challenge for etching process is anisotropic high aspect ratio etching *** etch profile is determined by the plasma parameters and process *** this study,the plasma state with each process parameters were analyzed through the optical emission spectroscopy(OES)plasma diagnostic sensor by both chemical and physical *** temperature and electron density were additionally acquired using the corona model with OES data that provides chemical species information,and the etch profile was evaluated through scanning electron microscope measurement *** results include changes in profile with gas ratio,bias power,and *** figure out that factors like ion energy and ion angular distribution as well as chemical reaction affect the anisotropic profile.

关键词： silicon etching profile optical emission spectroscopy plasma in-formation corona model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Two climate factors in May that affect Korean rainfall in September

引用

Acta Oceanologica Sinica 2013年第1期32卷 32-47页

作者： choi Ki-Seon MOON Il-ju National Typhoon Center Korea Meteorological Administration College of Ocean Science/Ocean and Environment Research Institute Jeju National University

This study revealed a high positive correlation between rainfall in Korea during September and the trade wind （TW）/Arctic Oscillation （AO） index in May that combines two climate factors, low-level TWs and the AO. This correlation was identified on the basis of the difference in the 850 hPa streamline analysis between the positive and negative phases selected using the combined TW/AO index. In May, the spatial pattern of the anomalous pressure systems is similar to that in the positive AO phase. These anomalous pressure sys- tems continue in june to August （JJA） and September, but the overall spatial distribution shifts a little to the south. Particularly in September, a huge anomalous anticyclone centered over the southeast seas of Japan strengthens in most of the western north Pacific region and supplies a large volume of warm and humid air to the region near Korea. This characteristic is confirmed by the facts that during the positive TW/AO phase, the subtropical western north Pacific high （SWNPH） is more developed to the north and that the continu- ous positioning of the upper troposphere jet over Korea from May to September strengthens the anomalous upward flow, bringing warm and humid air to all layers. These factors contribute to increasing September rainfall in Korea during the positive TW/AO phase. Because the SWNPH develops more to the north in the positive phase, tropical cyclones tend to make landfall in Korea frequently, which also plays a positive role in increasing September rainfall in *** above features are also reflected by the differences in average rainfall between the six years that had the highest May Nifio 3.4 indices （El Niflo phase） and the six years that had the lowest May Niflo 3.4 indices （La Nifia phase）.

关键词： anomalous pressure Arctic Oscillation Korea low-level trade wind rainfall tropical cyclone

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Flower morphology of Allium(Amaryllidaceae)and its systematic significance

引用

Plant Diversity 2024年第1期46卷 3-27页

作者： ju eun Jang Shukherdorj Baasanmunkh Nudkhuu Nyamgerel Seung-Yoon Oh jun-Ho Song Ziyoviddin Yusupov Komijlon Tojibaev Hyeok Jae choi Department of Biology and Chemistry Changwon National UniversityChangwon51140Republic of Korea Department of Forest Biodiversity and Herbarium Korea National ArboretumPocheon11186Republic of Korea Department of Biology Chungbuk National UniversityCheongju28644Republic of Korea International Joint Lab for Molecular Phylogeny and Biogeography Institute of BotanyAcademy of Sciences of UzbekistanTashkent100125Uzbekistan

Allium is a complicated genus that includes approximately 1000 *** its morphology is well studied,the taxonomic importance of many morphological traits,including floral traits,are poorly ***,we examined and measured the floral characteristics of 87 accessions of 74 Allium taxa(belonging to 30 sections and nine subgenera)from Central to Eastern Asian *** then examined the taxonomic relationships between select flower characteristics and a phylogenetic tree based on ITS *** results confirm that floral morphology provides key taxonomic information to assess species delimitation in *** found that perianth color is an important characteristic within the ***,Polyprason,and *** ***,Cepa,and Rhizirideum,significant characteristics include ovary shape,perianth shape,and inner tepal *** species in ***,the key taxonomic character is ovule number(only one ovule in per locule).In the ***,Cepa,Polyprason,and Reticulatobulbosa,which belong to the third evolutionary line of Allium,hood-like appendages occur in the ovary,although these do not occur in *** results also indicated that the flower morphology of several species in some sections are not clearly distinguished,e.g.,***(***)and ***(***).This study provides detailed photographs and descriptions of floral characteristics and information on general distributions,habitats,and phenology of the studied taxa.

关键词： Allium Flower morphology Pistil character Statistical analysis Significant characteristic Species level

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：