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Timing of upper gastrointestinal endoscopy does not influence short-term outcomes in patients with acute variceal bleeding

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World Journal of Gastroenterology 2018年第44期24卷 5025-5033页

作者： jeong-Ju Yoo Young Chang eun Ju Cho Ji eun Moon Sang Gyune Kim Young Seok Kim Yun Bin Lee jeong-Hoon Lee Su Jong Yu Yoon Jun Kim Jung-Hwan Yoon Department of Gastroenterology and Hepatology Soonchunhyang University school of Medicine Bucheon 14584 South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul 03080 South Korea Department of Biostatistics Clinical Trial Center Soonchunhyang University Bucheon Hospital Bucheon 14584 South Korea

AIM To examine the association between the timing of endo-scopy and the short-term outcomes of acute variceal bleeding in cirrhotic *** This retrospective study included 274 consecutive patients admitted with acute esophageal variceal bleeding of two tertiary hospitals in Korea. We adjusted confounding factors using the Cox proportional hazards model and the inverse probability weighting （IPW） method. The primary outcome was the mortality of patients within 6 *** A total of 173 patients received urgent endoscopy （ i.e. , ≤ 12 h after admission）, and 101 patients received non-urgent endoscopy （〉 12 h after admission）. The 6-wk mortality rate was 22.5% in the urgent endoscopy group and 29.7% in the non-urgent endoscopy group, and there was no significant difference between the two groups before （P = 0.266） and after IPW （P = 0.639）. The length of hospital stay was statistically different between the urgent group and non-urgent group （P = 0.033）; however, there was no significant difference in the in-hospital mortality rate between the two groups （8.1%vs 7.9%, P = 0.960）. In multivariate analyses, timing of endoscopy was not associated with 6-wk mortality （hazard ratio, 1.297; 95% confdence interval, 0.806-2.089; P = 0.284）.CONCLUSION In cirrhotic patients with acute variceal bleeding, the timing of endoscopy may be independent of short-term mortality.

关键词： Cirrhosis Endoscopy Upper gastrointestinal bleeding Gastroesophageal varices Timing

Prevalence of focal lamina cribrosa defects in eyes with pachychoroid disease spectrum

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 77-82页

作者： Hae Min Kang Na eun Lee jeong Hoon Choi Hyoung Jun Koh Sung Chul Lee Harvard School of Public Health BostonMA 02115USA Catholic Kwandong University Incheon 22711Republic of Korea Gongdoek Seoul Eye Clinic Seoul 04214Republic of Korea Choikang Seoul Eye Clinic Seoul 01110Republic of Korea Institute of Vision Research Department of OphthalmologyYonsei University College of MedicineSeoul 03722Republic of Korea Konyang University Hospital Daejeon 35365Republic of Korea

AIM:To determine the prevalence of focal lamina cribrosa(LC)defect among patients with pachychoroid disease spectrum(PDS)in the absence of peripapillary ***:This retrospective,cross-sectional study comprised of 180 patients with PDS,including polypoidal choroidal vasculopathy(PCV),central serous chorioretinopathy,and pachychoroidal *** records and optic ner ve head evaluations conducted using spectral-domain optical coherence tomography with enhanced depth imaging were *** a control group,236 patients who underwent ophthalmologic evaluation for vitreous floaters,without obvious ocular disease,were also ***:The mean age of the PDS group,which included 118 male patients(65.6%),was 57.4±11.1 *** was no significant difference between the two groups in age(P=0.710)or sex(P=0.248).Six patients(3.3%)in the PDS group and none in the control group showed focal LC defect(P=0.318).Among the six patients with focal LC defect in the PDS group,four eyes had PCV,one eye was the fellow eye of a PCV eye,and one eye had pachychoroidal ***:Focal LC defect can be defected in patients with PDS in the absence of peripapillar y ***,the prevalence of focal LC defect was not different significantly between PDS patients and those who did not have PDS.

关键词： central serous chorioretinopathy lamina cribrosa pachychoroid polypoidal choroidal vasculopathy

Sectoral changes of the peripapillary choroidal thickness in patients with unilateral branch retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 472-479页

作者： Na eun Lee Hae Min Kang jeong Hoon Choi Hyoung Jun Koh Sung Chul Lee Department of Ophthalmology Catholic Kwandong University College of Medicine International St. Mary's Hospital Choikang Seoul Eye Clinic Institute of Vision Research Department of Ophthalmology Yonsei University College of Medicine

AIM: To investigate sectoral changes in the mean peripapillary choroidal thickness(PCT) in patients with unilateral branch retinal vein occlusion(BRVO). METHODS: This retrospective, interventional study included 41 patients with acute, unilateral BRVO without macular edema. All patients completed at least a 6-month follow-up period. The PCT was measured at eight locations(temporal, superotemporal, superior, superonasal, nasal, inferonasal, inferior, and inferotemporal). In addition to calculating the average of all locations, the peripapillary choroidal area was divided into four sectors: superior(average of superotemporal PCT, superior PCT, and superonasal PCT), temporal, inferior(average of inferotemporal PCT, inferior PCT, and inferonasal PCT), and nasal. RESULTS: In the BRVO-affected eyes, the mean PCT was 177.7±69.8 μm(range, 70.1-396.0 μm) at baseline and 127.8±54.8 μm(range, 56.4-312.1 μm) at 6 mo(P<0.001). In the non-affected contralateral eyes, the mean PCT was 192.5±60.6 μm(range, 61.4-365.0 μm) at baseline and 165.9±61.1 μm(range, 56.8-326.8 μm) at 6 mo(P<0.001). In sectoral analysis, the mean PCT in each sector was significantly reduced in over 6 mo in the BRVO-affected eyes(all P<0.001). In the non-affected contralateral eyes, the mean PCT was not significantly changed in any sector over the 6-month follow-up period(superior sector, P=0.143; temporal sector, P=0.825; inferior sector, P=0.192; and nasal sector, P=0.599).CONCLUSION: Sectoral analysis shows that the mean PCTs in all sectors are reduced significantly over 6 mo in the BRVO-affected eyes, but not in the non-affected contralateral eyes.

关键词： branch retinal vein occlusion choroid choroidal thickness peripapillary choroidal thickness

Pemetrexed in Previously Treated Non-small Cell Lung Cancer Patients with Poor Performance Status

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中国肺癌杂志 2011年第1期14卷 33-38页

作者： Sun Young JUNG Su Jin YOO Ji Young SHIN Ji won PARK jeong eun LEE Hee Sun PARK Ju Ock KIM Sun Young KIM Department of Internal Medicine Chungnam National University Hospital

Background and objective Pemetrexed have been approved for the treatment of patients affected by advanced non-small cell lung cancner(NSCLC) in progression after first-line *** evaluated the activity and feasibility of pemetrexed in previously treated *** Patients with histologically or cytologically confirmed NSCLC were evaluated from April 2007 to March *** patients had relapsed or progressed after prior chemotherapy ***(500 mg/m2) was administered intravenously once every 3 weeks after progression to prior *** tumor response was evaluated according to RECIST criteria by chest CT at every 2 cycles of *** A total 61 patients were eligible for *** status of them(100%) was over *** response rate and disease control rate were 14.7% and 37.7% ***-squamous cell carcinoma histology was significantly associated with a superior response rate(P=0.045) and disease control rate(P=0.008).The median survival time and the median progression free survival(PFS) time were 6.11 months and 2.17 months,*** the efficacy of pemetrexed in these two settings [second-line versus(12/61) more than third(49/61)],there was no significant difference in regard to median survival(11.18 months vs 11.46 months,P=0.922,5),but PFS was more longer in third-or further-line groups than second-line group(1.39 months vs 2.25 months,P=0.015,3).Conclusion Pemetrexed is a feasible regimen in previously treated NSCLC with poor performance status.

关键词：肺癌症状化学疗法临床治疗

Neutrophil-to-lymphocyte ratio and carbohydrate antigen 19-9 as prognostic markers for advanced pancreatic cancer patients receiving first-line chemotherapy

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World Journal of Gastrointestinal Oncology 2021年第8期13卷 915-928页

作者： Kabsoo Shin eun-Kyo Jung Se Jun Park Sangwoon jeong In-Ho Kim Myung-ah Lee Division of Medical Oncology Department of Internal MedicineSeoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Catholic Cancer Research Institute College of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND A decline in serum carbohydrate antigen 19-9(CA19-9)levels during systemic chemotherapy is considered as a prognostic marker for patients with advanced pancreatic ***-to-lymphocyte ratio(NLR)has been extensively studied as a simple and useful indicator of prognosis in various cancers including pancreatic *** To assess the prognostic significance of NLR and CA19-9 in patients with advanced pancreatic adenocarcinoma received first-line chemotherapy according to CA19-9 *** We retrospectively analyzed patients diagnosed with advanced pancreatic cancer who received first-line chemotherapy between January 2010 and July 2017 at the Catholic University of Seoul ***’s *** were divided according to CA19-9 positivity(CA19-9-positive vs-negative groups)and pre-and posttreatment NLR *** determine cut-off value of NLR and CA19-9 reduction,time-dependent receiver operating characteristic curve was *** evaluated overall survival(OS)and progression-free survival(PFS)for each group using Kaplan-Meier method,and we performed multivariate analyses on the entire *** We included 271 patients in this ***-off value of NLR and CA19-9 reduction was determined as 2.62 and 18%.Multivariate analysis showed that post-treatment NLR<2.62 and reduction of≥18%of baseline CA19-9 were significantly associated with OS and ***-treatment NLR≥2.62 showed hazard ratio(HR)of 2.47[95%confidence interval(CI):1.84-3.32,P<0.001]and CA19-9 decline(≥18%)showed HR of 0.51(95%CI:0.39-0.67,P<0.001)for *** CA19-9-positive patients were divided into groups according to CA19-9 response(responder vs non-responder)and post-treatment NLR(<2.62 vs≥2.62),CA19-9 responder and post-treatment NLR<2.62 group showed better survival than CA19-9 non-responder and post-treatment NLR≥2.62 group(OS 11.0 mo vs 3.9 mo,P<0.001;PFS 6.3 mo vs 2.0 mo,P<0.001).The combination of CA19-9 decline and post-treatment NLR showed a significant c

关键词： Pancreatic adenocarcinoma Serum carbohydrate antigen 19-9 Neutrophil-tolymphocyte ratio Multivariate analysis Prognosis Chemotherapy

Reactive oxygen species involved in sulforaphane-induced STAT3 inactivation and apoptosis in DU145 prostate cancer cells

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Chinese Science Bulletin 2010年第34期55卷 3922-3928页

作者： KOH wonil AHN Kwang Seok jeong Soo-Jin LEE Hyo-Jung KIM Minseok LEE Hyo-jeong LEE eun-Ok KIM Sung-Hoon College of Oriental Medicine Kyung Hee University College of Dental Medicine Tufts UniversityBoston

Signal transducer and activator of transcription factor 3(STAT3)is a transcription factor that regulates various cellular processes such as proliferation,survival and angiogenesis in cancer *** the present study,we investigated the mechanisms whereby isothiocyanate sulforaphane(SFN)suppresses STAT3 activation in DU145 prostate cancer *** significantly inhibited SFN-inhibited STAT3 phosphorylation at Tyr705 as well as the deoxyribonucleic acid(DNA)binding capability in electrophoresis mobility shift assay(EMSA)in time-and concentration-dependent *** also abrogated the Janus activated kinase 2(JAK2)*** addition,SFN down-regulated STAT3-related gene products including Bcl-2,Bcl-xL,and cyclin D1 and vascular endothelial growth factor(VEGF),and inhibited the proliferation and induced ***,SFN mediated reactive oxygen species(ROS)production at the early ***,these results demonstrate that ROS generation may be involved in the inhibition of JAK2/STAT3 activation and apoptosis in DU145 cells.

关键词：前列腺癌细胞 STAT3 细胞凋亡活性氧活化诱导硫素萝卜

Evaluation of vitamin D level in patients from neurosurgical intensive care unit

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Neural Regeneration Research 2013年第16期8卷 1528-1534页

作者： Ho Jun Yi Je Hoon jeong eun-Sun Jin Il Young Shin Hyung Sik Hwang Seung-Myung Moon Department of Neurosurgery Hangang Sacred Heart Hospital College of Medicine Hallym University Department of Neurosurgery Soon Chun Hyang University Bucheon Hospital Gyeonggi-do Department of Cardiology Kyung Hee University Hospital at Kangdong Kyung Hee University

Vitamin D plays an important role in maintaining normal bone metabolism. Recent studies have suggested that vitamin D influences many other physiological processes, including muscle function, cardiovascular homeostasis, nerve function, and immune response. Furthermore, accumulated evidence suggests that vitamin D also mediates the immune system response to infection. Critical neurosurgical patients have higher infection and mortality rates. To correlate vitamin D deficiency to the immunological status of neurosurgical intensive care unit patients, we detected serum vitamin D level in 15 patients with clinically suspected infection and 10 patients with confirmed infection. Serum level of 25-hydroxyvitamin D, the primary circulating form of vitamin D, was significantly decreased in patients with suspected or confirmed infection after a 2-week neurosurgical intensive care unit hospitalization, while serum level of 1,25-dihydroxyvitamin D, the active form of vitamin D, was significantly decreased in patients after a 4-week neurosurgical intensive care unit hospitalization. These findings suggest that vitamin D deficiency is linked to the immunological status of neurosurgical intensive care unit patients and vitamin D supplementation can improve patient＇s immunological status.

关键词： neural regeneration vitamin D white blood cell immune deficiency infectious diseases intensivecare unit neurosurgery neuroregeneration

Evaluating the benefit of adjuvant chemotherapy in patients with ypT0-1 rectal cancer treated with preoperative chemoradiotherapy

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World Journal of Gastrointestinal Surgery 2021年第9期13卷 1000-1011页

作者： Ye won Jeon In Ja Park jeong eun Kim Jin-Hong Park Seok-Byung Lim Chan Wook Kim Yong Sik Yoon Jong Lyul Lee Chang Sik Yu Jin Cheon Kim Department of Surgery Asan Medical Center and University of Ulsan College of MedicineSeoul 05505South Korea Department of Colon and Rectal Surgery Asan Medical Center and University of Ulsan College of MedicineSeoul 05505South Korea Department of Oncology Asan Medical Center and University of Ulsan College of MedicineSeoul 05505South Korea Department of Radiation Oncology Asan Medical Center and University of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Adjuvant chemotherapy(ACTx)is recommended in rectal cancer patients after preoperative chemoradiotherapy(PCRT),but its efficacy in patients in the early post-surgical stage who have a favorable prognosis is *** To evaluate the long-term survival benefit of ACTx in patients with ypT0–1 rectal cancer after PCRT and surgical *** We identified rectal cancer patients who underwent PCRT followed by surgical resection at the Asan Medical Center from 2005 to *** with ypT0–1 disease and those who received ACTx were *** 5-year overall survival(OS)and 5-year recurrence-free survival(RFS)were analyzed according to the status of the *** Of 520 included patients,413 received ACTx(ACTx group)and 107 did not(no ACTx group).No significant difference was observed in 5-year RFS(ACTx group,87.9%vs no ACTx group,91.4%,P=0.457)and 5-year OS(ACTx group,90.5%vs no ACTx group,86.2%,P=0.304)between the *** stage was associated with RFS and OS in multivariate analysis[hazard ratio(HR):2.57,95%confidence interval(CI):1.07–6.16,P=0.04 and HR:2.27,95%CI:1.09–4.74,P=0.03,respectively].Furthermore,ypN stage was associated with RFS and OS(HR:4.74,95%CI:2.39–9.42,P<0.00 and HR:4.33,95%CI:2.20–8.53,P<0.00,respectively),but only in the radical resection *** Oncological outcomes of patients with ypT0–1 rectal cancer who received ACTx after PCRT showed no improvement,regardless of the radicality of *** trials are needed to evaluate the efficacy of ACTx in these group of patients.

关键词： Rectal neoplasm Adjuvant chemotherapy ypT0-1 Radical resection Local excision

Long-term outcomes of very low birth weight infants with intraventricular hemorrhage:a nationwide population study from 2011 to 2019

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World Journal of Pediatrics 2024年第7期20卷 692-700页

作者： Joonsik Park Sook-Hyun Park Yu-ra Kwon So Jin Yoon Joo Hee Lim Jung Ho Han jeong eun Shin Ho Seon eun Min Soo Park Soon Min Lee Department of Pediatrics Yonsei University College of Medicine211 Eonjuro GangnamguSeoul 06273Republic of Korea

Background Advancements in neonatal care have increased preterm infant survival but paradoxically raised intraventricular hemorrhage(IVH)*** study explores IVH prevalence and long-term outcomes of very low birth weight(VLBW)infants in Korea over a *** Using Korean National Health Insurance data(NHIS,2010-2019),we identified 3372 VLBW infants with IVH among 4,129,808 live ***-related claims data,encompassing diagnostic codes,diagnostic test costs,and administered procedures were sourced from the NHIS *** results of the developmental assessments are categorized into four groups based on standard deviation(SD)*** characteristics and complications were compared among the *** regression models were employed to identify significant changes in the incidence of complications and to calculate odds ratios with corresponding 95%confidence intervals for each risk factor associated with mortality and morbidity in ***-term growth and development were compared between the two groups(years 2010-2013 and 2014-2017).Results IVH prevalence was 12%in VLBW and 16%in extremely low birth weight(ELBW)*** the past decade,IVH rates increased significantly in ELBW infants(P=0.0113),while mortality decreased(P=0.0225).Major improvements in certain neurodevelopmental outcomes and reductions in early morbidities have been observed among VLBW infants with *** percent of the population received surgical treatments such as external ventricular drainage(EVD)or a ventriculoperitoneal(VP)shunt,with the choice of treatment methods remaining consistent over *** IVH with surgical intervention group exhibited higher incidences of delayed development,cerebral palsy,seizure disorder,and growth failure(height,weight,and head circumference)up to 72 months of age(P<0.0001).Surgical treatments were also significantly associated with abnormal developmental screening test *** The neurodevelopmental outcomes of infa

关键词： Cerebral intraventricular hemorrhage Developmental Hydrocephalus Mortality Posthemorrhagic ventricular dilatation Surgery