检索结果-南通市图书馆

Circulating immune cell landscape in patients who had mild ischaemic stroke

Stroke & Vascular Neurology 2022年第4期7卷 319-327,I0020-I0022页

作者： young-eun cho Hyangkyu Lee Heekyong R.Bae Hyungsuk Kim Sijung Yun Rany Vorn Ann Cashion Mary Jo Rucker Mariam Afzal Lawrence Latour Jessica Gill College of Nursing The University of IowaIowa CityIowaUSA National Institute of Nursing Research National Institutes of HealthBethesdaMarylandUSA Mo-Im Kim Nursing Research Institute College of NursingYonsei UniversitySeoulSouth Korea National Eye Institute National Institutes of HealthBethesdaMarylandUSA Predictiv Care IncSunnyvaleCaliforniaUSA School of Nursing Johns Hopkins UniversityBaltimoreMarylandUSA College of Nursing University of Tennessee Health Science CenterMemphisTennesseeUSA Suburban Hospital BethesdaMarylandUSA National Institute of Neurological Disorders and Stroke National Institutes of HealthBethesdaMarylandUSA

Introduction Patients who had a mild ischaemic stroke who present with subtle or resolving symptoms sometimes go undiagnosed,are excluded from treatment and in some cases clinically *** immune cells are potential biomarkers that can assist with diagnosis in ischaemic *** the transcriptomic changes of each cell population caused by ischaemic stroke is critical because they work closely in a complicated *** this study,we investigated peripheral blood mononuclear cells(PBMCs)transcriptomics of patients who had a stroke using a single-cell RNA sequencing to understand peripheral immune response after mild stroke based on the gene expression in an unbiased *** Transcriptomes of PBMCsfrom 10 patients who had an acute ischaemic stroke within 24 hours after stroke onset were compared with 9 race-matched/age-matched/gender-matched *** PBMCs were prepared with ddSeqTM(Illumina-BioRad)and sequenced on the Illumina NovaSeq 6000 *** Notable population changes were observed in patients who had a stroke,especially in NK cells and CD14+*** number of NK cells was increased,which was further confirmed by flow *** analysis implied that the activity of NK cells also is enhanced in patients who had a ***14+monocytes were clustered into two groups;dendritic cell-related CD14+monocytes and NK cell-related CD14+*** found CD14+monocyte subclusters were dramatically reduced in patients who had a *** This is the first study demonstrating the increased number of NK cells and new monocyte subclusters of mild ischaemic stroke based on the transcriptomic *** findings provide the dynamics of circulating immune response that could assist diagnosis and potential therapeutic development of mild ischaemic stroke.

关键词： patients diagnosis Circulating

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cerebral and pulmonary embolisms after transcatheter arterial chemoembolization for hepatocellular carcinoma

引用

World Journal of Gastroenterology 2008年第30期14卷 4834-4837页

作者： Chang Soo choi Ki Hoon Kim Geom Seog Seo eun young cho Hyo Jeong Oh Suck Chei choi Tae Hyeon Kim Haak Cheoul Kim Byung Suk Roh Department of Internal Medicine and Digestive Disease Research Institute Wonkwang University School of Medicine Department of Radiology Wonkwang University School of Medicine

A cerebral lipiodol embolism is an extremely rare complication of transcatheter arterial chemoembolization for hepatocellular carcinoma. We present a case of cerebral lipiodol embolism that occurred after the third ar... 详细信息

关键词： Transcatheter arterial chemoembolization Cerebral embolism Complication Hepatocellular carcinoma Lipiodol

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

引用

Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin cho Xuelian Jin Byung Gon Kim Jun young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

14-Day Repeated Dose Toxicity and Genotoxicity Studies of Cimicifuga heracleifolia Komarov Water Extract

14-Day Repeated Dose Toxicity and Genotoxicity Studies of Ci...

引用

亚洲实验动物学会联合会（AFLAS）第三次会议暨中国实验动物学会（CALAS）第八届学术年会

作者： Jong-Rhan Kim Ji-Ran You Seung-Hyun Kim euna Kwon Yun-Soon Kim eun-young cho Jung-Hee Yoon Soon-Duk Lee Yoon-Mi Hwang Hye-Jung Jeong Dae-young Seok Jung-Gi Kim Hyun-Il Won Ja-June Jang Doo-Hyun Jeong Hee-Chan Kim Byeong-Cheol Kang Kook-Hyun Lee Jeong-Hwan Che Clinical Research Institute Seoul National University Hospital Seoul National University College of Medicine Seoul 110-744KOREA

Cimicifuga heracleifolia Komarov(CH) is used traditionally as a herbal remedy for many ***,published literature suggests that large doses of cimicifuga racemosa might be associated with ***,its long-term toxicity was not evaluated *** study was performed to evaluate 14-day repeated dose toxicity(RDT) and genotoxicity of CH extract according to the USNTP protocol and GLP guideline. To determine the appropriate dosage of CH extract administration,14-days RDT study were performed.14-days repeated dose study was performed to dosage levels of 0.125,0.25,0.5,1 and 2g/kg/day in F344/N *** test substance-related effect were observed in some criteria included mortality;clinical signs;body weight changes;urinalysis,organ weight,gross findings and histopathological findings. In reverse mutation assay of CH extract using Salmonella typhimurium TA98,TA100,TA102,TA1535 and TA1537,test substance was diluted to 5 dosage levels of 312.5,625,1,250,2,500 and 5,000μg/plate with D.D.W..Each tester strain was exposed to the test item with and without metabolic activation *** extract might not have reverse mutagenicity under the condition of this study. Chromosome aberration test of CH extract was performed to evaluate its clastogenic potential in Chinese Hamster Lung fibroblast(CHL) cell *** test substance was diluted to 3 dosage levels of 2,500,1,250,625fig/*** were exposed to test items for 6 or 24 hours in the absence of metabolic activation system,or for 6 hours in the presence of metabolic activation *** was no statistically significant increase in the number of structural or numeric aberrant metaphases at any dose both in the presence and absence of metabolic activation. A micronucleus test o{ CH extract was performed using ICR *** test substance was orally administered to 3 groups of 8-week old male ICR mice at dosage levels of 2,1,and 0.5g/kg *** 3 *** male mice were used in each test *** anim

关键词： Good Laboratory Practice(GLP) Cimicifuga heracleifolia water extract Korea National Toxicology Program

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Nitrile Electrolyte Strategy for 4.9 V-Class Lithium-Metal Batteries Operating in Flame

引用

Energy & Environmental Materials 2023年第3期6卷 229-237页

作者： Hyunseok Moon Sung-Ju cho Dae-eun Yu Sang-young Lee Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Korea Molecular Foundry Lawrence Berkeley National LaboratoryBerkeley CA USA Batteries R&D Center LG Energy SolutionDaejeon 34122Korea

Challenges facing high-voltage/high-capacity cathodes,in addition to the longstanding problems pertinent to lithium(Li)-metal anodes,should be addressed to develop high-energy-density Li-metal *** issue mostly stems from interfacial instability between electrodes and *** carbonate-or ether-based liquid electrolytes suffer from not only volatility and flammability but also limited electrochemical stability ***,we report a nitrile electrolyte strategy based on concentrated nitrile electrolytes(CNEs)with *** CNE consists of high-concentration lithium bis(fluorosulfonyl)imide(LiFSI)in a solvent mixture of succinonitrile(SN)/acetonitrile(AN).The SN/AN solvent mixture is designed to ensure high oxidation stability along with thermal stability,which are prerequisites for high-voltage Li-metal *** CNE exhibits interfacial stability with Li metals due to the coordinated solvation *** nitrate(LiNO_(3))and indium fluoride(InF_(3))are incorporated in the CNE as synergistic co-additives to further stabilize solid-electrolyte interphase(SEI)on Li *** resulting electrolyte(CNE+LiNO_(3)/InF_(3))enables stable cycling performance in Li||LiNi_(0.8)Co_(0.1)Mn_(0.1)and 4.9 V-class Li||LiNi_(0.5)Mn_(1.5)O_(4)***,the Li||LiNi_(0.5)Mn_(1.5)O_(4)cell maintains its electrochemical activity at high temperature(100℃)and even in flame without fire or explosion.

关键词： 4.9 V-class cathodes electrolyte-electrode interfaces lithium-metal batteries nitrile electrolytes safety

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Byte Frequency Based Indicators for Crypto-Ransomware Detection from Empirical Analysis

引用

Journal of Computer Science & Technology 2022年第2期37卷 423-442页

作者： Geun Yong Kim Joon-young Paik Yeongcheol Kim eun-Sun cho Department of Computer Science and Engineering Chungnam National UniversityDaejeon 34134South Korea School of Computer Science and Technology Tiangong UniversityTianjin 300387China

File entropy is one of the major indicators of crypto-ransomware because the encryption by ransomware increases the randomness of file ***,entropy-based ransomware detection has certain limitations;for example,when distinguishing ransomware-encrypted files from normal files with inherently high-level entropy,misclassification is very *** addition,the entropy evaluation cost for an entire file renders entropy-based detection impractical for large *** this paper,we propose two indicators based on byte frequency for use in ransomware detection;these are termed EntropySA and DistSA,and both consider the interesting characteristics of certain file subareas termed“sample areas”(SAs).For an encrypted file,both the sampled area and the whole file exhibit high-level randomness,but for a plain file,the sampled area embeds informative structures such as a file header and thus exhibits relatively low-level randomness even though the entire file exhibits high-level *** and DistSA use“byte frequency”and a variation of byte frequency,respectively,derived from sampled *** indicators cause less overhead than other entropy-based detection methods,as experimentally proven using realistic ransomware *** evaluate the effectiveness and feasibility of our indicators,we also employ three expensive but elaborate classification models(neural network,support vector machine and threshold-based approaches).Using these models,our experimental indicators yielded an average Fl-measure of 0.994 and an average detection rate of 99.46%for file encryption attacks by realistic ransomware samples.

关键词： computer security cryptography machine learning ransomware

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SANDWICH-TYPE THEOREMS FOR MEROMORPHIC MULTIVALENT FUNCTIONS ASSOCIATED WITH THE LIU-SRIVASTAVA OPERATOR

引用

Acta Mathematica Scientia 2012年第3期32卷 929-941页

作者： Nak eun cho Department of Applied Mathematics Pukyong National UniversityBusan 608-737Korea

The purpose of this article is to obtain some subordination and superordi- nation preserving properties of meromorphic multivalent functions in the punctured open unit disk associated with the Liu-Srivastava operator.... 详细信息

关键词： Subordination superordination meromorphic multivalent function Liu- Srivastava operator sandwich-type result

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of itraconazole on the cornea in a murine suture model and penetrating keratoplasty model

引用

International Journal of Ophthalmology(English edition) 2017年第11期10卷 1647-1654页

作者： Yang Kyung cho eun young Shin Hironori Uehara Balamurali Ambati Department of Ophthalmology St.Vincent's Hospital College of Medicine the Catholic University of Korea 93 Ji-Dong Paldal-Gu Suwon Gyeonggi-Do 16247 Korea Research Institute of Medical Science St.Vincent's Hospital the Catholic University of Korea 93 Ji-Dong Paldal-Gu Suwon Gyeonggi-Do 16247 Korea Department of Ophthalmology School of Medicine University of Utah Salt Lake City Utah 84132 USA

AIM： To investigate the anti-（lymph）angiogenic and/or anti-inflammatory effect of itraconazole in a corneal suture model and penetrating keratoplasty（PK） model. METHODS： Graft survival, corneal neovascularization, and corneal lymphangiogenesis were compared among itraconazole, amphotericin B, dexamethasone, phosphate buffered saline（PBS） and surgery-only groups following subconjunctival injection in mice that underwent PK and corneal suture. Immunohistochemical staining and analysis were performed in each group. Real-time polymerase chain reaction（RT-PCR） was performed to quantify the expression of inflammatory cytokines（TNF-alpha, IL-6） and vascular endothelial growth factor（VEGF）-A, VEGF-C, VEGFR-2, and ***： In the suture model, the itraconazole group showed less angiogenesis, less lymphangiogenesis, and less inflammatory infiltration than the PBS group（all P〈0.05）. The itraconazole group showed reduced expression of VEGF-A, VEGFR-2, TNF-alpha, IL-6 than the PBS group（all P〈0.05）. In PK model, the two-month graft survival rate was 28.57% in itraconazole group, 62.50% in dexamethasone group, 12.50% in PBS group, 0 in amphotericin B group and 0 in surgery-only group. Graft survival in the itraconazole group was higher than that in the amphotericin, PBS and surgery-only group（P=0.057, 0.096, 0.012, respectively）. The itraconazole group showed less total angiogenesis and lymphangiogenesis than PBS group（all P〈0.05）.CONCLUSION： Itraconazole decrease neovascularization, lymphangiogenesis, and inflammation in both a corneal suture model and PK model. Itraconazole has anti-（lymph）-angiogenic and anti-inflammatory effects in addition to its intrinsic antifungal effect and is therefore an alternative treatment option in cases where steroids cannot be used.

关键词： itraconazole amphotericin B neovascularization graft survival lymphangiogenesis dexamethasone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transverse myelitis after infection with varicella zoster virus in patient with normal immunity: A case report

引用

World Journal of Clinical Cases 2021年第33期9卷 10308-10314页

作者： Daehun Yun Soo young cho Wan Ju eun Hyoung Seo Department of Anesthesiology and Pain Medicine Kwangju Christian HospitalGwangju 61661South Korea

BACKGROUND Varicella zoster virus(VZV)is a human neurotropic and double-stranded DNA alpha-herpes *** infection with VZV usually occurs during childhood,manifesting as *** of latent VZV can lead to various neurological complications,including transverse myelitis(TM);although cases of the latter are very rare,particularly in newly active VZV *** SUMMARY We report here an unusual case of TM in a middle-aged adult immunocompetent patient that developed concomitant to an active VZV *** 46-year-old male presented with painful vesicular eruption on his left chest that had steadily progressed to involvement of his back over a 3-d *** fluid testing was denied,but findings from magnetic resonance imaging and collective symptomology indicated *** was administered antiviral drugs and corticosteroids immediately but his symptom improvement waxed and waned,necessitating multiple hospital *** about a month of repeated treatments,he was deemed sufficiently improved for hospital discharge to *** VZV myelitis should be suspected when a patient visits the outpatient pain clinic with herpes zoster showing neurological symptoms.

关键词： Herpes zoster Postherpetic neuralgia Transverse myelitis Varicella zoster virus Motor weakness Vesicular Pain Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Serial evaluation of myocardial function using the myocardial performance index in Kawasaki disease

引用

World Journal of Pediatrics 2018年第3期14卷 259-268页

作者： eun Song Song Somy Yoon Joo Hyun cho eun Mi Yang Hwa Jin cho young Youn choi Jae Sook Ma Gwang Hyeon Eom young Kuk cho Department of Pediatrics Chonnam National University HospitalChonnam National University Medical School42 Jebong-roDong-guGwangju 501-757South Korea Department of Pharmacology and Medical Research Center for Gene Regulation Chonnam National University Medical School160 Baekseo-roDong-guGwangju 61469South Korea Department of Pediatrics KS HospitalGwangjuSouth Korea

Background Kawasaki disease (KD) is known as systemic vasculitis, and more than half of the patients with KD have myo-carditis, which can induce ventricular dysfunction. In this study, we evaluate left ventricular (LV) dysfunction in patients with KD based on the myocardial performance index (MPI) using pulse Doppler (PD) and tissue Doppler imaging (TDI), from the acute to convalescent phases. Methods We retrospectively studied 89 children diagnosed with KD from January 2010 to August 2012. We assessed the presence of coronary artery lesions (CALs) and the LV ejection fraction, PD-MPI, and TDI-MPI at diagnosis, and 2, 14, and 56 days after intravenous immunoglobulin (IVIG) treatment. We enrolled 70 healthy children as a control group. Results The ejection fraction in patients with KD at diagnosis (67.3 ± 0.9%) was lower than that in the control group (69.8 ± 0.8%,P = 0.035), and the LV TDI-MPIs for patients with KD at diagnosis (0.49 ± 0.01) and 2 days after IVIG treatment (0.48 ± 0.01) were higher than those in the control group (0.45 ± 0.01,P = 0.002,P = 0.033, respectively). No signifi cant diff erences were found in the LV dysfunction between the patients with complete and incomplete KD. Septal TDI-MPIs in patients with KD with CAL at diagnosis (0.52 ± 0.02) were higher than those in patients with KD without CAL (0.47 ± 0.01,P = 0.019). Conclusions Transient LV dysfunction occurred in patients with complete and incomplete KD in the acute stage. In patients with KD with CAL at diagnosis, the LV dysfunction was more prominent. The PD-MPI and TDI-MPI are useful parameters for assessing LV function in patients with KD.

关键词： Kawasaki disease Myocardial function Myocardial performance index Tissue Doppler imaging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：