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Horticulture Research 2023年第6期10卷 135-143页

作者： Ye-Rin Lee Muhammad Irfan Siddique Do-sun Kim eun Su Lee Koeun Han Sang-Gyu Kim Hye-eun Lee Vegetable Research Division National Institute of Horticultural and Herbal ScienceRural Development AdministrationWanju55365Republic of Korea Department of Horticultural Sciences North Carolina State University Mountain Horticultural Crops ResearchExtension Center 455 Research DriveMills RiverNC 28759USA Department of Biological Sciences Korea Advanced Institute for Science and TechnologyDaejeon34141Republic of Korea

Genome editing approaches,particularly the CRISPR/Cas9 technology,are becoming state-of-the-art for trait development in numerous breeding *** advances in improving plant traits are enabled by this influential tool,especially for disease resistance,compared to traditional *** of the potyviruses,the turnip mosaic virus(TuMV),is the most widespread and damaging virus that infects Brassica *** generated the targeted mutation at the eIF(iso)4E gene in the TuMV-susceptible cultivar“Seoul”using CRISPR/Cas9 to develop TuMV-resistant Chinese *** detected several heritable indel mutations in the edited T0 plants and developed T1 through generational *** was indicated in the sequence analysis of the eIF(iso)4E-edited T1 plants that the mutations were transferred to succeeding *** edited T1 plants conferred resistance to *** was shown with ELISA analysis the lack of accumulation of viral ***,we found a strong negative correlation(r=-0.938)between TuMV resistance and the genome editing frequency of eIF(iso)***,it was revealed in this study that CRISPR/Cas9 technique can expedite the breeding process to improve traits in Chinese cabbage plants.

关键词： CRISPR/Cas9 TuMV breeding

Outcome after endoscopic submucosal dissection for early gastric cancer in Korea

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World Journal of Gastroenterology 2011年第31期17卷 3591-3595页

作者： Jun Haeng Lee Su Jin Hong Jae Young jang Seong eun Kim Sang Young Seol Department of Medicine Samsung Medical CenterSungkyunkwan University School of Medicine Department of Internal Medicine Digestive Disease CenterInstitute for Digestive ResearchSoon Chun Hyang University College of Medicine Department of Internal Medicine Kyung Hee University College of Medicine Department of Internal Medicine Ewha Womans University School of MedicineEwha Medical Research Institute Division of Gastroenterology and Hepatology Department of Internal MedicineInje University College of Medicine

Endoscopic treatment,such as endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD),has been established as one of the treatment options for selected cases with early gastric cancer(EGC).Most studies on this topic have been carried out by researchers in ***,the experience in EMR/ESD for EGC outside Japan is increasingly *** Korea,gastric cancer is the most common malignant disease,and the second leading cause of cancer ***,EMR for EGC is widely performed in many centers in *** results with a shortterm follow-up period are very promising in *** resection rate of EMR was 37.8%-94.3%,and that of ESD was 77.4%-93.1%.In this review,we will provide an overview of the outcomes of endoscopic treatments in Korea.

关键词： Early gastric cancer Endoscopic mucosal resection Endoscopic submucosal dissection Outcome

β-Arrestin 2 suppresses the activation of YAP by promoting LATS kinase activity

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Genes & Diseases 2023年第2期10卷 348-351页

作者： Minsuh Kim Ji Min Kim eun Jeong Cho Chang Ohk sung Joon Kim Se Jin jang Asan Institute for Life Sciences Asan Medical CenterSeoul 05505Republic of Korea University of Ulsan College of Medicine Seoul 05505Republic of Korea Department of Pathology Asan Medical CenterSeoul 05505Republic of Korea Graduate School of Medical Science and Engineering KAISTDaejeon 34141Republic of Korea OncoClew Life Science Co. LtdSeoul 05505Republic of Korea

Dysregulation of the Hippo pathway has been frequently identified in various human cancers. The Hippo pathway is a highly complex pathway involving multiple types of proteins, and the activation of YAP by LATS kinase is the final effector step in the transcription process. In this study, we linked the roles of the multifunctional adapter proteins β-arrestins (β-arrestin 1 and 2) in cooperation with other signaling pathways such as GPCR and Wnt to essential cellular functions involved in carcinogenesis, including the regulation of cell proliferation, migration, and differentiation as well as stem cell properties.1 Although β-arrestin 1 and 2 have high structural similarities, they have different roles in carcinogenesis as β-arrestin 1 aids cancer cell survival and metastasis2 and β-arrestin 2 inhibits tumor growth.1 In the Hippo signaling pathway, β-arrestins function as scaffold proteins that mediate the phosphorylation of key molecules, and their association with human cancers is a major research topic. In this study, we demonstrated that β-arrestin 2 inhibits YAP activation through the formation of the β-arrestin 2-LATS-YAP trimeric complex, which results in the promotion of the kinase activity of LATS in cancer cell lines and patient-derived colon cancer organoids.

关键词： cancer carcinogenesis activation

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World Journal of Clinical Cases 2020年第21期8卷 5341-5346页

作者： eun-A jang Tae-Young Kim Eu-Gene Jung Seongtae Jeong Hong-Beom Bae Seongheon Lee Department of Anesthesiology and Pain Medicine Chonnam National University Medical SchoolChonnam National University HospitalGwangju 61469South Korea

BACKGROUND Donepezil is an acetylcholinesterase inhibitor used to improve cognition and delay disease progression in dementia patients by increasing acetylcholine *** drug may potentially interact with neuromuscular blocking agents(NMBAs)that act on muscular acetylcholine receptors during general ***,we present a case of inadequate neuromuscular blockade with rocuronium,a nondepolarizing NMBA,in a dementia patient who had taken *** SUMMARY A 71-year-old man was scheduled for laparoscopic *** had been taking donepezil 5 mg for *** anesthesia was induced with propofol and *** depth of neuromuscular blockade was monitored by train-of-four(TOF)*** the administration of rocuronium,the TOF ratio decreased at an unusually slow rate,and a TOF count of 0 was detected 7 min *** intubation,a TOF count of 1 was detected within 1 min,and a TOF ratio of 12%was detected within 2 *** TOF count remained at 4 even with an additional bolus and continuous infusion of rocuronium,suggesting resistance to this *** of propofol,an inhalation anesthetic was administered alongside another NMBA(cisatracurium).Then,the quality of neuromuscular blockade improved,and the TOF count remained at 0-1 for the next 70 *** further problems were encountered with respect to surgery or *** Donepezil may be responsible for inadequate neuromuscular blockade during anesthesia,especially when total intravenous anesthesia is used.

关键词： Donepezil Dementia General anesthesia Rocuronium Neuromuscular blocking agents Case report

Predicting Bitcoin Trends Through Machine Learning Using Sentiment Analysis with Technical Indicators

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Computer Systems Science & Engineering 2023年第8期46卷 2231-2246页

作者： Hae sun Jung Seon Hong Lee Haein Lee jang Hyun Kim Department of Applied Artificial Intelligence/Department of Human-Artificial Intelligence Interaction Sungkyunkwan UniversitySeoul03063Korea Department of Interaction Science/Department of Human-Artificial Intelligence Interaction Sungkyunkwan UniversitySeoul03063Korea

Predicting Bitcoin price trends is necessary because they represent the overall trend of the cryptocurrency *** the history of the Bitcoin market is short and price volatility is high,studies have been conducted on the factors affecting changes in Bitcoin *** have been conducted to predict Bitcoin prices using Twitter ***,the amount of data was limited,and prices were predicted for only a short period(less than two years).In this study,data from Reddit and LexisNexis,covering a period of more than four years,were *** data were utilized to estimate and compare the performance of the six machine learning techniques by adding technical and sentiment indicators to the price data along with the volume of *** accuracy of 90.57%and an area under the receiver operating characteristic curve value(AUC)of 97.48%were obtained using the extreme gradient boosting(XGBoost).It was shown that the use of both sentiment index using valence aware dictionary and sentiment reasoner(VADER)and 11 technical indicators utilizing moving average,relative strength index(RSI),stochastic oscillators in predicting Bitcoin price trends can produce significant ***,the input features used in the paper can be applied on Bitcoin price ***,this approach allows investors to make better decisions regarding Bitcoin-related investments.

关键词： Bitcoin cryptocurrency sentiment analysis price trends prediction natural language processing machine learning

Safety assessment of condensed phosphate intake from fishery and processed marine food products in Korea with respect to gender,age,and region

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Food Quality and Safety 2021年第2期5卷 161-169页

作者： Hyung Soo Kim Dae Yong jang Ye Ji Koo eun Chul Pack Seung Ha Lee Dal Woong Choi Health Science Research Center Korea UniversitySeoulRepublic of Korea department of Public Health Sciences Graduate SchoolKorea UniversitySeoulRepublic of Korea School of Health and Environmental Sciences Korea UniversitySeoulRepublic of Korea and department of Health and Safety Convergence Science Graduate SchoolKorea UniversitySeoulRepublic of Korea.

Condensed phosphates are used as food additives,especially in marine products and meat,to improve food *** import and consumption of fishery and processed marine food products in Republic of Korea have reportedly increased by~5 per cent ***,processed marine food products are often intentionally adulterated with excessive amounts of condensed phosphates to increase their *** intake of condensed phosphates via consuming processed marine food products can lead to various adverse effects on human health due to anionic ***,we conducted a safety assessment of condensed phosphates in 14 types of fishery and processed marine food products in Korea for the first *** analysis of various factors including gender,age,and region was also performed,and the risk level of exposure for each group was *** assessments by age and gender indicated that infants were at the highest *** the regional safety assessment,Chungnam,the most inland region,showed the lowest *** both the general and the high-intake groups(95th percentile)in all classifications,the risk was lower(<20 per cent)than the international standard,and the phosphorus content of the 14 types of processed marine products in Korea was confirmed to be safe for human consumption.

关键词： Condensed phosphates safety assessment ion chromatography fishery and processed marine food products

Application of powdered activated carbon coating to fabrics in a hybrid filter to enhance mercury removal

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Journal of Environmental Sciences 2019年第6期31卷 58-65页

作者： Jin-Ho sung Seung-Ki Back eun-Song Lee Ha-Na jang Yong-Chil Seo Youn-Suk Kang Myong-Hwa Lee Department of Environmental Engineering Yonsei University J-E Tech Co. Ltd Department of Environmental Engineering Kangwon National University

Elemental mercury(Hg0) is predominant constituent of flue gas emitted from coal-fired power plants. Adsorption has been considered the best available technology for removal of Hg0 from flue gas. However, adsorbent injection increases the amount of ash generated. In the present study, powdered activated carbon(PAC) was coated on polytetrafluoroethylene/glass fiber filters to increase Hg0 removal while concurrently reducing the amount of ash generated. The optimal PAC coating rate was determined in laboratory experiments to ensure better Hg0 removal with low pressure drop. When PAC of particle size less than 45 μm was used, and the areal density was 50 g/m2, the pressure drop remained under 30 Pa while the Hg0 removal efficiency increased to 15.8% from4.3%. The Hg0 removal efficiency also increased with decrease in filtration velocity. The optimal PAC coating rate was applied on a hybrid filter(HF), which was combined with a bag filter and an electrostatic precipitator in a single chamber. Originally designed to remove fine particulates matter, it was retrofitted to the flue gas control device for simultaneous Hg0 removal. By employing the PAC coating, the Hg removal efficiency of the HF increased to 79.79% from 66.35%. Also, a temporary reduction in Hg removal was seen but this was resolved following a cleaning cycle in which the dust layer was removed.

关键词： Mercury Hybrid filter Activated carbon Coating filter Coal-fired power plant

Gradient Si-and Ti-doped Fe_(2)O_(3) hierarchical homojunction photoanode for efficient solar water splitting:Effect of facile microwave-assisted growth of Si-FeOOH on Ti-FeOOH nanocorals

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Journal of Energy Chemistry 2023年第2期77卷 27-37,I0002页

作者： Tae Sik Koh Periyasamy Anushkkaran Weon-Sik Chae Hyun Hwi Lee sun Hee Choi Jum Suk jang Division of Biotechnology College of Environmental and Bioresource SciencesJeonbuk National UniversityIksan 54596Republic of Korea Daegu Center Korea Basic Science InstituteDaegu 41566Republic of Korea Pohang Accelerator Laboratory Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

The construction of a homojunction is an effective approach for addressing issues such as slow charge separation and charge-transfer kinetics in *** the present work,we designed a gradient Si-and Ti-doped Fe_(2)O_(3) homojunction photoanode to improve the photoelectrochemical(PEC)performance of a Ti-doped Fe_(2)O_(3) ***-FeOOH nanocorals were synthesized using a hydrothermal process,and Si-FeOOH was grown on Ti-FeOOH nanocorals using a rapid and facile microwaveassisted(MW)*** varying the MW irradiation time,the thickness of the Si/Ti:Fe_(2)O_(3) photoanode was adjusted and an optimized 3-Si/Ti:Fe_(2)O_(3) photoelectrode was achieved with a significantly enhanced photocurrent density(1.37 mA cm^(-2) at 1.23 V ***)and a cathodic shift of the onset potential(150 mV)compared with that of bare Ti-Fe_(2)O_(3).This enhanced PEC performance can be ascribed to homojunction formation and Si gradient *** Si dopant increased the donor concentration and the formation of a homojunction improved the intrinsic built-in electric field,thereby promoting charge separation and charge ***,the as-formed homojunction passivated the surfacetrapping states,consequently improving the charge transfer efficiency(60%at 1.23 VRHE)at the photoanode/electrolyte *** findings could pave the way for the microwave-assisted fabrication of diverse efficient homojunction photoanodes for PEC water splitting applications.

关键词： Homojunction Microwave-assisted Hematite Gradient doping PEC water splitting

Association between the early high level of serum tacrolimus and recurrence of hepatocellular carcinoma in ABO-incompatible liver transplantation

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2727-2738页

作者： Ji Won Han Jong Young Choi eun sun Jung Ji Hoon Kim Hee sun Cho Jae-sung Yoo Pil Soo sung Jeong Won jang Seung Kew Yoon Ho Joong Choi Young Kyoung You Department of Internal Medicine The Catholic University of KoreaSeoul 06591South Korea The Catholic University Liver Research Center College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Hospital Pathology The Catholic University of KoreaSeoul 06591South Korea Department of Surgery The Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Clinical factors predicting graft survival(GS)after ABO-incompatible(ABOi)liver transplantation(LT),and differences between recipients with and without hepatocellular carcinoma(HCC)are *** To analyze the impact of serial serum tacrolimus trough concentration in recipients with or without(HCC)in ABOi living-donor liver transplantation(LDLT).METHODS We analyzed a historical cohort of 89 recipients who underwent ABOi LDLT,including 47 patients with *** The 1-,3-,5-,and 10-year GS rates were 85.9%,73.3%,71.4%,and 71.4%,respectively,and there were no significant differences between HCC and non-HCC *** multivariate Coxregression analyses,tacrolimus trough concentrations below 5.4 ng/mL at 24 wk post-LT,in addition to the antibody-mediated rejection(AMR)were associated with poor-graft *** HCC patients,AMR[hazard ratio(HR)=63.20,P7.3 ng/mL were significant predictive factors for HCC *** propensity score matching,patients with high tacrolimus concentrations at 4 wk had significantly poor recurrence-free *** Elevated tacrolimus levels at 4 wk after ABOi LDLT have been found to correlate with HCC ***,careful monitoring and control of tacrolimus levels are imperative in ABOi LT recipients with HCC.

关键词： ABO-incompatible Liver transplantation Tacrolimus Hepatocellular carcinoma

Anti-Proliferative Effects of Ginsenosides Extracted from Mountain Ginseng on Lung Cancer

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Chinese Journal of Integrative Medicine 2016年第5期22卷 344-352页

作者： Dong Gyu Lee sung-ll jang Young-Rang Kim Kyeong eun Yang So Jung Yoon Zee-Won Lee Hyun Joo An Ik-Soon jang Jong-Soon Choi Hwa-Seung Yoo Division of Life Science Korea Basic Science InstituteDaejeon 305-333Korea East-West Cancer Center Dunsan Oriental Hospital of Daejeon UniversityDaejeon 302-122Korea Graduate School of Analytical Science and Technology Chungnam National UniversityDaejeon 305-764Korea

Objective： To investigate the effect of three major ginsenosides from mountain ginseng as anti- cancer substance and explore the underlying mechanism involved in lung cancer. Methods： The inhibitory proliferation of lung cancer by major five ginsenosides （Rbl, Rb2, Rgl, Rc, and Re） was examined using 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl tetrazolium bromide assay. Calculated 50% inhibition （IC50） values of five ginsenosides were determined and compared each other. Apoptosis by the treatment of single ginsenoside was performed by fluorescence-assisted cytometric spectroscopy. The alterations of apoptosis-related proteins were evaluated by Western blot analysis. Results： The abundance of ginsenosides in butanol extract of mountain ginseng （BX-MG） was revealed in the order of Rbl, Rgl, Re, Rc and Rb2. Among them, Rbl was the most effective to lung cancer cell, followed by Rb2 and Rgl on the basis of relative IC50 values of IMR90 versus A549 cell. The alterations of apoptotic proteins were confirmed in lung cancer A549 cells according to the administration of Rbl, Rb2 and Rgl. The expression levels of caspase-3 and caspase-8 were increased upon the treatment of three ginsenosides, however, the levels of caspase-9 and anti-apoptotic protein Bax were not changed. Conclusion： Major ginsenosides such as Rbl, Rb2 and Rgl comprising BX-MG induced apoptosis in lung cancer cells via extrinsic apoptotic pathway rather than intrinsic mitochondrial pathway.

关键词： Butanol extract of mountain ginseng ginsenoside lung cancer apoptosis