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Open Journal of Nursing 2016年第11期6卷 958-968页

作者： eun kyung chang Heeok Park Miran Jung Hae Kyeong Lee Jieun Park Mijung Park Minsuk Gang Nursing Department Daegu Health College Daegu South Korea College of Nursing Keimyung University Daegu South Korea Nursing Department Daegu Fatima Hospital Daegu South Korea Nursing Department Keimyung University Dongsan Medical Center Daegu South Korea Nursing Department Kyungpook National University Medical Center Daegu South Korea School of Nursing Youngjin College Daegu South Korea

The current study examined the effects of band therapy using music on grasping power, depression, and personal relationships among residents of a nursing home. Thirty subjects participated in the study. The band therapy included greetings, warm-up exercises with music, singing with dance, playing instruments, closing speech, and stretching with background music. Band therapy was held for 40 minutes once per week, for a total of four sessions, in the activity room of the nursing home. Findings showed that grasping power, depression, and personal relationships were improved at posttest, but the differences were not statistically significant. A better study design to compare the effects of band therapy with the other group, and a more simple and repeated intervention for the elderly to follow without stress might be necessary.

关键词： Band Therapy Music Grasping Power Depression Personal Relationships Nursing Home

Colorectal cancer in inflammatory bowel disease:The risk,pathogenesis,prevention and diagnosis

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World Journal of Gastroenterology 2014年第29期20卷 9872-9881页

作者： eun Ran Kim Dong kyung chang Division of Gastroenterology Department of Internal MedicineSamsung Medical CenterSungkyunkwan University School of Medicine

Patients with inflammatory bowel disease(IBD)are at increased risk for developing colorectal cancer(CRC),although the overall incidence of IBD-associated CRC has been diminishing in recent decades in western *** demonstrated in previous studies,the risk of CRC in IBD increases with longer duration,extent of colitis,a familial history of CRC,coexistent primary sclerosing cholangitis,and the degree of *** pathogenesis of CRC in IBD is poorly *** to sporadic CRC,IBD-associated CRC is a consequence of sequential episodes of genomic *** inter-related pathways,including immune response by mucosal inflammatory mediators,oxidative stress,and intestinal microbiota,are also involved the pathogenesis of IBD-associated *** colonic inflammation appears to be a factor in the development of CRC;therefore,anti-inflammatory agents such as5-aminosalicylate compounds and immune modulators have been considered as potential chemopreventive *** surveillance is widely accepted as being effective in reducing the risk of IBD-associated CRC,although no clear evidence has confirmed that surveillance colonoscopy prolongs survival in patients with extensive *** traditional recommendation has been quadrantic random biopsies throughout the entire colon;however,several guidelines now have endorsed chromoendoscopy with a target biopsy because of increasing diagnostic yields and reduced workloads for endoscopists and *** technologies such as narrow band imaging,confocal endomicroscopy,and autofluorescence imaging have not yet been confirmed as surveillance strategies in IBD.

关键词： Inflammatory bowel disease Colorectal cancer Pathogenesis Chemoprevention Surveillance

The effectiveness of emotion-focused art therapy on the resilience and self-image of emergency physicians

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World Journal of Emergency Medicine 2022年第6期13卷 479-484页

作者： Soo kyung Eo Chanwoong Kim kyung Hye Park eun kyung Eo Graduate School of Art Therapy at CHA University Pocheon 11160Republic of Korea Department of Emergency Medicine Chung-Ang University College of MedicineSeoul 06974Republic of Korea Department of Medical Education Yonsei University Wonju College of MedicineWonju 26426Republic of Korea Department of Emergency Medicine Wonju Severance Christian HospitalWonju 26426Republic of Korea Department of Emergency Medicine Soonchunhyang University Bucheon HospitalBucheon 14584Republic of Korea

INTRODUCTION Resilience refers to the quality of being able to overcome adversity.[1]Studies conducted in the United States[2]and China[3]following the 2019 coronavirus disease(COVID-19)pandemic reported reduced resilience levels among medical *** resilience levels are associated with low burnout levels among residents.[4]Physician burnout affects patients’safety and quality of care.[5]In particular,emergency physicians(EPs)are more prone to exhaustion or poor resilience,as their turnover intention tends to be higher.[6]Therefore,improving EPs’resilience is imperative.

关键词： image physician overcome

Tensor based non-photo realistic rendering for Korean architectural images

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Journal of Central South University 2014年第10期21卷 3805-3810页

作者： Do kyung Shin eun Young Ahn Deprtment of Computer Science and Engineering Hanyang University Deprtment of Communication Infromation & Computer Engineering Hanbat National University

Existing pen and ink sketch technologies can be applied to general images, but they could not produce optimal output for images of traditional architecture, because most images consist of exquisite straight lined patterns in traditional architecture, such as root tiles and window bars. The lines of roofs and eaves need to be described delicately to express pen and ink sketch most effectively. Therefore, by proposing a method to create white noise for light and shade of input images, to extract input vector directions from the white noise, and to determine the direction and length of stroke, a new expression technique is proposed for pen and ink sketch that could best reflect the characteristics of traditional architecture.

关键词： non-photo realistic rendering pen and ink sketch tensor

Pharmacokinetic characteristics of L-valyl-ara-C and its implication on the oral delivery of ara-C

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Acta Pharmacologica Sinica 2007年第2期28卷 268-272页

作者： eun-pa CHEON Hyo-kyung HAN College of Pharmacy Chosun UniversityGwangju 501-759Korea

Aim:To evaluate the pharmacokinetic characteristics of L-valyl-ara-C,apeptidomimetic prodrug of ***:After the synthesis of L-valyl-ara-C,the in vitro stability of L-valyl-ara-C was examined in various biological *** pharmacokinetic profiles of ara-C and L-valyl-ara-C were also evaluated ***:The degradation of L-valyl-ara-C was negligible in fresh plasmaand also in the presence of plasmin over a 2 h incubation ***,L-valyl-ara-C appeared to be stable in the leukemia cell homogenates,andsubsequently,it was far less cytotoxic than the parent,ara-C in AML2 and *** chemical hydrolysis of L-valyl-ara-C was rather accelerated in *** an oral administration of L-valyl-ara-C,the appearance of ara-Cwas observed in plasma although the systemic exposure of the prodrug was muchhigher than that of *** bioavailability of ara-C was about 4% via ***:The amide bond of L-valyl-ara-C was stable againstthe enzymatic hydrolysis,and the utility of L-valyl-ara-C as an oral delivery sys-tem of ara-C appeared to be limited by its low metabolic conversion to ara-C in rats.

关键词： ara-C L-valyl-ara-C prodrug pharmacokinetics rats

Extraction and Purification of Depigmenting Agents from Chinese Plants

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Chemical Research in Chinese Universities 2006年第2期22卷 162-167页

作者： AHN So-young ROW kyung-ho KIM eun-ki School of Chemical and Biological Engineering Center for Advanced Bioseparation Technology Inha University Nam-Ku Incheon 402-751 Korea

Depigmenting agents were solvent-extracted and purified by preparative and analytical HPLC from three Chinese plants; Chrysanthemum morifolium Ramat（ Xizang Caijuhua）, Rhodiola sachalinensis, and Terminalia chebula Retzius. Four fractions obtained from the ethyl ether layer of C. m. Rama and two fractions from the ethyl acetate layer of Rhodiola salientness show depigmenting effects. At 8 200, the ethyl acetate layers of Chrysanthemum morifolium Ramat, Rhodiola sachalinensis and the methanol extract of Terminalia chebula Retzius, can inhibit the melanin production of mouse B16 melanoma cells by 92%, 60% and 90%, respectively, whereas 46% inhibition was observed by commercially available depigmenting agents（arbutin）. These results show the potential of these three Chinese plants as a novel resource for depigmenting agents in the cosmetic industry.

关键词： Chrysanthemum Morifolium Ramat Rhodiola Sachalinensis Terminalia Chebula Retzius Melanin Inhibitory Effect HPLC

Improvement of machining quality of copper-plated roll mold by controlling temperature variation

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 37-41页

作者： Tae-Jin JE eun-Chae JEON Sang-Cheon PARK Doo-Sun CHOI kyung-Hyun WHANG Myung-chang KANG Division of Nano-Mechanical Systems Korea Institute of Machinery and Materials Daejeon 305-343 Korea National Core Research Center for Hybrid Materials Solution Pusan National University

Micro prism film used in LCD industry can be manufactured by roll to roll method with copper-plated roll mold. As copper-plated roll mold is getting larger, pitch error is getting severer. The pitch error drops the quality of micro prism film. The main cause of the pitch error was investigated during machining large roll mold whose machined length was 1 200 mm. The temperature of machining system was elevated during machining roll mold, and this elevation induced thermal expansion of the system. The temperature variation around the roll mold also made thermal expansion of the roll mold. The amount of thermal expansion had strong relationship to the amount of pitch error. Therefore, the roll mold was machined after warming-up of machining system and precise temperature controller around copper-plated roll mold was installed, which minimized the temperature variation. Finally, precise micro prism patterns without pitch error were machined on the large roll mold.

关键词： copper-plated roll mold machining prism pattern temperature variation

Injection molding of micro patterned PMMA plate

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 148-152页

作者： Yeong-eun YOO Tae-Hoon KIM Tae-Jin JE Doo-Sun CHOI chang-Wan KIM Sun-kyung KIM Department of Nanomanufacturing Technology KIMM 171 Jang-dong Yusung-gu Daejeon 305-343 Korea Department of Product Design and Manufacturing Seoul National University of Technology

A plastic plate with surface micro features was injection molded to investigate the effect of pressure rise of melt on the replication of the micro structures. Prism pattern, which is used in many optical applications, was selected as a model pattern. The prism pattern is 50 μm in pitch and 108° in the vertical angle. The overall size of the plate was 335 minx213 mm and the thickness of the plate varied linearly from 2.6 mm to 0.7 ram. The prism pattern was firstly machined on the nickel plated core block using micro diamond tool and this machined pattern core was installed in a mold for injection molding of prism patterned plate. Polymethyl methacrylate （PMMA） was used as a molding material. The pressure and temperature of the melt in the cavity were measured at different positions in the cavity and the replication of the pattern was also measured at the same positions. The results show that the pressure or temperature profile through the process depends on the shape and the size of the plate. The replication is affected by the temperature and pressure profiles at the early stage of filling, which is right after the melt reaches the position to be measured.

关键词： micro prism pattern injection molding replication pressure profile temperature profile

Efficacy of uncovered self-expandable metallic stent for colorectal obstruction by extracolonic malignancy

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World Journal of Gastrointestinal Oncology 2020年第9期12卷 1005-1013页

作者： Joon Seong Ahn Sung Noh Hong Dong kyung chang Young-Ho Kim eun-Ran Kim Department of Internal Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea

BACKGROUND Self-expandable metallic stent(SEMS)is widely used for malignant colorectal ***,SEMS has been used for palliative option for colorectal obstruction caused by extracolonic malignancy(ECM).AIM To evaluate the efficacy of SEMS for colorectal obstruction caused by ECM,and to identify the factors associated with stent *** Seventy-two patients who were treated with uncovered SEMS insertion for malignant colorectal obstructions caused by colorectal metastasis or peritoneal seeding of ECM at Samsung Medical Center between April 2012 to March 2016 were *** analyzed technical and clinical outcomes of stent insertion,the factors associated with stent occlusion and long term outcomes after stent *** Technical success rate was determined as 90.3%with a clinical success rate of 87.7%.Stent occlusion developed in 28.1%,with a median duration of 51 ***,81.3%with stent occlusion could be treated with secondary stent *** failure was observed to be related to the male sex(P=0.020)and right colon obstruction(P=0.017).Stent length≤10 cm was found to be associated with stent occlusion(P=0.003).Median survival time after stent insertion was 4.7 mo and 40.4%were able to receive their oncological treatments after stent insertion without *** Uncovered SEMS is effective for the treatment of colorectal obstruction caused by ECM,considering life expectancy of patients with ECM.

关键词： Self-expandable metallic stent Colorectal stent Colorectal obstruction Extracolonic malignancy Retrospective study

Experience of primary intestinal lymphangiectasia in adults: Twelve case series from a tertiary referral hospital

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World Journal of Clinical Cases 2024年第4期12卷 746-757页

作者： Ji eun Na Ji eun Kim Sujin Park eun Ran Kim Sung Noh Hong Young-Ho Kim Dong kyung chang Department of Internal Medicine Inje University Haeundae Paik HospitalBusan 48108South Korea Department of Medicine Samsung Medical CenterSeoul 06351South Korea Department of Pathology Samsung Medical CenterSeoul 06351South Korea

BACKGROUND While primary intestinal lymphangiectasia(PIL)is considered a rare condition,there have been several reported cases in ***,the absence of clear guidance from diagnosis to treatment and prognosis poses challenges for both physicians and *** To enhance understanding by investigating clinical presentation,diagnosis,treatment,complications,and prognoses in adult PIL *** We enrolled adult patients diagnosed with PIL between March 2016 and September *** primary outcome involved examining the diagnosis and treatment process of these *** secondary outcomes included identifying complications(infections,thromboembolism)and assessing prognoses(frequency of hospitalization and mortality)during the follow-up *** Among the 12 included patients,peripheral edema(100%)and diarrhea(75%)were the main presenting *** tests showed that all the pati-ents exhibited symptoms of hypoalbuminemia and ***,the predominant findings were edema of the small intestine(67%)and ascites(58%).The typical endoscopic finding with a snowflake appearance was observed in 75%of *** the 12 patients,two responded positive-ly to octreotide and sirolimus,and eight who could undergo maintenance therapy discontinued *** due to PIL led to infection in half of the patients,thromboembolism in three patients,and one *** PIL can be diagnosed in adults across various age groups,with different severity and treatment responses among patients,leading to diverse complications and ***,tailored treatments will be *** anticipate that our findings will contribute to the management of PIL,an etiology of protein-losing enteropathy.

关键词： Primary intestinal lymphangiectasia in adults Protein-losing enteropathy Diagnosis Treatment Prognosis