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The nature of active sites in pt–ReO_X/TiO_2 catalysts for selective hydrogenation of carboxylic acids to alcohols

Journal of Energy Chemistry 2015年第5期24卷 646-654页

作者： Alexey Suknev Vladimir Zaikovskii Vasily Kaichev eugenii p.ukshtis Ekaterina Sadovskaya Bair Bal'zhinimaev Boreskov Institute of Catalysis SB RAS Novosibirsk State University

The highly dispersed pt-ReOx （x _〈 1 ） sites ca. 0.5 nm in size were formed via a successive and strong inter- action of the Re precursor with titania and then of the pt complex with deposited low-valent rhenium oxide clusters. The size, charge and chemical composition were characterized by means of HRTEM/STEM with EDX mapping, XpS, and FTIRS. These sites with Re/pt = 2 were shown to be highly active and selective in the hydrogenation of carboxylic acid to alcohol under very mild conditions （T = 130 ℃, p = 50 bar）. The reaction rate constant for the hydrogenation of hexanoic acid increased linearly with the pt content. As for the homogeneous pincer-type Ru-organic complexes, the active pt-ReOx sites can dissociate heterolytically the molecular hydrogen with the formation of hydroxyl groups and pt hydride for hydrogenation of the carboxylic group. Indeed, TOF of 20 h 1 and selectivity of 98%-99% are approaching the values typical of homogeneous catalysts. The first order kinetics described well the experimental data obtained in a wide range of reaction conditions.

关键词： Selective hydrogenation Hexanoic acid Hexanol platinumRhenium Nanoparticles

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Linagliptin alleviates fatty liver disease in diabetic db/db mice

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World Journal of Diabetes 2016年第19期7卷 534-546页

作者： Svetlana V Michurina Irina Ju Ishenko Vadim V Klimontov Sergey A Archipov Natalia E Myakina Marina A Cherepanova eugenii L Zavjalov Galina V Koncevaya Vladimir I Konenkov Laboratory of Functional Morphology Scientific Institute of Clinical and Experimental Lymphology Laboratory of Endocrinology Scientific Institute of Clinical and Experimental Lymphology SpF-vivarium Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences Laboratory of Clinical Immunogenetics Scientific Institute of Clinical and Experimental Lymphology

AIM To study the effects of linagliptin on the structural signs of non-alcoholic fatty liver disease(NAFLD) in db/db mice. METHODS Male diabetic db /db mice(***-Dock7m+/+Leprdb/J) aged 10 wk received the dipeptidyl peptidase 4(Dpp4) inhibitor linagliptin(10 mg/kg) or saline as a placebo once per day by gavage for 8 wk. Intact db/db mice served as controls. Structural changes in the liver were analyzed from light and electron microscopic images of sections from intact, placebo-treated and linagliptin-treated animals. We estimated the changes in hepatocytes, sinusoidal cells, liver microvasculature and lymphatic roots. Hepatic staining for lymphatic vessel endothelial hyaluronan receptor-1(LYVE-1) was assessed by immunohistochemistry. RESULTS In 18-wk-old diabetic mice, liver steatosis(predominantly microvesicular and mediovesicular steatosis) was accompanied by dilation of the roots of the lymphatic system, interlobular blood vessels and bile canaliculi. Compared to saline-treated mice, linagliptin-treated mice exhibited a reduction in the mean numeral densities of hepatocytes with lipid droplets(92.4% ± 1.7% vs 64.9% ± 5.8% per field of view, p = 0.0002) and a lower proportion of hepatocytes with a high density of lipid droplets(20.7% ± 3.6% vs 50.4% ± 3.1%, p = 0.0007). We observed heterogeneous hepatocytes and relatively preserved cell structures in the linagliptin group. Dilation of blood and lymphatic vessels, as well as ultrastructural changes in the hepatocyte endoplasmic reticulum and mitochondria, were alleviated by linagliptin treatment. In intact and placebo-treated mice, immunohistochemical staining for LYVE-1 was observed in the endothelial cells of interlobular lymphatic vessels and on the membranes of some endothelial sinusoidal cells. We observed an enlarged LYVE-1 reaction area in linagliptin-treated mice compared to intact and placebo-treated mice. The improvement in the structural parameters of the liver in linagliptin-treated mice was independe

关键词： Diabetes Obesity Non-alcoholic fatty liver disease Dipeptidyl peptidase 4 Linagliptin

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