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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 569-571页

作者： Hyun Yang Pil Soo Sung Jaejun Lee Seung Kew Yoon eun Sun jung Cheon-Soo Park Si Hyun Bae The Catholic University Liver Research Center College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea Department of Internal medicine College of MedicineEunpyeong St.Mary’s HospitalThe Catholic University of KoreaSeoulRepublic of Korea Department of Internal Medicine College of MedicineSeoul St.Mary’s HospitalThe Catholic University of KoreaSeoulRepublic of Korea Department of Hospital Pathology College of MedicineEunpyeong St.Mary’s HospitalThe Catholic University of KoreaSeoulRepublic of Korea Department of Surgery College of MedicineEunpyeong St.Mary’s HospitalThe Catholic University of KoreaSeoulRepublic of Korea

A recent report demonstrated immune heterogeneityof hepatocellular carcinoma(HCC)(1).The objectiveresponse rates of sorafenib-treated global and Asian patientsby nivolumab,the monoclonal antibody to programmedcell dea... 详细信息

关键词： hepatocellular nivolumab surgery

impact of guideline adherence on the prognosis of Barcelona clinic liver cancer stage B hepatocellular carcinoma

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World Journal of Gastroenterology 2023年第47期29卷 6122-6137页

作者： Ji eun Han Hyo jung Cho Jae Youn Cheong Sun Gyo Lim Min Jae Yang Choong-Kyun Noh Gil Ho Lee Soon Sun Kim Department of Gastroenterology Ajou University School of MedicineSuwon 16499Gyeonggi-doSouth Korea

BACKGROUND Patients with Barcelona clinic liver cancer(BCLC)stage B hepatocellular carcinoma(HCC)are considerably heterogeneous in terms of tumor burden,liver function,and performance *** improve the poor survival outcomes of these patients,treatment approaches other than transarterial chemoembolization(TACE),which is recommended by HCC guidelines,have been adopted in realworld clinical *** hypothesize that this non-adherence to treatment guidelines,particularly with respect to the use of liver resection,improves survival in patients with stage B *** To assess guideline adherence in South Korean patients with stage B HCC and study its impact on *** A retrospective analysis was conducted using data from 2008 to 2016 obtained from the Korea Central Cancer *** with stage B HCC were categorized into three treatment groups,guideline-adherent,upward,and downward,based on HCC guidelines recommended by the Asian Pacific Association for the Study of the Liver(APASL),the European Association for the Study of the Liver(EASL),and the American Association for the Study of Liver Diseases(AASLD).The primary outcome was HCC-related deaths;tumor recurrence served as the secondary *** among the groups was compared using the Kaplan-Meier method and the log-rank *** of survival outcomes were identified using multivariable Cox regression *** In South Korea, over the study period from 2008 to 2016, a notable trend was observed in adherence to HCCguidelines. Adherence to the EASL guidelines started relatively high, ranging from 77% to 80% between 2008 and2012, but it gradually declined to 58.8% to 71.6% from 2013 to 2016. Adherence to the AASLD guidelines began at71.7% to 75.9% from 2008 to 2010, and then it fluctuated between 49.2% and 73.8% from 2011 to 2016. In contrast,adherence to the APASL guidelines remained consistently high, staying within the range of 90.14% to 94.5%throughout the entire study per

关键词： Hepatocellular carcinoma Barcelona clinic liver cancer stage B Guideline adherence Liver neoplasms Transarterial chemoembolization Liver resection

Preoperative colonoscopy through the colonic stent in patients with colorectal cancer obstruction

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World Journal of Gastroenterology 2014年第30期20卷 10570-10576页

作者： Jin Su Kim Kang Moon Lee Sang Woo Kim eun jung Kim Chul Hyun Lim Seong Taek Oh Myung Gyu Choi Kyu Yong Choi Division of Gastroenterology Department of Internal MedicineCatholic University of Korea College of MedicineSeoul 137-701South Korea Department of surgery Catholic University of Korea College of MedicineSeoul 137-701South Korea

Aim: To evaluate the feasibility of a preoperative colonoscopy through a self-expendable metallic stent (SEMS) and to identify the factors that affect complete colonoscopy.

关键词： Colon cancer Stent Preoperative colonoscopy Complete colonoscopy

Thermal Stabilization of EDFA gain by hybrid concatenation of antimony-doped silica EDF

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光学学报 2003年第S1期23卷 419-420页

作者： Young-eun im Uh-Chan Ryu P. Babu Won-Taek Han K. Oh David J. DiGiovanni Baishi Wang Anand Hariharan Department of Information and Communications K-JIST Kwangju 500712 Rep. of Korea OFS Laboratories 700 Moutain Ave. Murray Hill NJ 07974 USA OFS Fitel SPD 19 Schoolhouse Road Somerset NJ 08873 USA

Sb-doped silica EDF showed an opposite temperature dependent gain profile compared to Al-doped silica EDF. Concatenation of those two EDFs showed a gain variation less than ?0.4 dB over 40nm of C-band with the 15dB ga... 详细信息

关键词： range of

Exercise improves the effects of testosterone replacement therapy and the durability of response after cessation of treatment： a pilot randomized controlled trial

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Asian Journal of Andrology 2017年第5期19卷 602-607页

作者： Dae-Yeon Cho Jeong Kyun Yeo Seung Ik Cho Jae eun jung Sang Jin Yang Doo Hwan Kong Jeong Ku Ha Jin Goo Kim Min Gu Park Inje University Sanggye Paik Hospital Department of Urology Seoul Korea Inje University Seoul Paik Hospital Department of Urology Seoul Korea KonKuk University Medical Center Department of Orthopedics Seoul Korea Inje University Seoul Paik Hospital Department of Orthopedics Sports Medical Center Seoul Korea

The effects of the combination of exercise and TRT on symptoms of late-onset hypogonadism （LOH） and the durability of response after cessation of TRT were investigated. A total of fifty patients with erectile dysfunction （ED） who had a sedentary lifestyle and low serum total testosterone （T） levels were enrolled and followed for 20 weeks. Patients were randomly divided into two groups; all of them received T gel for 12 weeks and it was discontinued for 8 weeks. Patients assigned to Group II were offered a supervised exercise program for 20 weeks. Measurement of serological testing was performed and self-assessment questionnaires and Global Assessment Question （GAQ） were asked. Baseline characteristics and the initial symptom scores showed no significant difference between the two groups. Serum total T levels and the symptom scores were increased at 12 weeks in both groups, and Group II showed better results with statistical significance. There was a decrease in T levels and worsening of symptom scores at week 20 compared to week 12 in both groups, and Group II showed better results with statistical significance. On the GAQ, Group II showed higher ratio of ＂yes＂ at week 12 and the same tendency was sustained at week 20 with significant difference between two groups. The combination of exercise and TRT showed significant improvements in serum T levels and LOH symptoms compared to TRT alone. In addition, these improvements were maintained in the combination group with continuous exercise, even after cessation of TRT.

关键词： erectile dysfunction exercise hypogonadism testosterone

Gyejibokryeong-Hwan improves recovery of injured muscles in mouse model of muscle contusion

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Journal of Traditional Chinese Medicine 2021年第3期41卷 406-413页

作者： Chi Ho Lee Jeong June Choi Joo Hye Sim Younmin Shin Seung-Joon Oh Ji-Hyang Gu Hyun Ju Ha Dong Hwi Jeon eun-jung Lee Min-Seok Oh Department of Korean Medicine Rehabilitation College of Korean MedicineDaejeon UniversityDaejeon 34520Republic of Korea Laboratory of Molecular Medicine College of Korean MedicineDaejeon UniversityDaejeon 34520Republic of Korea

OBJECTIVE: To investigate the effects of Gyejibokryeong-Hwan(Guizhifuling-wan, GBH) on muscle injury in a mouse model of muscle ***: C57/BL6 mouse biceps femoris muscles were injured using the drop-mass method and injured animals were treated orally with GBH(50,100, or 500 mg/kg) once a day for 7 d. Open field and treadmill running tests were performed to assess functional recovery from muscle injury. The production of pro-inflammatory cytokines was examined by enzyme-linked immunosorbent assay and Western blotting analysis. Expression of the muscle regeneration biomarkers, myoblast determination(Myo D), myogenic factor 5(Myf5), and smooth muscle actin(α-SMA), in the biceps femoris muscle was investigated at the protein and m RNA level by Western blotting and real time-PCR, respectively. Histological analysis was performed using hematoxylin and eosin staining. Finally, myosin heavy chain production was investigated in differentiated C2C12 myoblasts in the presence of ***: GBH treatment markedly improved locomotion and running behavior. GBH significantly inhibited the secretion of monocyte chemoattractant protein-1 into the bloodstream in muscle-contused animals. The levels of Myo D, Myf5, and α-SMA protein and m RNA were significantly up-regulated by GBH in injured muscle tissue. Histological studies suggested that GBH facilitated recovery from muscle damage. However, GBH did not induce the production of myosin heavy chain in ***: Overall, the present study suggested that GBH improves the recovery of the injured muscles in the mouse model of muscle contusion.

关键词： muscles wounds and injuries contusions regeneration muscle skeletal myogenic regulatory factor 5 Gyejibokryeong-Hwan

TomatoNet A Genome-wide Co-functional Network for Unveiling Complex Traits of Tomato, a Model Crop for Fleshy Fruits

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Molecular Plant 2017年第4期10卷 652-655页

作者： Hyojin Kim Bong Suk Kim jung eun Shim Sohyun Hwang Sunmo Yang Eiru Kim Aniafi S. Iver-Pascuzzi2 Insuk Lee Department of Biotechnology College of Life Science and Biotechnology Yonsei University Seou1120-749 Korea Department of Botany and Plant Pathology Purdue University West Lafayette IN 47907 USA

Tomato （Solanum lycopersicum） is the second most important vegetable crop globally, with a total world production valued at over $74 billion （FAOSTAT Statistics Database, 2009）. Tomato is also an important model c... 详细信息

关键词： Genome-wide Co-functional Network Unveiling Complex Traits Tomato

Younger patients have poorer biochemical outcome after radical prostatectomy in high-risk prostate cancer

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Asian Journal of Andrology 2011年第5期13卷 719-723页

作者： Sung Kyu Hong jung Soo Nam Woong Na Jong Jin Oh Cheol Yong Yoon Chang Wook Jeong Hyun June Kim Seok-Soo Byun Sang eun Lee Department of Urology Seoul National University Bundang Hospital Seongnam Kyunggi-do 463-707 Korea

The aim of this study was to investigate the prognostic significance of patient age with respect to tumour aggressiveness in men who underwent radical prostatectomy （RP） for prostate cancer. In this study, we reviewed the records of 743 patients who received RP without neoadjuvant or adjuvant therapy at our institution and were followed up for 〉2 years postoperatively. For our analyses, the patients were divided into two groups according to age： younger （〈60 years） and older （≥ 60 years）. Through uni- and multivariate analyses, associations of various clinicopathological parameters, including biochemical recurrence-free survival, with patient age, were evaluated among all patients, and the patients were stratified according to their D＇Amico risk classification. Among all subjects, younger （n= 126） and older （n=617） patients showed no significant differences regarding pathological parameters and biochemical recurrence-free survival （P=0.288）. For the high-risk group （n= 206）, younger patients had a lower rate of biochemical recurrence-free survival following surgery than older patients （P=0.017）, despite the fact that no significant differences were observed regarding various known prognostic parameters between the two age groups. In addition, multivariate analysis revealed that age was an independent predictor of biochemical recurrence-free survival among the high-risk group （P=O.O03）. Our results showed that relatively younger patients have a comparable biochemical outcome compared with their older counterparts following RP performed for prostate cancer. However, among patients with high-risk disease, younger patients have a worse biochemical outcome following RP compared with older patients.

关键词： age factors biochemical outcome prostate prostatic neoplasms prostatectomy

Delayed diagnosis of imperforate hymen with huge hematocolpometra:A case report

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World Journal of Clinical Cases 2021年第29期9卷 8901-8905页

作者： eunbi Jang Kyeong A So Bomin Kim A Jin Lee Nae Ri Kim eun jung Yang Seung-Hyuk Shim Sun Joo Lee Tae Jin Kim Department of Obstetrics and Gynecology Konkuk University School of MedicineSeoul 05030South Korea

BACKGROUND imperforate hymen is a rare obstructive anomaly of the female reproductive *** is associated with complications,such as cyclical abdominal pain,urinary retention,and pelvic *** SUMMARY A 13-year-old girl presented several times to the emergency room with lower abdominal pain for a *** received conservative treatment,such as pain control,at each *** visited our gynecological clinic for worsening pain,and a 14-cm hematocolpos was found on *** was finally diagnosed with an imperforate hymen with *** was performed,which resulted in event-free regular cyclical *** imperforate hymen should be considered in a premenarcheal adolescent girl with periodic abdominal pain.

关键词： Hematocolpos imperforate hymen Abdominal pain Amenorrhea Case report

Rapid Establishment of Tracheal Stenosis in Pigs Using Endotracheal Tube Cuff Overpressure and Electrocautery

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Current Medical Science 2021年第2期41卷 329-335页

作者： Jin Hyoung Kim Jong Joon Ahn Yangin Jegal Soohyun Bae Soon eun Park Moon Sik jung Ju Ik Park Hee Jeong Cha Yongjik Lee Taehoon Lee Division of Respiratory and Critical Care Medicine Department of Intemnal MedicineUlsan University HospitalUniversity of Ulsan College of MedicineUlsan 44033Korea Department of Anesthesiology and Pain Medicine UIsan University HospitalUniversity of Ulsan College of MedicineUlsan 44033Korea Department of Pathology Ulsan University HospitalUniversity of Ulsan College of MedicineUlsan 44033Korea Department of Thoracic and Cardiovascular Surgery Ulsan University HospitalUniversity of Ulsan College of MedicineUlsan 44033Korea

To apply a new airway treatment to humans, preclinical studies in an appropriate animalmodel is needed. Canine, porcine and leporine tracheas have been employed as animal airwaystenosis models using various methods such as chemical caustic agents, laser, and ***, existing models take a long time to develop (3- 8 weeks) and the mechanism of stenosisis different from that in humans. The aim of the present study was to establish a new and fasttracheal stenosis model in pigs using a combination of cuff overpressure intubation (COI) andelectrocautery. Fourteen pigs were divided into three groups: tracheal cautery (TC) group (n=3),COI group (n=3), and COI-TC combination group (n=8). Cuff overpressure (200/400/500 mmHg)was applied using a 9-mm endotracheal tube. Tracheal cautery (40/60 watts) was performed usinga rigid bronchoscopic electrocoagulator. After intervention, the pigs were observed for 3 weeks andbronchoscopy was performed every 7 days. When the cross-sectional area decreased by > 50%, itwas confirmed that tracheal stenosis was established. The time for tracheal stenosis was 14 days inthe TC group and 7 days in the COI-TC combination group. In the COI group, no stenosis *** the COI-TC group, electrocautery (40 watts) immediately after intubation for>1 h with a cufpressure of 200 mmHg or more resulted in suficient tracheal stenosis within 7 days. Moreover, thedegree of tracheal stenosis increased in proportion to the cuff pressure and tracheal intubation *** combined use of cuf overpressure and electrocautery helped to establish tracheal stenosis inpigs rapidly.

关键词： pig tracheal stenosis model cuff overpressure electrocautery