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Umbilical cord blood mesenchymal stem cells protect amyloid-β42 neurotoxicity via paracrine

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World Journal of Stem Cells 2012年第11期4卷 110-116页

作者： Ju-Yeon Kim Dong Hyun Kim Ji Hyun Kim Yoon Sun Yang Wonil Oh eun hui lee Jong Wook Chang Biomedical Research Institute R & D CenterMEDIPOST Co.Ltd.Seoul 137-874South Korea Department of Physiology College of MedicineThe Catholic University of KoreaSeoul 137-701South Korea

AIM:To understand the neuroprotective mechanism of human umbilical cord blood-derived mesenchymal stem cells(hUCB-MSCs) against amyloid-β42(Aβ42) exposed rat primary ***:To evaluate the neuroprotective effect of hUCB-MSCs,the cells were co-cultured with Aβ42-exposed rat primary neuronal cells in a Transwell *** assess the involvement of soluble fac-tors released from hUCB-MSCs in neuroprotection,an antibody-based array using co-cultured media was *** neuroprotective roles of the identified hUCB-MSC proteins was assessed by treating recombi-nant proteins or specific small interfering RNAs(siRNAs) for each candidate protein in a co-culture ***:The hUCB-MSCs secreted elevated levels ofdecorin and progranulin when co-cultured with rat pri-mary neuronal cells exposed to Aβ*** with recombinant decorin and progranulin protected from Aβ42-neurotoxicity in *** addition,siRNA-mediat-ed knock-down of decorin and progranulin production in hUCB-MSCs reduced the anti-apoptotic effects of hUCB-MSC in the co-culture ***:Decorin and progranulin may be involved in anti-apoptotic activity of hUCB-MSCs exposed to Aβ42.

关键词： Human umbilical cord blood-derived mes-enchymal stem cells Decorin Progranulin Aβ42 Anti-apoptosis

Employment of encapsulated Si with mesoporous TiO_2 layer as anode material for lithium secondary batteries

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中国有色金属学会会刊：英文版 2009年第4期19卷 1023-1026页

作者： Sang-eun PARK Bo-eun KIM Sang-Wha lee Joong-Kee lee Advanced Energy Materials Processing Laboratory Korea Institute of Science and Technology Department of Chemical & Bio Engineering Kyungwon University

Silicon composite of nano-capsule type is newly applied as an active anode material for lithium ion ***2-encapsulated silicon powders were synthesized by a sol-gel reaction with titanium *** nanoparticles were successfully embedded into porous titanium oxide capsules that played as a buffer layer against drastic volume changes of silicon during the charge-discharge cycling,consequently leading to the retardation of the capacity fading of intrinsic silicon *** electrochemical and structural properties of silicon nanocomposites with different surface areas of encapsulating TiO2 layer were characterized by X-ray diffraction(XRD),nitrogen gas adsorption analysis by the Brunauer-Emmett-Teller(BET) equation,transmission electron microscopy(TEM),and galvanostatic charge-discharge experiments.

关键词：二氧化钛硅材料锂二次电池负极材料封装纳米复合材料透射电子显微镜就业

Curcumin-induced cell death depends on the level of autophagic flux in A172 and U87MG human glioblastoma cells

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Chinese Journal of Natural Medicines 2020年第2期18卷 114-122页

作者： lee Jong-eun Yoon Sung Sik lee Jae-Wook Moon eun-Yi Department of Bioscience and Biotechnology Sejong UniversitySeoul 05006Republic of Korea

Glioblastoma is the deadliest neoplasm with the worst 5-year survival rate among all human *** promotes autophagic cell death or blocks the induction of apoptosis in eukaryotic ***,we investigated whether varying levels of autophagic flux in glioblastoma lead to different efficacies of curcumin treatment using U87 MG and A172 human glioblastoma *** number of LC3 puncta,the number of cells with LC3 puncta and the level of LC3 Ⅱ,Atg5 and Atg7 protein were higher in U87 MG cells compared with A172 *** the cells were incubated with curcumin for 24 or 48 h,the percentage of cell death was higher in A172 cells compared with U87 MG *** the level of LC3 was lower,that of curcumin-induced LC3 was higher,in A172 cells than in U87 MG *** relative increases in cell death and LC3-mediated autophagy were greater under serum starvation in A172 cells compared with U87 MG ***-induced A172 cell death was reduced by serum *** both types of cells were transfected with LC3-GFP,the percentage of cell death was higher in A172 cells than that in U87 MG *** together,the data demonstrate that curcumin-mediated tumor cell death is regulated by the basal level of autophagic flux in different glioblastoma *** suggests that prior to the use of various curcumin therapeutics,the level of basal or induced autophagic flux should be carefully examined in tumor cells for the best efficacy.

关键词： Glioblastoma A172 U87MG Autophagic flux Curcumin

Methanol-based biomanufacturing of fuels and chemicals using native and synthetic methylotrophs

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Synthetic and Systems Biotechnology 2023年第3期8卷 396-415页

作者： Arslan Sarwar eun Yeol lee Department of Chemical Engineering(BK21 FOUR Integrated Engineering Program) Kyung Hee UniversityYongin-siGyeonggi-do17104Republic of Korea

Methanol has recently gained significant attention as a potential carbon substrate for the production of fuels and chemicals,owing to its high degree of reduction,abundance,and low *** methylotrophic yeasts and bacteria have been investigated for the production of fuels and ***,synthetic methylotrophic strains are also being developed by reconstructing methanol utilization pathways in model microorganisms,such as Escherichia *** to the complex metabolic pathways,limited availability of genetic tools,and methanol/formaldehyde toxicity,the high-level production of target products for industrial applications are still under development to satisfy commercial *** article reviews the production of biofuels and chemicals by native and synthetic methylotrophic *** also highlights the advantages and limitations of both types of methylotrophs and provides an overview of ways to improve their efficiency for the production of fuels and chemicals from methanol.

关键词： Native methylotrophs Synthetic methylotrophs Pichia pastoris Methylobacterium extorquens Bacillus methanolicus Escherichia coli

Mechanical strength and corrosion resistance of Al-additive friction stir welded AZ31B joints

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Journal of Magnesium and Alloys 2023年第5期11卷 1519-1535页

作者： Jae-Yeon Kim eun-Woo Kim Dong-O Kim eun-Kyo Ju Ji-eun lee Jaeheon lee Jai-Won Byeon Mining Engineering Department Colorado School of MinesGoldenCO 80401USA Department of Materials Science and Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea

Compared to other structural alloys,magnesium alloys have a relatively poor corrosion resistance and low mechanical strength,which can be further deteriorated when these alloys are subjected to joining processes using the existing joining ***,we propose for the first time an additive friction stir-welding(AFSW)using fine Al powder as an additive to improve the mechanical strength as well as corrosion resistance of AZ31B weld *** is a solid-state welding method of forming a high-Al AZ31B joint via an in-situ reaction between pure Al powders filled in a machined groove and the AZ31B *** optimize the process parameters,AFSW was performed under different rotational and transverse speeds,and number of passes,using tools with a square or screw *** particular,to fabricate a weld zone,where the Al was homogenously dispersed,the effects of the groove shape were investigated using three types of grooves:surface one-line groove,surface-symmetric grooves,and inserted symmetric *** homogenous and defect-less AFS-welded AZ31B joint was successfully fabricated with the following optimal parameters:1400 rpm,25 mm/min,four passes,inserted symmetric grooves,and the tool with a square *** AFSW fully dissolved the additive Al intoα-Mg and in-situ precipitated Mg_(17)Al_(12)particles,which was confirmed via scanning electron microscopy,transmission electron microscope,and X-ray diffraction *** microhardness,joint efficiency,and elongation at the fracture point of the AFS-welded AZ31B joint were 80 HV,101%,and 8.9%,*** values are higher than those obtained for the FS-welded AZ31 joint in previous *** corrosion resistance of the AFS-welded AZ31B joint,evaluated via hydrogen evolution measurements and potentiodynamic polarization tests,was enhanced to 55%relative to the FS-welded AZ31B joint.

关键词： AZ31B magnesium alloy Additive friction stir-welding In-situ reaction Mg_(17)Al_(12)particles Joint efficiency Corrosion resistance

Filling up complex spectral regions through non-Hermitian disordered chains

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Chinese Physics B 2022年第5期31卷 1-9页

作者： hui Jiang Ching Hua lee Department of Physics National University of SingaporeSingapore 117551Republic of Singapore

Eigenspectra that fill regions in the complex plane have been intriguing to many,inspiring research from random matrix theory to esoteric semi-infinite bounded non-Hermitian *** this work,we propose a simple and robust ansatz for constructing models whose eigenspectra fill up generic prescribed *** approach utilizes specially designed non-Hermitian random couplings that allow the co-existence of eigenstates with a continuum of localization lengths,mathematically emulating the effects of semi-infinite *** some of these couplings are necessarily long-ranged,they are still far more local than what is possible with known random matrix *** ansatz can be feasibly implemented in physical platforms such as classical and quantum circuits,and harbors very high tolerance to imperfections due to its stochastic nature.

关键词： non-Hermitian skin effect disordered chain disorder localization non-Hermitian spectra

A global multiplicity result for two-point boundary value problems of p-Laplacian systems

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Science China Mathematics 2010年第4期53卷 967-984页

作者： lee eun Kyoung lee Yong-Hoon Department of Mathematics Pusan National University

In this paper,we consider the existence,nonexistence and multiplicity of positive solutions for two-point boundary value problems of p-Laplacian systems which have a singular indefinite weight and real *** proofs,we mainly make use of the upper and lower solution method and the fixed point index *** obtain a global multiplicity result,we construct a weighted space to benefit richer topology of the solution space than C 0-space.

关键词： p-Laplacian system singular indefinite weight multiparameters upper solution and lower solution fixed point index theorem weighted space

Synthesis of Fe_3O_4-coated silica aerogel nanocomposites

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中国有色金属学会会刊：英文版 2012年第S3期22卷 702-706页

作者： Jun Sung lee eun Jung lee Hae Jin HWANG Devision of Materials Science and Engineering Inha University

Fe3O4:SiO2 nanocomposite powders were synthesized by a two-step process,which included the precipitation of FeCl2 and FeCl3 and the gelation of silicic acid solution derived from water *** first,Fe3O4 nanoparticles having a crystallite size of 20 nm were obtained by controlling the ratio of Fe(II) and Fe(III) *** the second step,Fe3O4 particles were embedded in SiO2 matrix by the hydrolysis and subsequent condensation of the silicic acid solution containing Fe3O4 *** was found that the Fe3O4 nanoparticles homogenously disperse in the SiO2 *** Fe3O4:SiO2 nanocomposite exhibited an enhanced thermal stability against oxidation compared with pure ***-IR analysis indicates the presence of the Si-O-Fe bond in the Fe3O4:SiO2 (1:10,mole fraction) nanocomposite.

关键词： nanocomposite Fe3O4 SiO2 sol gel synthesis

Imaging diagnosis of pancreatic cancer:A state-of-the-art review

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World Journal of Gastroenterology 2014年第24期20卷 7864-7877页

作者： eun Sun lee Jeong Min lee Department of Radiology Seoul National University HospitalSeoul 110-744South Korea Institute of Radiation Medicine Seoul National University College of MedicineSeoul 110-744South Korea

Pancreatic cancer(PC)remains one of the deadliest cancers worldwide,and has a poor,five-year survival rate of 5%.Although complete surgical resection is the only curative therapy for pancreatic cancer,less than20%of newly-diagnosed patients undergo surgical resection with a curative *** to the lack of early symptoms and the tendency of pancreatic adenocarcinoma to invade adjacent structures or to metastasize at an early stage,many patients with pancreatic cancer already have advanced disease at the time of their diagnosis and,therefore,there is a high mortality *** improve the patient survival rate,early detection of PC is *** diagnosis of PC relies on computed tomography(CT)and/or magnetic resonance imaging(MRI)with magnetic resonance cholangiopancreatography(MRCP),or biopsy or fine-needle aspiration using endoscopic ultrasound(EUS).Although multi-detector row computed tomography currently has a major role in the evaluation of PC,MRI with MRCP facilitates better detection of tumors at an early stage by allowing a comprehensive analysis of the morphological changes of the pancreas parenchyma and pancreatic *** diagnosis could be improved using positron emission tomography techniques in special conditions in which CT and EUS are not completely *** is essential for clinicians to understand the advantages and disadvantages of the various pancreatic imaging modalities in order to be able to make optimal treatment and management *** study investigates the current role and innovative techniques of pancreatic imaging focused on the detection of pancreatic cancer.

关键词： Pancreatic neoplasms Multi-detector computed tomography Magnetic resonance imaging Ultrasonography Endoscopic ultrasound-guided fine needle aspiration Positron-emission tomography