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Effect of Meteorological Data Assimilation on Regional Air Quality Forecasts over the Korean Peninsula

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Journal of Meteorological Research 2024年第2期38卷 262-284页

作者： Yunjae CHO Hyun Mee KIM eun-Gyeong YANG Yonghee LEE Jae-Bum LEE Soyoung ha Department of Atmospheric Sciences Yonsei UniversitySeoul 03722Republic of Korea Air Quality Forecasting Center National Institute of Environmental ResearchIncheon 22689Republic of Korea National Center for Atmospheric Research BoulderCO 80305USA University of Maryland Baltimore County BaltimoreMD 21250USA Global Modeling and Assimilation Office NASA Goddard Space Flight CenterGreenbeltMD 20771USA

The Weather Research and Forecasting model coupled with Chemistry(WRF-Chem),a type of online coupled chemistry-meteorology model(CCMM),considers the interaction between air quality and meteorology to improve air quality *** data assimilation(DA)can be used to reduce uncertainty in meteorological field,which is one factor causing prediction uncertainty in the *** this study,WRF-Chem and three-dimensional variational DA were used to examine the impact of meteorological DA on air quality and meteorological forecasts over the Korean *** nesting model domains were configured over East Asia(outer domain)and the Korean Peninsula(inner domain).Three experiments were conducted by using different DA domains to determine the optimal model domain for the meteorological *** the meteorological DA was performed in the outer domain or both the outer and inner domains,the root-mean-square error(RMSE),bias of the predicted particulate matter(PM)concentrations,and the RMSE of predicted meteorological variables against the observations were smaller than those in the experiment where the meteorological DA was performed only in the inner *** indicates that the improvement of the synoptic meteorological fields by DA in the outer domain enhanced the meteorological initial and boundary conditions for the inner domain,subsequently improving air quality and meteorological *** to the experiment without meteorological DA,the RMSE and bias of the meteorological and PM variables were smaller in the experiments with *** effect of meteorological DA on the improvement of PM predictions lasted for approximately 58-66 h,depending on the ***,the uncertainty reduction in the meteorological initial condition by the meteorological DA contributed to a reduction of the forecast errors of both meteorology and air quality.

关键词： meteorological data assimilation regional air quality forecast particulate matter concentration optimal model domain forecast error WRF-Chem

Etanercept-synthesizing adipose-derived stem cell secretome:A promising therapeutic option for inflammatory bowel disease

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 882-892页

作者： Say-June Kim Ok-Hee Kim ha-eun Hong Ji Hyeon Ju Do Sang Lee Department of Surgery Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Catholic Central Laboratory of Surgery Institute of Biomedical IndustryCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Division of Rheumatology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Inflammatory bowel disease(IBD)is a chronic inflammatory condition of the gastrointestinal tract,with tumor necrosis factor(TNF)-αplaying a key role in its ***,a decoy receptor for TNF,is used to treat inflammatory *** secretome derived from adipose-derived stem cells(ASCs)has anti-inflammatory effects,making it a promising therapeutic option for *** To investigate the anti-inflammatory effects of the secretome obtained from ASCs synthesizing etanercept on colon cells and in a dextran sulfate sodium(DSS)-induced IBD mouse *** ASCs were transfected with etanercept-encoding mini-circle plasmids to create etanercept-producing *** secretory material from these cells was then tested for anti-inflammatory effects both in vitro and in a DSS-induced IBD mouse *** This study revealed promising results indicating that the group treated with the secretome derived from etanercept-synthesizing ASCs[Etanercept-Secretome(Et-Sec)group]had significantly lower expression levels of inflammatory mediators,such as interleukin-6,Monocyte Chemoattractant Protein-1,and TNF-α,when compared to the control secretome(Ct-Sec).Moreover,the Et-Sec group exhibited a marked therapeutic effect in terms of preserving the architecture of intestinal tissue compared to the *** These results suggest that the secretome derived from ASCs that synthesize etanercept has potential as a therapeutic agent for the treatment of IBD,potentially enhancing treatment efficacy by merging the anti-inflam-matory qualities of the ASC secretome with etanercept's targeted approach to better address the multifaceted pathophysiology of IBD.

关键词： Adipose-derived stem cells Etanercept Inflammatory bowel disease Secretome Tumor necrosis factor-α

M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3169-3183页

作者： ha eun Shin Jun-Hyeok han Seungyong Shin Ga-Hyun Bae Boram Son Tae-Hyung Kim Hee Ho Park Chun Gwon Park Wooram Park Department of Integrative Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea Department of MetaBioHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Department of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea Department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biomedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of Science and Technology(KIST) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel biomaterial-based platform,M1-polarized macrophage-derived cellular nanovesicle-coated LNPs(M1-C-LNPs),specifically engineered for a combined gene-immunotherapy approach against solid *** dual-function system of M1-C-LNPs encapsulates Bcl2-targeting siRNA within LNPs and immune-modulating cytokines within M1 macrophage-derived cellular nanovesicles(M1-NVs),effectively facilitating apoptosis in cancer cells without impacting T and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was observed upon intratumoral administration of M1-C-LNPs,owing to the presence of adhesion molecules on M1-NVs,thereby contributing to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-based cancer genetic-immunotherapy,with significant implications for advancing biomaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy M1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy siRNA Cancer immunotherapy Solid tumor Tumor microenvironment(TME)

Neural Wiskott-Aldrich syndrome protein(N-WASP)promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

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Oncology Research 2024年第4期32卷 615-624页

作者： HYUNG SUN KIM YUN SUN LEE SeunG MYUNG DONG HYO JUNG KIM DA eun LEE HYEON WOONG KANG MYEONG JIN KIM JOON SEONG PARK Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoulKorea Department of Surgery Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulKorea Gibiome Co. Ltd.Gyeonggi-doKorea

Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive solid malignancies.A specific mechanism of its metastasis has not been *** this study,we investigated whether Neural Wiskott-Aldrich syndrome protein(N-WASP)plays a role in distant metastasis of *** found that N-WASP is markedly expressed in clinical patients with *** analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group.N-WASP was noted to be a novel mediator of epithelialmesenchymal transition(EMT)via gene expression profile *** of N-WASP in pancreatic cancer cells significantly inhibited cell invasion,migration,and *** also observed positive association of lysyl oxidase-like 2(LOXL2)and focal adhesion kinase(FAK)with the N-WASP-mediated response,wherein EMT and invadopodia function were *** N-WASP and LOXL2 depletion significantly reduced the incidence of liver and lung metastatic lesions in orthotopic mouse models of pancreatic *** results elucidate a novel role for N-WASP signaling associated with LOXL2 in EMT and invadopodia function,with respect to regulation of intercellular communication in tumor cells for promoting pancreatic cancer *** findings may aid in the development of therapeutic strategies against pancreatic cancer.

关键词： Pancreatic cancer Neural Wiskott-Aldrich syndrome protein(N-WASP)signaling Metastasis Epithelial-mesenchymal transition(EMT) Lysyl oxidase-like 2(LOXL2)

Fatal rhabdomyolysis and disseminated intravascular coagulation after total knee arthroplasty under spinal anesthesia:A case report

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World Journal of Clinical Cases 2022年第4期10卷 1349-1356页

作者： Dae Hun Yun eun ha Suk Wan Ju eun Hyoung Seo Hyun Kang Department of Anesthesiology and Pain Medicine Kwangju Christian HospitalGwangju 61661South Korea

BACKGROUND Rhabdomyolysis develops as a result of skeletal muscle cell collapse from leakage of the intracellular contents into *** severe cases,it can be associated with acute kidney injury and disseminated intravascular coagulation,leading to life threatening *** can occur in the perioperative period from various etiologies but is rarely induced by tourniquet use during orthopedic *** SUMMARY A 77-year-old male underwent right total knee arthroplasty using a tourniquet under spinal *** 24 h after surgery,he was found in a drowsy mental state and manifested features of severe rhabdomyolysis,including fever,hypotension,oliguria,high creatine kinase,myoglobinuria,and disseminated intravascular *** supportive care,cardiac arrest developed abruptly,and the patient was not able to be *** Severe rhabdomyolysis and disseminated intravascular coagulation can develop from surgical tourniquet,requiring prompt,aggressive treatments to save the patient.

关键词： Rhabdomyolysis Total knee arthroplasty Tourniquet Disseminated intravascular coagulation Case report

Massive hemothorax following internal jugular vein catheterization under ultrasound guidance:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5776-5782页

作者： Hyun Kang Soo Young Cho eun ha Suk Wan Ju Joon Yong Choi Department of Anesthesiology and Pain Medicine Kwangju Christian HospitalGwangju 61661South Korea

BACKGROUND Hemothorax is a rare but life-threatening complication of central venous *** reports suggest that ultrasound guidance may reduce complications however,it does not guarantee safety CASE SUMMARY A 75-year-old male patient was admitted for laparoscopic radical *** ultrasound guidance,right internal jugular vein catheterization was successfully achieved after failure to aspirate blood from the catheter in the first *** hypotension developed after surgical positioning and persisted until the end of the operation,lasting for about 4 *** the recovery room,a massive hemothorax was identified on chest radiography and computed *** patient recovered following chest tube drainage of 1.6 L *** Hemothorax must be suspected when unexplained hemodynamic instability develops after central venous catheterization despite ultrasound *** the proper use of ultrasound is important.

关键词： Central venous catheterization Hemothorax Ultrasound guidance Internal jugular vein Case report

Nitric-oxide enriched plasma-activated water inactivates 229E coronavirus and alters antiviral response genes in human lung host cells

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生物活性材料(英文) 2023年第1期19卷 569-580页

作者： Nagendra Kumar Kaushik Pradeep Bhartiya Neha Kaushik Yungoh Shin Linh Nhat Nguyen Jang Sick Park Doyoung Kim eun ha Choi Department of Electrical and Biological Physics Plasma Bioscience Research CenterKwangwoon UniversitySeoul01897Republic of Korea Department of Biotechnology College of EngineeringThe University of SuwonHwaseong-si18323Republic of Korea

The ongoing pandemic caused by the novel coronavirus,SARS-CoV-2,is influencing global ***,there is a major threat of future coronaviruses affecting the entire world in a similar,or even more dreadful,***,effective and biocompatible therapeutic options against coronaviruses are urgently *** address this challenge,medical specialists require a well-informed and safe approach to treating human coronaviruses(HCoVs).Herein,an environmental friendly approach for viral inactivation,based on plasma technology,was considered.A microwave plasma system was employed for the generation of the high amount of gaseous nitric oxide to prepare nitric oxide enriched plasma-activated water(NO-PAW),the effects of which on coronaviruses,have not been reported to *** determine these effects,alpha-HCoV-229E was used in an experimental *** found that NO-PAW treatment effectively inhibited coronavirus infection in host lung cells,visualized by evaluating the cytopathic effect and expression level of spike ***,NO-PAW showed minimal toxicity towards lung host cells,suggesting its potential for therapeutic ***,this new approach resulted in viral inactivation and greatly improved the gene levels involved in host antiviral ***,our findings provide evidence of an initiation point for further progress toward the clinical development of antiviral treatments,including such coronaviruses.

关键词： Nitric oxide enriched plasma-activated water Microwave plasma Coronavirus Virus inactivation Gene expression

Globus pharyngeus:A review of its etiology,diagnosis and treatment

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World Journal of Gastroenterology 2012年第20期18卷 2462-2471页

作者： Bong eun Lee Gwang ha Kim Department of Internal Medi cine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University Hospital Busan 602-739South Korea

Globus is a persistent or intermittent non-painful sensation of a lump or foreign body in the *** is a commonly encountered clinical condition that is usually long-lasting,difficult to treat,and has a tendency to ***,due to the uncertain etiology of globus,it remains difficult to establish standard investigation and treatment strategies for affected patients. As a first step for managing globus,careful history taking and nasolaryngoscopy are *** the benign nature of the condition and the recent notion that gastroesophageal reflux disease is a major cause of globus,empirical therapy with a high dose of proton pump inhibitors is reasonable for patients with typical *** patients are nonresponsive to this therapy, definitive assessments such as endoscopy,multichannel intraluminal impedance/pH monitoring,and ma-nometry should be *** and language therapy,anti-depressants,and cognitive-behavioral therapy can be helpful in patients whose symptoms persist despite negative investigations.

关键词：治疗病因审查诊断 Globus 质子泵抑制剂苍白球 pH监测

Water stable and matrix addressable OLED fiber textiles for wearable displays with large emission area

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npj Flexible Electronics 2022年第1期6卷 664-671页

作者： hayoung Song Young Jin Song Jinwook Hong Ki Suk Kang Sera Yu ha-eun Cho Jae-Hun Kim Sung-Min Lee School of Materials Science and Engineering Kookmin UniversitySeoul 02707Republic of Korea School of Electrical Engineering KAISTDaejeon 34141Republic of Korea

Organic light-emitting diode(OLED)fibers with favorable electroluminescence properties and interconnectable pixel configurations have represented the potential for wearable electronic textile ***,the current technology of OLED fiber-based textile displays still leaves to be desired due to several challenges,including limited emission area and lack of encapsulation *** we present a fibrous OLED textile display that can attain a large emission area and long-term stability by implementing addressable networks comprised of integrated phosphorescence OLED fibers and by designing multilayer *** integrated fiber configuration offers decoupled functional fiber surfaces for an interconnectable 1-dimensional OLED pixel array and a data-addressing *** triadic metal/ultrathin oxide/polymer multilayer enables not only the oxygen/water permeation inhibition but also the controllable conductive channels of dielectric *** with reliable bending stability,the long-term operation of OLED textiles in water manifests the feasibility of the present device concept toward water-resistant full-emitting-area fibrous textile displays.

关键词： fiber OLED wear