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Imaging diagnosis of pancreatic cancer:A state-of-the-art review

World Journal of Gastroenterology 2014年第24期20卷 7864-7877页

作者： eun sun lee Jeong Min lee Department of Radiology Seoul National University HospitalSeoul 110-744South Korea Institute of Radiation Medicine Seoul National University College of MedicineSeoul 110-744South Korea

Pancreatic cancer(PC)remains one of the deadliest cancers worldwide,and has a poor,five-year survival rate of 5%.Although complete surgical resection is the only curative therapy for pancreatic cancer,less than20%of newly-diagnosed patients undergo surgical resection with a curative *** to the lack of early symptoms and the tendency of pancreatic adenocarcinoma to invade adjacent structures or to metastasize at an early stage,many patients with pancreatic cancer already have advanced disease at the time of their diagnosis and,therefore,there is a high mortality *** improve the patient survival rate,early detection of PC is *** diagnosis of PC relies on computed tomography(CT)and/or magnetic resonance imaging(MRI)with magnetic resonance cholangiopancreatography(MRCP),or biopsy or fine-needle aspiration using endoscopic ultrasound(EUS).Although multi-detector row computed tomography currently has a major role in the evaluation of PC,MRI with MRCP facilitates better detection of tumors at an early stage by allowing a comprehensive analysis of the morphological changes of the pancreas parenchyma and pancreatic *** diagnosis could be improved using positron emission tomography techniques in special conditions in which CT and EUS are not completely *** is essential for clinicians to understand the advantages and disadvantages of the various pancreatic imaging modalities in order to be able to make optimal treatment and management *** study investigates the current role and innovative techniques of pancreatic imaging focused on the detection of pancreatic cancer.

关键词： Pancreatic neoplasms Multi-detector computed tomography Magnetic resonance imaging Ultrasonography Endoscopic ultrasound-guided fine needle aspiration Positron-emission tomography

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Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

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Research 2024年第1期2023卷 637-649页

作者： Hyun-Kyung So Hyebeen Kim Jinwoo lee Chang-Lim You Chae-eun Yun Hyeon-Ju Jeong eun-Ju Jin Yunju Jo Dongryeol Ryu Gyu-Un Bae Jong-sun Kang Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonKorea Single Cell Network Research Center Sungkyunkwan University School of MedicineSuwonKorea Research Institute of Aging-Related Diseases AniMusCureInc.SuwonKorea Drug Information Research Institute Muscle Physiome Research CenterCollege of PharmacySookmyung Women’s UniversitySeoulKorea

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or due to degenerative ***,the molecular mechanisms underlying neuromuscular dysfunction are currently *** studies have proposed important roles of Protein arginine methyltransferase 1(Prmt1)in muscle stem cell function and muscle *** the current study,we set out to determine the role of Prmt1 in neuromuscular function by generating mice with motor neuron-specific ablation of Prmt1(mnKO)using *** exhibited age-related motor neuron degeneration and neuromuscular dysfunction leading to premature muscle loss and ***1 deficiency also impaired motor function recovery and muscle reinnervation after sciatic nerve *** transcriptome analysis of aged mnKO lumbar spinal cords revealed alterations in genes related to inflammation,cell death,oxidative stress,and ***,mnKO lumbar spinal cords of sciatic nerve injury model or aged mice exhibited elevated cellular stress response in motor ***,Prmt1 inhibition in motor neurons elicited mitochondrial *** findings demonstrate that Prmt1 ablation in motor neurons causes agerelated motor neuron degeneration attributing to muscle ***,Prmt1 is a potential target for the prevention or intervention of sarcopenia and neuromuscular dysfunction related to aging.

关键词： degeneration impaired prevention

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Neural Wiskott-Aldrich syndrome protein(N-WASP)promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

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Oncology Research 2024年第4期32卷 615-624页

作者： HYUNG sun KIM YUN sun lee SeunG MYUNG DONG HYO JUNG KIM DA eun lee HYEON WOONG KANG MYEONG JIN KIM JOON SEONG PARK Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoulKorea Department of Surgery Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulKorea Gibiome Co. Ltd.Gyeonggi-doKorea

Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive solid malignancies.A specific mechanism of its metastasis has not been *** this study,we investigated whether Neural Wiskott-Aldrich syndrome protein(N-WASP)plays a role in distant metastasis of *** found that N-WASP is markedly expressed in clinical patients with *** analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group.N-WASP was noted to be a novel mediator of epithelialmesenchymal transition(EMT)via gene expression profile *** of N-WASP in pancreatic cancer cells significantly inhibited cell invasion,migration,and *** also observed positive association of lysyl oxidase-like 2(LOXL2)and focal adhesion kinase(FAK)with the N-WASP-mediated response,wherein EMT and invadopodia function were *** N-WASP and LOXL2 depletion significantly reduced the incidence of liver and lung metastatic lesions in orthotopic mouse models of pancreatic *** results elucidate a novel role for N-WASP signaling associated with LOXL2 in EMT and invadopodia function,with respect to regulation of intercellular communication in tumor cells for promoting pancreatic cancer *** findings may aid in the development of therapeutic strategies against pancreatic cancer.

关键词： Pancreatic cancer Neural Wiskott-Aldrich syndrome protein(N-WASP)signaling Metastasis Epithelial-mesenchymal transition(EMT) Lysyl oxidase-like 2(LOXL2)

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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young Park Chulhwan Kwak Yoonji lee Dae-Geun Song Jae Woo Jung Haesong lee eun-Ae Shin Yangie Pinanga Kyung-hee Pyo eun Hae lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

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Changes in microorganisms and metabolites during long-term fermentation of commercially manufactured anchovy sauce

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Food Science and Human Wellness 2024年

作者： Daehyeon Kim Seong-eun Park eun-Ju Kim Seung-Ho Seo Kwang-Moon Cho sun Jae Kwon Hong-Seok Son Department of Biotechnology， College of Life Sciences and Biotechnology， Korea University Sonlab Inc. 3. AccuGene Inc.

This study was performed to investigate the changes in microbial communities and metabolites during the long-term fermentation of commercially manufactured anchovy sauce. Samples of commercial anchovy sauce were collected from large-scale fermentation tanks with fermentation periods of up to 7.87 years. The complex bacterial community was simplified to two genera， Tetragenococcus and Halanaerobium， after approximately 0.55 years of fermentation. Although genera， such as Saccharomyces， Cladosporium， Candida， and Aspergillus， were relatively dominant， no clear pattern was identified in fungal community analysis. The longitudinal metabolite profile demonstrated that approximately half (55.8%) of the metabolites present in anchovy sauce were produced within a year of fermentation due to rapid fermentation. Despite the static microbial community， the contents of several metabolites including amino acids and biogenic amines changed continuously during the long-term fermentation of anchovy sauce. This study provides novel insights into the changes in microbiota and metabolites in fish sauce produced without any starter inoculation.

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An Effective Threat Detection Framework for Advanced Persistent Cyberattacks

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Computers, Materials & Continua 2023年第5期75卷 4231-4253页

作者： So-eun Jeon sun-Jin lee eun-Young lee Yeon-Ji lee Jung-Hwa Ryu Jung-Hyun Moon sun-Min Yi Il-Gu lee Department of Future Convergence Technology Engineering Sungshin Women’s UniversitySeoul02844Korea Department of Convergence Security Engineering Sungshin Women’s UniversitySeoul02844Korea

Recently,with the normalization of non-face-to-face online environments in response to the COVID-19 pandemic,the possibility of cyberattacks through endpoints has *** endpoint devices are managed meticulously to prevent cyberattacks and ensure timely responses to potential security *** particular,because telecommuting,telemedicine,and teleeducation are implemented in uncontrolled environments,attackers typically target vulnerable endpoints to acquire administrator rights or steal authentication information,and reports of endpoint attacks have been increasing *** persistent threats(APTs)using various novel variant malicious codes are a form of a sophisticated ***,conventional commercial antivirus and anti-malware systems that use signature-based attack detectionmethods cannot satisfactorily respond to such *** this paper,we propose a method that expands the detection coverage inAPT attack *** this model,an open-source threat detector and log collector are used synergistically to improve threat detection *** the scope of attack log collection through interworking between highly accessible open-source tools can efficiently increase the detection coverage of tactics and techniques used to deal with APT attacks,as defined by MITRE Adversarial Tactics,Techniques,and Common Knowledge(ATT&CK).We implemented an attack environment using an APT attack scenario emulator called Carbanak and analyzed the detection coverage of Google Rapid Response(GRR),an open-source threat detection tool,and Graylog,an open-source log *** proposed method expanded the detection coverage against MITRE ATT&CK by approximately 11%compared with that conventional methods.

关键词： Advanced persistent threat cybersecurity endpoint security MITRE ATT&CK open-source threat detector threat log collector

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Machine Learning-Based Efficient Discovery of Software Vulnerability for Internet of Things

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Intelligent Automation & Soft Computing 2023年第8期37卷 2407-2419页

作者： So-eun Jeon sun-Jin lee Il-Gu lee Department of Future Convergence Technology Engineering Sungshin Women’s UniversitySeoul02844Korea

With the development of the 5th generation of mobile communi-cation(5G)networks and artificial intelligence(AI)technologies,the use of the Internet of Things(IoT)has expanded throughout *** IoT networks have improved industrial productivity and convenience,they are highly dependent on nonstandard protocol stacks and open-source-based,poorly validated software,resulting in several security ***-ever,conventional AI-based software vulnerability discovery technologies cannot be applied to IoT because they require excessive memory and com-puting *** study developed a technique for optimizing training data size to detect software vulnerabilities rapidly while maintaining learning *** results using a software vulnerability classification dataset showed that different optimal data sizes did not affect the learning performance of the learning ***,the minimal data size required to train a model without performance degradation could be determined in *** example,the random forest model saved 85.18%of memory and improved latency by 97.82%while maintaining a learning accuracy similar to that achieved when using 100%of data,despite using only 1%.

关键词： Lightweight devices machine learning deep learning software vulnerability detection common weakness enumeration

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CRISPR/Cas9-mediated gene editing to confer turnip mosaic virus (TuMV) resistance in Chinese cabbage (Brassica rapa)

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Horticulture Research 2023年第6期10卷 135-143页

作者： Ye-Rin lee Muhammad Irfan Siddique Do-sun Kim eun Su lee Koeun Han Sang-Gyu Kim Hye-eun lee Vegetable Research Division National Institute of Horticultural and Herbal ScienceRural Development AdministrationWanju55365Republic of Korea Department of Horticultural Sciences North Carolina State University Mountain Horticultural Crops ResearchExtension Center 455 Research DriveMills RiverNC 28759USA Department of Biological Sciences Korea Advanced Institute for Science and TechnologyDaejeon34141Republic of Korea

Genome editing approaches,particularly the CRISPR/Cas9 technology,are becoming state-of-the-art for trait development in numerous breeding *** advances in improving plant traits are enabled by this influential tool,especially for disease resistance,compared to traditional *** of the potyviruses,the turnip mosaic virus(TuMV),is the most widespread and damaging virus that infects Brassica *** generated the targeted mutation at the eIF(iso)4E gene in the TuMV-susceptible cultivar“Seoul”using CRISPR/Cas9 to develop TuMV-resistant Chinese *** detected several heritable indel mutations in the edited T0 plants and developed T1 through generational *** was indicated in the sequence analysis of the eIF(iso)4E-edited T1 plants that the mutations were transferred to succeeding *** edited T1 plants conferred resistance to *** was shown with ELISA analysis the lack of accumulation of viral ***,we found a strong negative correlation(r=-0.938)between TuMV resistance and the genome editing frequency of eIF(iso)***,it was revealed in this study that CRISPR/Cas9 technique can expedite the breeding process to improve traits in Chinese cabbage plants.

关键词： CRISPR/Cas9 TuMV breeding

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Predicted pro-inflammatory hs-CRP score and non-alcoholic fatty liver disease

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Gastroenterology Report 2023年第1期11卷 462-468页

作者： Akinkunmi Paul Okekunle Jiyoung Youn Sihan Song Goh eun Chung sun Young Yang Young sun Kim Jung eun lee Department of Food and Nutrition College of Human EcologySeoul National UniversitySeoulKorea Research Institute of Human Ecology Seoul National UniversitySeoulKorea Healthcare System Gangnam Center Healthcare Research InstituteSeoul National University HospitalSeoulKorea

Background:Non-alcoholic fatty liver disease(NAFLD)is a major contributor to liver diseases globally,yet there are limited studies investigating the impact of diet and lifestyle factors on its *** study aimed to examine the association between the prevalence of NAFLD and predicted pro-inflammatory high-sensitivity C-reactive protein(hs-CRP)***:We included 1,076 Korean adults who underwent a medical examination at the Seoul National University Hospital Gangnam Healthcare Center in Korea between May and December 2011 and updated in *** predicted pro-inflammatory hs-CRP score was derived from pro-inflammatory demographic,lifestyle,dietary,and anthropometric factors,and NAFLD was diagnosed using liver ***-adjusted odds ratios(ORs)and 95%confidence intervals(CIs)of NAFLD odds according to predicted pro-inflammatory hs-CRP score were estimated using logistic regression at a two-sided P<***:Among the 1,076 participants,320 had *** multivariable-adjusted ORs and 95%CIs for NAFLD by tertiles of predicted pro-inflammatory hs-CRP score were 1.00,3.30(2.06,5.30),18.25(10.47,31.81;P<0.0001)in men and women combined,1.00,1.77(1.10,2.84),and 3.26(2.02,5.28;P<0.0001)among men only,and 1.00,3.03(1.39,6.62),and 16.71(7.05,39.63;P<0.0001)among women ***:Predicted pro-inflammatory hs-CRP score was associated with higher odds of *** dietary and lifestyle changes related to lower inflammation might be a valuable strategy for preventing NAFLD.

关键词： non-alcoholic fatty liver disease fatty liver high-sensitivity C-reactive protein pro-inflammation

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Enhancing ammonia production rates from electrochemical nitrogen reduction by engineering three-phase boundary with phosphorus-activated Cu catalysts

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Journal of Energy Chemistry 2023年第9期84卷 394-401页

作者： Jeehye Kim Cho Hee lee Yong Hyun Moon Min Hee lee eun Hyup Kim sun Hee Choi Youn Jeong Jang Jae sung lee School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Department of Chemical Engineering Hanyang UniversitySeoul 04763Republic of Korea Pohang Accelerator Laboratory(PAL) Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Electrochemical N_(2) reduction reaction(eNRR) over Cu-based catalysts suffers from an intrinsically low activity of Cu for activation of stable N_(2) molecules and the limited supply of N_(2) to the catalyst due to its low solubility in aqueous ***,we propose phosphorus-activated Cu electrocatalysts to generate electron-deficient Cu sites on the catalyst surface to promote the adsorption of N_(2) *** eNRR system is further modified using a gas diffusion electrode(GDE) coated with polytetrafluoroethylene(PTFE) to form an effective three-phase boundary of liquid water-gas N_(2)-solid catalyst to facilitate easy access of N_(2) to the catalytic *** a result,the new catalyst in the flow-type cell records a Faradaic efficiency of 13.15% and an NH_(3) production rate of 7.69 μg h^(-1) cm^(-2) at-0.2 V_(RHE),which represent 3.56 and 59.2 times increases from those obtained with a pristine Cu electrode in a typical electrolytic *** work represents a successful demonstration of dual modification strategies;catalyst modification and N_(2) supplying system engineering,and the results would provide a useful platform for further developments of electrocatalysts and reaction systems.

关键词： Electrochemical nitrogen reduction reaction Ammonia production Phosphorous modified copper electrodes Gas diffusion electrodes Three-phase boundary PTFE coating

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