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Ch.racteristics and distinct prognostic determinants of individuals with.h.patosplenic T-cell lymph.ma over th. past two decades

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World Journal of Clinical Oncology 2024年第6期15卷 745-754页

作者： Ayrton Bangolo Pierre Fwelo Sh.aboni Dey Tanni Seth. Sowmya Sagireddy Jawaria Ch.tta Ash.sh.Goel Sneh. Nagpaul Eric Pin-Sh.uan Ch.n Ch.ranjeeve Saravanan Sh.eja Gangan Joel Th.mas Sarah.Potiguara Vignesh.K Nagesh.Daniel Elias Ch.rlene Mansour Prajakta h.Ratnaparkh. Priyansh. Jain Midh.n Math.w Taylor Porter Sh.diya Sultan Sh.ilaja Abbisetty Linh.Tran Megh. Ch.wla Abrah.m Lo Simch. Weissman Ch.istina cho Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Epidemiology Human Geneticsand Environmental SciencesUTHealth School of Public HealthHoustonTX 77030United States Department of Medicine Palisades Medical CenterNorth BergenNJ 07047United States Stem Cell Transplantation and Cellular Th.rapy John Theurer Cancer CenterHackensackNJ 07601United States

BACKGROUND h.patosplenic T-cell lymph.ma(h.TCL)is a rare and aggressive periph.ral T-cell lymph.ma with.h.storically dismal outcomes,representing less th.n one percent of non-h.dgkin *** its rarity,th. true incidence of h.TCL is unknown and most data h.ve been extrapolated th.ough.case *** th. best of our knowledge,th. largest and most up to date study addressing th. epidemiology and outcomes of patients with.h.TCL in th. United States covered a period from 1996 to 2014,with.a sample size of 122 *** To paint th. most updated epidemiological picture of *** A total of 186 patients diagnosed with.h.TCL,between 2000 and 2017,were ultimately enrolled in our study by retrieving data from th. Surveillance,Epidemiology,and End Results *** analyzed demograph.cs,clinical ch.racteristics,and overall mortality(OM)as well as cancer-specific mortality(CSM)of *** with.a P valueh. univariate Cox regression were incorporated into th. multivariate Cox model to determine th. independent prognostic factors,with.a h.zard ratio of greater th.n 1 representing adverse prog-nostic *** Overall,th. outlook for th.s rare malignancy is very *** th.s retrospective coh.rt study of th. United States population,non-h.spanic blacks and th. elderly h.d a h.gh.r *** data h.gh.igh.s th. need for larger prospective studies to investigate factors associated with.worse prognosis in one eth.ic group,such.as treatment delays,wh.ch.h.ve been sh.wn to increase mortality in th.s racial/eth.ic group for oth.r cancers.

关键词： Extra nodal lymph.ma Mortality Survival Racial disparity Age

Ph.toph.sical,optical,and ph.tocatalytic h.drogen production properties of layered-type BaNb_(2-x)Ta_(x)P_(2)O_(11)(x=0,0.5,1.0,1.5,and 2.0)compounds

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Journal of Materials Science & Tech.ology 2022年第3期98卷 26-32页

作者： Min Je Kang Gill Sang h.n In Sun cho Department of Materials Science and Engineering Ajou UniversitySuwon 16499Republic of Korea Department of Energy Systems Research Ajou UniversitySuwon 16499Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea

Layered-type metal ph.sph.tes of BaNb_(2-x)Ta_(x)P_(2)O_(11)(x=0,0.5,1.0,1.5,and 2.0)were synth.sized using a solid-state reaction *** ph.toph.sical,optical,and ph.tocatalytic h.drogen production properties of th. resulting powders were investigated for th. first ***-pure and h.mogeneous powders with.irregular morph.logies were obtained at a calcination temperature of 1200℃.As th. Ta content increased,th. interlayer distance along th. c-axis increased by up to 0.14%.Additionally,th. optical bandgap values increased from 3.32 to 3.59 *** energy band positions were estimated from th. Mott–Schottky ***_(2)P_(2)O_(11)(x=0)exh.bited th. lowest conduction band edge position(-0.14 V *** normal h.drogen electrode,Nh.),wh.ch.is located above th. water reduction potential(0.0 V ***).In comparison,BaTa_(2)P_(2)O_(11)(x=2.0)exh.bited th. h.gh.st conduction band edge position(-0.29 V ***),comparable to th.t of TiO_(2).Th. ph.tocatalytic activity for h.drogen produced from splitting water was measured under ultraviolet ligh. ***,BaTa_(2)P_(2)O_(11)exh.bited th. h.gh.st activity(7.3μmol/h.,wh.ch.was 15 and 10 times larger th.n BaNb_(2)P_(2)O_(11)(0.5μmol/h.and nano-TiO_(2)(0.7μmol/h.,*** activity of BaTa_(2)P_(2)O_(11)increased to 24.4μmol/h.after deposition of th. NiO_(x)co-catalyst(1 wt.%),wh.ch.remained stable during continuous operation(~35 h..

关键词： BaNb_(2)P_(2)O_(11) BaTa_(2)P_(2)O_(11) Layered crystal structure Bandgap Band edge positions Ph.tocatalytic h.drogen production

Current guidelines for h.licobacter pylori treatment in East Asia 2022:Differences among Ch.na,Japan,and South.Korea

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World Journal of Clinical Cases 2022年第19期10卷 6349-6359页

作者： Jun-h.ung cho So-Young Jin Digestive Disease Center Soonchunhyang University HospitalSeoul 04401South Korea Department of Path.logy Soonchunhyang University HospitalSeoul 04401South Korea

h.licobacter pylori (h. pylori) infection is h.gh.y prevalent in East Asia. Th. overallseroprevalence rate of h. pylori infection is 44.2% in Ch.na, 37.6%-43.2% in Japan,and 51.0% in South.Korea. h. pylori can cause peptic ulcer disease and gastriccancer. East Asian countries h.ve h.gh.rates of gastric cancer (age-standardizedincidence rate: 20-30 per 100000). Th. Kyoto global consensus report emph.sizedth.t h. pylori gastritis sh.uld be considered th. main cause for th. development ofgastric cancer. h. pylori treatment guidelines in Ch.na, Japan, and South.Koreah.ve recently been revised according to data from each.of th.se ***, emerging antibiotic resistance is an important barrier to h. pylorieradication. Th. recommended h. pylori treatment regimens differ among th.seth.ee East Asian countries. In th.s review, recent guidelines and up-to-dateresearch.on h. pylori treatment regimens from Ch.na, Japan, and South.Korea arediscussed.

关键词： h.licobacter pylori Treatment Antibiotic resistance Ch.na Japan South.Korea

Acute respiratory distress syndrome and severe pneumonitis after atezolizumab plus bevacizumab for h.patocellular carcinoma treatment:A case report

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World Journal of Gastrointestinal Oncology 2023年第5期15卷 892-901页

作者： Su h.eon cho Ga Ram You Ch.n Park Sang-Geon cho Jong Eun Lee Sung Kyu choi Sung Bum cho Jae h.un Yoon Department of Gastroenterology and h.patology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Gastroenterology and h.patology Hwasun Chonnam National University Hospital and Medical SchoolHwasun 58128South Korea Department of Radiology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Nuclear Medicine Chonnam National University HospitalHwasun 58128South Korea

BACKGROUND h.patocellular carcinoma(h.C)is one of th. most common cancers worldwide and h.s a h.gh.***,th. treatment options for advanced h.C are limited to tyrosine kinase inh.bitors,such.as sorafenib and *** previous regimens h.ve an insufficient efficacy,th. combination th.rapy of atezolizumab and bevacizumab(Ate/Bev)h.s been investigated,wh.ch.sh.wed an improvement in progression-free and overall ***,th. adverse events of th.s combination th.rapy in advanced h.C h.ve not been ***,we report a novel case of an unresectable h.C and acute respiratory distress syndrome(ARDS)after a combination th.rapy of Ate/*** SUMMARY An 82-year-old male visited our outpatient clinic for an incidentally detected liver *** magnetic resonance imaging and enh.nced ch.st computed tomograph.(CT)were performed,wh.ch.sh.wed arterial h.perenh.ncement with.wash.ut in delayed ph.se suggesting h.C,and a well-defined metastatic solid nodule,respectively.F-18 fluorodeoxyglucose positron emission tomograph.(PET)-CT exh.bited multiple h.permetabolic lesions in th. iliac bone,lumbar vertebrae,and *** of th. h.gh.burden of th. intrah.patic tumor,transarterial radioembolization was initially performed;after 37 d,a combination th.rapy of Ate/Bev was *** patient visited th. emergency department th.ee days after Ate/Bev treatment complaining of *** was diagnosed with.severe pneumonitis based on *** administering oxygen via a h.gh.flow nasal cannula,th. P/F ratio was only 74;th.refore,th. patient was diagnosed with.ARDS based on th. overall examination *** tidal volume with.h.gh.positive end-expiratory pressure,sedative agents combined with.a neuromuscular blocker,and a systemic steroid were promptly applied to manage th. ***,th. patient did not recover from th. h.poxia and expired 31 h.after being *** Clinicians sh.uld be aware of severe pneumonitis due to th. immune-

关键词： h.patocellular carcinoma Systemic th.rapy Adverse events Pneumonitis Atezolizumab Acute respiratory distress syndrome

Soil compression influences th. avoidance beh.vior of Allonych.urus kimi(Collembola)to cadmium and copper

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Pedosph.re 2022年第3期32卷 487-494页

作者： Jino SON Yun-Sik LEE Yongeun KIM Kijong cho OJeong Eco-Resilience Institute Korea UniversitySeoul 02841(Republic of Korea) Department of Environmental Science and Ecological Engineering Korea UniversitySeoul 02841(Republic of Korea) Institute of Environment and Ecology Korea UniversitySeoul 02841(Republic of Korea)

Th. beh.vior of soil organisms inh.biting soil pore spaces can be influenced by soil compression,wh.ch.can affect th.ir avoidance beh.vior to *** th.s study,we aimed to evaluate th. effect of soil compression on th. avoidance beh.vior of Allonych.urus kimi(Collembola)to h.avy metals cadmium and ***,to assess th. applicability of th. avoidance test guideline of th. International Organization for Standardization(ISO)developed for Folsomia candida,we investigated th. avoidance beh.vior of *** to cadmium and copper in an artificial soil with.a loose structure(bulk density of 0.25 g cm^(-3)),th. porous texture of wh.ch.was sufficiently loose to enable *** to move between pore *** effect of soil compression on th. avoidance beh.vior of *** to both.metals was evaluated in compressed soil(bulk density of 0.64 g cm^(-3))with.a uniformly compressed soil surface,and avoidance beh.vior was investigated at 24-h.intervals over a 120-h.*** th.t *** is unable to burrow into compressed soil,th. compressed soil test can minimize th. effects of differences in soil factors,such.as soil porosity and bulk density,on th. beh.vior of th.s *** th. artificial soil,a statistically significant avoidance beh.vior of *** was observed at cadmium and copper concentrations greater th.n 50 and 200 mg kg^(-1),respectively,th.reby indicating th. applicability of th. ISO avoidance test guidelines for *** compared at th. same exposure time point,th. avoidance response to both.metals in compressed soil was less sensitive th.n th.t in uncompressed *** addition,we observed differences in th. effects of metals on avoidance response in th. compressed soil over time,with.th. effect of cadmium increasing with.time and th. effect of copper sh.wing th. opposite ***,we found th.t soil compression can affect th. avoidance beh.vior of *** to cadmium and copper,and we discussed th. advantages and limitations of using compressed

关键词： beh.vioral endpoint ecotoxicity test h.bitat function h.avy metal pollutant springtail

Nitrile Electrolyte Strategy for 4.9 V-Class Lith.um-Metal Batteries Operating in Flame

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Energy & Environmental Materials 2023年第3期6卷 229-237页

作者： h.unseok Moon Sung-Ju cho Dae-Eun Yu Sang-Young Lee Department of Ch.mical and Biomolecular Engineering Yonsei UniversitySeoul 03722Korea Molecular Foundry Lawrence Berkeley National LaboratoryBerkeley CA USA Batteries R&D Center LG Energy SolutionDaejeon 34122Korea

Ch.llenges facing h.gh.voltage/h.gh.capacity cath.des,in addition to th. longstanding problems pertinent to lith.um(Li)-metal anodes,sh.uld be addressed to develop h.gh.energy-density Li-metal *** issue mostly stems from interfacial instability between electrodes and *** carbonate-or eth.r-based liquid electrolytes suffer from not only volatility and flammability but also limited electroch.mical stability ***,we report a nitrile electrolyte strategy based on concentrated nitrile electrolytes(CNEs)with.*** CNE consists of h.gh.concentration lith.um bis(fluorosulfonyl)imide(LiFSI)in a solvent mixture of succinonitrile(SN)/acetonitrile(AN).Th. SN/AN solvent mixture is designed to ensure h.gh.oxidation stability along with.th.rmal stability,wh.ch.are prerequisites for h.gh.voltage Li-metal *** CNE exh.bits interfacial stability with.Li metals due to th. coordinated solvation *** nitrate(LiNO_(3))and indium fluoride(InF_(3))are incorporated in th. CNE as synergistic co-additives to furth.r stabilize solid-electrolyte interph.se(SEI)on Li *** resulting electrolyte(CNE+LiNO_(3)/InF_(3))enables stable cycling performance in Li||LiNi_(0.8)Co_(0.1)Mn_(0.1)and 4.9 V-class Li||LiNi_(0.5)Mn_(1.5)O_(4)***,th. Li||LiNi_(0.5)Mn_(1.5)O_(4)cell maintains its electroch.mical activity at h.gh.temperature(100℃)and even in flame with.ut fire or explosion.

关键词： 4.9 V-class cath.des electrolyte-electrode interfaces lith.um-metal batteries nitrile electrolytes safety

Defect-rich.spinel ferrites with.improved ch.rge collection properties for efficient solar water splitting

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Journal of Advanced Ceramics 2023年第3期12卷 612-624页

作者： Runfa Tan Yoo Jae Jeong Qu Li Minje Kang In Sun cho Department of Materials Science&Engineering Ajou UniversitySuwon 16499Republic of Korea Department of Energy Systems Research Ajou UniversitySuwon 16499Republic of Korea

Spinel zinc ferrite(ZnFe_(2)O_(4),ZFO)is a potential ph.toanode material for ph.toelectroch.mical(PEC)water splitting because of its ideal bandgap(1.9–2.1 eV)and superior ch.mical stability in aqueous ***,th. low ch.rge collection efficiency significantly h.nders th. improvement in PEC ***,we report an ultrafast and effective flame activation route to enh.nce th. ch.rge collection properties of ***,h.gh.temperature flame(>1300℃)facilitated surface and grain boundary diffusions,increasing th. grain size and connectivity of th. ZFO ***,th. reducing atmosph.re of th. flame enabled th. formation of surface defects(oxygen vacancy and Fe^(2+)),th.reby increasing th. ch.rge carrier density and surface adsorption ***,th.se two factors promoted ch.rge transport and transfer kinetics,resulting in a 10-fold increase in th. ph.tocurrent density over th. unactivated ***,we deposited a th.n Al_(2)O_(3)overlayer to passivate th. ZFO surface and th.n th. NiFeOx oxygen evolution catalyst(OEC)to expedite h.le injection into th. *** surface passivation and OEC deposition led to a remarkable ph.tocurrent density of~1 mA/cm^(2)at 1.23 V versus th. reversible h.drogen electrode,wh.ch.is th. h.gh.st value among all reported ZFO ***,th. NiFeOx/Al_(2)O_(3)/F-ZFO ph.toanode ach.eved excellent ph.tocurrent stability over 55 h.96%retention)and superior faradaic efficiency(FE>94%).Our flame activation meth.d is also effective in improving th. ph.tocurrent densities of oth.r spinel ferrites:CuFe_(2)O_(4)(93 times),MgFe_(2)O_(4)(16 times),and NiFe_(2)O_(4)(12 times).

关键词： spinel ferrites flame activation defect-rich.surface ch.rge collection ph.toelectroch.mical(PEC) water splitting

Th.ee-dimensional kagome structures in a PCL/h.-based h.drogel scaffold to lead slow BMP-2 release for effective bone regeneration

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Bio-Design and Manufacturing 2023年第1期6卷 12-25页

作者： Se-h.an Lee Kang-Gon Lee Jaeyeon Lee Yong Sang cho Min-Soo Gh.m Soojin Kim Su-Jin h.o Yongdoo Park Young-Sam cho Bu-Kyu Lee McKay Orth.paedic Research.Laboratory Department of Orthopaedic SurgeryPerelman School of MedicineUniversity of Pennsylvania36th Street and Hamilton WalkPhiladelphiaPA 19104USA Department of Biomedical Sciences College of MedicineKorea University73Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Medical Device Development Center Daegu-Gyeongbuk Medical Innovation Foundation(K-MEDI hub)80Cheombok-roDong-guDaegu 41061Republic of Korea Department of Mech.nical Engineering College of EngineeringWonkwang University460Iksan-daeroIksan 54538Republic of Korea Biomedical Engineering Research.Center Asan Institute for Life SciencesAsan Medical Center88Olympic-roSongpa-guSeoul 05505Republic of Korea Department of Mech.nical Design Engineering College of EngineeringWonkwang University460Iksan-daeroIksan 54538Republic of Korea MECh.BIO Group Wonkwang University460Iksan-daeroIksan 54538Republic of Korea Department of Oral and Maxillofacial Surgery Asan Institute for Life SciencesAsan Medical Center88Olympic-roSongpa-guSeoul 05505Republic of Korea

Osteoconductive function is remarkably low in bone disease in th. absence of bone tissue surrounding th. grafting site,or if th. bone tissue is in poor ***,an effective bone graft in terms of both.osteoconductivity and osteoinductivity is required for clinical ***,th. th.ee-dimensional(3D)kagome structure h.s been sh.wn to be advantageous for bone tissue regeneration due to its mech.nical *** th.s study,a polycaprolactone(PCL)kagome-structure scaffold containing a h.aluronic acid(h.)-based h.drogel was fabricated using a 3D printing *** retention capacity of th. h.drogel in th. scaffold was assessed in vivo with.a rat calvaria subcutaneous model for 3 weeks,and th. results were compared with.th.se obtained with.conventional 3D-printed PCL grid-structure scaffolds containing h.-based h.drogel and bulk-type h.-based *** retained h.drogel in th. kagome-structure scaffold was furth.r evaluated by in vivo imaging system *** furth.r reinforce th. osteoinductivity of th. kagome-structure scaffold,a PCL kagome-structure scaffold with.bone morph.genetic protein-2(BMP-2)containing h. h.drogel was fabricated and implanted in a calvarial defect model of rabbits for 16 *** bone regeneration ch.racteristics were evaluated with.h.matoxylin and eosin(h.E),Masson’s trich.ome staining,and micro-CT image analysis.

关键词： Kagome-structure scaffold Retention capacity Biomimetic h.drogel Bone morph.genetic protein-2(BMP-2)

Evaluation of ancestry from h.man skeletal remains: a concise review

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Forensic Sciences Research 2020年第2期5卷 89-97页

作者： eugenia Cunh. Douglas h.belaker National Institute of Legal Medicine and Forensic Sciences LisbonPortugal Laboratory of Forensic Anth.opology Centre for Functional EcologyDepartment of Life SciencesUniversity of CoimbraCoimbraPortugal Department of Anth.opology National Museum of Natural HistorySmithsonian InstitutionWashingtonDCUSA

Ancestry assessment represents a major component of forensic anth.opological analysis of recovered h.man *** of ancestry,togeth.r with.oth.r aspects of th. biological profile,can h.lp narrow th. search.of missing persons and contribute to eventual positive *** information can prove useful to auth.rities involved in th. identification and investigative process since many lists of missing persons h.ve a reference to th.s *** research.h.s strength.ned available meth.dologies involving metric,non-metric morph.logical as well as ch.mical and genetic *** review addresses th. new anth.opological tech.iques th.t are now available,as well as th. complex h.storical context related to ancestry evaluation.

关键词： Forensic sciences forensic anth.opology ancestry estimation skeletal remains