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Dynamic behaviour of axially moving nanobeams based on nonlocal elasticity approach

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Acta Mechanica Sinica 2010年第5期26卷 755-765页

作者： c. W. Lim c. Li ji-Lin Yu Department of Building and construction City Universityof Hong Kong Tat Chee Avenue KowloonHong Kong SAR China State Key Laboratory of Structural Analysis for IndustrialEquipment Dalian University of TechnologyDalian 116024 China Department of Modem Mechanics University of Scienceand Technology of China Hefei 230026 China

In this article, transverse free vibrations of axially moving nanobeams subjected to axial tension are studied based on nonlocal stress elasticity theory. A new higher-order differential equation of motion is derived from the variational principle with corresponding higher-order, non-classical boundary conditions. Two supporting conditions are investigated, i.e. simple supports and clamped supports. Effects of nonlocal nanoscale, dimensionless axial velocity, density and axial tension on natural frequencies are presented and discussed through numerical examples. It is found that these factors have great influence on the dynamic behaviour of an axially moving nanobeam. In particular, the nonlocal effect tends to induce higher vibration frequencies as compared to the results obtained from classical vibration theory. Analytical solutions for critical velocity of these nanobeams when the frequency vanishes are also derived and the influences of nonlocal nanoscale and axial tension on the critical velocity are discussed.

关键词： Axially moving nanobeams critical velocity Free vibration Natural frequency Nonlocal elasticity

Role of nutrition in diabetes mellitus and infections

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World Journal of clinical cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu Li-Yun Zhou Xiao Huang Xin-Yue Li Ming-Ke Wang ji-Shun Yang Naval Medical center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins c,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

Midazolam dose is associated with recurrence of paradoxical reactions during endoscopy

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World Journal of clinical cases 2021年第29期9卷 8763-8772页

作者： eun Hyo jin ji Hyun Song Jooyoung Lee Jung Ho Bae Su jin c.ung Department of Internal Medicine Healthcare Research InstituteHealthcare System Gangnam CenterSeoul National University HospitalSeoul 06236South Korea

BAcKGROUND Midazolam is commonly used for sedation during gastrointestinal ***,some patients experience paradoxical reactions characterized by excessive movement or *** To investigate the rate of recurrence of paradoxical reactions to midazolam during an upper *** We retrospectively reviewed 122152 sedative endoscopies among a total of 58553 patients at the Seoul National University Hospital,Healthcare System Gangnam center,from July 2013 to December *** them,361 patients with a history of paradoxical reaction during sedative upper endoscopy were *** characteristics of patients in the recurrent and non-recurrent groups were compared via multivariable analysis using logistic *** Paradoxical reactions occurred in 0.86%(1054/122152)of endoscopies,and in 1.51%(888/58553)of *** the 361 subjects with previous paradoxical reactions in sedative endoscopies,111(30.7%)experienced further paradoxical *** analysis revealed that the total midazolam dose used was higher in the recurrent group(6.74±2.58 mg)than in the non-recurrent group(5.49±2.04 mg;Pcurrent group and 2 mg less in the non-recurrent *** analysis showed that the midazolam dose difference was an independent risk factor for recurrent paradoxical reaction(odds ratio:1.213,95%cI:1.099-1.338,P=0.0001).cONcLUSION The rate of recurrence of paradoxical reactions is significantly associated with midazolam *** dose of midazolam administered to patients with previous paradoxical reactions should be less than that previously used.

关键词： Gastroscopy Endoscopy conscious sedation Midazolam Flumazenil

β-Arrestin 2 suppresses the activation of YAP by promoting LATS kinase activity

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Genes & Diseases 2023年第2期10卷 348-351页

作者： Minsuh Kim ji Min Kim eun Jeong cho chang Ohk Sung Joon Kim Se jin Jang Asan Institute for Life Sciences Asan Medical CenterSeoul 05505Republic of Korea University of Ulsan college of Medicine Seoul 05505Republic of Korea Department of Pathology Asan Medical CenterSeoul 05505Republic of Korea Graduate School of Medical Science and Engineering KAISTDaejeon 34141Republic of Korea Oncoclew Life Science co. LtdSeoul 05505Republic of Korea

Dysregulation of the Hippo pathway has been frequently identified in various human cancers. The Hippo pathway is a highly complex pathway involving multiple types of proteins, and the activation of YAP by LATS kinase is the final effector step in the transcription process. In this study, we linked the roles of the multifunctional adapter proteins β-arrestins (β-arrestin 1 and 2) in cooperation with other signaling pathways such as GPcR and Wnt to essential cellular functions involved in carcinogenesis, including the regulation of cell proliferation, migration, and differentiation as well as stem cell properties.1 Although β-arrestin 1 and 2 have high structural similarities, they have different roles in carcinogenesis as β-arrestin 1 aids cancer cell survival and metastasis2 and β-arrestin 2 inhibits tumor growth.1 In the Hippo signaling pathway, β-arrestins function as scaffold proteins that mediate the phosphorylation of key molecules, and their association with human cancers is a major research topic. In this study, we demonstrated that β-arrestin 2 inhibits YAP activation through the formation of the β-arrestin 2-LATS-YAP trimeric complex, which results in the promotion of the kinase activity of LATS in cancer cell lines and patient-derived colon cancer organoids.

关键词： cancer carcinogenesis activation

Evaluation of the safety of anterior capsule staining with trypan blue under air: a retrospective analysis

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 432-437页

作者： Young Min Park Jong Soo Lee ji eun Lee Yeon ji Jo Ik Soo Byon Sung Who Park centum Bright Light Eye clinic 20Centum 2-roHaeundaeguBusanKorea 48060Republic of Korea Department of Ophthalmology School of MedicinePusan National University and Medical Research InstitutePusan 49241Republic of Korea

AIM: To evaluate the safety of using 0.03% trypan blue under air for anterior capsule staining in cataract ***: The current study involved a retrospective analysis of the medical records of 86 patients with vitreous hemorrhage, who underwent pars plana vitrectomy and cataract *** patients were classified into two *** trypan blue group(n=45) comprised patients who underwent anterior capsule staining with 0.03% trypan blue under an air *** control group(n=41) comprised of patients who underwent intracameral illuminator-assisted *** status of endothelial cell density(EcD) in both the groups was ***: The trypan blue group displayed significant decline in EcD at 1 mo(7.91% loss, Pcant changes were observed in the control ***, the number of patients who did not display a postoperative decline in EcD was significantly higher in the control group(43.9%;18 patients) than in the trypan blue group(17.1%;7 patients, P=0.004).cONcLUSION: Anterior capsule staining with trypan blue under the air bubble would not be as safe as the intracameral *** EcD loss might be attributed to the air bubble rather than to the deleterious effects of 0.03% trypan *** studies are required to clarify this.

关键词： anterior capsule cataract endothelium trypan blue vitreous hemorrhage

colonic lipoma covered by hyperplastic epithelium: case report

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World Journal of clinical cases 2013年第3期1卷 124-127页

作者： Ju-Ok Yeom Sun-Young Kim eun-chul Jang ji-Youn Yu eun Deok chang Young-Seok cho Division of Gastroenterology Department of Internal MedicineUijeongbu St. Mary’s Hospitalthe Catholic University of Korea College of MedicineUijeongbu 480-717South Korea Departement of cilinical Pathology Uijeong-bu St. Mary’s Hospitalthe Catholic University of Korea College of MedicineUijeongbu 480-717South Korea

colonic lipomas are submucosal nonepithelial tumors covered by intact or eroded mucosa. In rare cases, alterations in the mucosa covering a lipoma include hyperplasia, adenoma, atrophy, ulceration, and necrosis. Here, we report a case of a colonic lipoma covered by hyperplastic epithelium in a 68-year-old woman. Based on the colonoscopy findings, a snare polypectomy was performed for a presumptive diagnosis of an epithelial lesion; however, the histological examination revealed a colonic submucosal lipoma with overlying hyperplastic epithelium.

关键词： Lipoma colonic lipomas Hyperplastic colonoscopy

circulating levels of vitamin D and colorectal adenoma: A case-control study and a meta-analysis

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World Journal of Gastroenterology 2015年第29期21卷 8868-8877页

作者： Yoon ji choi Young Ha Kim chang Ho cho Sung Hi Kim Jung eun Lee Department of Food and Nutrition Sookmyung Women’s University Department of Pathology Daegu Catholic University Medical Center Department of Family Medicine Daegu Catholic University Medical Center

AIM: To examine the association between circulating 25-hydroxyvitamin D [25(OH)D] levels and colorectal adenoma in a case-control study and a meta-analysis. METHODS: We conducted a matched case-control study(112 cases and 112 matched controls) and combined 15 studies, including our study, in a metaanalysis. The study-specific odds ratios(ORs) and 95% confidence intervals(cIs) were pooled using a randomeffects model. In total, 5454 colorectal adenomas and 6656 controls were included in the meta-analysis. RESULTS: In a meta-analysis including 14 previous studies and our study, we observed a significant inverse association between circulating 25(OH)D levels and colorectal adenoma(OR = 0.68; 95%cI: 0.54-0.82) when comparing the highest category with the lowest category. Stratification by adenoma location(proximal or distal adenoma) showed similar estimates. When we stratified by study region, the ORs(95%cIs) were 0.70(0.52-0.88) in the US and 0.66(0.34-0.97) in Asia. cONcLUSION: These data suggest an inverse association between circulating 25(OH) Dlevels and colorectal adenoma in both Western and Asian populations.

关键词： 25-hydroxyvitamin D levels colorectaladenoma cancer prevention

Structural Analysis of FRIGIDA Flowering-Time Regulator

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Molecular Plant 2016年第4期9卷 618-620页

作者： Kyung-gi Hyun Jee eun Oh jihye Park Yoo-Sun Noh ji-Joon Song Department of Biological Sciences KAIST Institute of the BioCentury KAIST Daejeon 34141 Korea School of Biological Sciences Seoul National University Seoul 151-747 Korea

Dear Editor,Flowering is a major developmental switch in the life cycle of flowering plants. FRIGIDA （FRI） activates FLOWERING LOcUS c （FLc） transcription, a major repressor of this switch regulating flow- ering time （Johanson et al., 2000）. FRI is highly conserved and many natural variations in FRI are found to affect flowering time. However, little is known about the molecular characteristics of FRI.

关键词： Flowering major developmental

Safety assessment of condensed phosphate intake from fishery and processed marine food products in Korea with respect to gender,age,and region

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Food Quality and Safety 2021年第2期5卷 161-169页

作者： Hyung Soo Kim Dae Yong Jang Ye ji Koo eun chul Pack Seung Ha Lee Dal Woong choi Health Science Research center Korea UniversitySeoulRepublic of Korea department of Public Health Sciences Graduate SchoolKorea UniversitySeoulRepublic of Korea School of Health and Environmental Sciences Korea UniversitySeoulRepublic of Korea and department of Health and Safety convergence Science Graduate SchoolKorea UniversitySeoulRepublic of Korea.

condensed phosphates are used as food additives,especially in marine products and meat,to improve food *** import and consumption of fishery and processed marine food products in Republic of Korea have reportedly increased by~5 per cent ***,processed marine food products are often intentionally adulterated with excessive amounts of condensed phosphates to increase their *** intake of condensed phosphates via consuming processed marine food products can lead to various adverse effects on human health due to anionic ***,we conducted a safety assessment of condensed phosphates in 14 types of fishery and processed marine food products in Korea for the first *** analysis of various factors including gender,age,and region was also performed,and the risk level of exposure for each group was *** assessments by age and gender indicated that infants were at the highest *** the regional safety assessment,c.ungnam,the most inland region,showed the lowest *** both the general and the high-intake groups(95th percentile)in all classifications,the risk was lower(cent)than the international standard,and the phosphorus content of the 14 types of processed marine products in Korea was confirmed to be safe for human consumption.

关键词： condensed phosphates safety assessment ion chromatography fishery and processed marine food products