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Breast adenoid cystic carcinoma arising in microglandular adenosis:A case report and review of literature

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World Journal of Clinical Cases 2021年第25期9卷 7579-7587页

作者： Jin Kyung An Jeong joo Woo eun Kyung Kim Hee Yong Kwak Department of Radiology Nowon Eulji Medical CenterEulji University School of MedicineSeoul 01830South Korea Department of Pathology Nowon Eulji Medical CenterEulji University School of MedicineSeoul 01830South Korea Department of Surgery Nowon Eulji Medical CenterEulji University School of MedicineSeoul 01830South Korea

BACKGROUND Breast adenoid cystic carcinoma(AdCC)is a rare invasive carcinoma composed of epithelial and myoepithelial *** adenosis(MGA)is a rare benign proliferative lesion consisting of small,uniform,and round glands formed by a single layer of epithelial cells and basement membrane without a myoepithelial cell *** may progress to atypical MGA and carcinoma arising in *** various invasive carcinomas from MGA,AdCC has been rarely ***,we report a case of AdCC arising in *** SUMMARY A 59-year-old woman was diagnosed with a newly developed density on a routine *** density was similar to or slightly lower than that of the breast *** showed an irregular mass with a slightly higher echo than that of *** resonance imaging showed an irregular mass with a similar T1 signal intensity and a slightly higher T2 signal intensity compared to muscles or the breast *** lesion showed heterogeneous internal enhancement with an initially slow and delayed persistent enhancing ***,the tumor was composed of invasive AdCC,in situ AdCC,and *** is composed of basaloid and ductal epithelial cells forming cribriform or solid sheets,or haphazardly scattered small cribriform or tubular *** showed small glands with a single epithelial lining and retained lumen.S-100 staining was strongly positive in MGA *** patient underwent breast-conserving surgery with sentinel lymph node *** Breast AdCC arising in MGA showed unique imaging findings that was different from usual invasive cancer.

关键词： Breast neoplasms Fibrocystic breast disease Carcinoma Adenoid cystic Case report

Possibility of Solid Hydrometeor Growth Zone Identification Using Radar Spectrum Width

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Advances in Atmospheric Sciences 2023年第2期40卷 317-332页

作者： Sung-Ho SUH eun-Ho choi Hong-Il KIM Woonseon JUNG Flight Safety Technology Division NARO Space CenterKorea Aerospace Research Institute(KARI)508 Haban-roBongrae-myeonGoheung-gunJeollanam-do 59571Republic of Korea Research Applications Department National Institute of Meteorological Sciences33Seohobuk-roSeoqwipo-siJeju-do 63568Republic of Korea

In this study,the correlation between simulated and measured radar velocity spectrum width(σ_(v))is *** results show that the dendrites growth zones(DGZs)and needles growth zones(NGZs)mostly contain dendrites(DN)and needles(NE),***σ_(v) zones(1.11.2 m s^(-1),a differential reflectivity(ZDR)higher than 0 dB,and a cross-correlation coefficient(ρhv)less than *** contrast,prolate particles with relatively uniform shapes were observed in the NGZ withσ_(v)<0.6 m s^(-1),a ZDR less than 0 dB,andρhv higher than *** simulation results show that the DN exhibited a largerσ_(v) compared to the NE,and this observedσ_(v) was strongly dependent on the wind fluctuations(v’)due to turbulence or wind *** contrast,the NE exhibited a significantly smallσ_(v)~0.55 m s^(-1),which converges irrespective of v’.In addition,a strong correlation between the measuredσ_(v) values at five radar elevation angles(θ=6.2°,9.1°,13.1°,19°,and 80°)and those simulated in this study confirmed the significance of the analysis results.

关键词： spectrum width weather radar aerodynamic properties dendritic growth zone hydrometeor classifications

Involvement of heme oxygenase-1 induction in anti-vascular inflammation effects of Xanthoceras sorbifolia in human umbilical vein endothelial cells

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Journal of Traditional Chinese Medicine 2018年第6期38卷 803-814页

作者： Jung joo Yoon Byung Hyuk Han eun Sik choi Seung Namgung Da Hye Jeong Song Nan Jin Yun Jung Lee Dae Gill Kang Ho Sub Lee College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang University Hanbang Cardio-Renal Syndrome Research Center Wonkwang University Institute of Materia Medica Taishan Medical University

OBJECTIVE: To define the effects of Xanthoceras sorbifolia(EXS) on vascular inflammation and the mechanisms in endothelial ***: Vascular protective effects of an ethanol extract of seeds from EXS(1-50 μg/mL) against tumor necrosis factor-α(TNF-α)-induced vascularinflammation were examined in human umbilical vein endothelial cells(HUVECs).RESULTS: EXS significantly decreased TNF-α-induced expression of cell adhesion molecules, such as intracellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial cell selectin,in a dose-dependent manner. Pre-treatment with EXS significantly inhibited translocation and transcriptional activity of nuclear factor-κB(NF-κB) increased by TNF-α. EXS also significantly inhibited formation of intracellular reactive oxygen species(ROS). Moreover, the vascular protective effects of EXS were linked to up-regulation of heme oxygenase-1(HO-1) and nuclear factor E2-related factor-2(Nrf-2) expression. EXS-induced HO-1 expression was significantly decreased in SnPP(HO-1 inhibitor)-and HO-1 siRNA-treated cells, whereas an increase was found in cobalt protoporphyrin IX(CoPP)(HO-1 inducer)-treated cells. In addition, pretreatment with EXS increased HO-1 and Nrf-2 expression under TNF-α stimulation with or without N-acetyl-L-cysteine. Furthermore, the inhibitory effects of EXS on TNF-α-induced vascular inflammation were partially reversed in SnPP-and of HO-1siRNA-treated cells but increased by ***: These results suggest that EXS may have important implications for prevention of vascular complications associated with vascular inflammation by inhibition of the NF-κB/ROS pathway and activation of the Nrf-2/HO-1 pathway.

关键词： Sapindaceae Vascular disease inflammation Human umbilical vein endothelial cells Cell adhesion molecules NF-kappa B Heme oxy-genase-1

Pravastatin activates the expression of farnesoid X receptor and liver X receptor alpha in Hep3B cells

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 65-73页

作者： Hyun Woo Byun eun Mi Hong Soo Hee Park Dong Hee Koh Min Ho choi Hyun joo Jang Sea Hyub Kae Jin Lee Division of Gastroenterology Department of Internal Medicine Hallym University College of Medicine Dongtan Sacred Heart Hospital

BACKGROUND: Statins are suggested to preserve gallbladder function by suppressing pro-inflammatory cytokines and preventing cholesterol accumulation in gallbladder epithelial cells. They also affect cross-talk among the nuclear hormone receptors that regulate cholesterol-bile acid metabolism in the nuclei of hepatocytes. However, there is controversy over whether or how statins change the expression of peroxisome proliferator-activated receptor(PPAR)α, PPARγ, liver X receptor α(LXRα), farnesoid X receptor(FXR), ABCG5, ABCG8, and 7α-hydroxylase(CYP7A1) which are directly involved in the cholesterol saturation index in bile. METHODS: Human Hep3B cells were cultured on dishes. MTT assays were performed to determine the appropriate concentrations of reagents to be used. The protein expression of PPARα and PPARγ was measured by Western blotting analysis, and the mRNA expression of LXRα, FXR, ABCG5, ABCG8 and CYP7A1 was estimated by RT-PCR. RESULTS: In cultured Hep3B cells, pravastatin activated PPARα and PPARγ protein expression, induced stronger expression of PPARγ than that of PPARα, increased LXRα mRNA expression, activated ABCG5 and ABCG8 mRNA expression mediated by FXR as well as LXRα, enhanced FXR mRNA expression, and increased CYP7A1 mRNA expression mediated by the PPARγ and LXRα pathways, together or independently. CONCLUSION: Our data suggested that pravastatin prevents cholesterol gallstone diseases via the increase of FXR, LXRαand CYP7A1 in human hepatocytes.

关键词： pravastatin PPARγ liver X receptor α farnesoid X receptor gallstone disease

Association of visceral obesity and early colorectal neoplasia

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World Journal of Gastroenterology 2013年第45期19卷 8349-8356页

作者： eun Kyung Choe Donghee Kim Hwa Jung Kim Kyu joo Park Department of Surgery Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam Center Seoul 135-984 South Korea Department of Internal Medicine Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam Center Seoul 135-984 South Korea Department of Clinical Epidemiology and Biostatistics Asan Medical Center University of Ulsan College of Medicine Seoul 138-736 South Korea Department of Surgery Seoul National University College of Medicine Seoul 110-799 South Korea

AIM:To examine whether visceral adipose tissue(VAT)serves as a risk factor for colorectal adenoma-early colorectal cancer(CRC)***:A retrospective case-control study was conducted with 153 patients with stageⅠCRC,age/sex-matched 554 patients with colorectal adenoma and557 normal *** subjects underwent various laboratory tests,abdominal fat computed tomography(CT),and *** was defined as an intraabdominal adipose tissue area measured by CT *** tissue area was measured at the level of the umbilicus from CT *** used the lowest quartile of VAT and subcutaneous adipose tissue area as a reference ***:The body mass index(BMI),total cholesterol,fasting glucose and VAT areas were significantly different among normal,adenoma and CRC *** VAT area was 120.6±49.0 cm2in normal controls,130.6±58.4 cm2in adenoma group and 117.6±51.6cm2in CRC group(P=0.002).In univariate analysis,increased BMI was a risk factor for CRC compared to control(P=0.025).However,VAT area was not a risk factor for CRC compared to *** multivariate analysis that adjusted for smoking,alcohol consumption and subcutaneous adipose tissue area,VAT area was inversely related to CRC,compared to the adenoma(OR=0.53,95%CI:0.31-0.92,highest quartile vs lowest quartile).CONCLUSION:Our study shows that visceral obesity is not a risk factor for early *** obesity might influence the normal-adenoma sequence but not the adenoma-early carcinoma sequence.

关键词： Adipose tissue Visceral fat Obesity Colorectal cancer Colorectal adenoma Abdominal computed tomography

Hwangryunhaedoktang exerts anti-inflammation on LPS-induced NO production by suppressing MAPK and NF-κB activation in RAW264.7 macrophages

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Journal of Integrative Medicine 2017年第4期15卷 326-336页

作者： Byung Hyuk Han Yun Jung Lee Jung joo Yoon eun Sik choi Seung Namgung Xian Jun Jin Da Hye Jeong Dae Gill Kang Ho Sub Lee College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang University Hanbang Body-fluid Research Center Wonkwang University

OBJECTIVE： This study aimed to evaluate whether Hwangryunhaedoktang （HHT）, a herbal compound, has an inhibitory effect on lipopolysaccharide （LPS）-induced inflammation in RAW264.7 macrophages. METHODS： The effects of HHT were evaluated by confirming nitric oxide （NO） production and expression of inducible NO synthase （iNOS） and mitogen-activated protein kinases （MAPKs） in LPS-stimulated RAW264.7 macrophages via the Griess assay, Western blotting, and real-time reverse transcription quantitative polymerase chain reaction. Western blot analyses and luciferase assays were used to evaluate whether HHT has an effect on the phosphorylation and translocation of nuclear factor-κB （NF-κB）. The secretion and expression of tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） were determined via enzyme-linked immunosorbent assay and Western blot analyses. RESULTS： HHT suppressed LPS-induced NO production and expression of iNOS in a dose-dependent manner. Additionally, MAPKs activation was also attenuated via inhibition of phosphorylation of extracellular signal-regulated kinases 1/2, c-Jun N-terminal kinase and p38 which were related to inflammatory pathway. Furthermore, HHT also effectively attenuated NF-κB activation and its translocation to the nucleus, a process that is closely linked to inflammation. LPS normally induced the expression of inflammatory cytokines such as TNF-α and IL-6, but the secretion and expression of TNF-α and IL-6 were significantly attenuated by pretreating the cells with HHT. CONCLUSION： HHT suppressed LPS-induced NO production by blocking the activation of NF-κB and MAPK signaling pathways in RAW264.7 macrophages. Furthermore, HHT may have an anti-inflammatory effect by suppressing the LPS-induced secretion of TNF-α and IL-6. Therefore, the traditional herbal formula HHT might be a useful potential therapeutic agent for inflammation.

关键词： medicine, Chinese traditional lipopolysaccharide nitric oxide nuclear factor-κB mitogen-activatedprotein kinases tumor necrosis factor-a inflammation

Primary rectal mucosa-associated lymphoid tissue lymphoma treated with only endoscopic submucosal dissection:A case report

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World Journal of Clinical Cases 2023年第14期11卷 3362-3368页

作者： Wan-Sik Lee Myung-Giun Noh Young-eun joo Department of Internal Medicine Chonnam National University Medical SchoolHwasun-eup 58128South Korea Department of Pathology Chonnam National University Medical SchoolHwasun-eup 58128South Korea

BACKGROUND Mucosa-associated lymphoid tissue(MALT)lymphoma is a distinct subtype of non-Hodgkin B cell lymphoma that mostly involves the gastrointestinal *** stomach is the most commonly affected site whereas colorectal involvement occurs very *** its rarity,the management and clinical outcome of colorectal MALT lymphoma are not well established *** SUMMARY From the superficial capillary bed in the lower *** ultrasonography showed homogenous hypoechoic lesions in the deep mucosal *** submucosal dissection(ESD)was done for accurate histologic diagnosis and treatment and both the rectal lesions were completely removed en bloc and subsequently diagnosed as primary rectal MALT ***,we report a case of primary rectal MALT lymphoma in a 68-year-old woman that was treated by only ESD,and the 12-month follow-up revealed no tumour *** These results of our case and previous reports suggest that endoscopic resection alone may be a feasible and safe treatment for primary colorectal MALT lymphoma and allows organ preservation.

关键词： Rectum Mucosa-associated lymphoid tissue lymphoma Endoscopic submucosal dissection

Performance evaluation of the use of tire-derived fuel fly ash as mineral filler in hot mix asphalt concrete

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第2期7卷 249-258页

作者： Min Ju choi Yong joo Kim Hyeok Jung Kim Jae Jun Lee BILTZONE Co. Ltd.Hwaseong 18514South Korea Korea Institute o f Civil Engineering and Building Technology Goyang-Si 10223South Korea Industry-Academic Cooperation Foundation Center Hankyong National UniversityAnseong-si 17579South Korea Department of Civil Engineering Chonbuk National UniversityJeonju 54896South Korea

According to deplete natural resources and need to protect the environment,the demand of a usage of waste material has significantly *** studies are currently being carried out on the development of innovative and environmentally friendly materials for securing the safety of road users and improving the performance and durability of *** example,studies are currently being conducted on the use of waste tires as a substitute for currently used *** the development of the automobile industry,the amount of waste tire has continuously increased in accordance with the increased vehicle ***-derived fuel(TDF)has been used as a fuel source with generated TDF fly *** filler,made of fine mineral particles of a physical size passing the number 200 standard mesh sieve(75 micron),plays an important role in asphalt mixtures *** paper presents an application of TDF fly ash as filler in hot mix asphalt(HMA).In this study,the performance of TDF fly ash was confirmed through a comparison with three other mineral fillers:stone dust,cement,and hydrated *** tests including Marshall stability test,moisture sensitivity test,dynamic immersion test,and a wheel tracking test were performed to investigate the difference in the behaviors of the samples with different parameters considered in this *** results show that the mechanical performance of hot mix asphalt using TDF fly ash satisfied the quality standard specification of the Ministry of Land,Infrastructure and Transport(MOLIT),*** can be concluded that the use of TDF fly ash as a mineral filler in HMA not only satisfied the mechanical properties,but also reduced the volume of the pollutants waste in the environment.

关键词： Asphalt mixture TDF fly ash Marshal stability Moisture sensitive TSR

Gyejibokryeong-Hwan improves recovery of injured muscles in mouse model of muscle contusion

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Journal of Traditional Chinese Medicine 2021年第3期41卷 406-413页

作者： Chi Ho Lee Jeong June choi joo Hye Sim Younmin Shin Seung-joon Oh Ji-Hyang Gu Hyun Ju Ha Dong Hwi Jeon eun-Jung Lee Min-Seok Oh Department of Korean Medicine Rehabilitation College of Korean MedicineDaejeon UniversityDaejeon 34520Republic of Korea Laboratory of Molecular Medicine College of Korean MedicineDaejeon UniversityDaejeon 34520Republic of Korea

OBJECTIVE: To investigate the effects of Gyejibokryeong-Hwan(Guizhifuling-wan, GBH) on muscle injury in a mouse model of muscle ***: C57/BL6 mouse biceps femoris muscles were injured using the drop-mass method and injured animals were treated orally with GBH(50,100, or 500 mg/kg) once a day for 7 d. Open field and treadmill running tests were performed to assess functional recovery from muscle injury. The production of pro-inflammatory cytokines was examined by enzyme-linked immunosorbent assay and Western blotting analysis. Expression of the muscle regeneration biomarkers, myoblast determination(Myo D), myogenic factor 5(Myf5), and smooth muscle actin(α-SMA), in the biceps femoris muscle was investigated at the protein and m RNA level by Western blotting and real time-PCR, respectively. Histological analysis was performed using hematoxylin and eosin staining. Finally, myosin heavy chain production was investigated in differentiated C2C12 myoblasts in the presence of ***: GBH treatment markedly improved locomotion and running behavior. GBH significantly inhibited the secretion of monocyte chemoattractant protein-1 into the bloodstream in muscle-contused animals. The levels of Myo D, Myf5, and α-SMA protein and m RNA were significantly up-regulated by GBH in injured muscle tissue. Histological studies suggested that GBH facilitated recovery from muscle damage. However, GBH did not induce the production of myosin heavy chain in ***: Overall, the present study suggested that GBH improves the recovery of the injured muscles in the mouse model of muscle contusion.

关键词： muscles wounds and injuries contusions regeneration muscle skeletal myogenic regulatory factor 5 Gyejibokryeong-Hwan