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Autoimmune hepatitis in a patient with immunoglobulin A nephropathy:A case report

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World Journal of Clinical Cases 2020年第17期8卷 3828-3834页

作者： You Hyun Jeon Da Woon Kim So Jeong Lee young Joo Park Hyo Jin Kim Miyeun Han Il young Kim Dong Won Lee Sang Heon Song Soo Bong Lee eun young seong Department of Internal Medicine Pusan National University School of MedicineBusan 49241South Korea Department of Pathology Pusan National University HospitalBusan 49241South Korea Division of Gastroenterology Department of Internal MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Division of Nephrology Department of Internal MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Division of Nephrology Department of Internal MedicinePusan National University Yangsan HospitalYangsan 626-770South Korea

BACKGROUND Immunoglobulin A nephropathy(IgAN)is the most commonly encountered glomerular disease in Asian *** has a broad clinical presentation,and it is frequently associated with other *** liver disease is well recognized as the leading cause of secondary ***,cases of IgAN associated with autoimmune hepatitis(AIH)have seldom been *** SUMMARY A 63-year-old Korean woman was admitted to Pusan National University Hospital for an evaluation of abdominal pain and elevated liver *** weeks prior,she had presented to our hospital with proteinuria of approximately 1350 mg/d and hematuria and was diagnosed with *** profiles were highly positive for antinuclear antibodies,and symptoms related to portal hypertension including ascites and peripheral edema were present.A diagnosis of AIH was made according to the simplified scoring system of the International Autoimmune Hepatitis *** immunosuppression with prednisolone and azathioprine,rapid deterioration of liver function led to end-stage liver *** a living-donor liver transplantation,liver function gradually improved,and she had maintained stable liver and kidney function at the six months *** Cases of secondary IgAN with chronic liver disease have been frequently reported in the literature but are rarely associated with *** encountered an IgAN patient with concurrent progressive liver failure due to AIH.

关键词： Immunoglobulin A nephropathy Secondary immunoglobulin A nephropathy Autoimmune hepatitis Liver transplantation Case report

Advanced polymer materials-based electronic skins for tactile and non-contact sensing applications

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InfoMat 2023年第7期5卷 1-42页

作者： Feifei Yin Hongsen Niu eun-seong Kim young Kee Shin Yang Li Nam-young Kim Department of Electronics Engineering Kwangwoon UniversitySeoulRepublic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences Seoul National UniversitySeoulRepublic of Korea School of Information Science and Engineering University of JinanJinanthe People's Republic of China

Recently,polymer materials have been at the forefront of other materials in building high-performance flexible electronic skin(e-skin)devices due to con-spicuous advantages including excellent mechanical flexibility,good compatibil-ity,and high ***,most research works just paid considerable attention and effort to the design,construction,and possible application of e-skins that reproduce the tactile perception of the human skin sensory *** with tactile sensing devices,e-skins that aim to imitate the non-contact sensing features in the sensory system of human skin tend to avoid undesired issues such as bacteria spreading and mechanical *** further promote the development of e-skins to the human skin sensory system where tactile perception and non-contact sensing complement each other,significant progress and advances have been achieved in the field of polymer materials enabled e-skins for both tactile perception and non-contact sensing *** this review,the latest progress in polymer material-based e-skins with regard to tactile,non-contact sensing capabilities and their practical applications are *** fabrication strategies of polymer materials and their role in building high-performance e-skins for tactile and non-contact sensing are ***,we also review the research works that integrated the polymer-based tactile and non-contact e-skins into robots and prostheses,smart gloves,and VR/AR devices and addressed some representative problems to dem-onstrate their suitability in practical applications in human–machine ***,the current challenges in the construction of high-performance tactile and non-contact e-skins are highlighted and promising properties in this direction,by taking advantage of the polymer materials,are outlined.

关键词： electronic skins human-machine interaction non-contact sensing polymer materials tactile sensing

Electrophoretic deposition of a supercapacitor electrode of activated carbon onto an indium-tin-oxide substrate using ethyl cellulose as a binder

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Journal of Materials Science & Technology 2020年第23期58卷 188-196页

作者： Taeuk Kim seong-Hoon Yi Sang-eun Chun School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

A transparent energy storage device is an essential component for transparent *** increasing demand for high-power devices stimulates the development of transparent supercapacitors with high power density.A transparent electrode for such supercapacitors can be assembled via the electrophoretic deposition of an active material powder with a binder onto a transparent *** properties of the binder critically influence the electrochemical behavior and performance of the resulting *** cellulose(EC)is known as an eco-friendly,transparent,flexible,and inexpensive ***,we fabricated an electrode film with EC binder via electrophoretic deposition on an indium tin oxide(ITO)substrate instead of using the conventional polytetrafluoroethylene(PTFE)*** assembled electrodes with EC and PTFE were compared to investigate the feasibility of EC as a binder from different perspectives,including homogeneity,wettability,electrochemical behavior,and mechanical *** EC enabled the formation of a homogeneous film composed of smaller particles and with a higher specific capacitance compared with films prepared with *** annealing improved the adhesion strength of the EC because of its glass transition;however,its hydrophobic nature limited utilization of the active material for charge *** electrochemical activation improved the wettability of the electrode,resulting in an increased capacitance of 60 F g^(-1).Furthermore,even with the lower wettability of EC compared with that of PTFE,better rate performance was possible with the EC *** increased mechanical stability after the annealing process ensured an excellent cycle life of 95%capacitance retention for 15,000 cycles.

关键词： Electrophoretic deposition Transparent electrode Activated carbon Ethyl cellulose Indium tin oxide

Panax ginseng induces the expression of CatSper genes and sperm hyperactivation

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Asian Journal of Andrology 2014年第6期16卷 845-851页

作者： eun Hwa Park Do Rim Kim Ha young Kim seong Kyu Park Mun Seog Chang Department of Prescriptionology College of Korean Medicine Kyung Hee Unversity Seoul Korea.

The cation channel of sperm （CatSper） protein family plays important roles in male reproduction and infertility. The four members of this family are expressed exclusively in the testis and are localized differently in sperm. To investigate the effects of Panax ginseng treatment on the expression of CatSper genes and sperm hyperactivation in male mice, sperm motility and CatSper gene expression were assessed using a computer-assisted semen analysis system, a Fluoroskan Ascent microplate fluorometer to assess Ca2＊ influx, *** polymerase chain reaction, Western blotting and immunofluorescence. The results suggested that the Ca2＊ levels of sperm cells treated with P. ginseng were increased significantly compared with the normal group. The P. ginseng-treated groups showed increased sperm motility parameters, such as the curvilinear velocity and amplitude of lateral head displacement. Taken together, the data suggest that CatSper messenger ribonucleic acid levels were increased significantly in mouse testes in the P. ginseng-treated group, as was the protein level, with the exception of CatSper2. In conclusion, P. ginseng plays an important role in improving sperm hyperactivation via CatSper gene expression.

关键词： Ca2+ CatSper hyperactivation panax Einseng

Substructure imaging of heterogeneous nanomaterials with enhanced refractive index contrast by using a functionalized tip in photoinduced force microscopy

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Light(Science & Applications) 2018年第1期7卷 322-330页

作者： Junghoon Jahng Heejae Yang eun seong Lee Center for Nanocharacterization Korea Research Institute of Standards and Science(KRISS)Daejeon 34113Republic of Korea Department of Materials Engineering Advanced Fibrous Materials LaboratoryUniversity of British ColumbiaVancouverBC V6T 1Z4Canada

The opto-mechanical force response from light-illuminated nanoscale materials has been exploited in many tip-based imaging applications to characterize various heterogeneous *** a force can have two origins:thermal expansion and induced *** thermal expansion reflects the absorption of the material,which enables one to chemically characterize a material at the absorption *** induced dipole interaction reflects the local refractive indices of the material underneath the tip,which is useful to characterize a material in the spectral region where no absorption resonance occurs,as in the infrared(IR)-inactive ***,the dipole force is relatively small,and the contrast is rarely discernible for most organic materials and biomaterials,which only show a small difference in refractive indices for their *** this letter,we demonstrate that refractive index contrast can be greatly enhanced with the assistance of a functionalized *** the enhanced contrast,we can visualize the substructure of heterogeneous biomaterials,such as a polyacrylonitrile-nanocrystalline cellulose(PAN-NCC)*** substructural visualization,we address the issue of the tensile strength of PAN-NCC fibers fabricated by several different mixing *** understanding from the present study will open up a new opportunity to provide enhanced sensitivity for substructure mapping of nanobiomaterials,as well as local field mapping of photonic devices,such as surface polaritons on semiconductors,metals and van der Waals materials.

关键词： refractive biomaterials functional

Advances in flexible sensors for intelligent perception system enhanced by artificial intelligence

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InfoMat 2023年第5期5卷 55-110页

作者： Hongsen Niu Feifei Yin eun-seong Kim Wenxiao Wang Do-young Yoon Cong Wang Junge Liang Yang Li Nam-young Kim RFIC Centre Kwangwoon UniversitySeoulRepublic of Korea Department of Electronics Engineering Kwangwoon UniversitySeoulRepublic of Korea NDAC Centre Kwangwoon UniversitySeoulRepublic of Korea Department of Chemical Engineering Kwangwoon UniversitySeoulRepublic of Korea School of Electronics and Information Engineering Harbin Institute of TechnologyHarbinthe People's Republic of China Department of Electronic Engineering Jiangnan UniversityWuxithe People's Republic of China School of Information Science and Engineering University of JinanJinanthe People's Republic of China

Intelligent perception means that with the assistance of artificial intelligence(AI)-motivated brain,flexible sensors achieve the ability of memory,learning,judgment,and reasoning about external information like the human *** to the superiority of machine learning(ML)algorithms in data processing and intelligent recognition,intelligent perception systems possess the ability to match or even surpass human perception ***,the built-in flexible sensors in these systems need to work on dynamic and irregular surfaces,inevitably affecting the precision and fidelity of the acquired *** recent years,the strategy of introducing the developed functional materials and innovative structures into flexible sensors has made some progress toward the above challenges,and with the blessing of ML algorithms,accurate perception and reasoning in various scenarios have been ***,the most representative functional materials and innovative structures for constructing flexible sensors are comprehensively reviewed,the research progress of intelligent perception systems based on flexible sensors and ML algorithms is further summarized,and the intersection of the two is expected to unlock new opportunities for next-stage AI development.

关键词： flexible sensor intelligent perception artificial intelligence machine learning

Enhanced stability and rate performance of zinc-doped cobalt hexacyanoferrate (CoZnHCF) by the limited crystal growth and reduced distortion

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Journal of Energy Chemistry 2022年第6期31卷 649-658,I0018页

作者： Jihwan Kim seong-Hoon Yi Li Li Sang-eun Chun School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina School of Industrial Technology Advances Kyungpook National UniversityDaegu 41566Republic of Korea

Cobalt hexacyanoferrate (CoHCF) is a potential cathode for aqueous Na-ion batteries due to its high theoretical specific capacity (170 m Ah g^(-1));however,its lower rate capability and cyclability limit its *** distortion at a weak N-coordinated crystal field during cycling disintegrates Co,yielding an irreversible *** Zn amounts ranging 0–1 were added to the Co site to suppress the structural irreversibility of CoHCF,yielding Co_(1-x)Zn_(x)HCF powder;this Zn (x≤0.09) addition reduced the powder’s dimension because the lower four coordination of Zn–N,not the six coordination of Co–N,limits the powder ***,a small lattice parameter and interaxial angle (~90°) are obtained,implying that a narrower Co_(1-x)Zn_(x)HCF inner structure is formed to accommodate Na ***,the electronic conductivity of Co_(1-x)Zn_(x)HCF gradually increased within 0–0.09 range.A smaller particle size with a high surface area leads to a near-surface-limited redox process,similar to a capacitive *** the surface-limited reaction and electronic conductivity enhances the reversibility due to the smaller charge transfer resistance at the electrode/electrolyte interface caused by Zn *** redox-active Co with non-active Zn amount of 0.07 (Co_(1-x)Zn_(x)HCF) slightly reduces the specific capacity from 127 to 119 mAh g^(-1)at 0.1 A g^(-1)due to the shrunken Co charging *** performance is enhanced by compromising the capacity and reduced distortion,resulting in 81%retention at a 20-times-faster charging ***,the Co_(1-x)Zn_(x)HCF sample exhibited the good stability while preserving 74%of the initial capacity at 0.5 A g^(-1)after 200 cycles.

关键词： Cobalt hexacyanoferrate Rate capability Stability Growth limitation Structural distortion Near-surface-limited redox process

Efficacy of uncovered self-expandable metallic stent for colorectal obstruction by extracolonic malignancy

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World Journal of Gastrointestinal Oncology 2020年第9期12卷 1005-1013页

作者： Joon seong Ahn Sung Noh Hong Dong Kyung Chang young-Ho Kim eun-Ran Kim Department of Internal Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea

BACKGROUND Self-expandable metallic stent(SEMS)is widely used for malignant colorectal ***,SEMS has been used for palliative option for colorectal obstruction caused by extracolonic malignancy(ECM).AIM To evaluate the efficacy of SEMS for colorectal obstruction caused by ECM,and to identify the factors associated with stent *** Seventy-two patients who were treated with uncovered SEMS insertion for malignant colorectal obstructions caused by colorectal metastasis or peritoneal seeding of ECM at Samsung Medical Center between April 2012 to March 2016 were *** analyzed technical and clinical outcomes of stent insertion,the factors associated with stent occlusion and long term outcomes after stent *** Technical success rate was determined as 90.3%with a clinical success rate of 87.7%.Stent occlusion developed in 28.1%,with a median duration of 51 ***,81.3%with stent occlusion could be treated with secondary stent *** failure was observed to be related to the male sex(P=0.020)and right colon obstruction(P=0.017).Stent length≤10 cm was found to be associated with stent occlusion(P=0.003).Median survival time after stent insertion was 4.7 mo and 40.4%were able to receive their oncological treatments after stent insertion without *** Uncovered SEMS is effective for the treatment of colorectal obstruction caused by ECM,considering life expectancy of patients with ECM.

关键词： Self-expandable metallic stent Colorectal stent Colorectal obstruction Extracolonic malignancy Retrospective study

Inhibitory potential of three Yin-tonification herbal formulas on the activities of human major cytochrome P450 and UDP-glucuronosyltransferases isozymes in vitro

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Journal of Traditional Chinese Medicine 2018年第4期38卷 511-522页

作者： seong eun Jin Hyeun-Kyoo Shin Hyekyung Ha K-herb Research Center Korea Institute of Oriental Medicine Daejeon 34054 Republic of Korea

OBJECTIVE:To investigate the influence of Yin-tonification herbal formulas Jaeumganghwa-tang(Ziyin Jianghuo Tang,JEGHT),Ssanghwa-tang(Shuanghe Tang,SHT) and Yukmijihwang-tang(Liuwei Di huang Tang,YMJHT) on the activities of human major cytochrome P450(CYP450 s) and UDP-glucuronosyltransferases isozymes(UGTs) in ***:The activities of CYP450 s(CYP1 A2,CYP3 A4,CYP2 B6,CYP2 C9,CYP2 C19,CYP2 D6 and CYP2 E1) and UGTs(UGT1 A1,UGT1 A4 and UGT2 B7)were assessed using in vitro fluorescence-and luminescence-based enzyme assays,*** effects of herbal formulas on the activities of CYP450 s and UGTs were presented as IC50 ***:JEGHT showed the potent inhibition of the CYP2 D6 activity,with weak inhibition on the activities of CYP1 A2,CYP2 B6,CYP2 C9,CYP2 C19,CYP2 E1,CYP3 A4,UGT1 A1,UGT1 A4 and UGT2 *** inhibited the activities of CYP1 A2 and CYP2 E1,whereas the negligible inhibition of the activities of CYP2 B6,CYP2 C9,CYP2 C19,CYP2 D6,CYP3 A4,UGT1 A1,UGT1 A4 and UGT2 B7 through SHT was *** inhibited CYP2 E1 activity,with a negligible inhibition on the activities of CYP1 A2,CYP2 B6,CYP2 C9,CYP2 C19,CYP2 D6,CYP3 A4,UGT1 A1,UGT1 A4 and UGT2 ***:These findings provide information about the potential interactions between three Yin-tonification herbal formulas and conventional drugs.

关键词： Yin reinforcing agents CytochromeP-450 enzyme system Uridine diphosphate gluc-uronic acid Transferases Herb-drug interactions