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Breast adenoid cystic carcinoma arising in microglandular adenosis:A case report and review of literature

World Journal of Clinical Cases 2021年第25期9卷 7579-7587页

作者： Jin kyung An Jeong Joo Woo eun kyung kim Hee Yong Kwak Department of Radiology Nowon Eulji Medical CenterEulji University School of MedicineSeoul 01830South Korea Department of Pathology Nowon Eulji Medical CenterEulji University School of MedicineSeoul 01830South Korea Department of Surgery Nowon Eulji Medical CenterEulji University School of MedicineSeoul 01830South Korea

BACKGROUND Breast adenoid cystic carcinoma(AdCC)is a rare invasive carcinoma composed of epithelial and myoepithelial *** adenosis(MGA)is a rare benign proliferative lesion consisting of small,uniform,and round glands formed by a single layer of epithelial cells and basement membrane without a myoepithelial cell *** may progress to atypical MGA and carcinoma arising in *** various invasive carcinomas from MGA,AdCC has been rarely ***,we report a case of AdCC arising in *** SUMMARY A 59-year-old woman was diagnosed with a newly developed density on a routine *** density was similar to or slightly lower than that of the breast *** showed an irregular mass with a slightly higher echo than that of *** resonance imaging showed an irregular mass with a similar T1 signal intensity and a slightly higher T2 signal intensity compared to muscles or the breast *** lesion showed heterogeneous internal enhancement with an initially slow and delayed persistent enhancing ***,the tumor was composed of invasive AdCC,in situ AdCC,and *** is composed of basaloid and ductal epithelial cells forming cribriform or solid sheets,or haphazardly scattered small cribriform or tubular *** showed small glands with a single epithelial lining and retained lumen.S-100 staining was strongly positive in MGA *** patient underwent breast-conserving surgery with sentinel lymph node *** Breast AdCC arising in MGA showed unique imaging findings that was different from usual invasive cancer.

关键词： Breast neoplasms Fibrocystic breast disease Carcinoma Adenoid cystic Case report

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Alleviatory effect of isoquercetin on benign prostatic hyperplasia via IGF-1/PI3K/Akt/mTOR pathway

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Food Science and Human Wellness 2024年第3期13卷 1698-1710页

作者： Young-Jin Choi Meiqi Fan Nishala Erandi Wedamulla Yujiao Tang eun-kyung kim Department of Food Science and Nutrition Dong-A UniversityBusan 49315Republic of Korea Center for Silver-targeted Biomaterials Brain Busan 21 Plus programDong-A UniversityBusan 49315Republic of Korea Department of Health Sciences the Graduate School of Dong-A UniversityBusan 49315Republic of Korea Division of Food Bioscience College of Biomedical and Health SciencesKonkuk UniversityChungju 27478Republic of Korea Department of Export Agriculture Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadulla 90000Sri Lanka School of Bio-Science and Food Engineering Changchun University of Science and TechnologyChangchun 130600China Nutritional Education Major Graduate School of EducationDong-A UniversityBusan 49315Republic of Korea Nutrinomics Lab.Co. Ltd.Busan 49315Republic of Korea

We evaluated the effect of isoquercetin(quercetin-O-3-glucoside-quercetin,IQ)as a functional component of Abeliophyllum disistichum Nakai ethanol extract(ADLE)on prostate cell proliferation and apoptosis and its effects on the IGF-1/PI3K/Akt/mTOR pathway in benign prostatic hyperplasia(BPH).Metabolites in ADLE were analyzed using UHPLC-qTOF-MS and *** was orally administered(1 or 10 mg/kg)to a testosterone propionate-induced BPH rat model,and its effects on the prostate weight were *** effect of IQ on androgen receptor(AR)signaling was analyzed in LNCaP *** IGF-1 and IQ affect the IGF-1/PI3K/Akt/mTOR pathway in BPH-1 cells was also *** metabolites in ADLE were identified and quantified,which confirmed that ADLE contained abundant IQ(20.88 mg/g).IQ significantly reduced the prostate size in a concentration-dependent manner in a BPH rat model,and significantly decreased the expression of AR signaling factors in the rat prostate tissue and LNCaP cells in a concentration-dependent *** also inhibited the PI3K/AKT/mTOR pathway activated by IGF-1 treatment in BPH-1 *** BPH-1 cells,IQ led to G0/G1 arrest and suppressed the expression of proliferation factors while inducing ***,IQ shows potential for use as a pharmaceutical and nutraceutical for BPH.

关键词： Isoquercetin Benign prostatic hyperplasia Androgen receptor signaling PI3K/Akt/mtor pathway

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Molecular mechanisms of apoptosis induced by Scorpio water extract in human hepatoma HepG2 cells

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World Journal of Gastroenterology 2005年第7期11卷 943-947页

作者： Kang-Beom Kwon eun-kyung kim Jung-Gook Lim eun-Sil Jeong Byung-Cheul Shin Young-Se Jeon Kang-San kim eun-A Seo Do-Gon Ryu Department of Physiology Department of Rehabilitation Medicine Department of Internal Medicine Department of Food and Nutrition

AIM: To clarify the mechanism underlying the anti-mutagenic and anti-cancer activities of Scorpio water extract (SWE). METHODS: Human hepatoma HepG2 cells were incubated with various concentrations of SWE. After 24-h incubation, cytotoxicity and apoptosis evaluations were determined by MTT and DNA fragmentation assay, respectively. After treatment with SWE, mitochondrial membrane potential (MMP) was determined by measuring the retention of the dye 3,3'-dihexyloxacarbocyanine (DiOC6(3)) and the protein expression including cytochrome C and poly-(ADPribose) polymerase (PARP) were measured by Western blotting. Caspase-3 and -9 enzyme activities were measured using specific fluorescence dyes such as Ac-DEVD-AFC and Ac-LEHD-AFC. RESULTS: We found that treatment with SWE induced apoptosis as confirmed by discontinuous DNA fragmentation in cultured human hepatoma HepG2 cells. Our investigation also showed that SWE-induced apoptosis of HepG2 cells were associated with intracellular events including disruption of MMP, increased translocation of cytochrome C from mitochondria to cytosol, activation of caspase-3, and PARP. Pre-treatment of N-acetyl-Asp-Glu-Val-Asp-CHO (Ac-DEVD-CHO), a caspase-3 specific inhibitor, or cyclosporin A (CsA), an inhibitor of MMP disruption, completely abolished SWE-induced DNA fragmentation. CONCLUSION: These results suggest that SWE possibly causes mitochondrial damage, leading to cytochrome C release into cytosol and activation of caspases resulting in PARP cleavage and execution of apoptotic cell death in HepG2 cells. These results further suggest that Scorpio may be a valuable agent of therapeutic intervention of human hepatomas.

关键词： Scorpio Human hepatoma HepG2 cell Apoptosis

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Cortex cinnamomi extract prevents streptozotocin- and cytokine-induced β-cell damage by inhibiting NF-κB

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World Journal of Gastroenterology 2006年第27期12卷 4331-4337页

作者： Kang-Beom Kwon eun-kyung kim eun-Sil Jeong Young-Hoon Lee Young-Rae Lee Jin-Woo Park Do-Gon Ryu Byung-Hyun Park Department of Physiology School of Oriental MedicineWonkwang UniversityIksan 570-749South Korea Department of Oral Anatomy School of DentistryChonbuk National UniversityJeonju 561-756JeonbukSouth Korea Department of Biochemistry Medical SchoolInstitute for Healthcare Technology DevelopmentMedical Research CenterChonbuk National UniversityJeonju 561-756JeonbukSouth Korea

AIM： To clarify the mechanism underlying the antidiabetic activities of cortex cinnamomi extract （CCE）. METHODS： To induce in vivo diabetes, mice were injected with streptozotocin （STZ） via a tail vein （100 mg STZ/kg body weight）. To determine the effects of CCE, mice were administered CCE twice daily for 7 d by oral gavage starting 1 wk before the STZ injection. Blood glucose and plasma insulin concentration were measured as an index of diabetes. Also, to induce cytotoxicity of RINm5F cells, we treated with cytokines （IL-1β （2.0 ng/mL） and IFN-γ （100 U/mL））. Cell viability and nitric oxide production were measured colorimetrically. Inducible nitric oxide synthase （iNOS） mRNA and protein expression were determined by RT-PCR and Western blotting, respectively. The activation of NF-κβ was assayed by using gel mobility shift assays of nuclear extracts. RESULTS： Treatment of mice with STZ resulted in hyperglycemia and hypoinsulinemia, which was further evidenced by immunohistochemical staining of islets. However, the diabetogenic effects of STZ were completely prevented when mice were pretreated with CCE. The inhibitory effect of CCE on STZ-induced hyperglycemia was mediated through the suppression of iNOS expression. In rat insulinoma RINm5F cells,CCE completely protected against interleukin-1β and interferon-y-mediated cytotoxicity. Moreover, RINm5F cells incubated with CCE showed significant reductions in interleukin-1β and interferon-y-induced nitric oxide production and in iNOS mRNA and protein expression, and these findings correlated well with in vivo observations. CONCLUSION： The molecular mechanism by which CCE inhibits iNOS gene expression appears to involve the inhibition of NF-κβ activation, These results reveal the possible therapeutic value of CCE for the prevention of diabetes mellitus progression,

关键词： Cortex cinnamomi Diabetes Streptozotocin Cytokine NF-κβ

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Anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium-induced colitis model

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World Journal of Gastroenterology 2017年第25期23卷 4559-4568页

作者： Seung Kak Shin Jae Hee Cho Eui Joo kim eun-kyung kim Dong Kyun Park Kwang An Kwon Jun-Won Chung Kyoung Oh kim Yoon Jae kim Division of Gastroenterology and Hepatology Department of Internal Medicine Gachon University Gil Medical Center

To evaluate the anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium (DSS)-induced colitis model. METHODSAn acute colitis mouse model was induced by oral administration of 5% DSS in the drinking water for 7 d. In the treated group, rosuvastatin (0.3 mg/kg per day) was administered orally before and after DSS administration for 21 d. On day 21, mice were sacrificed and the colons were removed for macroscopic examination, histology, and Western blot analysis. In the in vitro study, IEC-6 cells were stimulated with 50 ng/mL tumor necrosis factor (TNF)-α and then treated with or without rosuvastatin (2 μmol/L). The levels of reactive oxygen species (ROS), inflammatory mediators, and apoptotic markers were measured. RESULTSIn DSS-induced colitis mice, rosuvastatin treatment significantly reduced the disease activity index and histological damage score compared to untreated mice (P < 0.05). Rosuvastatin also attenuated the DSS-induced increase of 8-hydroxy-2’-deoxyguanosine and NADPH oxidase-1 expression in colon tissue. Multiplex ELISA analysis revealed that rosuvastatin treatment reduced the DSS-induced increase of serum IL-2, IL-4, IL-5, IL-6, IL-12 and IL-17, and G-CSF levels. The increased levels of cleaved caspase-3, caspase-7, and poly (ADP-ribose) polymerase in the DSS group were attenuated by rosuvastatin treatment. In vitro, rosuvastatin significantly reduced the production of ROS, inflammatory mediators and apoptotic markers in TNF-α-treated IEC-6 cells (P < 0.05). CONCLUSIONRosuvastatin had the antioxidant, anti-inflammatory and anti-apoptotic effects in DSS-induced colitis model. Therefore, it might be a candidate anti-inflammatory drug in patients with inflammatory bowel disease.

关键词： Oxidative stress Inflammatory bowel disease Rosuvastatin Apoptosis

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Osthol attenuates hepatic steatosis via decreased triglyceride synthesis not by insulin resistance

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World Journal of Gastroenterology 2014年第33期20卷 11753-11761页

作者： Ho Hyun Nam Dae Won Jun Hye Joon Jeon Jai Sun Lee Waqar Khalid Saeed eun kyung kim Department of Translational Medicine Hanyang University Graduate School of Biomedical Science and Engineering Seoul 133-791 South Korea Department of Internal Medicine Hanyang University School of Medicine Seoul 133-791 South Korea Department of Pathology Eulji University College of Medicine Seoul 139-872 South Korea

AIM: To evaluate the effects of osthol on intrahepatic fat synthesis, β-oxidation, inflammation, and insulin resistance by multifaceted analysis.

关键词： Osthol Non-alcoholic fatty liver disease Ste-rol regulatory element binding protein

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Factors Affecting Verbal Agitation in Dementia Patients Living in Nursing Homes, South Korea

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Open Journal of Nursing 2018年第6期8卷 339-354页

作者： eun kyung kim Heeok Park College of Nursing Research Institute of Nursing Science Keimyung University Daegu South Korea

The purpose of this study using secondary data analysis was to identify factors affecting verbal agitation in patients with dementia staying at nursing home. This study is a secondary analysis of an existing original quantitative data set (n = 193). A total of 166 subjects’ data were included in this current study after 27 subjects’ data were excluded from the original data because they did not appear verbal agitation. Multiple regression analyses identified hallucination (β = 0.27), total number of physiologic discomforts (β = 0.19) and pain (β = 0.17) as significant predictors of verbal agitation and these factors explained 27.8% of the variance in the model. The findings of this study showed that hallucination, total number of physiologic discomforts and pain with dementia need to be considered when intervention programs to control verbal agitation in patients with dementia were developed.

关键词： Dementia Nursing Home Psychomotor Agitation

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Melatonin modulates adiponectin expression on murine colitis with sleep deprivation

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World Journal of Gastroenterology 2016年第33期22卷 7559-7568页

作者： Tae Kyun kim Young Sook Park Haing-Woon Baik Jin Hyun Jun eun kyung kim Jae Woong Sull Ho Joong Sung Jin Woo Choi Sook Hee Chung Myung Chan Gye Ju Yeon Lim Jun Bong kim Seong Hwan kim Department of Gastroenterology Eulji University School of MedicineEulji Hospital Department of Biochemistry and Molecular Biology Eulji University School of Medicine Departemnt of Biomedical Laboratory Science Graduate School of Health ScienceEulji University Departemnt of Senior Healthcare BK21 plus ProgramGraduate SchoolEulji University Department of Pathology Eulji University School of Medicine Department of Gastroenterology Ajou University School of Medicine Department of Life Science and Institute of Natural Sciences Hanyang University

AIM To determine adiponectin expression in colonic tissue of murine colitis and systemic cytokine expression after melatonin treatments and sleep *** The following five groups of C57BL/6 mice were used in this study:(1) group Ⅰ,control;(2) group Ⅱ,2% DSS induced colitis for 7 d;(3) group Ⅲ,2% DSS induced colitis and melatonin treatment;(4) group Ⅳ,2% DSS induced colitis with sleep deprivation(SD) using specially designed and modified multiple platform water baths; and(5) group V,2% DSS induced colitis with SD and melatonin treatment. Melatonin(10 mg/kg) or saline was intraperitoneally injected daily to mice for 4 d. The body weight was monitored daily. The degree of colitis was evaluated histologically after sacrificing the mice. Immunohistochemical staining and Western blot analysis was performed using anti-adiponectin antibody. After sampling by intracardiac punctures,levels of serum cytokines were measured by ELISA. RESULTS Sleep deprivation in water bath exacerbated DSS induced colitis and worsened weight loss. Melatonin injection not only alleviated the severity of mucosal injury,but also helped survival during stressful condition. The expression level of adiponectin in mucosa was decreased in colitis,with the lowest level observed in colitis combined with sleep deprivation. Melatonin injection significantly(P < 0.05) recovered the expression of adiponectin. The expression levels of IL-6 and IL-17 were increased in the serum of mice with DSS colitis but decreased after melatonin injection. CONCLUSION This study suggested that melatonin modulated adiponectin expression in colonic tissue and melatonin and adiponectin synergistically potentiated antiinflammatory effects on colitis with sleep deprivation.

关键词： Colitis Melatonin Adiponectin Sleep deprivation

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A Consideration on the Effectiveness of Sleeping Controlled Protocol for Sedation in Pediatric MRI

A Consideration on the Effectiveness of Sleeping Controlled ...

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2010中华医学会影像技术分会第十八次全国学术大会

作者： Tac-Han Jung Myung-Ju Cho Jae-Bum Seo Bong-Seon kim eun-kyung kim Hyung-Ki kim Department of Radiology Seoul National University Pediatric HospitalSeoulKorea

Objective:Sedation is frequently required in pediatric Magnetic Resonance Imaging and also managed for its successful examinations in order to reduce the failures of that which cause

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The effectiveness of emotion-focused art therapy on the resilience and self-image of emergency physicians

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World Journal of Emergency Medicine 2022年第6期13卷 479-484页

作者： Soo kyung Eo Chanwoong kim kyung Hye Park eun kyung Eo Graduate School of Art Therapy at CHA University Pocheon 11160Republic of Korea Department of Emergency Medicine Chung-Ang University College of MedicineSeoul 06974Republic of Korea Department of Medical Education Yonsei University Wonju College of MedicineWonju 26426Republic of Korea Department of Emergency Medicine Wonju Severance Christian HospitalWonju 26426Republic of Korea Department of Emergency Medicine Soonchunhyang University Bucheon HospitalBucheon 14584Republic of Korea

INTRODUCTION Resilience refers to the quality of being able to overcome adversity.[1]Studies conducted in the United States[2]and China[3]following the 2019 coronavirus disease(COVID-19)pandemic reported reduced resilience levels among medical *** resilience levels are associated with low burnout levels among residents.[4]Physician burnout affects patients’safety and quality of care.[5]In particular,emergency physicians(EPs)are more prone to exhaustion or poor resilience,as their turnover intention tends to be higher.[6]Therefore,improving EPs’resilience is imperative.

关键词： image physician overcome

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