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Preschoolers＇ Learni.g Di.abi.i.i.s Assessment： New Perspecti.es i. Computeri.ed Cli.i.al Tools

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Si.o-US Engli.h Teachi.g 2014年第6期11卷 401-410页

作者： eugenia i. toki Vi.tori. Zakopoulou Jenny Pange TEl of Epi.us loannina Greece Uni.ersi.y of i.anni.a Ioannina Greece

Thi. study looks i.to new perspecti.es i. preschoolers＇ assessment of bei.g at ri.k for learni.g di.abi.i.i.s. Preci.ely, two i.novati.e assessment approaches are exami.ed i. order to reveal new research perspecti.es. The fi.st tool, a tradi.i.nal approach, i. the ＂Early Dyslexi. i.enti.i.ati.n Test＂ and the second tool, a computeri.ed approach, i. an lnternet based Speech Pathology Di.gnosti. Expert System named ＂APLo＂. Both evaluate the sectors of phonologi.al awareness, memory, psychomotor development, pre-wri.i.g and pre-readi.g ski.ls i. Greek. The fi.di.gs o f the current study formulate three di.ecti.ns：（1） the complementary of speech language and learni.g di.orders as a systemi. approach, （2） the di.gnosi. of suspi.i.us factors and compati.i.i.i.s of learni.g di.abi.i.i.s even at the preschool age, and （3） the appli.ati.n of alternati.e methods of assessment ai.i.g for a multi.i.enti.nal approach wi.h the combi.ed prospect and potenti.l of web tools i. the early di.gnosi. and i.terventi.n i. learni.g di.abi.i.i.s.

关键词： computer-based assessment tools e-assessment learni.g di.abi.i.i.s Greek language preschoolers

Contemporary cli.ate i.fuence on vari.bi.i.y patterns of Anadenanthera colubri.a ***,a key speci.s i. seasonally dry tropi.al forests

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Journal of Forestry Research 2022年第1期33卷 89-101页

作者： María Vi.tori. García María eugenia Barrandeguy Kathleen Pri.z Genéti.a de Poblaci.nes y Cuanti.ati.a-Departamento de Genéti.a-Facultad de Ci.nci.s Exactas Químicas y Naturales-Universidad Nacional deMisionesInstituto de Biología Subtropical(UNaM-CONICET)Nodo PosadasFélix de Azara 15523300 PosadasArgentina Consejo Naci.nal de i.vesti.aci.nes Ci.ntífi.as Y Técni.as(CONi.ET) PosadasMisionesArgentina i.sti.ute of Systemati. Botany Wi.h Herbari.m Haussknecht and Botani.al Gardens Friedrich-Schiller-University Jena07743 JenaGermany

The di.tri.uti.n of many plant speci.s has been shaped by cli.ate changes,and thei. current phenotypi. and geneti. vari.bi.i.y refect mi.rocli.ati.ally sui.able *** study relates contemporary cli.ate to vari.bi.i.y patterns of phenotypi. trai.s and molecular markers i. the Argenti.ean di.tri.uti.n of Anadenanthera colubri.a ***,as well as to i.enti.y the most relevant phenotypi. trai. or molecular marker associ.ted wi.h those *** from four populati.ns i. both bi.geographi. provi.ces,Paranaense and Yungas,were *** analyses and multi.le li.ear regressi.ns were carri.d out to determi.e relati.nshi.s among phenotypi. trai.s and nuclear mi.rosatelli.es,respecti.ely,to cli.ati. vari.bles,and to i.enti.y the phenotypi. trai.s as well as nuclear mi.rosatelli.e loci.most sensi.i.e to *** and three clusters of i.di.i.uals were detected based on geneti. and phenotypi. data,*** clusters based on geneti. data refected the bi.geographi. ori.i. of *** trai.s were the most relevant i.di.ators of cli.ati. *** mi.rosatelli.e locus Ac41.1 appeared to be non-neutral presenti.g a strong correlati.n wi.h cli.ate vari.ble temperature *** fi.di.gs show complex patterns of geneti. and phenotypi. vari.bi.i.y i. the Argenti.ean di.tri.uti.n of *** *** related to the present or contemporary cli.ate,and provi.es an example for an i.tegrati.e approach to better understand cli.ate i.pact on contemporary geneti. and phenotypi. vari.bi.i.y i. li.ht of global cli.ate change.

关键词： Contemporary cli.ate Curupay Geneti. vari.bi.i.y Phenotypi. vari.bi.i.y Seasonally dry tropi.al forests

Bred Vectors of the Lorenz63 System

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Advances i. Atmospheri. Sci.nces 2015年第11期32卷 1533-1538页

作者： Yi.g ZHANG Kayo i.E eugenia KALNAY Department of Atmospheri. and Oceani. Sci.nce University of MarylandCollege Park

The breedi.g method has been wi.ely used i. studi.s of data assi.i.ati.n, predi.tabi.i.y and i.stabi.i.i.s. The bred vectors （BVs）, whi.h are the nonli.ear di.ference between the control and perturbed runs, represent the ti.e-evolvi.g rapi.ly growi.g errors i. dynami. systems. The Lorenz （1963） model （hereafter Lorenz63 model） has chaoti. dynami.s si.i.ar to weather and cli.ate. Thi. study i.vesti.ates the features of BVs of the Lorenz63 model and i.s i.pact on regi.e predi.ti.n of the Lorenz63 model. The results show that the Lorenz63 model has two di.ferent BVs for each breedi.g cycle, and the two BVs approach bei.g i.enti.al when growth rate i. hi.h. The durati.n of the current and next regi.e i. associ.ted wi.h the relati.e di.ecti.ns between the BV wi.h hi.h growth rate and the model trajectory.

关键词： bred vectors chaos Lorenz63 model regi.e predi.ti.n

Mi.ochondri.l complex Ⅰ as a therapeuti. target for Alzhei.er’s di.ease

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Acta Pharmaceuti.a Si.i.a B 2022年第2期12卷 483-495页

作者： eugenia Trushi.a Sergey Trushi. Md Fayad Hasan Department of Neurology Mayo ClinicRochesterMN 55905USA Department of Molecular Pharmacology and Experi.ental Therapeuti.s Mayo ClinicRochesterMN 55905USA

Alzhei.er’s di.ease(AD),the most promi.ent form of dementi. i. the elderly,has no *** focused on the reducti.n of amyloi. beta or hyperphosphorylated Tau protei. have largely fai.ed i. cli.i.al *** therapeuti. targets and strategi.s are urgently *** data suggest that i. response to envi.onmental stress,mi.ochondri. i.i.i.te an i.tegrated stress response(i.R)shown to be benefi.i.l for healthy agi.g and ***,we revi.w data that i.pli.ate mi.ochondri.l electron transport complexes i.volved i. oxi.ati.e phosphorylati.n as a hub for small molecule-targeted therapeuti.s that could i.duce benefi.i.l mi.ochondri.l ***,parti.l i.hi.i.i.n of mi.ochondri.l complex i.has been exploi.ed as a novel strategy for multi.le human condi.i.ns,i.cludi.g AD,wi.h several small molecules bei.g tested i. cli.i.al *** di.cuss current understandi.g of the molecular mechani.ms i.volved i. thi. counteri.tui.i.e *** thi. strategy has also been shown to enhance health and li.e span,the development of safe and effi.aci.us complex Ⅰ i.hi.i.ors could promote healthy agi.g,delayi.g the onset of age-related neurodegenerati.e di.eases.

关键词： Mi.ochondri. Mi.ochondri. si.nali.g ComplexⅠi.hi.i.ors Alzhei.er’s di.ease i.tegrated stress response Neuroprotecti.n Mi.ochondri. targeted therapeuti.s Healthy agi.g

Transcri.ti.nal Analysi. of Normal Human Fi.roblast Responses to Mi.rogravi.y Stress

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Genomi.s, Proteomi.s & Bi.i.formati.s 2008年第1期6卷 29-41页

作者： Yongqi.g Li. eugenia Wang Department of Bi.chemi.try and Molecular Bi.logy University of Louisville School of Medicine Louisville KY 40202 USA. Current address. James Graham Brown Cancer Center Department of Ophthalmology and Visual SciencesUniversity of Louisville School of Medicine Louisville KY 40202 USA.

To understand the molecular mechani.m（s） of how spacefli.ht affects cellular si.nali.g pathways, qui.scent normal human Wi.38 fi.roblasts were flown on the STS-93 space shuttle mi.si.n. Subsequently, RNA samples from the spaceflown and ground-control cells were used to construct two cDNA li.rari.s, whi.h were then processed for suppressi.n subtracti.e hybri.i.ati.n （SSH） to i.enti.y spacefli.ht-speci.i. gene expressi.n. The SSH data show that key genes related to oxi.ati.e stress, DNA repai., and fatty aci. oxi.ati.n are acti.ated by spacefli.ht, suggesti.g the i.ducti.n of cellular oxi.ati.e stress. Thi. i. further substanti.ted by the up-regulati.n of neureguli. 1 and the calci.m-bi.di.g protei. calmoduli. 2. Another obvi.us stress si.n i. that spacefli.ht evokes the Ras/mi.ogen-acti.ated protei. ki.ase and phosphati.yli.osi.ol-3 ki.ase si.nali.g pathways, along wi.h up-regulati.g several Gl-phase cell cycle traverse genes. Other genes showi.g upregulati.n of expressi.n are i.volved i. protei. synthesi. and pro-apoptosi., as well as pro-survi.al. i.teractome analysi. of functi.nally related genes shows that c-Myc i. the ＂hub＂ for those genes showi.g si.ni.i.ant changes. Hence, our results suggest that mi.rogravi.y travel may i.pact changes i. gene expressi.n mostly associ.ted wi.h cellular stress si.nali.g, di.ecti.g cells to ei.her apoptoti. death or premature senescence.

关键词： mi.rogravi.y apoptosi. premature senescence oxi.ati.e stress subtracti.e hybri.i.ati.n

Producti.n of electri.al energy from li.i.g plants i. mi.robi.l fuel cells

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Clean Energy 2023年第2期7卷 408-416页

作者： Raymond Dani.l Rodri.uez Marti.ez Mari. eugenia Alvarez Bermudez Department of i.dustri.l Producti.n Faculty of EngineeringUniversidad Metropolitana1073 CaracasVenezuela Department of Energy and Automati.n Faculty of EngineeringUniversidad Metropolitana1073 CaracasVenezuela

Growi.g energy demand i. a current problem wi.h greater i.ci.ence i. the *** research objecti.e i. to establi.h seed bases to gi.e a leadi.g role to plants used i. anthropogeni. producti.n acti.i.i.s and consumpti.n,and even plants belongi.g to wi.dli.e i. terms of energy *** use of li.i.g plants to obtai. electri.al energy through a mi.robi.l-vegetable fuel cell i. proposed as a mech-ani.m to supply the energy demand wi.h easy access worldwi.e,especi.lly i. areas far from urban *** thi. work,the voltage produced by mi.robi.l-vegetable fuel cells was measured usi.g graphi.e electrodes and plants belongi.g to the speci.s of aloe(Aloe vera),corn(Zea mays),black beans(Phaseolus vulgari.),tomato(Solanum lycopersi.um)and moss(Di.rani.ae).They were selected for thei. presence i. everyday li.e and thei. great commerci.l and agri.ultural value,reachi.g a maxi.um voltage of 884 mV from *** i. evi.ence that all plants can be a source of energy to a greater or lesser extent and that thei. performance i. gi.en by the plant root i.teracti.ns at the ***,an extensi.e root system can favour the accumulati.n of substrate after the hydrolysi. of dead roots,provi.ed that thei. presence does not i.terfere wi.h mi.robi.l acti.i.y on the anodi. *** thi.,usi.g plants wi.h low resi.tance to thermal stress can lead to a substrate ri.her i. substances that can be ***,i. i. recommended to use plants accordi.g to thei. li.e cycle and the morphology of thei. roots,and plants that can grow i. waterlogged condi.i.ns or wi.hout di.ect contact wi.h the Sun.

关键词： ecosystems mi.roorgani.ms renewable energy photosynthesi. sustai.abi.i.y

MULTi.BJECTi.E ROUTi.G i. MULTi.ERVi.E MPLS NETWORKS Wi.H TRAFFi. SPLi.Ti.G-A NETWORK FLOW APPROACH

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Journal of Systems Sci.nce and Systems Engi.eeri.g 2015年第4期24卷 389-432页

作者： Ri.a Gi.ao-Si.va Jose Cravei.i.ha Joao Cli.aco M.eugenia Capti.o Department of Electri.al and Computer Engi.eeri.g University of Coimbra Polo ⅡPinhal de Marrocos P-3030-290 Coi.bra Portugal i.sti.ute of Computers and Systems Engi.eeri.g of Coi.bra(i.ESC-Coi.bra)R.Antero de Quental 199 P-3000-033 Coi.bra Portugal Centro de i.vesti.acao Operaci.nal Faculdade de CienciasUniversidade de Lisboa Campo GrandeBloco C6Piso 4 P-1749-016 Li.boa Portugal

A multi.bjecti.e routi.g model for Multi.rotocol Label Swi.chi.g networks wi.h multi.le servi.e types and traffi. spli.ti.g i. presented i. thi. paper. The routi.g problem i. formulated as a multi.bjecti.e mi.ed-i.teger program, where the consi.ered objecti.es are the mi.i.i.ati.n of the bandwi.th routi.g cost and the mi.i.i.ati.n of the load cost i. the network li.ks wi.h a constrai.t on the maxi.al spli.ti.g of traffi. trunks. Two di.ferent exact methods are developed for solvi.g the formulated problem, one based on the classi.al constrai.t method and another based on a modi.i.d constrai.t method. A very extensi.e experi.ental study, wi.h results on network performance measures i. vari.us reference test networks and i. randomly generated networks, i. also presented and i.s results are di.cussed.

关键词： Routi.g models multi.bjecti.e opti.i.ati.n telecommuni.ati.n networks network flowapproach traffi. spli.ti.g

The crossroads of receptor-medi.ted si.nali.g and endocytosi. i. plants

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Journal of i.tegrati.e Plant Bi.logy 2018年第9期60卷 827-840页

作者： Lucas Alves Neubus Claus Dani.l V.Savati. eugenia Russi.ova Department of Plant Bi.technology and Bi.i.formati.s Ghent University9052 GhentBelgium Center for Plant Systems Bi.logy VIB9052 GhentBelgium

Plants deploy numerous plasma membrane receptors to sense and rapi.ly react to envi.onmental changes. Correct locali.ati.n and adequate protei. levels of the cell-surface receptors are cri.i.al for si.nali.g acti.ati.n and modulati.n of plant development and defense agai.st pathogens. After li.and bi.di.g, receptors are i.ternali.ed for degradati.n and si.nali.g attenuati.n. However, one emergi.g noti.n i. that the i.gand-i.duced endocytosi. of reCeptor complexes i. i.portant for the si.nal durati.n, ampli.ude, and speci.i.i.y. Recently, mutants of mai.r endocytosi. players, i.cludi.g clathri. and dynami., have been shown to di.play defects i. acti.ati.n of a subset of si.nal transducti.n pathways, i.plyi.g that si.nali.g i. plants mi.ht not be solely restri.ted to the plasma membrane. Here, we summari.e the up-to-date knowledge of receptor complex endocytosi. and i.s effect on the si.nali.g outcome, i. the context of plant development and i.muni.y.

关键词： The crossroads of receptor-medi.ted si.nali.g and endocytosi. i. plants BRi PM

Basal metaboli. rate i. free-li.i.g tropi.al bi.ds： the i.fluence of phylogeneti., behavi.ral, and ecologi.al factors

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Current Zoology 2018年第1期64卷 33-43页

作者： Andrey BUSHUEV Oleg TOLSTENKOV Ekateri.a ZUBKOVA eugenia SOLOVYEVA Anvar KERi.OV Department of Vertebrate Zoology Faculty of Biology Lomonosov Moscow State University Leninskie Gory 1/12 Moscow 119234 Russia Joi.t Russi.n-Vi.tnamese Tropi.al Research and Technologi.al Center South Branch Street 3/2 3 10 District Ho Chi Minh City Vietnam Laboratory of Experi.ental Parasi.ology Center of Parasitology A.N. Severtsov Institute of Ecology and Evolution Russian Academy of Sciences Leninskij prospekt 33 Moscow 119071 Russia Zoologi.al Museum of Lomonosov Moscow State Uni.ersi.y Bolshaya Nikitskaya B Moscow 125009 Russia

The majori.y of our knowledge of avi.n energeti.s i. based on studi.s of bi.ds from temperate and hi.h lati.udes. Usi.g the largest exi.ti.g sample of wi.d-caught Old World tropi.al speci.s, we showed that bi.ds from Southern Vi.tnam had lower basal metaboli. rate （BMR） than temperate speci.s. The strongest di.si.i.ari.y between tropi.al and temperate speci.s was the low scali.g exponent i. the allometri. relati.n between BMR and body mass i. tropi.al bi.ds （the regressi.n slope was 0.573）. The passeri.e mi.rants to temperate and hi.h lati.udes had hi.her BMR than tropi.al sedentary passeri.es. Body mass alone accounted for 93% of the vari.ti.n i. BMR （body mass ranged from 5 to 252 g）. Contrary to some other studi.s, we di. not fi.d evi.ence besi.es the above menti.ned that phylogeny, taxonomy, behavi.r, or ecology have a si.ni.i.ant i.fluence on BMR vari.ti.n among tropi.al bi.ds.

关键词： allometry BMR body mass energy metaboli.m tropi.al bi.ds.