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long-lasting microbial larvicides for controlling insecticide resistant and outdoor transmitting vectors:a cost-effective supplement for malaria interventions

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Infectious Diseases of Poverty 2020年第6期9卷 83-90页

作者： Guofa Zhou eugenia lo Andrew K.Githeko Yaw A.Afrane Guiyun Yan Program in Public Health University of CaliforniaIrvineCA92697USA Department of Biological Sciences University of North CarolinaCharlotteNC28223USA Central for Global Health Research Kenya Medical Research InstituteKisumuKenya Department of Medical Microbiology University of GhanaAccraGhana

The issues of pyrethroid resistance and outdoor malaria parasite transmission have prompted the WHO to call for the development and adoption of viable alternative vector control *** source management is one of the core malaria vector interventions recommended by the Ministry of Health in many African countries,but it is rarely implemented due to concerns on its *** long-lasting microbial larvicide can be a promising cost-effective supplement to current vector control and elimination methods because microbial larvicide uses killing mechanisms different from pyrethroids and other chemical *** has been shown to be effective in reducing the overall vector abundance and thus both indoor and outdoor *** our opinion,the long-lasting formulation can potentially reduce the cost of larvicide field application,and should be evaluated for its cost-effectiveness,resistance development,and impact on non-target organisms when integrating with other malaria vector control *** this opinion,we highlight that long-lasting microbial larvicide can be a potential cost-effective product that complements current front-line long-lasting insecticidal nets(LLINs)and indoor residual spraying(IRS)programs for malaria control and *** larviciding targets immature mosquitoes,reduces both indoor and outdoor transmission and is not affected by vector resistance to synthetic *** control method is a shift from the conventional LLINs and IRS programs that mainly target indoor-biting and resting adult mosquitoes.

关键词： long-lasting microbial larvicide Cost-effectiveness Supplemental tool Malaria control and elimination

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The LEAFY floral regulator displays pioneer transcription factor properties

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Molecular Plant 2021年第5期14卷 829-837页

作者： Xuelei Lai Romain Blanc-Mathieu loïc GrandVuillemin Ying Huang Arnaud Stigliani Jeremy Lucas Emmanuel Thevenon Jeanne loue-Manifel Laura Turchi Hussein Daher eugenia Brun-Hernandez Gilles Vachon David Latrasse Moussa Benhamed Renaud Dumas Chloe Zubieta François Parcy Laboratoire Physiologie Cellulaire et Vegetale Universite Grenoble AlpesCNRSCEAINRAEIRIG-DBSCI-LPCV17 avenue des martyrs38054GrenobleFrance Universite Paris-Saclay CNRSINRAEUniversite d'EvryInstitute of Plant Sciences Paris-Saclay(IPS2)91405OrsayFrance The Bioinformatics Centre Department of Biology and Biotech and Research Innovation CentreUniversity of CopenhagenOle Maalces Vej 5DK2200 Copenhagen NDenmark Laboratoire Reproduction et Developpement des Plantes Universite de LyonENS de LyonUCB Lyon 1CNRSINRA69342 LyonFrance Institut de Biologie Structurale Universite Grenoble AlpesCEACNRSGrenobleFrance Universite de Paris Institute of Plant Sciences Paris-Saclay(IPS2)75006 ParisFrance

Pioneer transcription factors(TFs)are a special category of TFs with the capacity to bind to closed chromatin regions in which DNA is wrapped around histones and may be highly ***,pioneer TFs are able to modify the chromatin state to initiate gene *** plants,LEAFY(LFY)is a master floral regulator and has been suggested to act as a pioneer TF in ***,we demonstrate that LFY is able to bind both methylated and non-methylated DNA using a combination of in vitro genomewide binding experiments and structural *** between regions bound by LFY in vivo and chromatin accessibility data suggest that a subset of LFY bound regions is occupied by *** confirm that LFY is able to bind nucleosomal DNA in vitro using reconstituted ***,we show that constitutive LFY expression in seedling tissues is sufficient to induce chromatin accessibility in the LFY direct target genes APETALA1 and *** together,our study suggests that LFY possesses key pioneer TF features that contribute to launching the floral gene expression program.

关键词： flower development pioneer transcription factor gene regulation chromatin remodeling

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