检索结果-南通市图书馆

Oral TNF-αsiRNA delivery via milk-derived exosomes for effective treatment of inflammatory bowel disease

Bioactive Materials 2024年第4期34卷 138-149页

作者： Geonhee Han Hyosuk kim Hochung Jang eun sun kim sun Hwa kim Yoosoo Yang KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea Medicinal Materials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and TechnologySeoul02792Republic of Korea Department of Internal Medicine Korea University College of MedicineSeoul02841Republic of Korea

Oral administration facilitates the direct delivery of drugs to lesions within the small intestine and colon,making it an ideal approach for treating patients with inflammatory bowel ***,multiple physical barriers impede the delivery of oral RNA drugs through the gastrointestinal ***,we developed a novel oral siRNA delivery system that protects nucleic acids in extreme environments by employing exosomes derived from milk to encapsulate tumor necrosis factor-alpha(TNF-α)siRNA *** remarkable structural stability of milk-derived exosomes(M-Exos),as opposed to those from HEK293T cells,makes them exceptional siRNA *** demonstrate that milk exosomes loaded with TNF-αsiRNA(M-Exo/siR)can effectively inhibit the expression of TNF-α-related inflammatory ***,given that milk exosomes are composed of unique lipids with high bioavailability,orally administered M-Exo/siR effectively reach colonic tissues,leading to decreased TNF-αexpression and successful alleviation of colitis symptoms in a dextran sulfate sodium-induced inflammatory bowel disease murine ***,milk-derived exosomes carrying TNF-αsiRNA can be effectively employed to treat inflammatory bowel ***,using exosomes naturally derived from milk may shift the current paradigm of oral gene delivery,including siRNA.

关键词： Milk-derived exosome Oral gene delivery siRNA Inflammatory bowel disease TNF-α

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multiphoton microscopy:An introduction to gastroenterologists

引用

World Journal of Gastroenterology 2011年第40期17卷 4456-4460页

作者： Hye Jin Cho Hoon Jai Chun eun sun kim Bong Rae Cho Institute of Digestive Disease and Nutrition Department of Internal Medicine Korea University College of Medicine 136-705 Seoul South Korea Department of Chemistry Korea University 136-705 Seoul South Korea

Multiphoton microscopy, relying on the simultaneous absorption of two or more photons by a fluorophore, has come to occupy a prominent place in modern biomedical research with its ability to allow real-time observation of a single cell and molecules in intact tissues. Multiphoton microscopy exhibits nonlinear optical contrast properties, which can make it possible to provide an exceptionally large depth penetration with less phototoxicity. This system becomes more and more an inspiring tool for a non-invasive imaging system to realize "optical biopsy" and to examine the functions of living cells. In this review, we briefly present the physical principles and properties of multiphoton microscopy as well as the current applications in biological fields. In addition, we address what we see as the future potential of multiphoton microscopy for gastroenterologic research.

关键词： Multiphoton microscopy Optical biopsy Gastrointestinal disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Air in the main pancreatic duct:A case of innocent air

引用

World Journal of Gastroenterology 2012年第36期18卷 5142-5144页

作者： Yun Ji kim Hyung Keun kim Young Seok Cho sung Soo kim Hiun Suk Chae Seung Kyong kim eun sun kim Su Yeon Lee Division of Gastroenterology Department of Internal MedicineCollege of MedicineUijeongbu St.Mary's HospitalThe Catholic University of KoreaUijeongbu 480717South Korea

Air in the main pancreatic duct has been reported only rarely and might be associated with either a spontane- ous or a surgically induced alteration of the anatomy of the biliary tract. We report a case of ＂innocent＂ air found incidentally in the main pancreatic duct. To our knowledge, this is only the third such case reported. A 54-year-old woman presented with hemoptysis that had lasted for 3 d. She underwent a chest computed tomography scan, which revealed not only focal bron- chiectasis in the left lower lobe, but also air in the main pancreatic duct and dilatation of the common bile duct. She was managed conservatively for the hemop- blsis and no further problems developed. She had no specific gastrointestinal symptoms and had no history of surgery or medication. Her laboratory parameters were normal. Magnetic resonance cholangiopancrea- tography also demonstrated air in the main pancreatic duct and a dilated common bile duct （CBD）. Duode- noscopy revealed separate biliary and pancreatic ori-rices with patulous openings and some air bubbles ap- pearing in the pancreatic orifice. Endoscopic retrograde cholangiopancreatography （ERCP） showed the dilated CBD and pancreatic duct with some air bubbles, but no other abnormal lesions. She was discharged with no further problems. Most patients with air in the main pancreatic duct have had a pancreatobiliary disease, or a history of pancreatobiliary disease, pancreatobiliary surgery or sphincterotomy. If the air is innocent, as in our case, ERCP should be performed to evaluate any altered sphincteric function or anatomy such as patu- Ious openings.

关键词： Air Main pancreatic duct Endoscopic retro-grade cholangiopancreatography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current status of intragastric balloon for obesity treatment

引用

World Journal of Gastroenterology 2016年第24期22卷 5495-5504页

作者： Seung Han kim Hoon Jai Chun Hyuk Soon Choi eun sun kim Bora Keum Yoon Tae Jeen Division of Gastroenterology and Hepatology Department of Internal Medicine Institute of Gastrointestinal Medical Instrument Research Korea University College of Medicine

Endoscopic bariatric therapy may be a useful alternative to pharmacological treatment for obesity, and it provides greater efficacy with lower risks than do conventional surgical procedures. Among the various endoscopic treatments for obesity, the intragastric balloon is associated with significant efficacy in body weight reduction and relief of comorbid disease symptoms. Anatomically, this treatment is based on gastric space-occupying effects that increase the feeling of satiety and may also affect gut neuroendocrine signaling. The simplicity of the intragastric balloon procedure may account for its widespread role in obesity treatment and its applicability to various degrees of obesity. However, advances in device properties and procedural techniques are still needed in order to improve its safety and cost-effectiveness. Furthermore, verification of the physiological outcomes of intragastric balloon treatment and the clinical predictive factors for treatment responses should be considered. In this article, we discuss the types, efficacy, safety, and future directions of intragastric balloon treatment.

关键词： Intragastric balloon Obesity Bariatric Metabolic Endoscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interference-Based Optical Measurement of Fluidic Flow in a Hollow-Core Fiber

引用

Photonic Sensors 2018年第1期8卷 7-12页

作者： Min-Hwan LEE sung-Hyun kim eun-sun kim In-Kag HWANG Department of Physics Chonnam National University 33 Yongbong-ro Buk-gu Gwang/u 61186 Republic of Korea

In this study, we present speed and displacement measurements of micro-fluid in a hollow-core optical fiber, where an optical interference signal is created by two guided beams reflected at a fixed facet and a moving fluid end. By counting the number of intensity oscillations of the signal, the movement of the fluid end is successfully traced with high accuracy. Furthermore, we could detect the change in curvature diameters of the fluid end depending on the flow direction by monitoring the visibility of the interference signal.

关键词： Fiber optic sensing micro channel fluidic flow fluidic velocimetry optical fiber interferometry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Endoscopic en bloc resection of an exophytic gastrointestinal stromal tumor with suction excavation technique

引用

World Journal of Gastroenterology 2016年第23期22卷 5454-5458页

作者： Hyuk Soon Choi Hoon Jai Chun Kyoung-Oh kim eun sun kim Bora Keum Yoon-Tae Jeen Hong Sik Lee Chang Duck kim Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Gastrointestinal Medical Instrument ResearchKorea University College of MedicineKorea University Medical Center Department of Internal Medicine Gachon University Gil Medical CenterGachon University of Medicine and Science

Here, we report the first successful endoscopic resection of an exophytic gastrointestinal stromal tumor (GIST) using a novel perforation-free suction excavation technique. A 49-year-old woman presented for further management of a gastric subepithelial tumor on the lesser curvature of the lower body, originally detected via routine upper gastrointestinal endoscopy. Abdominal computed tomography and endoscopic ultrasound showed a 4-cm extraluminally protruding mass originating from the muscularis propria layer. The patient firmly refused surgical resection owing to potential cardiac problems, and informed consent was obtained for endoscopic removal. Careful dissection and suction of the tumor was repeated until successful extraction was achieved without serosal injury. We named this procedure the suction excavation technique. The tumor’s dimensions were 3.5 cm × 2.8 cm × 2.5 cm. The tumor was positive for C-KIT and CD34 by immunohistochemical staining. The mitotic count was 6/50 high-power fields. The patient was followed for 5 years without tumor recurrence. This case demonstrated the use of endoscopic resection of an exophytic GIST using the suction excavation technique as a potential therapy without surgical resection.

关键词： Gastrointestinal stromal tumor Endoscopic resection Submucosal tumor Subepithelial tumor En bloc resection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sensitivity of the suspected blood indicator:An experimental study

引用

World Journal of Gastroenterology 2012年第31期18卷 4169-4174页

作者： sung Chul Park Hoon Jai Chun eun sun kim Bora Keum Yeon Seok Seo Yong Sik kim Yoon Tae Jeen Hong Sik Lee Soon Ho Um Chang Duck kim Ho Sang Ryu Division of Gastroenterology and Hepatology Department of Internal MedicineKangwon National University School of MedicineChuncheon 200-722South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University College of MedicineSeoul 136-705South Korea

AIM： To investigate whether suspected blood indicator （SBI） in capsule endoscopy （CE） is affected by back- ground color and capsule passage velocity. METHODS： Experimental models of the small intestine constructed from paper in a variety of colors were used to simulate the background colors observed in CE im- ages. The background colors studied included very pale yellow, yellow, very pale magenta, light grayish pink, burnt sienna, and deep and dark brown, and red spots were attached inside them. An endoscopic capsule was manually passed through the models. The rate of detection of the red spots by the SBI was evaluated based on the colors of the models and the capsule pas- sage velocities （0.5 cm/s, 1 cm/s, and 2 cm/s）.RESULTS： The rate of detection of the red spots byground color of the model （P 〈 0.001）. Detection rates were highest for backgrounds of very pale magenta, burnt sienna, and yellow, in that order. They were lowest for backgrounds of dark brown and very pale yellow. The rate of detection of red spots by the SBI tended to decrease at rapid capsule passage velocities （1-2 cm/s） compared to slow velocities （0.5 cm/s） for backgrounds of very pale yellow （P = 0.042）, yellow （P = 0.001）, very pale magenta （P = 0.002）, and burnt sien- na （P = 0.001）. No significant differences in the rate of detection were observed according to velocity for light grayish pink （P = 0.643） or dark brown （P = 0.396）. CONCLUSION： SBI sensitivity was affected by back- ground color and capsule passage velocity in the models. These findings may facilitate the rapid detection of bleeding lesions by CE.

关键词： Capsule endoscopy Suspected blood indi-cator Sensitivity Background color Passage velocity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Self-expandable metal stents in patients with postoperative delayed gastric emptying after distal gastrectomy

引用

World Journal of Gastroenterology 2018年第40期24卷 4578-4585页

作者： Seung Han kim Bora Keum Hyuk Soon Choi eun sun kim Yeon Seok Seo Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Soon Ho Um Chang Duck kim sungsoo Park Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Gastrointestinal Medical Instrument ResearchKorea University College of MedicineSeoul 02841South Korea Department of Surgery Korea University College of MedicineSeoul 02841South Korea

AIM To investigate the efficacy and safety of endoscopic stent insertion in patients with delayed gastric emptying after *** In this study, we prospectively collected data from patients who underwent stent placement for delayed gastric emptying(DGE) after distal gastrectomy between June 2010 and April 2017, at a tertiary referral academic center. Clinical improvement, complications, and consequences after stent insertion were *** Technical success was achieved in all patients(100%). Early symptom improvement was observed in 15 of 20 patients(75%) and clinical success was achieved in all patients. Mean follow-up period was 1178.3 ± 844.1 d and median stent maintenance period was 51 d(range 6-2114 d). During the follow-up period, inserted stents were passed spontaneously per rectum without any complications in 14 of 20 patients(70%). Symptom improvement was maintained after stent placement without the requirement of any additional intervention in 19 of 20 patients(95%).CONCLUSION Endoscopic stent placement provides prompt relief of obstructive symptoms. Thus, it can be considered an effective and safe salvage technique for post-operative DGE.

关键词： Self-expandable metal stent Delayed gastric emptying Gastrectomy Salvage technique Symptom improvement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intraductal papillary bile duct adenocarcinoma and gastrointestinal stromal tumor in a case of neurofibromatosis type 1

引用

World Journal of Gastroenterology 2018年第4期24卷 537-542页

作者： Jung Min Lee Jae Min Lee Jong Jin Hyun Hyuk Soon Choi eun sun kim Bora Keum Yoon Tae Jeen Hoon Jai Chun Hong Sik Lee Chang Duck kim Dong Sik kim Joo Young kim Division of Gastroenterology and Hepatology Department of Internal Medicine Institute of Gastrointestinal Medical Instrument Research Korea University College of Medicine Division of Gastroenterology and Hepatology Department of Internal Medicine Korea University Anam Hospital Division of HBP Surgery and Liver Trans- plantation Department of Surgery Korea University College of Medicine Department of Pathology Korea University College of Medicine

We report our experience with a synchronous case of gastrointestinal stromal tumor(GIST) and intraductal papillary neoplasm of the bile duct(IPNB) in anelderly woman with neurofibromatosis type 1(NF-1). A 72-year-old woman presented with a 2-mo history of right upper abdominal pain unrelated to diet and indigestion. Fourteen years earlier, she had been diagnosed with NF-1, which manifested as café au lait spots and multiple nodules on the skin. Computed tomography(CT) revealed a multilocular low-density mass with septation, and mural nodules in the right hepatic lobe, as well as a 1.7-cm-sized well-demarcated enhancing mass in the third portion of the duodenum. The patient subsequently underwent right hepatectomy and duodenal wedge resection. We present here the first report of a case involving a synchronous IPNB and GIST in a patient with NF-1. Our findings demonstrate the possibility of various tumors in NF-1 patients and the importance of diagnosis at an early

关键词： Neurofibromatosis type 1 Intraductal papillary neoplasm of the bile duct Gastrointestinal stromal tumor Synchronous

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predictors of the patency of self-expandable metallic stents in malignant gastroduodenal obstruction

引用

World Journal of Gastroenterology 2015年第30期21卷 9134-9141页

作者： Seung Han kim Hoon Jai Chun In Kyung Yoo Jae Min Lee Seung Joo Nam Hyuk Soon Choi eun sun kim Bora Keum Yeon Seok Seo Yoon Tae Jeen Hong Sik Lee Soon Ho Um Chang Duck kim Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University College of Medicine

AIM:To investigate the predictive factors of selfexpandable metallic stent patency after stent placement in patients with inoperable malignant gastroduodenal obstruction. METHODS:A total of 116 patients underwent stent placements for inoperable malignant gastroduodenal obstruction at a tertiary academic center. Clinical success was defined as acceptable decompression of the obstructive lesion within the malignant gastroduodenal neoplasm. We evaluated patient comorbidities and clinical statuses using the World Health Organization's scoring system and categorized patient responses to chemotherapy using the Response Evaluation Criteria in Solid Tumors criteria. We analyzed the relationships between possible predictive factors and stent patency. RESULTS:Self-expandable metallic stent placement was technically successful in all patients(100%),and the clinical success rate was 84.2%. In a multivariate Cox proportional hazards model,carcinoembryonic antigen(CEA) levels were correlated with a reduction in stent patency [P = 0.006; adjusted hazard ratio(a HR)= 2.92,95%CI:1.36-6.25]. Palliative chemotherapy was statistically associated with an increase in stent patency(P = 0.009; a HR = 0.27,95%CI:0.10-0.72).CONCLUSION:CEA levels can easily be measured at the time of stent placement and may help clinicians to predict stent patency and determine the appropriate stent procedure.

关键词： Malignant gastroduodenal obstruction Stent Patency Predictive factor Carcinoembryonicantigen

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：